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  1. Article ; Online: Prostaglandin I

    Norlander, Allison E / Peebles, R Stokes

    DNA and cell biology

    2021  Volume 40, Issue 10, Page(s) 1231–1234

    Abstract: Tregulatory cells (Tregs) are an important member of the adaptive immune system and function to reduce and resolve inflammation. Prostaglandin ... ...

    Abstract Tregulatory cells (Tregs) are an important member of the adaptive immune system and function to reduce and resolve inflammation. Prostaglandin I
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Autoimmune Diseases/drug therapy ; Epoprostenol/metabolism ; Epoprostenol/pharmacology ; Epoprostenol/therapeutic use ; Humans ; Lymphopoiesis ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Anti-Inflammatory Agents ; Epoprostenol (DCR9Z582X0)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2021.0515
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  2. Article ; Online: Mouse Models of Respiratory Syncytial Virus Infection.

    Ceneviva, Zachary J / Norlander, Allison E / Stokes Peebles, R

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2506, Page(s) 19–41

    Abstract: Respiratory syncytial virus (RSV) infection causes considerable mortality and morbidity in infants and young children. RSV infection appears to elicit a mixed immune response characterized by both Th1-type cells and Th2-type cells. This immune response, ... ...

    Abstract Respiratory syncytial virus (RSV) infection causes considerable mortality and morbidity in infants and young children. RSV infection appears to elicit a mixed immune response characterized by both Th1-type cells and Th2-type cells. This immune response, along with clinical features such as bronchiolitis, wheezing, and respiratory distress caused by RSV infection, presents similarly to many features of asthma and has led to an investigation into the link between severe RSV infection and asthma. RSV infection in mice is a powerful and useful tool for eliciting a Th2-type-driven immune response, lending mechanistic insight into severe RSV infection. Here we present several materials and methods used for propagating and purifying RSV, infecting mice with RSV, and analyzing samples from RSV-infected mice.
    MeSH term(s) Animals ; Asthma/etiology ; Child, Preschool ; Disease Models, Animal ; Humans ; Mice ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Viruses ; Th1 Cells ; Th2 Cells
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2364-0_2
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  3. Article ; Online: Innate Type 2 Responses to Respiratory Syncytial Virus Infection.

    Norlander, Allison E / Peebles, R Stokes

    Viruses

    2020  Volume 12, Issue 5

    Abstract: Respiratory syncytial virus (RSV) is a common and contagious virus that results in acute respiratory tract infections in infants. In many cases, the symptoms of RSV remain mild, however, a subset of individuals develop severe RSV-associated bronchiolitis. ...

    Abstract Respiratory syncytial virus (RSV) is a common and contagious virus that results in acute respiratory tract infections in infants. In many cases, the symptoms of RSV remain mild, however, a subset of individuals develop severe RSV-associated bronchiolitis. As such, RSV is the chief cause of infant hospitalization within the United States. Typically, the immune response to RSV is a type 1 response that involves both the innate and adaptive immune systems. However, type 2 cytokines may also be produced as a result of infection of RSV and there is increasing evidence that children who develop severe RSV-associated bronchiolitis are at a greater risk of developing asthma later in life. This review summarizes the contribution of a newly described cell type, group 2 innate lymphoid cells (ILC2), and epithelial-derived alarmin proteins that activate ILC2, including IL-33, IL-25, thymic stromal lymphopoietin (TSLP), and high mobility group box 1 (HMGB1). ILC2 activation leads to the production of type 2 cytokines and the induction of a type 2 response during RSV infection. Intervening in this innate type 2 inflammatory pathway may have therapeutic implications for severe RSV-induced disease.
    MeSH term(s) Animals ; Cytokines/genetics ; Cytokines/immunology ; Humans ; Immunity, Innate ; Respiratory Syncytial Virus Infections/genetics ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Viruses/genetics ; Respiratory Syncytial Viruses/immunology
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12050521
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  4. Article ; Online: Reply to Yasuma

    Norlander, Allison E / Abney, Masako / Cephus, Jacqueline-Yvonne / Roe, Caroline E / Irish, Jonathan M / Shelburne, Nicholas J / Newcomb, Dawn C / Hemnes, Anna R / Peebles, R Stokes

    American journal of respiratory and critical care medicine

    2024  Volume 208, Issue 11, Page(s) 1249–1250

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202309-1622LE
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  5. Article ; Online: Bovine Serum Albumin Elicits IL-33-Dependent Adipose Tissue Eosinophilia: Potential Relevance to Ovalbumin-induced Models of Allergic Disease.

    Caslin, Heather L / Bolus, W Reid / Thomas, Christopher / Toki, Shinji / Norlander, Allison E / Peebles, R Stokes / Hasty, Alyssa H

    ImmunoHorizons

    2023  Volume 7, Issue 12, Page(s) 842–852

    Abstract: All cells of the immune system reside in adipose tissue (AT), and increasing type 2 immune cells may be a therapeutic strategy to improve metabolic health. In our previous study using i.p. IL-5 injections to increase eosinophils, we observed that a ... ...

    Abstract All cells of the immune system reside in adipose tissue (AT), and increasing type 2 immune cells may be a therapeutic strategy to improve metabolic health. In our previous study using i.p. IL-5 injections to increase eosinophils, we observed that a standard vehicle control of 0.1% BSA also elicited profound AT eosinophilia. In this study, we aimed to determine whether BSA-induced AT eosinophilia results in metabolic benefits in murine models of diet-induced obesity. I.p. 0.1% BSA injections increased AT eosinophils after 4 wk. Despite elevating eosinophils to >50% of immune cells in the AT, body weight and glucose tolerance were not different between groups. Interestingly, BSA elicited epithelial IL-33 production, as well as gene expression for type 2 cytokines and IgE production that were dependent on IL-33. Moreover, multiple models of OVA sensitization also drove AT eosinophilia. Following transplantation of a donor fat pad with BSA-induced eosinophilia, OVA-sensitized recipient mice had higher numbers of bronchoalveolar lavage eosinophils that were recipient derived. Interestingly, lungs of recipient mice contained eosinophils, macrophages, and CD8 T cells from the donor AT. These trafficked similarly from BSA- and non-BSA-treated AT, suggesting even otherwise healthy AT serves as a reservoir of immune cells capable of migrating to the lungs. In conclusion, our studies suggest that i.p. injections of BSA and OVA induce an allergic response in the AT that elicits eosinophil recruitment, which may be an important consideration for those using OVA in animal models of allergic disease.
    MeSH term(s) Mice ; Animals ; Ovalbumin ; Serum Albumin, Bovine ; Interleukin-33 ; Hypersensitivity ; Eosinophilia ; Adipose Tissue
    Chemical Substances Ovalbumin (9006-59-1) ; Serum Albumin, Bovine (27432CM55Q) ; Interleukin-33
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2300061
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  6. Article ; Online: Correction: The immunology of hypertension.

    Norlander, Allison E / Madhur, Meena S / Harrison, David G

    The Journal of experimental medicine

    2018  Volume 215, Issue 2, Page(s) 719

    Language English
    Publishing date 2018-01-05
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2017177301022018c
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  7. Article ; Online: Prostaglandin I

    Norlander, Allison E / Abney, Masako / Cephus, Jacqueline-Yvonne / Roe, Caroline E / Irish, Jonathan M / Shelburne, Nicholas J / Newcomb, Dawn C / Hemnes, Anna R / Peebles, R Stokes

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 6, Page(s) 737–739

    MeSH term(s) Humans ; Epoprostenol/therapeutic use ; Pulmonary Arterial Hypertension/drug therapy ; T-Lymphocytes, Regulatory ; Hypertension, Pulmonary/drug therapy ; Familial Primary Pulmonary Hypertension
    Chemical Substances Epoprostenol (DCR9Z582X0)
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202304-0716LE
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  8. Article ; Online: Inflammatory cytokines regulate renal sodium transporters: how, where, and why?

    Norlander, Allison E / Madhur, Meena S

    American journal of physiology. Renal physiology

    2017  Volume 313, Issue 2, Page(s) F141–F144

    Abstract: Hypertension is growing in epidemic proportions worldwide and is now the leading preventable cause of premature death. For over a century, we have known that the kidney plays a critical role in blood pressure regulation. Specifically, abnormalities in ... ...

    Abstract Hypertension is growing in epidemic proportions worldwide and is now the leading preventable cause of premature death. For over a century, we have known that the kidney plays a critical role in blood pressure regulation. Specifically, abnormalities in renal sodium transport appear to be a final common pathway that gives rise to elevated blood pressure regardless of the nature of the initial hypertensive stimulus. However, it is only in the past decade that we have come to realize that inflammatory cytokines secreted by innate and adaptive immune cells, as well as renal epithelial cells, can modulate the expression and activity of sodium transporters all along the nephron, leading to alterations in pressure natriuresis, sodium and water balance, and ultimately hypertension. This mini-review highlights specific cytokines and the transporters that they regulate and discusses why inflammatory cytokines may have evolved to serve this function.
    MeSH term(s) Animals ; Blood Pressure ; Cytokines/immunology ; Cytokines/metabolism ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Epithelial Sodium Channels/immunology ; Epithelial Sodium Channels/metabolism ; Humans ; Hypertension/immunology ; Hypertension/metabolism ; Hypertension/physiopathology ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Kidney/immunology ; Kidney/metabolism ; Kidney/physiopathology ; Membrane Transport Proteins/immunology ; Membrane Transport Proteins/metabolism ; Renal Reabsorption ; Signal Transduction ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Cytokines ; Epithelial Sodium Channels ; Inflammation Mediators ; Membrane Transport Proteins ; Sodium Chloride, Dietary
    Language English
    Publishing date 2017-08-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00465.2016
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  9. Article ; Online: Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33-Dependent Inflammation.

    Cook, Daniel P / Thomas, Christopher M / Wu, Ashley Y / Rusznak, Mark / Zhang, Jian / Zhou, Weisong / Cephus, Jacqueline-Yvonne / Gibson-Corley, Katherine N / Polosukhin, Vasiliy V / Norlander, Allison E / Newcomb, Dawn C / Stoltz, David A / Peebles, R Stokes

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 11, Page(s) 1486–1497

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Mice ; Animals ; Humans ; Cystic Fibrosis/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Interleukin-33/metabolism ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Inflammation/metabolism ; Cytokines/metabolism ; Allergens ; Epithelial Cells/metabolism
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; Cytokines ; Allergens
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202211-2096OC
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  10. Article ; Online: The immunology of hypertension.

    Norlander, Allison E / Madhur, Meena S / Harrison, David G

    The Journal of experimental medicine

    2017  Volume 215, Issue 1, Page(s) 21–33

    Abstract: Although systemic hypertension affects a large proportion of the population, its etiology remains poorly defined. Emerging evidence supports the concept that immune cells become activated and enter target organs, including the vasculature and the kidney, ...

    Abstract Although systemic hypertension affects a large proportion of the population, its etiology remains poorly defined. Emerging evidence supports the concept that immune cells become activated and enter target organs, including the vasculature and the kidney, in this disease. Mediators released by these cells, including reactive oxygen species, metalloproteinases, cytokines, and antibodies promote dysfunction of the target organs and cause damage. In vessels, these factors enhance constriction, remodeling, and rarefaction. In the kidney, these mediators increase expression and activation of sodium transporters, and cause interstitial fibrosis and glomerular injury. Factors common to hypertension, including oxidative stress, increased interstitial sodium, cytokine production, and inflammasome activation promote immune activation in hypertension. Recent data suggest that isolevuglandin-modified self-proteins in antigen-presenting cells are immunogenic, promoting cytokine production by the cells in which they are formed and T cell activation. Efforts to prevent and reverse immune activation may prove beneficial in preventing the long-term sequelae of hypertension and its related cardiovascular diseases.
    MeSH term(s) Animals ; Gastrointestinal Microbiome ; Humans ; Hypertension/etiology ; Hypertension/metabolism ; Hypertension/physiopathology ; Immune System/immunology ; Immune System/metabolism ; Immunity ; Lymphocyte Activation/immunology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Organ Specificity/immunology
    Language English
    Publishing date 2017-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20171773
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