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Article: Primary thrombophilia in Mexico XVIII: Increased rate of thrombosis in persons with the sticky platelet syndrome in the COVID-19 era.

Melgar-de-la-Paz, Miranda / Gallardo-Pérez, Moises M / Olivares-Gazca, Juan C / Ruiz-Argüelles, Guillermo J

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2024

Language	English
Publishing date	2024-01-29
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.23000276
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Article ; Online: Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons.

Murrieta-Álvarez, Iván / A Fernández-Gutiérrez, José / A Pérez, Carlos / León-Peña, Andrés A / Reyes-Cisneros, Óscar A / Benítez-Salazar, José M / Sánchez-Bonilla, Daniela / Olivares-Gazca, Juan C / Fernández-Lara, Danitza / Pérez-Padilla, Rogelio / Ruiz-Delgado, Guillermo J / Ruiz-Argüelles, Guillermo J

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2023 Volume 44, Issue 12, Page(s) 4429–4439

Abstract: Introduction: Abnormal lung function in people with multiple sclerosis (PwMS) could be considered as the result of muscle weakness or MS-specific structural central nervous system (CNS) abnormalities as a precipitant factor for the worsening of motor ... ...

Abstract	Introduction: Abnormal lung function in people with multiple sclerosis (PwMS) could be considered as the result of muscle weakness or MS-specific structural central nervous system (CNS) abnormalities as a precipitant factor for the worsening of motor impairment or cognitive symptoms. Methods: This is a cross-sectional observational study in PwMS. Forced spirometry was conducted, and normative metrics of forced vital capacity (FVC), forced expiratory volume in the first second (FEV Results: A total of 371 PwMS were included in the study. Of those, 196 (53%) had RRMS, 92 (25%) SPMS, and 83 (22%) PPMS. Low FVC and FEV Conclusions: We observed an incremental prevalence of abnormally low pulmonary function tests that parallels a sequence from more early relapsing courses to long-standing progressive courses (RRMS to PPMS or SPMS).
MeSH term(s)	Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/pathology ; Cross-Sectional Studies ; Magnetic Resonance Imaging ; Vital Capacity ; Lung/diagnostic imaging ; Multiple Sclerosis, Chronic Progressive
Language	English
Publishing date	2023-07-06
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-06914-6
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Article ; Online: Treatment of Persons with Multiple Myeloma in Underprivileged Circumstances: Real-World Data from a Single Institution.

Murrieta-Álvarez, Iván / Steensma, David P / Olivares-Gazca, Juan Carlos / Olivares-Gazca, Mauricio / León-Peña, Andrés / Cantero-Fortiz, Yahveth / García-Navarrete, Yarely Itzayana / Cruz-Mora, Antonio / Ruiz-Argüelles, Alejandro / Ruiz-Delgado, Guillermo José / Ruiz-Argüelles, Guillermo José

Acta haematologica

2020 Volume 143, Issue 6, Page(s) 552–558

Abstract: ... day. Bor-tezomib (1.75 mg s.c. every week) was administered to those who could afford it. After 4-6 ...

Abstract	Background: The treatment of patients with multiple myeloma (MM) has evolved in recent years, and the disease-associated prognosis has improved substantially. This improvement has been driven largely by the approval of novel agents, many of which are expensive and not universally available. Less expensive but effective approaches would be of value globally. Patients and methods: All consecutive MM patients diagnosed in the Centro de Hematología y Medicina Interna de Puebla after 1993 were included in this study. Patients were given oral thalidomide (100 mg/day), oral dexamethasone (36-40 mg/week), and aspirin 100 mg/day. Bor-tezomib (1.75 mg s.c. every week) was administered to those who could afford it. After 4-6 weeks of treatment, patients were offered an outpatient-based hematopoietic cell transplant (HCT). After the recovery of granulocytes following HCT, patients continued indefinitely on thalidomide; those who failed to tolerate thalidomide were switched to lenalidomide (25 mg/day). Results: The median overall survival (OS) for all patients has not been reached and is >157 months. Median follow-up of the patients lasted 14 months (range 1.3-157). The median OS of patients with and without HCT was similar. The response rate (complete remission or very good partial remission) was 72% for those given thalidomide plus dexamethasone versus 88% for those given bortezomib, thalidomide, and dexamethasone before HCT, but OS was not different. As post-HCT maintenance, 37 patients received thalidomide; 26 of those (70%) could be maintained indefinitely on thalidomide, whereas 11 were switched to lenalidomide after a median of 7 months; median OS of patients maintained on thalidomide or lenalidomide after HCT was not different. Conclusion: In this series, a regimen incorporating low-cost novel agents and outpatient HCT was associated with excellent long-term survival in the treatment of MM patients. This approach may be a model for MM treatment in underprivileged circumstances.
MeSH term(s)	Adult ; Aged ; Allografts ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Aspirin/administration & dosage ; Bortezomib/administration & dosage ; Dexamethasone/administration & dosage ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation ; Humans ; Maintenance Chemotherapy ; Male ; Middle Aged ; Multiple Myeloma/mortality ; Multiple Myeloma/therapy ; Retrospective Studies ; Survival Rate ; Thalidomide/administration & dosage
Chemical Substances	Thalidomide (4Z8R6ORS6L) ; Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2020-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000505606
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Article: The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge.

Murrieta-Álvarez, Iván / Cantero-Fortiz, Yahveth / León-Peña, Andrés A / Olivares-Gazca, Juan C / Priesca-Marín, José Manuel / Ruiz-Delgado, Guillermo J / Gómez-De-León, Andrés / Gonzalez-Lopez, Elías Eugenio / Jaime-Pérez, José Carlos / Gómez-Almaguer, David / Ruiz-Argüelles, Guillermo J

Frontiers in neurology

2021 Volume 12, Page(s) 647425

Abstract: After gaining experience conducting both auto and allografts in persons with hematological diseases in the HSCT programs in Puebla and Monterrey, México, this study outlines subsequent program autografting patients with autoimmune conditions. The first ... ...

Abstract	After gaining experience conducting both auto and allografts in persons with hematological diseases in the HSCT programs in Puebla and Monterrey, México, this study outlines subsequent program autografting patients with autoimmune conditions. The first transplant in multiple sclerosis was conducted in Puebla on July 5, 2006. From 2015 we increased activity autografting persons with autoimmune conditions in the two campuses of the HSCT-México program: Puebla and Monterrey. By December 6, 2020, patient number 1,000 in the program was autografted. In our experience, a significant reduction in the expanded disability status scale score was achieved in all of the three phenotypes of the disease (from a median of 5.1 to 4.5 points), whereas the response rate (defined as a decrease of at least 0.5 of EDSS score regardless of baseline EDSS, or unchanged EDSS) was 83, 78, and 73% after 12 months in the relapsing-remitting, primary-progressive and secondary-progressive forms of multiple sclerosis, respectively. In addition to analyzing the viability, safety, and efficacy of our method, this study contributes new knowledge to the field of both stem cell transplantation and multiple sclerosis.
Language	English
Publishing date	2021-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.647425
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Article: Mantle cell lymphoma may have a different clinical course in Mexican Mestizos: Real-world data from a single center.

Córdova-Ramírez, Alejandra C / Sánchez-Valledor, Luisa F / Colón-Otero, Gerardo / Rivera-Alvarez, Montserrat / Elías-de-la-Cruz, Gilberto D / Murrieta-Alvarez, Iván / Cantero-Fortiz, Yahveth / León-Peña, Andrés / Olivares-Gazca, Juan C / Ruiz-Delgado, Guillermo J / Ruiz-Argüelles, Guillermo J

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2020 Volume 73, Issue 5

Abstract: Background: The biology of some hematological diseases varies among different populations. No previous studies have evaluated the clinical behavior of mantle cell lymphoma (MCL) in México.: Objective and methods: This is a retrospective review of MCL ...

Abstract	Background: The biology of some hematological diseases varies among different populations. No previous studies have evaluated the clinical behavior of mantle cell lymphoma (MCL) in México. Objective and methods: This is a retrospective review of MCL cases seen in Mexico from January 2003 to June 2020. A total of 12 cases were identified. Results: There were nine males and three females; median age was 56 years. Eight patients had a high MCL international prognostic index score, one was intermediate, and three were low. Five patients had circulating malignant monoclonal cells. Initial treatment included rituximab, cyclophosphamide, daunorubicin, vincristine, and prednisone (R-CHOP) and CHOP. Subsequent treatment included hematopoietic stem cell transplantation in five patients; two were given maintenance therapy. Splenectomy was done in four patients. Median overall survival (OS) for all the patients has not been reached and exceeds 162 mos: OS at 162 mos was 56%. Achieving a complete remission (CR) after the first treatment was a significant prognostic factor, with a median OS exceeding 141 mos in patients achieving CR, and 16 mos among those not achieving CR (p = 0.0006). Conclusion: Some of MCL patients in Mexico have an indolent clinical course, particularly patients who achieve a CR to initial treatment and who undergo splenectomy.
Language	English
Publishing date	2020-10-19
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.20000381
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Zs.A 288: Show issues

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Article: INFUSION OF CONVALESCENT PLASMA IS ASSOCIATED WITH CLINICAL IMPROVEMENT IN CRITICALLY ILL PATIENTS WITH COVID-19: A PILOT STUDY.

Olivares-Gazca, Juan C / Priesca-Marín, Jose M / Ojeda-Laguna, Martín / Garces-Eisele, Javier / Soto-Olvera, Silvia / Palacios-Alonso, Abraham / Izquierdo-Vega, Judith / Chacon-Cano, Rómulo / Arizpe-Bravo, Daniel / López-Trujillo, Miguel A / Cantero-Fortiz, Yahveth / Fernandez-Lara, Danitza / Ruiz-Delgado, Guillermo J / Ruiz-Argüelles, Guillermo J

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2020 Volume 72, Issue 3, Page(s) 159–164

Abstract: Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed.: Objective: The objective of the study was to study the safety and outcomes of the administration ...

Abstract	Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed. Objective: The objective of the study was to study the safety and outcomes of the administration of CoPla to individuals with severe COVID-19 in an academic medical center. Methods: Ten patients were prospectively treated with plasma from COVID-19 convalescent donors. Results: Over 8 days, the sequential organ failure assessment score dropped significantly in all patients, from 3 to 1.5 (p = 0.014); the Kirby index (PaO Conclusions: Although other treatments were also administered to the patients and as a result data are difficult to interpret, it seems that the addition of CoPla improved pulmonary function.
MeSH term(s)	Adult ; Aged ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; Biomarkers ; Body Temperature ; C-Reactive Protein/analysis ; COVID-19 ; Combined Modality Therapy ; Convalescence ; Coronavirus Infections/blood ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Coronavirus Infections/therapy ; Female ; Ferritins/blood ; Humans ; Immunization, Passive ; Kaplan-Meier Estimate ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pilot Projects ; Plasma ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/therapy ; Prospective Studies ; Respiration, Artificial ; SARS-CoV-2 ; Severity of Illness Index ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
Chemical Substances	Antibodies, Viral ; Biomarkers ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2)
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Mexico
Document type	Clinical Trial ; Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.20000237
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Zs.A 288: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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Article: Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial.

Vallejo-Villalobos, Ma Fernanda / León-Peña, Andrés / León-González, Mónica / Núñez-Cortés, Ana Karen / Olivares-Gazca, Juan Carlos / Valdés-Tapia, Patricia / Garcés-Eisele, Javier / Ruiz-Argüelles, Alejandro / Ruiz-Argüelles, Guillermo J

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

2016 Volume 33, Issue 3, Page(s) 375–379

Abstract: Activated protein C resistance (aPCR) phenotypes represent around 20% of the laboratory findings ...

Abstract	Activated protein C resistance (aPCR) phenotypes represent around 20% of the laboratory findings in Mexican Mestizos having suffered thrombosis and displaying clinical markers of thrombophilia. In a single institution for a 276-month period, 96 Mexican mestizos with a history of thrombosis and clinical markers of a primary thrombophilic state were prospectively studied to identify a thrombophilic condition. An abnormal aPCR phenotype was identified in 18 individuals. Evaluation of those with an abnormal aPCR phenotype, identified that 44% had factor V Leiden mutation, 22% increased levels of factor VIII, 16% anti-phospholipid antibodies and 6% a lupus anticoagulant. In the remaining 22%, the use of direct oral anticoagulants (DOACs) in the past period of 12-24 h was recorded. We found significant associations between abnormal aPCR phenotype and the factor V Leiden mutation (
Language	English
Publishing date	2016-12-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2422370-0
ISSN	0974-0449 ; 0971-4502
ISSN (online)	0974-0449
ISSN	0971-4502
DOI	10.1007/s12288-016-0767-7
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Article: Infusion of Convalescent Plasma Is Associated with Clinical Improvement in Critically Ill Patients with Covid-19: a Pilot Study

Rev Invest Clin

Abstract: ... computerized tomography scans also revealed improvement of the lung injury. Decreases in C-reactive protein and ...

Abstract	Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed. Objective: The objective of the study was to study the safety and outcomes of the administration of CoPla to individuals with severe COVID-19 in an academic medical center. Methods: Ten patients were prospectively treated with plasma from COVID-19 convalescent donors. Results: Over 8 days, the sequential organ failure assessment score dropped significantly in all patients, from 3 to 1.5 (p = 0.014); the Kirby index (PaO2/FiO2) score increased from 124 to 255, (p < 0.0001), body temperature decreased significantly from 38.1 to 36.9°C (p = 0.0058), and ferritin levels also dropped significantly from 1736.6 to 1061.8 ng/ml (p = 0.0001). Chest X-rays improved in 7/10 cases and in 6/10, computerized tomography scans also revealed improvement of the lung injury. Decreases in C-reactive protein and D-dimer levels were also observed. Three of five patients on mechanical ventilation support could be extubated, nine were transferred to conventional hospital floors, and six were sent home; two patients died. The administration of CoPla had no side effects and the 24-day overall survival was 77%. Conclusions: Although other treatments were also administered to the patients and as a result data are difficult to interpret, it seems that the addition of CoPla improved pulmonary function.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #617018
Database	COVID19

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Article: Primary thrombophilia in Mexico XVIII: Increased rate of thrombosis in persons with the sticky platelet syndrome in the COVID-19 era.

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Article ; Online: Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons.

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Article ; Online: Treatment of Persons with Multiple Myeloma in Underprivileged Circumstances: Real-World Data from a Single Institution.

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Article: The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge.

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Article: Mantle cell lymphoma may have a different clinical course in Mexican Mestizos: Real-world data from a single center.

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Article: INFUSION OF CONVALESCENT PLASMA IS ASSOCIATED WITH CLINICAL IMPROVEMENT IN CRITICALLY ILL PATIENTS WITH COVID-19: A PILOT STUDY.

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Article: Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial.

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Article: Infusion of Convalescent Plasma Is Associated with Clinical Improvement in Critically Ill Patients with Covid-19: a Pilot Study

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