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Article ; Online: Impact of Nonpharmaceutical Interventions during the COVID-19 Pandemic on the Prevalence of Respiratory Syncytial Virus in Hospitalized Children with Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis.

Leija-Martínez, José J / Esparza-Miranda, Luis A / Rivera-Alfaro, Gerardo / Noyola, Daniel E

2024 Volume 16, Issue 3

Abstract: During the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were implemented in order to control the transmission of SARS-CoV-2, potentially affecting the prevalence of respiratory syncytial virus (RSV). This review evaluated the impact of NPIs ... ...

Abstract	During the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were implemented in order to control the transmission of SARS-CoV-2, potentially affecting the prevalence of respiratory syncytial virus (RSV). This review evaluated the impact of NPIs on RSV-related hospitalizations in children during the lockdown (2020-2021) compared to the pre-pandemic (2015-2020) and post-lockdown (2021-2022) periods. In this systematic review and meta-analysis, we searched through PubMed, Scopus, and Web of Science for studies published in English between 1 January 2015 and 31 December 2022. Additionally, we conducted hand searches of other records published between 1 January 2023 and 22 January 2024. Our target population was hospitalized children aged 0-18 years with RSV-related lower respiratory tract infections confirmed through immunofluorescence, antigen testing, or molecular assays. We focused on peer-reviewed observational studies, analyzing the primary outcome of pooled RSV prevalence. A generalized linear mixed model with a random-effects model was utilized to pool each RSV prevalence. Heterogeneity was assessed using Cochran's Q and
MeSH term(s)	Child ; Humans ; Child, Hospitalized ; Communicable Disease Control ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics ; Prevalence ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Respiratory Tract Infections/virology ; Infant, Newborn ; Infant ; Child, Preschool ; Adolescent
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16030429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Whole Blood Expression Levels of Long Noncoding RNAs: HOTAIRM1, GAS5, MZF1-AS1, and OIP5-AS1 as Biomarkers in Adolescents with Obesity-Related Asthma.

Leija-Martínez, José J / Guzmán-Martín, Carlos A / González-Ramírez, Javier / Giacoman-Martínez, Abraham / Del-Río-Navarro, Blanca E / Romero-Nava, Rodrigo / Villafaña, Santiago / Flores-Saenz, José Luis / Sánchez-Muñoz, Fausto / Huang, Fengyang

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Asthma is a heterogeneous entity encompassing distinct endotypes and varying phenotypes, characterized by common clinical manifestations, such as shortness of breath, wheezing, and variable airflow obstruction. Two major asthma endotypes based on ... ...

Abstract	Asthma is a heterogeneous entity encompassing distinct endotypes and varying phenotypes, characterized by common clinical manifestations, such as shortness of breath, wheezing, and variable airflow obstruction. Two major asthma endotypes based on molecular patterns are described: type 2 endotype (allergic-asthma) and T2 low endotype (obesity-related asthma). Long noncoding RNAs (lncRNAs) are transcripts of more than 200 nucleotides in length, currently involved in many diverse biological functions, such as chromatin remodeling, gene transcription, protein transport, and microRNA processing. Despite the efforts to accurately classify and discriminate all the asthma endotypes and phenotypes, if long noncoding RNAs could play a role as biomarkers in allergic asthmatic and adolescent obesity-related asthma, adolescents remain unknown. To compare expression levels of lncRNAs: HOTAIRM1, OIP5-AS1, MZF1-AS1, and GAS5 from whole blood of Healthy Adolescents (HA), Obese adolescents (O), allergic asthmatic adolescents (AA) and Obesity-related asthma adolescents (OA). We measured and compared expression levels from the whole blood of the groups mentioned above through RT-q-PCR. We found differentially expressed levels of these lncRNAs between the groups of interest. In addition, we found a discriminative value of previously mentioned lncRNAs between studied groups. Finally, we generated an interaction network through bioinformatics. Expression levels of OIP5-AS1, MZF1-AS1, HOTAIRM1, and GAS5 in whole blood from the healthy adolescent population, obese adolescents, allergic asthma adolescents, and obesity-related asthma adolescents are differently expressed. Moreover, these lncRNAs could act as molecular biomarkers that help to discriminate between all studied groups, probably through molecular mechanisms with several genes and miRNAs implicated.
MeSH term(s)	Adolescent ; Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Pediatric Obesity/complications ; Pediatric Obesity/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Asthma/genetics ; Biomarkers ; Cell Proliferation/genetics ; Kruppel-Like Transcription Factors
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; Biomarkers ; MZF1 protein, human ; Kruppel-Like Transcription Factors
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076481
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Article ; Online: The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D

Hernández-Díazcouder, Adrián / Romero-Nava, Rodrigo / Del-Río-Navarro, Blanca E / Sánchez-Muñoz, Fausto / Guzmán-Martín, Carlos A / Reyes-Noriega, Nayely / Rodríguez-Cortés, Octavio / Leija-Martínez, José J / Vélez-Reséndiz, Juan Manuel / Villafaña, Santiago / Hong, Enrique / Huang, Fengyang

Nutrients

2024 Volume 16, Issue 3

Abstract: Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway ... ...

Abstract	Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D
MeSH term(s)	Humans ; Cholecalciferol/pharmacology ; Cholecalciferol/therapeutic use ; MicroRNAs/genetics ; Airway Remodeling ; Asthma/drug therapy ; Asthma/genetics ; Asthma/complications ; Lung ; Inflammation/complications ; Dietary Supplements
Chemical Substances	Cholecalciferol (1C6V77QF41) ; MicroRNAs ; MIRN145 microRNA, human
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16030341
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Article ; Online: Negative Effects of Chronic High Intake of Fructose on Lung Diseases.

Hernández-Díazcouder, Adrián / González-Ramírez, Javier / Sanchez, Fausto / Leija-Martínez, José J / Martínez-Coronilla, Gustavo / Amezcua-Guerra, Luis M / Sánchez-Muñoz, Fausto

Nutrients

2022 Volume 14, Issue 19

Abstract: In the modern diet, excessive fructose intake (>50 g/day) had been driven by the increase, in recent decades, of the consumption of sugar-sweetened beverages. This phenomenon has dramatically increased within the Caribbean and Latin American regions. ... ...

Abstract	In the modern diet, excessive fructose intake (>50 g/day) had been driven by the increase, in recent decades, of the consumption of sugar-sweetened beverages. This phenomenon has dramatically increased within the Caribbean and Latin American regions. Epidemiological studies show that chronic high intake of fructose related to sugar-sweetened beverages increases the risk of developing several non-communicable diseases, such as chronic obstructive pulmonary disease and asthma, and may also contribute to the exacerbation of lung diseases, such as COVID-19. Evidence supports several mechanisms—such as dysregulation of the renin−angiotensin system, increased uric acid production, induction of aldose reductase activity, production of advanced glycation end-products, and activation of the mTORC1 pathway—that can be implicated in lung damage. This review addresses how these pathophysiologic and molecular mechanisms may explain the lung damage resulting from high intake of fructose.
MeSH term(s)	Aldehyde Reductase ; Fructose/adverse effects ; Humans ; Lung Diseases/epidemiology ; Lung Diseases/physiopathology ; Mechanistic Target of Rapamycin Complex 1 ; Sweetening Agents/adverse effects ; Uric Acid
Chemical Substances	Sweetening Agents ; Uric Acid (268B43MJ25) ; Fructose (30237-26-4) ; Aldehyde Reductase (EC 1.1.1.21) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
Language	English
Publishing date	2022-10-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14194089
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Article ; Online: Promoter methylation status of RORC, IL17A, and TNFA in peripheral blood leukocytes in adolescents with obesity-related asthma

Leija-Martínez, José J. / Giacoman-Martínez, Abraham / Del-Río-Navarro, Blanca E. / Sanchéz-Muñoz, Fausto / Hernández-Diazcouder, Adrián / Muñoz, Onofre / Romero-Nava, Rodrigo / Villafaña, Santiago / Marchat, Laurence A. / Hong, Enrique / Huang, Fengyang

Heliyon. 2022 Dec., v. 8, no. 12 p.e12316-

2022

Abstract: A higher Th17-immune response characterises obesity and obesity-related asthma phenotype. Nevertheless, obesity-related asthma has a more significant Th17-immune response than obesity alone. Retinoid-related orphan receptor C (RORC) is the essential ... ...

Abstract	A higher Th17-immune response characterises obesity and obesity-related asthma phenotype. Nevertheless, obesity-related asthma has a more significant Th17-immune response than obesity alone. Retinoid-related orphan receptor C (RORC) is the essential transcription factor for Th17 polarisation. Previous studies have found that adolescents with obesity-related asthma presented upregulation of RORC, IL17A, and TNFA. However, the mechanisms that cause these higher mRNA expression levels in this asthmatic phenotype are poorly understood. Methylation directly regulates gene expression by adding a methyl group to carbon 5 of dinucleotide CpG cytosine. Thus, we evaluated the relationship between RORC, IL17A, and TNFA methylation status and mRNA expression levels to investigate a possible epigenetic regulation. A total of 102 adolescents (11–18 years) were studied in the following four groups: 1) healthy participants (HP), 2) allergic asthmatic participants (AAP), 3) obese participants without asthma (OP), and 4) non-allergic obesity-related asthma participants (OAP). Real-time qPCR assessed the methylation status and gene expression levels in peripheral blood leukocytes. Remarkably, the OAP and AAP groups have lower promoter methylation patterns of RORC, IL17A, and TNFA than the HP group. Notably, the OAP group presents lower RORC promoter methylation status than the OP group. Interestingly, RORC promoter methylation status was moderately negatively associated with gene expression of RORC (rₛ = −0.39, p < 0.001) and IL17A (rₛ = −0.37, p < 0.01), respectively. Similarly, the promoter methylation pattern of IL17A was moderately negatively correlated with IL17A gene expression (rₛ = −0.3, p < 0.01). There is also a moderate inverse relationship between TNFA promoter methylation status and TNFA gene expression (rₛ = −0.3, p < 0.01). The present study suggests an association between lower RORC, IL17A, and TNFA gene promoter methylation status with obesity-related asthma and allergic asthma. RORC, IL17A, and TNFA gene promoter methylation patterns are moderately inversely correlated with their respective mRNA expression levels. Therefore, DNA methylation may regulate RORC, IL17A, and TNF gene expression in both asthmatic phenotypes.
Keywords	DNA methylation ; asthma ; blood ; carbon ; cytosine ; epigenetics ; gene expression ; genes ; obesity ; phenotype ; transcription factors ; IL17A ; Methylation ; Non-allergic ; Obesity-related asthma ; RORC ; TNFA
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12316
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Whole Blood Expression Levels of Long Noncoding RNAs

José J. Leija-Martínez / Carlos A. Guzmán-Martín / Javier González-Ramírez / Abraham Giacoman-Martínez / Blanca E. Del-Río-Navarro / Rodrigo Romero-Nava / Santiago Villafaña / José Luis Flores-Saenz / Fausto Sánchez-Muñoz / Fengyang Huang

International Journal of Molecular Sciences, Vol 24, Iss 6481, p

HOTAIRM1, GAS5, MZF1-AS1, and OIP5-AS1 as Biomarkers in Adolescents with Obesity-Related Asthma

2023 Volume 6481

Abstract	Asthma is a heterogeneous entity encompassing distinct endotypes and varying phenotypes, characterized by common clinical manifestations, such as shortness of breath, wheezing, and variable airflow obstruction. Two major asthma endotypes based on molecular patterns are described: type 2 endotype (allergic-asthma) and T2 low endotype (obesity-related asthma). Long noncoding RNAs (lncRNAs) are transcripts of more than 200 nucleotides in length, currently involved in many diverse biological functions, such as chromatin remodeling, gene transcription, protein transport, and microRNA processing. Despite the efforts to accurately classify and discriminate all the asthma endotypes and phenotypes, if long noncoding RNAs could play a role as biomarkers in allergic asthmatic and adolescent obesity-related asthma, adolescents remain unknown. To compare expression levels of lncRNAs: HOTAIRM1, OIP5-AS1, MZF1-AS1, and GAS5 from whole blood of Healthy Adolescents (HA), Obese adolescents (O), allergic asthmatic adolescents (AA) and Obesity-related asthma adolescents (OA). We measured and compared expression levels from the whole blood of the groups mentioned above through RT-q-PCR. We found differentially expressed levels of these lncRNAs between the groups of interest. In addition, we found a discriminative value of previously mentioned lncRNAs between studied groups. Finally, we generated an interaction network through bioinformatics. Expression levels of OIP5-AS1, MZF1-AS1, HOTAIRM1, and GAS5 in whole blood from the healthy adolescent population, obese adolescents, allergic asthma adolescents, and obesity-related asthma adolescents are differently expressed. Moreover, these lncRNAs could act as molecular biomarkers that help to discriminate between all studied groups, probably through molecular mechanisms with several genes and miRNAs implicated.
Keywords	asthma ; obesity-related asthma ; long noncoding RNAs ; OIP5-AS1 ; HOTAIRM1 ; MZF1-AS1 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of supplementation with omega-3 fatty acids on hypertriglyceridemia in pediatric patients with obesity.

Del-Río-Navarro, Blanca E / Miranda-Lora, América L / Huang, Fengyang / Hall-Mondragon, Margareth S / Leija-Martínez, José J

Journal of pediatric endocrinology & metabolism : JPEM

2019 Volume 32, Issue 8, Page(s) 811–819

Abstract: Background The beneficial effects of treating hypertriglyceridemic adults with omega-3 fatty acids have been reported. However, information regarding omega-3 treatment of pediatric patients is limited. To evaluate the efficacy and safety of administering ...

Abstract	Background The beneficial effects of treating hypertriglyceridemic adults with omega-3 fatty acids have been reported. However, information regarding omega-3 treatment of pediatric patients is limited. To evaluate the efficacy and safety of administering omega-3 fatty acids (3 g/day for 12 weeks) to children/adolescents with obesity and hypertriglyceridemia. Methods A randomized, double-blind, placebo-controlled, parallel study involving pediatric patients (10-16 years old) with obesity and hypertriglyceridemia was conducted. The National Center for Health Statistics (CDC) defines obesity as a body mass index (BMI) ≥95th percentile. Subjects with triglyceride concentrations ranging from 150 to 1000 mg/dL were randomized into two groups: those receiving omega-3 fatty acids (eicosapentaenoic and docosahexaenoic acids) (n = 65) and those receiving a placebo (n = 65) for 12 weeks. Serum triglyceride concentrations were always measured from 8 to 9 am after a 12-h fast. Results By the end of treatment, triglyceride concentrations had decreased by 39.1% in the omega-3 group and 14.6% in the placebo group (p < 0.01). The incidence of adverse gastrointestinal events (e.g. flatulence, belching) was 41.2% and 6.2% in the omega-3 and placebo groups, respectively (p < 0.01). There were no serious drug-related adverse events. Conclusions Supplementation with 3 g/day of omega-3 fatty acids is a safe and effective option for treating hypertriglyceridemia in children and adolescents with obesity.
MeSH term(s)	Adolescent ; Biomarkers/blood ; Child ; Dietary Supplements ; Double-Blind Method ; Fatty Acids, Omega-3/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/drug therapy ; Hypertriglyceridemia/etiology ; Male ; Pediatric Obesity/complications ; Pediatric Obesity/drug therapy ; Treatment Outcome ; Triglycerides/blood
Chemical Substances	Biomarkers ; Fatty Acids, Omega-3 ; Triglycerides
Language	English
Publishing date	2019-07-04
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2018-0409
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Article ; Online: IL-17A and TNF-α as potential biomarkers for acute respiratory distress syndrome and mortality in patients with obesity and COVID-19.

Leija-Martínez, José J / Huang, Fengyang / Del-Río-Navarro, Blanca E / Sanchéz-Muñoz, Fausto / Muñoz-Hernández, Onofre / Giacoman-Martínez, Abraham / Hall-Mondragon, Margareth S / Espinosa-Velazquez, Dario

Medical hypotheses

2020 Volume 144, Page(s) 109935

Abstract: Coronavirus disease 2019 (COVID-19) was declared a pandemic and international health emergency by the World Health Organization. Patients with obesity with COVID-19 are 7 times more likely to need invasive mechanical ventilation than are patients without ...

Abstract	Coronavirus disease 2019 (COVID-19) was declared a pandemic and international health emergency by the World Health Organization. Patients with obesity with COVID-19 are 7 times more likely to need invasive mechanical ventilation than are patients without obesity (OR 7.36; 95% CI: 1.63-33.14, p = 0.021). Acute respiratory distress syndrome (ARDS) is one of the main causes of death related to COVID-19 and is triggered by a cytokine storm that damages the respiratory epithelium. Interleukins that cause the chronic low-grade inflammatory state of obesity, such as interleukin (IL)-1β, IL-6, monocyte chemoattractant peptide (MCP)-1, and, in particular, IL-17A and tumour necrosis factor alpha (TNF-α), also play very important roles in lung damage in ARDS. Therefore, obesity is associated with an immune state favourable to a cytokine storm. Our hypothesis is that serum concentrations of TNF-α and IL-17A are more elevated in patients with obesity and COVID-19, and consequently, they have a greater probability of developing ARDS and death. The immunobiology of IL-17A and TNF-α opens a new fascinating field of research for COVID-19.
MeSH term(s)	Biomarkers/blood ; COVID-19/complications ; COVID-19/immunology ; COVID-19/mortality ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/mortality ; Humans ; Interleukin-17/blood ; Models, Immunological ; Obesity/complications ; Obesity/immunology ; Pandemics ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/immunology ; Respiratory Distress Syndrome/mortality ; Respiratory Mucosa/immunology ; Respiratory Mucosa/injuries ; Risk Factors ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Biomarkers ; IL17A protein, human ; Interleukin-17 ; TNF protein, human ; Tumor Necrosis Factor-alpha
Keywords	covid19
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109935
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Article ; Online: Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents.

Leija-Martínez, José J / Del-Río-Navarro, Blanca E / Sanchéz-Muñoz, Fausto / Muñoz-Hernández, Onofre / Hong, Enrique / Giacoman-Martínez, Abraham / Romero-Nava, Rodrigo / Patricio-Román, Karla L / Hall-Mondragon, Margareth S / Espinosa-Velazquez, Dario / Villafaña, Santiago / Huang, Fengyang

Clinical immunology (Orlando, Fla.)

2021 Volume 229, Page(s) 108715

Abstract: Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and ... ...

Abstract	Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and RORC mRNA expression levels with the non-T2 phenotype. We conducted a cross-sectional study in adolescents, subdivided as follows: healthy (HA), allergic asthma without obesity (AA), obesity without asthma (OB), and non-allergic asthma with obesity (NAO). TNFA, IL17A, and RORC mRNA expression in peripheral blood leukocytes were assessed by RT-PCR. NAO exhibited higher TNFA mRNA expression levels than HA or OB, as well as the highest IL17A and RORC mRNA expression levels among the four groups. The best biomarker for discriminating non-allergic asthma among obese adolescents was RORC mRNA expression levels (area under the curve: 0.95). RORC mRNA expression levels were associated with the non-T2 asthma phenotype, hinting at a therapeutic target in obesity-related asthma.
MeSH term(s)	Adolescent ; Asthma/complications ; Asthma/genetics ; Asthma/immunology ; Biomarkers/blood ; Child ; Cross-Sectional Studies ; Female ; Gene Expression ; Humans ; Interleukin-17/blood ; Interleukin-17/genetics ; Leukocytes/immunology ; Male ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Obesity/complications ; Obesity/genetics ; Obesity/immunology ; Phenotype ; RNA, Messenger/blood ; RNA, Messenger/genetics ; Th17 Cells/immunology ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Biomarkers ; IL17A protein, human ; Interleukin-17 ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; RNA, Messenger ; RORC protein, human ; TNF protein, human ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2021.108715
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Article ; Online: Corrigendum to "Decreased methylation profiles in the TNFA gene promoters in type 1 macrophages and in the IL17A and RORC gene promoters in Th17 lymphocytes have a causal association with non-atopic asthma caused by obesity: A hypothesis" [Med. Hypotheses 2020 (134) 109527].

Leija-Martínez, José J / Huang, Fengyang / Del-Río-Navarro, Blanca E / Sanchéz-Muñoz, Fausto / Romero-Nava, Rodrigo / Muñoz-Hernández, Onofre / Rodríguez-Cortés, Octavio / Hall-Mondragon, Margareth S

Medical hypotheses

2020 Volume 144, Page(s) 110181

Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Published Erratum
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.110181
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