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  1. Article ; Online: The Dawn of a New Era in Kidney Transplantation: Promises and Limitations of Artificial Intelligence for Precision Diagnostics.

    Peloso, Andrea / Naesens, Maarten / Thaunat, Olivier

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 12010

    MeSH term(s) Humans ; Artificial Intelligence ; Kidney Transplantation ; Algorithms
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.12010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 vaccination in kidney transplant recipients.

    Caillard, Sophie / Thaunat, Olivier

    Nature reviews. Nephrology

    2021  Volume 17, Issue 12, Page(s) 785–787

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Humans ; Kidney Transplantation ; Transplant Recipients ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00491-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The authors reply.

    Thaunat, Olivier / Legeai, Camille / Bastien, Olivier / Caillard, Sophie

    Kidney international

    2021  Volume 99, Issue 3, Page(s) 771–772

    MeSH term(s) COVID-19 ; Epidemics ; Humans ; Kidney Transplantation ; Registries ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Microvascular inflammation: Gene expression changes do not necessarily reflect pathogenesis.

    Naesens, Maarten / Thaunat, Olivier / Mengel, Michael

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2022  Volume 22, Issue 12, Page(s) 3180–3181

    MeSH term(s) Humans ; Inflammation/pathology ; Microvessels/metabolism ; Gene Expression ; Microcirculation
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.17136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Authors' Reply.

    Vaulet, Thibaut / Thaunat, Olivier / Naesens, Maarten

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 9, Page(s) 2388–2389

    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021060796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Soothing touch of CD31 protects endothelium during cellular immune responses.

    Thaunat, Olivier

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 43, Page(s) 13133–13134

    MeSH term(s) Animals ; Endothelium, Vascular/immunology ; Platelet Endothelial Cell Adhesion Molecule-1/immunology
    Chemical Substances Platelet Endothelial Cell Adhesion Molecule-1
    Language English
    Publishing date 2015-10-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1517580112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Finding the safe place between the hammer and the anvil: sounding the depth of therapeutic immunosuppression.

    Thaunat, Olivier

    Kidney international

    2015  Volume 88, Issue 6, Page(s) 1226–1228

    Abstract: Transplanted organs express allogeneic epitopes against which a recipient's immune system mounts a destructive response. In the absence of a reliable strategy for induction of donor-specific tolerance, therapeutic immunosuppression remains the best ... ...

    Abstract Transplanted organs express allogeneic epitopes against which a recipient's immune system mounts a destructive response. In the absence of a reliable strategy for induction of donor-specific tolerance, therapeutic immunosuppression remains the best prospect to prevent rejection, but exposes recipients to increased risks of infection and cancer. Defining the individual upper and lower limits between which the transplanted patient is safe requires the validation of biomarkers able to depth-sound the recipient's immune system.
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2015.268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antibody Response to a Fourth Messenger RNA COVID-19 Vaccine Dose in Kidney Transplant Recipients: A Case Series.

    Caillard, Sophie / Thaunat, Olivier / Benotmane, Ilies / Masset, Christophe / Blancho, Gilles

    Annals of internal medicine

    2022  Volume 175, Issue 3, Page(s) 455–456

    MeSH term(s) Antibodies, Viral ; Antibody Formation ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; RNA, Messenger/genetics
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Allograft recognition by recipient's natural killer cells: Molecular mechanisms and role in transplant rejection.

    Hamada, Sarah / Dubois, Valérie / Koenig, Alice / Thaunat, Olivier

    HLA

    2021  Volume 98, Issue 3, Page(s) 191–199

    Abstract: The current transplant immunology dogma defends that allograft rejection is initiated by recipient's adaptive immune system. In this prevalent model, innate immune cells in general, and natural killer (NK) cells in particular, are merely considered as ... ...

    Abstract The current transplant immunology dogma defends that allograft rejection is initiated by recipient's adaptive immune system. In this prevalent model, innate immune cells in general, and natural killer (NK) cells in particular, are merely considered as downstream effectors which participate in the destruction of the graft only upon recruitment by adaptive effectors: alloreactive T cells or donor-specific antibodies (DSA). Challenging this vision, recent data demonstrated that recipients' NK cells are capable of a form of allorecognition because they can sense the absence of self HLA class I molecules on the surface of graft endothelial cells. Missing-self triggers mTORC1-dependent activation of NK cells, which in turn promote the development of graft microvascular inflammation and detrimentally impact graft survival. The fact that some patients develop chronic vascular rejection in absence of DSA or genetically-predicted missing self suggests that other molecular mechanisms could underly NK cell allorecognition. This review provides an overview of these proven and putative molecular mechanisms and discusses future research directions in this emerging field in organ transplant immunology.
    MeSH term(s) Alleles ; Allografts ; Endothelial Cells ; Graft Rejection/genetics ; Humans ; Killer Cells, Natural
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Covid-19 en transplantation rénale, leçons du registre français.

    Caillard, Sophie / Thaunat, Olivier / Hazzan, Marc

    Nephrologie & therapeutique

    2021  Volume 17, Issue 4, Page(s) 233–244

    Abstract: The Covid-19 pandemic hits the French transplant population on March 3, 2020. Very quickly, a French registry was set up on behalf of the French Society of Transplantation allowing the collection of confirmed cases of Covid-19 occurring in kidney ... ...

    Title translation Covid-19 in kidney transplantation: Lessons from the French Registry.
    Abstract The Covid-19 pandemic hits the French transplant population on March 3, 2020. Very quickly, a French registry was set up on behalf of the French Society of Transplantation allowing the collection of confirmed cases of Covid-19 occurring in kidney transplant recipients in almost all French centers. The analysis of this registry in conjunction with the data from the Agence de la Biomédecine (Cristal) has enabled us to obtain instructive results. We first showed that the incidence of severe forms among transplant patients hospitalized for Covid-19 was 46% and that their mortality was 22.8%. The risk factors for severe forms and mortality are described. Then we showed, by comparing transplant patients with immunocompetent patients matched for the main severity factors of the disease, that mortality among transplant patients was higher (17.9% vs 11.4%; P<0.001). In multivariate analysis, a creatinine level at admission above 115 μmol/L was associated with death, whereas being transplanted was not. Finally, comparing the transplant cohort with patients on the kidney transplant waiting list during the period from February to June 2020, we found that patients on the waiting list had a higher Covid-19-related excess mortality than transplant patients, mainly in areas of low viral circulation. In conclusion, the French Registry of transplant patients with Covid-19, which was rapidly set up at the beginning of the epidemic, has already enabled us to draw several lessons about this initially unknown infection, particularly in kidney transplant patients, a population which appeared to be particularly at risk.
    MeSH term(s) Aged ; COVID-19/mortality ; Creatinine/analysis ; Female ; France/epidemiology ; Hospitalization/statistics & numerical data ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Registries ; Transplant Recipients ; Waiting Lists
    Chemical Substances Creatinine (AYI8EX34EU)
    Language French
    Publishing date 2021-03-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2021.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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