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Article ; Online: B

Drabek, Marianne / Hodkinson, Duncan / Horvath, Suzanne / Millar, Bonnie / Pszczolkowski Parraguez, Stefan / Tench, Christopher R / Tanasescu, Radu / Lankappa, Sudheer / Morriss, Richard / Walsh, David / Auer, Dorothee P

BMJ open

2023 Volume 13, Issue 10, Page(s) e073378

Abstract: Introduction: Chronic pain is a common health problem that is not efficiently managed by standard analgesic treatments. There is evidence that treatment resistance may result from maladaptive brain changes in areas that are fundamental to the perception ...

Abstract	Introduction: Chronic pain is a common health problem that is not efficiently managed by standard analgesic treatments. There is evidence that treatment resistance may result from maladaptive brain changes in areas that are fundamental to the perception of pain. Knee osteoarthritis is one of the most prevalent causes of chronic pain and commonly associated with negative affect. Chronic knee osteoarthritis pain is also associated with altered right anterior insula functional connectivity. We posit that reversal of these brain circuit alterations may be critical to alleviate chronic pain and associated negative affect, and that this can be achieved through non-invasive neuromodulation techniques. Despite growing interest in non-invasive neuromodulation for pain relief and proven efficacy in depression, results in chronic pain are mixed with limited high-quality evidence for clinical and mechanistic efficacy. Limitations include patient heterogeneity, imprecision of target selection, uncertain blinding and protocols that may deliver pulses at subclinical efficacy. Methods and analysis: We hence developed an optimised treatment protocol of connectivity-guided intermittent theta-burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex with accelerated delivery on four consecutive days (allowing 4 days within the same week as protocol variation) with five daily treatment sessions that will be piloted in a sham-controlled design in 45 participants with chronic knee pain. This pilot study protocol will assess feasibility, tolerability and explore mechanistic efficacy through serial functional/structural magnetic resonance imaging (MRI) and quantitative sensory testing. Ethics and dissemination: This pilot trial has been approved by the Ethics Committee Cornwall and Plymouth.Results of the pilot trial will be submitted to peer-reviewed journals, presented at research conferences and may be shared with participants and PPI/E advisors. Trial registration number: ISRCTN15404076.
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation/methods ; Pilot Projects ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/therapy ; Chronic Pain/therapy ; Chronic Pain/complications ; Secondary Care ; Brain ; Neuralgia/complications ; United Kingdom ; Treatment Outcome ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073378
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Article ; Online: Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus.

Singh, Ankur / Lal, Bechan / Kumar, Pankaj / Parhar, Ishwar S / Millar, Robert P

Cell and tissue research

2023 Volume 393, Issue 2, Page(s) 377–391

Abstract: Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss ...

Abstract	Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss-GnRH neurons in vertebrate's brain. NKB is also characterized in gonadal tissues; however, its role in gonads is poorly understood. Therefore, in the present study, the effects of NKB on gonadal steroidogenesis and gametogenesis through in vivo and in vitro approaches using NKB antagonist MRK-08 were evaluated. The results suggest that the NKB antagonist decreases the development of advanced ovarian follicles and germ cells in the testis. In addition, MRK-08 further reduces the production of 17β-estradiol in the ovary and testosterone in the testis under both in vivo and in vitro conditions in a dose-dependent manner. Furthermore, the in vitro MRK-08 treatment of gonadal explants attenuated the expression of steroidogenic marker proteins, i.e., StAR, 3β-HSD, and 17β-HSD dose-dependently. Moreover, the MAP kinase proteins, pERK1/2 & ERK1/2 and pAkt & Akt were also downregulated by MRK-08. Thus, the study suggests that NKB downregulates steroidogenesis by modulating the expressions of steroidogenic marker proteins involving ERK1/2 & pERK1/2 and Akt/pAkt signalling pathways. NKB also appears to regulate gametogenesis by regulating gonadal steroidogenesis in the catfish.
MeSH term(s)	Male ; Animals ; Female ; Neurokinin B/metabolism ; Catfishes/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Testis/metabolism ; Gametogenesis
Chemical Substances	Neurokinin B (86933-75-7) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2023-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-023-03788-0
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Article ; Online: Correction to: Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus.

Singh, Ankur / Lal, Bechan / Kumar, Pankaj / Parhar, Ishwar S / Millar, Robert P

Cell and tissue research

2023 Volume 393, Issue 3, Page(s) 595–596

Language	English
Publishing date	2023-07-14
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-023-03812-3
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Article ; Online: The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application.

Anderson, Richard A / Millar, Robert P

Journal of neuroendocrinology

2021 Volume 34, Issue 5, Page(s) e13081

Abstract: ... secretion of GnRH. Subsequent studies have shown the importance of the neurokinin B (NKB) system ...

Abstract	The delivery of gonadotropin-releasing hormone (GnRH) in a pulsatile mode to the gonadotropes has long been known to be essential for normal reproductive function. There have been numerous studies aimed at dissecting out the mechanisms underlying GnRH pulse generation. The discovery of kisspeptin as an upstream regulator of GnRH attracted the possibility that pulsatile kisspeptin governed the pulsatile secretion of GnRH. Subsequent studies have shown the importance of the neurokinin B (NKB) system in modulating kisspeptin secretion and this GnRH. A number of studies in laboratory rodents have supported this notion. By contrast, we present data from clinical studies in men and women, in a range of contexts, showing that continuous infusion of kisspeptin 10 at receptor-saturating levels gives rise to an increase in luteinizing hormone (LH) (GnRH) pulse frequency. This has been demonstrated in normal healthy and hypogonadal men, in normal women during the mid-cycle LH surge, in men and women with mutations in the genes encoding NKB or its receptor, neurokinin 3 receptor (NK3R), in women with polycystic ovary syndrome treated with NK3R antagonist, and in women treated with NK3R antagonist during the LH surge. These finds indicate that pulsatile secretion and action of kisspeptin on GnRH neurons is not required for the generation of LH (GnRH) pulses in humans. We also report that there is an absence of desensitization in humans exposed to continuous infusion of kisspeptin-10 at receptor-saturating concentrations over 22 h and briefly review GnRH, kisspeptin and NKB analogs and their clinical application.
MeSH term(s)	Female ; Gonadotropin-Releasing Hormone ; Humans ; Kisspeptins ; Luteinizing Hormone ; Neurokinin B ; Neurons ; Receptors, Neurokinin-3
Chemical Substances	Kisspeptins ; Receptors, Neurokinin-3 ; Gonadotropin-Releasing Hormone (33515-09-2) ; Neurokinin B (86933-75-7) ; Luteinizing Hormone (9002-67-9)
Language	English
Publishing date	2021-12-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.13081
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Article: Hepatitis B Virus Prevalence and Mother-to-Child Transmission Risk in an HIV Early Intervention Cohort in KwaZulu-Natal, South Africa.

Millar, Jane / Cromhout, Gabriela Z L / Mchunu, Noxolo / Bengu, Nomonde / Ndung'u, Thumbi / Goulder, Philip J / Matthews, Philippa C / McNaughton, Anna L

Open forum infectious diseases

2023 Volume 10, Issue 8, Page(s) ofad366

Abstract: Background: HIV and hepatitis B virus (HBV) prevalence are both high in KwaZulu-Natal ...

Abstract	Background: HIV and hepatitis B virus (HBV) prevalence are both high in KwaZulu-Natal, South Africa. HIV coinfection negatively affects HBV prognosis and can increase the likelihood of HBV mother-to-child transmission (MTCT). In an early HIV infant treatment intervention cohort of HIV-transmitting mother-child pairs in KwaZulu-Natal, we characterized maternal HBV prevalence and screened infants at risk. Methods: Infants were treated for HIV MTCT at birth, and combination regimens incidentally active against HBV were initiated within 21 days. Maternal samples (N = 175) were screened at birth for HBV infection (HBV surface antigen [HBsAg]), exposure to HBV (HBV anti-core IgG), and vaccination responses (HBV anti-S positive without other HBV markers). Infants of mothers who were HBV positive were screened for HBsAg at 1 and 12 months. Results: Evidence of HBV infection was present in 8.6% (n = 15) of maternal samples. Biomarkers for HBV exposure were present in 31.4% (n = 55). Evidence of HBV vaccination was uncommon in mothers (8.0%; n = 14). Despite prescription of antiretroviral therapy (ART) active against HBV, HBV DNA was detectable in 46.7% (7/15) of mothers who were HBsAg positive. Three mothers had HBV viral loads >5.3 log Discussion: This vulnerable cohort of HIV-transmitting mothers had a high prevalence of undiagnosed HBV. Early infant ART may have reduced the risk of MTCT in high-risk cases. Current HBV guidelines recommend ART prophylaxis, but these data underline the pressing need to increase availability of birth dose vaccines.
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad366
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Article ; Online: Does social deprivation correlate with meningococcal MenACWY, Hib/MenC and 4CMenB/Meningococcal Group B vaccine uptake in Northern Ireland?

Brennan, Orlaith C / Moore, John E / Millar, Beverley C

The Ulster medical journal

2022 Volume 91, Issue 1, Page(s) 9–18

Abstract: Background: Several meningococcal vaccines have been recently introduced into the infant and adolescent vaccination schedules in Northern Ireland to promote immunity to : Methods: Vaccination data was retrieved from the Cover of Vaccination Evaluated ...

Abstract	Background: Several meningococcal vaccines have been recently introduced into the infant and adolescent vaccination schedules in Northern Ireland to promote immunity to Methods: Vaccination data was retrieved from the Cover of Vaccination Evaluated Rapidly (COVER) database, for meningococcal vaccines (MenACWY, HiB/MenC & 4CMenB, as well as for MMR vaccine as a non-meningococcal control). Vaccine coverage data assessed included (i). Two doses of MenB by 12 months, (ii). All 3 doses of MenB by 24 months, (iii). HiB/MenC coverage, (iv). MenACWY (Year 12s, for NI) (v). First dose of MMR. Northern Ireland Multiple Deprivation Measures 2017 (NIMDM2017) were examined against 38 indicators in 7 domains. NI HSCT vaccine uptake dataset for each vaccine was correlated with each indicator in the HSCT NIMDM2017 dataset. Regression analysis was performed to determine the relationship between vaccine uptake and deprivation indicators and coefficient of variation (R Results: For 4CMenB (all 3 doses by 24 Months), HiB/MenC, MenACWY and for MMR, correlation of variation (R Conclusions: Within the last two decades, incidence of meningococcal disease has been on the decline. The introduction of meningococcal vaccines has contributed to this decrease and uptake of such vaccines should remain a public health priority to maintain the decline in meningococcal disease. Identifying contributing factors to low vaccine uptake, such as, the association between local deprivation and uptake of meningococcal vaccines, should be of public health importance and acknowledged by local governments and policy makers in their efforts to enhance vaccine uptake, both infant and teenage vaccination. There is a clear correlation with educational deprivation measures such as absenteeism and poor educational attainment and reduced vaccine uptake, perhaps through lack of understanding and willingness to vaccinate. This is where the importance of a clear and coherent public health message surrounding meningococcal vaccination should be prioritised, particularly to establish innovative modalities in a multidisciplinary team approach, to reach out to and increase vaccine uptake rates in socially deprived communities in Northern Ireland.
MeSH term(s)	Adolescent ; Aged ; Haemophilus influenzae type b ; Humans ; Infant ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines ; Neisseria meningitidis ; Northern Ireland/epidemiology ; Social Deprivation ; Vaccines, Conjugate
Chemical Substances	MenACWY ; Meningococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2022-02-11
Publishing country	Northern Ireland
Document type	Journal Article
ZDB-ID	603342-8
ISSN	2046-4207 ; 0041-6193
ISSN (online)	2046-4207
ISSN	0041-6193
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Article ; Online: A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT.

Health technology assessment (Winchester, England)

2022 Volume 26, Issue 12, Page(s) 1–82

Abstract: Background: Mother-to-baby transmission of group B : Objectives: We investigated if intrapartum ... with usual care (i.e. risk factor-directed antibiotics), among women with risk factors for vertical group B ... for vertical group B : Main outcome measures: Primary outcomes were rates of intrapartum ...

Abstract	Background: Mother-to-baby transmission of group B Objectives: We investigated if intrapartum antibiotic prophylaxis directed by a rapid intrapartum test reduces maternal and neonatal antibiotic use, compared with usual care (i.e. risk factor-directed antibiotics), among women with risk factors for vertical group B Design: An unblinded cluster randomised controlled trial with a nested test accuracy study, an economic evaluation and a microbiology substudy. Setting: UK maternity units were randomised to either a strategy of rapid test or usual care. Participants: Vaginal and rectal swabs were taken from women with risk factors for vertical group B Main outcome measures: Primary outcomes were rates of intrapartum antibiotic prophylaxis administered to prevent early-onset group B Results: Twenty-two maternity units were randomised and 20 were recruited. A total of 722 mothers (749 babies) participated in rapid test units and 906 mothers (951 babies) participated in usual-care units. There were no differences in the rates of intrapartum antibiotic prophylaxis for preventing early-onset group B Conclusions: The Group B Streptococcus 2 (GBS2) trial found no evidence that the rapid test reduces the rates of intrapartum antibiotic prophylaxis administered to prevent early-onset group B Future work: The role of routine testing for prevention of neonatal infection requires evaluation in a randomised controlled trial. Trial registration: Current Controlled Trials ISRCTN74746075. Funding: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Cost-Benefit Analysis ; Female ; Humans ; Infant, Newborn ; Mothers ; Pregnancy ; Streptococcal Infections/diagnosis ; Streptococcal Infections/drug therapy ; Streptococcal Infections/prevention & control ; Streptococcus agalactiae
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2006765-3
ISSN	2046-4924 ; 1366-5278
ISSN (online)	2046-4924
ISSN	1366-5278
DOI	10.3310/BICF1187
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Article ; Online: Detection of VEGF-A(xxx)b isoforms in human tissues.

Bates, David O / Mavrou, Athina / Qiu, Yan / Carter, James G / Hamdollah-Zadeh, Maryam / Barratt, Shaney / Gammons, Melissa V / Millar, Ann B / Salmon, Andrew H J / Oltean, Sebastian / Harper, Steven J

PloS one

2013 Volume 8, Issue 7, Page(s) e68399

Abstract: Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified by ... ...

Abstract	Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified by VEGF-A165b. The practical determination of expression levels of alternative isoforms of the same gene may be complicated by experimental protocols that favour one isoform over another, and the use of specific positive and negative controls is essential for the interpretation of findings on expression of the isoforms. Here we address some of the difficulties in experimental design when investigating alternative splicing of VEGF isoforms, and discuss the use of appropriate control paradigms. We demonstrate why use of specific control experiments can prevent assumptions that VEGF-A165b is not present, when in fact it is. We reiterate, and confirm previously published experimental design protocols that demonstrate the importance of using positive controls. These include using known target sequences to show that the experimental conditions are suitable for PCR amplification of VEGF-A165b mRNA for both q-PCR and RT-PCR and to ensure that mispriming does not occur. We also provide evidence that demonstrates that detection of VEGF-A165b protein in mice needs to be tightly controlled to prevent detection of mouse IgG by a secondary antibody. We also show that human VEGF165b protein can be immunoprecipitated from cultured human cells and that immunoprecipitating VEGF-A results in protein that is detected by VEGF-A165b antibody. These findings support the conclusion that more information on the biology of VEGF-A165b isoforms is required, and confirm the importance of the experimental design in such investigations, including the use of specific positive and negative controls.
MeSH term(s)	Alternative Splicing ; Animals ; Antibodies/immunology ; Antibodies/metabolism ; Antibody Specificity/immunology ; Blotting, Western ; Cell Line ; Cell Line, Tumor ; DNA Primers/genetics ; Gene Amplification ; Gene Expression Profiling ; Humans ; Immunoprecipitation ; Mice ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Protein Isoforms/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reference Standards ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Reverse Transcriptase Polymerase Chain Reaction/standards ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/immunology ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Antibodies ; DNA Primers ; Protein Isoforms ; RNA, Messenger ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2013-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0068399
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Article ; Online: Search for a Structure in the B_{s}^{0}π^{±} Invariant Mass Spectrum with the ATLAS Experiment.

Aaboud, M / Aad, G / Abbott, B / Abdinov, O / Abeloos, B / Abidi, S H / AbouZeid, O S / Abraham, N L / Abramowicz, H / Abreu, H / Abulaiti, Y / Acharya, B S / Adachi, S / Adamczyk, L / Adelman, J / Adersberger, M / Adye, T / Affolder, A A / Afik, Y /

Agheorghiesei, C / Aguilar-Saavedra, J A / Ahlen, S P / Ahmadov, F / Aielli, G / Akatsuka, S / Akerstedt, H / Åkesson, T P A / Akilli, E / Akimov, A V / Alberghi, G L / Albert, J / Albicocco, P / Alconada Verzini, M J / Alderweireldt, S / Aleksa, M / Aleksandrov, I N / Alexa, C / Alexander, G / Alexopoulos, T / Alhroob, M / Ali, B / Aliev, M / Alimonti, G / Alison, J / Alkire, S P / Allbrooke, B M M / Allen, B W / Allport, P P / Aloisio, A / Alonso, A / Alonso, F / Alpigiani, C / Alshehri, A A / Alstaty, M I / Alvarez Gonzalez, B / Álvarez Piqueras, D / Alviggi, M G / Amadio, B T / Amaral Coutinho, Y / Amelung, C / Amidei, D / Amor Dos Santos, S P / Amoroso, S / Anastopoulos, C / Ancu, L S / Andari, N / Andeen, T / Anders, C F / Anders, J K / Anderson, K J / Andreazza, A / Andrei, V / Angelidakis, S / Angelozzi, I / Angerami, A / Anisenkov, A V / Anjos, N / Annovi, A / Antel, C / Antonelli, M / Antonov, A / Antrim, D J / Anulli, F / Aoki, M / Aperio Bella, L / Arabidze, G / Arai, Y / Araque, J P / Araujo Ferraz, V / Arce, A T H / Ardell, R E / Arduh, F A / Arguin, J-F / Argyropoulos, S / Arik, M / Armbruster, A J / Armitage, L J / Arnaez, O / Arnold, H / Arratia, M / Arslan, O / Artamonov, A / Artoni, G / Artz, S / Asai, S / Asbah, N / Ashkenazi, A / Asquith, L / Assamagan, K / Astalos, R / Atkinson, M / Atlay, N B / Augsten, K / Avolio, G / Axen, B / Ayoub, M K / Azuelos, G / Baas, A E / Baca, M J / Bachacou, H / Bachas, K / Backes, M / Bagnaia, P / Bahmani, M / Bahrasemani, H / Baines, J T / Bajic, M / Baker, O K / Bakker, P J / Bakshi Gupta, D / Baldin, E M / Balek, P / Balli, F / Balunas, W K / Banas, E / Bandyopadhyay, A / Banerjee, Sw / Bannoura, A A E / Barak, L / Barberio, E L / Barberis, D / Barbero, M / Barillari, T / Barisits, M-S / Barkeloo, J T / Barklow, T / Barlow, N / Barnes, S L / Barnett, B M / Barnett, R M / Barnovska-Blenessy, Z / Baroncelli, A / Barone, G / Barr, A J / Barranco Navarro, L / Barreiro, F / Barreiro Guimarães da Costa, J / Bartoldus, R / Barton, A E / Bartos, P / Basalaev, A / Bassalat, A / Bates, R L / Batista, S J / Batley, J R / Battaglia, M / Bauce, M / Bauer, F / Bauer, K T / Bawa, H S / Beacham, J B / Beattie, M D / Beau, T / Beauchemin, P H / Bechtle, P / Beck, H P / Beck, H C / Becker, K / Becker, M / Becot, C / Beddall, A J / Beddall, A / Bednyakov, V A / Bedognetti, M / Bee, C P / Beermann, T A / Begalli, M / Begel, M / Behr, J K / Bell, A S / Bella, G / Bellagamba, L / Bellerive, A / Bellomo, M / Belotskiy, K / Beltramello, O / Belyaev, N L / Benary, O / Benchekroun, D / Bender, M / Benekos, N / Benhammou, Y / Benhar Noccioli, E / Benitez, J / Benjamin, D P / Benoit, M / Bensinger, J R / Bentvelsen, S / Beresford, L / Beretta, M / Berge, D / Bergeaas Kuutmann, E / Berger, N / Bergsten, L J / Beringer, J / Berlendis, S / Bernard, N R / Bernardi, G / Bernius, C / Bernlochner, F U / Berry, T / Berta, P / Bertella, C / Bertoli, G / Bertram, I A / Bertsche, C / Besjes, G J / Bessidskaia Bylund, O / Bessner, M / Besson, N / Bethani, A / Bethke, S / Betti, A / Bevan, A J / Beyer, J / Bianchi, R M / Biebel, O / Biedermann, D / Bielski, R / Bierwagen, K / Biesuz, N V / Biglietti, M / Billoud, T R V / Bilokon, H / Bindi, M / Bingul, A / Bini, C / Biondi, S / Bisanz, T / Bittrich, C / Bjergaard, D M / Black, J E / Black, K M / Blair, R E / Blazek, T / Bloch, I / Blocker, C / Blue, A / Blumenschein, U / Blunier, Dr / Bobbink, G J / Bobrovnikov, V S / Bocchetta, S S / Bocci, A / Bock, C / Boehler, M / Boerner, D / Bogavac, D / Bogdanchikov, A G / Bohm, C / Boisvert, V / Bokan, P / Bold, T / Boldyrev, A S / Bolz, A E / Bomben, M / Bona, M / Bonilla, J S / Boonekamp, M / Borisov, A / Borissov, G / Bortfeldt, J / Bortoletto, D / Bortolotto, V / Boscherini, D / Bosman, M / Bossio Sola, J D / Boudreau, J / Bouhova-Thacker, E V / Boumediene, D / Bourdarios, C / Boutle, S K / Boveia, A / Boyd, J / Boyko, I R / Bozson, A J / Bracinik, J / Brandt, A / Brandt, G / Brandt, O / Braren, F / Bratzler, U / Brau, B / Brau, J E / Breaden Madden, W D / Brendlinger, K / Brennan, A J / Brenner, L / Brenner, R / Bressler, S / Briglin, D L / Bristow, T M / Britton, D / Britzger, D / Brock, I / Brock, R / Brooijmans, G / Brooks, T / Brooks, W K / Brost, E / Broughton, J H / Bruckman de Renstrom, P A / Bruncko, D / Bruni, A / Bruni, G / Bruni, L S / Bruno, S / Brunt, B H / Bruschi, M / Bruscino, N / Bryant, P / Bryngemark, L / Buanes, T / Buat, Q / Buchholz, P / Buckley, A G / Budagov, I A / Buehrer, F / Bugge, M K / Bulekov, O / Bullock, D / Burch, T J / Burdin, S / Burgard, C D / Burger, A M / Burghgrave, B / Burka, K / Burke, S / Burmeister, I / Burr, J T P / Büscher, D / Büscher, V / Buschmann, E / Bussey, P / Butler, J M / Buttar, C M / Butterworth, J M / Butti, P / Buttinger, W / Buzatu, A / Buzykaev, A R / Cabrera Urbán, S / Caforio, D / Cai, H / Cairo, V M M / Cakir, O / Calace, N / Calafiura, P / Calandri, A / Calderini, G / Calfayan, P / Callea, G / Caloba, L P / Calvente Lopez, S / 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Z D / Grefe, C / Gregersen, K / Gregor, I M / Grenier, P / Grevtsov, K / Griffiths, J / Grillo, A A / Grimm, K / Grinstein, S / Gris, Ph / Grivaz, J-F / Groh, S / Gross, E / Grosse-Knetter, J / Grossi, G C / Grout, Z J / Grummer, A / Guan, L / Guan, W / Guenther, J / Guescini, F / Guest, D / Gueta, O / Gugel, R / Gui, B / Guido, E / Guillemin, T / Guindon, S / Gul, U / Gumpert, C / Guo, J / Guo, W / Guo, Y / Gupta, R / Gurbuz, S / Gustavino, G / Gutelman, B J / Gutierrez, P / Gutierrez Ortiz, N G / Gutschow, C / Guyot, C / Guzik, M P / Gwenlan, C / Gwilliam, C B / Haas, A / Haber, C / Hadavand, H K / Haddad, N / Hadef, A / Hageböck, S / Hagihara, M / Hakobyan, H / Haleem, M / Haley, J / Halladjian, G / Hallewell, G D / Hamacher, K / Hamal, P / Hamano, K / Hamilton, A / Hamity, G N / Hamnett, P G / Han, K / Han, L / Han, S / Hanagaki, K / Hance, M / Handl, D M / Haney, B / Hankache, R / Hanke, P / Hansen, J B / Hansen, J D / Hansen, M C / Hansen, P H / Hara, K / Hard, A S / Harenberg, T 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A / Nishu, N / Nisius, R / Nitsche, I / Nitta, T / Nobe, T / Noguchi, Y / Nomachi, M / Nomidis, I / Nomura, M A / Nooney, T / Nordberg, M / Norjoharuddeen, N / Novgorodova, O / Novotny, R / Nozaki, M / Nozka, L / Ntekas, K / Nurse, E / Nuti, F / O'Connor, K / O'Neil, D C / O'Rourke, A A / O'Shea, V / Oakham, F G / Oberlack, H / Obermann, T / Ocariz, J / Ochi, A / Ochoa, I / Ochoa-Ricoux, J P / Oda, S / Odaka, S / Oh, A / Oh, S H / Ohm, C C / Ohman, H / Oide, H / Okawa, H / Okumura, Y / Okuyama, T / Olariu, A / Oleiro Seabra, L F / Olivares Pino, S A / Oliveira Damazio, D / Oliver, J L / Olsson, M J R / Olszewski, A / Olszowska, J / Onofre, A / Onogi, K / Onyisi, P U E / Oppen, H / Oreglia, M J / Oren, Y / Orestano, D / Orgill, E C / Orlando, N / Orr, R S / Osculati, B / Ospanov, R / Otero Y Garzon, G / Otono, H / Ouchrif, M / Ould-Saada, F / Ouraou, A / Oussoren, K P / Ouyang, Q / Owen, M / Owen, R E / Ozcan, V E / Ozturk, N / Pachal, K / Pacheco Pages, A / Pacheco Rodriguez, L / 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/ Santoni, C / Santos, H / Santoyo Castillo, I / Sapronov, A / Saraiva, J G / Sasaki, O / Sato, K / Sauvan, E / Savage, G / Savard, P / Savic, N / Sawada, R / Sawyer, C / Sawyer, L / Sbarra, C / Sbrizzi, A / Scanlon, T / Scannicchio, D A / Schaarschmidt, J / Schacht, P / Schachtner, B M / Schaefer, D / Schaefer, L / Schaeffer, J / Schaepe, S / Schäfer, U / Schaffer, A C / Schaile, D / Schamberger, R D / Schegelsky, V A / Scheirich, D / Schenck, F / Schernau, M / Schiavi, C / Schier, S / Schildgen, L K / Schillo, C / Schioppa, E J / Schioppa, M / Schlenker, S / Schmidt-Sommerfeld, K R / Schmieden, K / Schmitt, C / Schmitt, S / Schmitz, S / Schnoor, U / Schoeffel, L / Schoening, A / Schoenrock, B D / Schopf, E / Schott, M / Schouwenberg, J F P / Schovancova, J / Schramm, S / Schuh, N / Schulte, A / Schultens, M J / Schultz-Coulon, H-C / Schumacher, M / Schumm, B A / Schune, Ph / Schwartzman, A / Schwarz, T A / Schweiger, H / Schwemling, Ph / Schwienhorst, R / Schwindling, J / Sciandra, A 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Siragusa, G / Siral, I / Sivoklokov, S Yu / Sjölin, J / Skinner, M B / Skubic, P / Slater, M / Slavicek, T / Slawinska, M / Sliwa, K / Slovak, R / Smakhtin, V / Smart, B H / Smiesko, J / Smirnov, N / Smirnov, S Yu / Smirnov, Y / Smirnova, L N / Smirnova, O / Smith, J W / Smith, M N K / Smith, R W / Smizanska, M / Smolek, K / Snesarev, A A / Snyder, I M / Snyder, S / Sobie, R / Socher, F / Soffa, A M / Soffer, A / Søgaard, A / Soh, D A / Sokhrannyi, G / Solans Sanchez, C A / Solar, M / Soldatov, E Yu / Soldevila, U / Solodkov, A A / Soloshenko, A / Solovyanov, O V / Solovyev, V / Sommer, P / Son, H / Song, W / Sopczak, A / Sosa, D / Sotiropoulou, C L / Sottocornola, S / Soualah, R / Soukharev, A M / South, D / Sowden, B C / Spagnolo, S / Spalla, M / Spangenberg, M / Spanò, F / Sperlich, D / Spettel, F / Spieker, T M / Spighi, R / Spigo, G / Spiller, L A / Spousta, M / St Denis, R D / Stabile, A / Stamen, R / Stamm, S / Stanecka, E / Stanek, R W / Stanescu, C / Stanitzki, M M / Stapf, B 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/ Tanaka, R / Tanioka, R / Tannenwald, B B / Tapia Araya, S / Tapprogge, S / Tarem, S / Tartarelli, G F / Tas, P / Tasevsky, M / Tashiro, T / Tassi, E / Tavares Delgado, A / Tayalati, Y / Taylor, A C / Taylor, A J / Taylor, G N / Taylor, P T E / Taylor, W / Teixeira-Dias, P / Temple, D / Ten Kate, H / Teng, P K / Teoh, J J / Tepel, F / Terada, S / Terashi, K / Terron, J / Terzo, S / Testa, M / Teuscher, R J / Thais, S J / Theveneaux-Pelzer, T / Thiele, F / Thomas, J P / Thomas-Wilsker, J / Thompson, P D / Thompson, A S / Thomsen, L A / Thomson, E / Tian, Y / Ticse Torres, R E / Tikhomirov, V O / Tikhonov, Yu A / Timoshenko, S / Tipton, P / Tisserant, S / Todome, K / Todorova-Nova, S / Todt, S / Tojo, J / Tokár, S / Tokushuku, K / Tolley, E / Tomlinson, L / Tomoto, M / Tompkins, L / Toms, K / Tong, B / Tornambe, P / Torrence, E / Torres, H / Torró Pastor, E / Toth, J / Touchard, F / Tovey, D R / Treado, C J / Trefzger, T / Tresoldi, F / Tricoli, A / Trigger, I M / Trincaz-Duvoid, S / Tripiana, M F / Trischuk, W / Trocmé, B / Trofymov, A / Troncon, C / Trovatelli, M / Truong, L / Trzebinski, M / Trzupek, A / Tsang, K W / Tseng, J C-L / Tsiareshka, P V / Tsirintanis, N / Tsiskaridze, S / Tsiskaridze, V / Tskhadadze, E G / Tsukerman, I I / Tsulaia, V / Tsuno, S / Tsybychev, D / Tu, Y / Tudorache, A / Tudorache, V / Tulbure, T T / Tuna, A N / Turchikhin, S / Turgeman, D / Turk Cakir, I / Turra, R / Tuts, P M / Ucchielli, G / Ueda, I / Ughetto, M / Ukegawa, F / Unal, G / Undrus, A / Unel, G / Ungaro, F C / Unno, Y / Uno, K / Urban, J / Urquijo, P / Urrejola, P / Usai, G / Usui, J / Vacavant, L / Vacek, V / Vachon, B / Vadla, K O H / Vaidya, A / Valderanis, C / Valdes Santurio, E / Valente, M / Valentinetti, S / Valero, A / Valéry, L / Vallier, A / Valls Ferrer, J A / Van Den Wollenberg, W / van der Graaf, H / van Gemmeren, P / Van Nieuwkoop, J / van Vulpen, I / van Woerden, M C / Vanadia, M / Vandelli, W / Vaniachine, A / Vankov, P / Vardanyan, G / Vari, R / Varnes, E W 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Physical review letters

2018 Volume 120, Issue 20, Page(s) 202007

Abstract: ... X→B_{s}^{0}π^{±}, B_{s}^{0}→J/ψϕ, is presented. The analysis is based on a data sample recorded ... corresponding to those reported by D0, and on the X production rate relative to B_{s}^{0} mesons, ρ_{X}, were ... determined at 95% confidence level. The results are N(X)<382 and ρ_{X}<0.015 for B_{s}^{0} mesons ...

Abstract	A search for the narrow structure, X(5568), reported by the D0 Collaboration in the decay sequence X→B_{s}^{0}π^{±}, B_{s}^{0}→J/ψϕ, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the LHC corresponding to 4.9 fb^{-1} of pp collisions at 7 TeV and 19.5 fb^{-1} at 8 TeV. No significant signal was found. Upper limits on the number of signal events, with properties corresponding to those reported by D0, and on the X production rate relative to B_{s}^{0} mesons, ρ_{X}, were determined at 95% confidence level. The results are N(X)<382 and ρ_{X}<0.015 for B_{s}^{0} mesons with transverse momenta above 10 GeV, and N(X)<356 and ρ_{X}<0.016 for transverse momenta above 15 GeV. Limits are also set for potential B_{s}^{0}π^{±} resonances in the mass range 5550 to 5700 MeV.
Language	English
Publishing date	2018-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.120.202007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improving meningococcal MenACWY and 4CMenB/meningococcal group B vaccine-related health literacy in patients: Importance of readability of pharmaceutical Patient Leaflets.

Brennan, Orlaith C / Moore, John E / Nutt, Thomas W / Moore, Peter Ja / Millar, Beverley C

Journal of clinical pharmacy and therapeutics

2021 Volume 46, Issue 4, Page(s) 1109–1116

Abstract: What is known and objective: Patient information leaflets (PILs) or Patient Leaflets (PLs) formally accompany dispensed medicines and are intended to provide the patient with information on how to use the medicine safely. To date, there have been no ... ...

Abstract	What is known and objective: Patient information leaflets (PILs) or Patient Leaflets (PLs) formally accompany dispensed medicines and are intended to provide the patient with information on how to use the medicine safely. To date, there have been no studies that have examined the readability of meningococcal vaccine patient-facing information, including information contained within the vaccine PIL. Given the role of pharmacists in presenting PILs to patients, it was, therefore, the aim of this study to quantitatively analyse the readability of Patient Leaflets, which accompany licensed meningococcal vaccines in the UK and US and to compare PILs to vaccine pharmaceutical manufacturers' summary of product characteristics (SPC), as well as other patient-facing vaccine-related information. Methods: Five sources of meningococcal vaccine information were examined for the licensed meningococcal vaccines in the UK (Bexsero, Menveo, Menitorix, Trumenba, Nimenrix & NeisVac-C) and in the United States (Bexsero, Menveo, Trumenba, Menactra, Menomune-A/C/Y/W-135, Menquadfi), including as follows: (i) SPC (Electronic Medicines Compendium, UK), (ii) Package Insert (FDA; USA), (iii) Patient Leaflet (Electronic Medicines Compendium, UK), (iv) Vaccine pharmaceutical websites and (v) government web resources. Readability was examined employing 10 readability metrics, including the Flesch Reading Ease and the Flesch-Kincaid Grade level. Results and discussion: The information source with the greatest readability scores was the UK Patient Leaflet, which had a mean Flesch Reading Ease score of 58.1 and a mean Flesch-Kincaid Grade score of 7.3, followed by the US Department of Health & Human Services patient-facing website for vaccines (55.9 & 8, respectively), followed by the US Centers for Disease Control and Prevention Vaccine Information Statement (47.3 & 9.4, respectively). Pharmaceutical patient-facing websites for meningococcal vaccines had mean scores of 44.6 and 9.9, respectively. When compared with UK Patient Leaflets, pharmaceutical websites were statistically different with poorer readability with both Flesch Reading Ease and Flesch-Kincaid Grade Level indices (p = 0.02 & p = 0.04, respectively). What is new and conclusion: Pharmaceutical meningococcal vaccine PILs were easily read and had statistically significant good readability scores in comparison with vaccine SPCs and US Package Inserts, pharmaceutical product websites and other government patient-facing meningococcal vaccine information. Preparation of patient-facing materials of a complex topic, such as describing meningococcal vaccines, is difficult to accomplish. Although there is a plurality of sources of information through websites and social media, PILs are one of the few sources that are provided directly to patients. This underpins the potential importance of PILs and the importance of their readability. Adoption of readability calculators and scrutiny of materials for their readability will help authors develop materials with improved understanding for vaccine recipients, potentially leading to improved health literacy and vaccine uptake. Renewed efforts should be sought to promote the information within the PIL, thereby maximizing the value of this resource with vaccine recipients, their carers and family.
MeSH term(s)	Comprehension ; Consumer Health Information/standards ; Drug Industry/standards ; Health Literacy/standards ; Humans ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines/administration & dosage ; Pamphlets ; United Kingdom ; United States ; Vaccines, Conjugate
Chemical Substances	4CMenB vaccine ; MenACWY ; Meningococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/jcpt.13405
Database	MEDical Literature Analysis and Retrieval System OnLINE

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