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  1. Article ; Online: IL6-R blocking with tocilizumab in critically ill patients with hemophagocytic syndrome.

    Dufranc, Etienne / Del Bello, Arnaud / Belliere, Julie / Kamar, Nassim / Faguer, Stanislas

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 166

    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized ; Critical Illness ; Humans ; Interleukin-6 ; Lymphohistiocytosis, Hemophagocytic
    Chemical Substances Antibodies, Monoclonal, Humanized ; Interleukin-6 ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-02878-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU).

    Anthon, Carl Thomas / Pène, Frédéric / Perner, Anders / Azoulay, Elie / Puxty, Kathryn / Van De Louw, Andry / Barratt-Due, Andreas / Chawla, Sanjay / Castro, Pedro / Póvoa, Pedro / Coelho, Luis / Metaxa, Victoria / Kochanek, Matthias / Liebregts, Tobias / Kander, Thomas / Hästbacka, Johanna / Andreasen, Jo Bønding / Péju, Edwige / Nielsen, Lene Bjerregaard /
    Hvas, Christine Lodberg / Dufranc, Etienne / Canet, Emmanuel / Lundqvist, Linda / Wright, Christopher John / Schmidt, Julien / Uhel, Fabrice / Ait-Oufella, Hafid / Krag, Mette / Cos Badia, Elisabet / Díaz-Lagares, Cándido / Menat, Sophie / Voiriot, Guillaume / Clausen, Niels Erikstrup / Lorentzen, Kristian / Kvåle, Reidar / Hildebrandt, Thomas / Holten, Aleksander Rygh / Strand, Kristian / Tzalavras, Asterios / Bestle, Morten Heiberg / Klepstad, Pål / Fernandez, Sara / Vimpere, Damien / Paulino, Carolina / Graça, Carina / Lueck, Catherina / Juhl, Christian Svendsen / Costa, Carolina / Bådstøløkken, Per Martin / Miranda, Teresa / Lêdo, Lia Susana Aires / Sousa Torres, Joao Carlos / Granholm, Anders / Møller, Morten Hylander / Russell, Lene

    Intensive care medicine

    2023  Volume 50, Issue 1, Page(s) 154–155

    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07291-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU).

    Anthon, Carl Thomas / Pène, Frédéric / Perner, Anders / Azoulay, Elie / Puxty, Kathryn / Van De Louw, Andry / Barratt-Due, Andreas / Chawla, Sanjay / Castro, Pedro / Póvoa, Pedro / Coelho, Luis / Metaxa, Victoria / Kochanek, Matthias / Liebregts, Tobias / Kander, Thomas / Hästbacka, Johanna / Andreasen, Jo Bønding / Péju, Edwige / Nielsen, Lene Bjerregaard /
    Hvas, Christine Lodberg / Dufranc, Etienne / Canet, Emmanuel / Lundqvist, Linda / Wright, Christopher John / Schmidt, Julien / Uhel, Fabrice / Ait-Oufella, Hafid / Krag, Mette / Cos Badia, Elisabet / Díaz-Lagares, Cándido / Menat, Sophie / Voiriot, Guillaume / Clausen, Niels Erikstrup / Lorentzen, Kristian / Kvåle, Reidar / Hildebrandt, Thomas / Holten, Aleksander Rygh / Strand, Kristian / Tzalavras, Asterios / Bestle, Morten Heiberg / Klepstad, Pål / Fernandez, Sara / Vimpere, Damien / Paulino, Carolina / Graça, Carina / Lueck, Catherina / Juhl, Christian Svendsen / Costa, Carolina / Bådstøløkken, Per Martin / Miranda, Teresa / Lêdo, Lia Susana Aires / Sousa Torres, Joao Carlos / Granholm, Anders / Møller, Morten Hylander / Russell, Lene

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1327–1338

    Abstract: Purpose: Thrombocytopenia (platelet count < 150 × 10: Methods: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical ... ...

    Abstract Purpose: Thrombocytopenia (platelet count < 150 × 10
    Methods: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.
    Results: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).
    Conclusion: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Middle Aged ; Platelet Transfusion/adverse effects ; Cohort Studies ; Prospective Studies ; Thrombocytopenia/epidemiology ; Thrombocytopenia/etiology ; Intensive Care Units ; Hemorrhage/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07225-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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