LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 55

Search options

  1. Article ; Online: Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts.

    Balam, Saidou / Buchtler, Simone / Winter, Frederike / Schmidbauer, Kathrin / Neumayer, Sophia / Talke, Yvonne / Renner, Kerstin / Geissler, Edward K / Mack, Matthias

    Frontiers in immunology

    2022  Volume 12, Page(s) 816509

    Abstract: Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, ... ...

    Abstract Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, we sought to determine whether tissue-resident donor-derived cells or allograft-infiltrating recipient-derived cells are responsible for allograft fibrosis, and whether hematopoietic cells contribute to collagen production. A fully MHC-mismatched mouse heterotopic heart transplantation model was used, with transient depletion of CD4
    MeSH term(s) Animals ; Biomarkers ; Chronic Disease ; Collagen Type I/biosynthesis ; Collagen Type I/immunology ; Disease Models, Animal ; Disease Susceptibility ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Rejection/metabolism ; Heart Transplantation/adverse effects ; Heart Transplantation/methods ; Immunophenotyping ; Mice ; Mice, Transgenic ; Tissue Donors ; Transplantation, Homologous
    Chemical Substances Biomarkers ; Collagen Type I
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.816509
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online ; Thesis: Herstellung monoklonaler Antikörper gegen das menschliche Polycystin-2-Protein

    Renner, Kerstin

    2010  

    Author's details vorgelegt von Kerstin Renner, geb. Vogt
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 2010
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: [No title information]

    Kölch, Michael / Flechtner, Hans-Henning / Romanos, Marcel / Freitag, Christine M / Schepker, Renate / Konrad, Kerstin / Renner, Tobias

    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie

    2020  Volume 48, Issue 5, Page(s) 416–417

    Title translation Stellungnahme der DGKJP zum Studiengang Psychotherapie.
    MeSH term(s) Humans ; Psychotherapy
    Language German
    Publishing date 2020-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1312929-6
    ISSN 1664-2880 ; 1422-4917
    ISSN (online) 1664-2880
    ISSN 1422-4917
    DOI 10.1024/1422-4917/a000753
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1253: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: [No title information]

    Banaschewski, Tobias / Döpfner, Manfred / Fegert, Jörg M / Flechtner, Hans-Henning / Freitag, Christine M / Holtmann, Martin / Kamp-Becker, Inge / Konrad, Kerstin / Poustka, Luise / Renner, Tobias / Roessner, Veit / Romanos, Marcel / Schulte-Körne, Gerd / Thomasius, Rainer / Zepf, Florian / Kölch, Michael

    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie

    2022  Volume 50, Issue 2, Page(s) 85–89

    Title translation Psychische Gesundheit und Krankheit bei Kindern und Jugendlichen: Herausforderungen für die beiden neuen Deutschen Forschungszentren DZKJ und DZPG.
    MeSH term(s) Adolescent ; Child ; Humans ; Mental Disorders/psychology ; Mental Health
    Language German
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1312929-6
    ISSN 1664-2880 ; 1422-4917
    ISSN (online) 1664-2880
    ISSN 1422-4917
    DOI 10.1024/1422-4917/a000856
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1253: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online ; Thesis: Herstellung monoklonaler Antikörper gegen das menschliche Polycystin-2-Protein

    Renner, Kerstin [Verfasser]

    2010  

    Author's details vorgelegt von Kerstin Renner, geb. Vogt
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Receptor-Mediated

    Renner, Alexander M / Ilyas, Shaista / Schlößer, Hans A / Szymura, Annika / Roitsch, Stefan / Wennhold, Kerstin / Mathur, Sanjay

    Langmuir : the ACS journal of surfaces and colloids

    2020  Volume 36, Issue 48, Page(s) 14819–14828

    Abstract: Efficient therapies for breast cancer remain elusive because of the lack of strategies for targeted transport and receptor-mediated uptake of synthetic drug molecules by cancer cells. Conjugation of nanoparticles (NPs) with active targeting ligands ... ...

    Abstract Efficient therapies for breast cancer remain elusive because of the lack of strategies for targeted transport and receptor-mediated uptake of synthetic drug molecules by cancer cells. Conjugation of nanoparticles (NPs) with active targeting ligands enabling selective molecular recognition of antigens expressed on the surface of cancer cells is promising for localization and treatment of malignant cells. In this study, covalent attachment of synthetic estrogen 17α-ethynylestradiol on the silica (SiO
    MeSH term(s) Animals ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Doxorubicin ; Drug Carriers ; Drug Liberation ; Female ; Gold ; Humans ; Metal Nanoparticles ; Mice ; Nanoparticles ; Silicon Dioxide
    Chemical Substances Drug Carriers ; Gold (7440-57-5) ; Silicon Dioxide (7631-86-9) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c02820
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: B-cell modulation with anti-CD79b antibodies ameliorates experimental autoimmune encephalitis in mice.

    Renner, Kerstin / Neumayer, Sophia / Talke, Yvonne / Buchtler, Simone / Schmidbauer, Kathrin / Nimmerjahn, Falk / Lux, Anja / Winter, Frederike / Salewski, Jan-Nicklas / Mack, Matthias

    European journal of immunology

    2022  Volume 52, Issue 4, Page(s) 656–668

    Abstract: B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion ... ...

    Abstract B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on targeting CD79b that induces only partial B-cell depletion and achieves therapeutic effects by B-cell modulation. Prophylactic and therapeutic treatment with an antibody against CD79b and also a deglycosylated variant of this antibody, lacking effector function like antibody-dependent cellular cytotoxicity or complement activation, significantly reduced the development and progression of EAE in mice. Our data show that modulation of B cells via CD79b is equally effective as almost complete B-cell depletion with anti-CD20 antibodies and may constitute an alternative approach to treat MS.
    MeSH term(s) Animals ; Antibodies ; Antigens, CD20 ; Autoimmune Diseases ; Autoimmunity ; B-Lymphocytes ; Encephalitis/drug therapy ; Encephalitis/pathology ; Mice
    Chemical Substances Antibodies ; Antigens, CD20
    Language English
    Publishing date 2022-01-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149523
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Expression of IL-3 receptors and impact of IL-3 on human T and B cells.

    Renner, Kerstin / Metz, Sophia / Metzger, Anne-Mieke / Neumayer, Sophia / Schmidbauer, Kathrin / Talke, Yvonne / Buchtler, Simone / Halbritter, Dagmar / Mack, Matthias

    Cellular immunology

    2018  Volume 334, Page(s) 49–60

    Abstract: A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL- ... ...

    Abstract A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL-3 modulates the activation and survival of these cells. We show that the IL-3 receptor CD123 is substantially upregulated on proliferating CD4
    MeSH term(s) Autoimmune Diseases/immunology ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cytokines/immunology ; Humans ; Interleukin-3/immunology ; Interleukin-3 Receptor alpha Subunit/immunology ; Lymphocyte Activation/immunology ; Receptors, Interleukin-3/immunology ; Up-Regulation/immunology
    Chemical Substances Cytokines ; IL3 protein, human ; Interleukin-3 ; Interleukin-3 Receptor alpha Subunit ; Receptors, Interleukin-3
    Language English
    Publishing date 2018-09-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology.

    Mock, Andreas / Teleanu, Maria-Veronica / Kreutzfeldt, Simon / Heilig, Christoph E / Hüllein, Jennifer / Möhrmann, Lino / Jahn, Arne / Hanf, Dorothea / Kerle, Irina A / Singh, Hans Martin / Hutter, Barbara / Uhrig, Sebastian / Fröhlich, Martina / Neumann, Olaf / Hartig, Andreas / Brückmann, Sascha / Hirsch, Steffen / Grund, Kerstin / Dikow, Nicola /
    Lipka, Daniel B / Renner, Marcus / Bhatti, Irfan Ahmed / Apostolidis, Leonidas / Schlenk, Richard F / Schaaf, Christian P / Stenzinger, Albrecht / Schröck, Evelin / Hübschmann, Daniel / Heining, Christoph / Horak, Peter / Glimm, Hanno / Fröhling, Stefan

    NPJ precision oncology

    2023  Volume 7, Issue 1, Page(s) 109

    Abstract: Analysis of selected cancer genes has become an important tool in precision oncology but cannot fully capture the molecular features and, most importantly, vulnerabilities of individual tumors. Observational and interventional studies have shown that ... ...

    Abstract Analysis of selected cancer genes has become an important tool in precision oncology but cannot fully capture the molecular features and, most importantly, vulnerabilities of individual tumors. Observational and interventional studies have shown that decision-making based on comprehensive molecular characterization adds significant clinical value. However, the complexity and heterogeneity of the resulting data are major challenges for disciplines involved in interpretation and recommendations for individualized care, and limited information exists on how to approach multilayered tumor profiles in clinical routine. We report our experience with the practical use of data from whole-genome or exome and RNA sequencing and DNA methylation profiling within the MASTER (Molecularly Aided Stratification for Tumor Eradication Research) program of the National Center for Tumor Diseases (NCT) Heidelberg and Dresden and the German Cancer Research Center (DKFZ). We cover all relevant steps of an end-to-end precision oncology workflow, from sample collection, molecular analysis, and variant prioritization to assigning treatment recommendations and discussion in the molecular tumor board. To provide insight into our approach to multidimensional tumor profiles and guidance on interpreting their biological impact and diagnostic and therapeutic implications, we present case studies from the NCT/DKFZ molecular tumor board that illustrate our daily practice. This manual is intended to be useful for physicians, biologists, and bioinformaticians involved in the clinical interpretation of genome-wide molecular information.
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-023-00458-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils.

    Balam, Saidou / Schiechl-Brachner, Gabriela / Buchtler, Simone / Halbritter, Dagmar / Schmidbauer, Kathrin / Talke, Yvonne / Neumayer, Sophia / Salewski, Jan-Niklas / Winter, Frederike / Karasuyama, Hajime / Yamanishi, Yoshinori / Renner, Kerstin / Geissler, Edward K / Mack, Matthias

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 202, Issue 12, Page(s) 3514–3523

    Abstract: Chronic rejection is a major problem in transplantation medicine, largely resistant to therapy, and poorly understood. We have shown previously that basophil-derived IL-4 contributes to fibrosis and vasculopathy in a model of heart transplantation with ... ...

    Abstract Chronic rejection is a major problem in transplantation medicine, largely resistant to therapy, and poorly understood. We have shown previously that basophil-derived IL-4 contributes to fibrosis and vasculopathy in a model of heart transplantation with depletion of CD4
    MeSH term(s) Animals ; Basophils/immunology ; Cell Movement ; Cells, Cultured ; Chronic Disease ; Disease Models, Animal ; Graft Rejection/immunology ; Heart Transplantation ; Humans ; Interleukin-3/genetics ; Interleukin-3/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Transplantation, Homologous ; Up-Regulation
    Chemical Substances Interleukin-3 ; Interleukin-6
    Language English
    Publishing date 2019-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1801269
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top