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Article ; Online: National and cultural semantics of Russian anthropometaphors

Denisenko Elena Nikolaevna

SHS Web of Conferences, Vol 127, p

2021 Volume 02018

Abstract: The article belongs to the field of cognitive-oriented research and examines the role of humans in language and culture and the need to study their close relationships. Each culture generates certain types of anthropometaphors, and each such nomination ... ...

Abstract	The article belongs to the field of cognitive-oriented research and examines the role of humans in language and culture and the need to study their close relationships. Each culture generates certain types of anthropometaphors, and each such nomination reflects the elements of this culture. Lexical units in a figurative sense, being “universals of consciousness”, can have vivid national and cultural markings or function as globally precedent names. Anthropometaphors are an important source of not only linguistic but also historical and cultural knowledge. The article provides examples of the deconstruction of anthroponyms, filling them with the expressiveness of the appellative, and indicates the main factors in their rethinking.
Keywords	anthropometaphor ; appellative ; anthroponym ; national-cultural connotation ; linguoculture ; Social Sciences ; H
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biopolitics and legal issues of emergency situations in the context of coronavirus pandemic

Denisenko Vladislav / Trikoz Elena

E3S Web of Conferences, Vol 175, p

2020 Volume 14013

Abstract: It is difficult to overestimate the importance of biopolitical issues at the present time. The modern social state and the developing biolaw regulate a lot of private and public legal relations, especially the sensitive sphere of somatic and reproductive ...

Abstract	It is difficult to overestimate the importance of biopolitical issues at the present time. The modern social state and the developing biolaw regulate a lot of private and public legal relations, especially the sensitive sphere of somatic and reproductive human rights, and the biological status of citizens. The most important aspect of national legal regulation, such as the ratio of law and morality, international bio-standards, is being updated, and the status of bioethics and biolaw is being raised. The development of modern genetic engineering and biotechnologies raises the question of the legal boundaries of biopolitics. It has been found that national governments often expand biopolitical impact in situations of emergency and new biohazards, in particular, the COVID-19 pandemic. The paper is prepared using doctrinal-legal and comparative-synchronous analysis of legal measures applied by different countries in the field of biopolitics. The research is based on extensive scientific and regulatory material. As a result, it was concluded that at the current stage of countering the pandemic, many countries restrict the biological rights of citizens and activate genetic technologies. The Russian and foreign experience of biopolitics in the state of emergency wasstudied.
Keywords	Environmental sciences ; GE1-350 ; covid19
Subject code	340
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Museum and center for contemporary art

Bashirova Elza / Denisenko Elena / Akhmetova Kamilla / Kadirov Vilnur

E3S Web of Conferences, Vol 274, p

design principles and functional features

2021 Volume 01019

Abstract: The article discusses the topical issue of the establishment of museum and center for contemporary art. The objective of the research is to analyze the historical background of contemporary art museums; to review the world design practice of them ... ...

Abstract	The article discusses the topical issue of the establishment of museum and center for contemporary art. The objective of the research is to analyze the historical background of contemporary art museums; to review the world design practice of them according to urban planning, functional, architectural and expositional criteria; to reveal functional features’ trends and to identify the design principles of an advanced center for contemporary art. We collected more than 45 leading examples to compile a matrix using classification and analysis methods. As a result, we reached the museums’ functional features: administrative, exhibition, educational, recreational are fixed functions; storage and research functions are optional; cultural and entertainment are particularly additional functions. At first, art museums and centers are focused on adaption to visitors and intersection with them, secondly, on the exhibit. To sum up, we define the design principles of the ideal architectural model on the basis of urban planning, architectural, sociocultural and technological radicals. In conclusion, it is revealed that contemporary art centers have absorbed most of the historical functions of the museum and today are one of the developed types of the multifunctional architecture.
Keywords	architecture ; center for contemporary art ; museum ; contemporary art ; design principles ; functional features ; Environmental sciences ; GE1-350
Subject code	700
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Structural Analysis of Oxidized Cerebrosides from the Extract of Deep-Sea Sponge

Santalova, Elena A / Denisenko, Vladimir A / Dmitrenok, Pavel S

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 24

Abstract: The structural elucidation of primary and secondary peroxidation products, formed from complex lipids, is a challenge in lipid analysis. In the present study, rare minor oxidized cerebrosides, isolated from the extract of a far eastern deep-sea glass ... ...

Abstract	The structural elucidation of primary and secondary peroxidation products, formed from complex lipids, is a challenge in lipid analysis. In the present study, rare minor oxidized cerebrosides, isolated from the extract of a far eastern deep-sea glass sponge,
MeSH term(s)	Amides/chemistry ; Animals ; Cerebrosides/chemistry ; Chromatography, High Pressure Liquid/methods ; Chromatography, Reverse-Phase/methods ; Complex Mixtures/chemistry ; Fatty Acids/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Glycosphingolipids/chemistry ; Lipids/chemistry ; Oxygen/chemistry ; Porifera/chemistry
Chemical Substances	Amides ; Cerebrosides ; Complex Mixtures ; Fatty Acids ; Glycosphingolipids ; Lipids ; Oxygen (S88TT14065)
Language	English
Publishing date	2020-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25246047
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Zs.MO 81: Show issues

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Article ; Online: Role of Toll-Like Receptor 2 in Regulation of T-Helper Immune Response in Chronic Obstructive Pulmonary Disease.

Sidletskaya, Karolina A / Vitkina, Tatyana I / Denisenko, Yulia K / Mineeva, Elena E

Canadian respiratory journal

2021 Volume 2021, Page(s) 5596095

Abstract: Objective: According to modern views, the differences in the clinical course of chronic obstructive pulmonary disease (COPD) are associated with certain types of T-helper (Th) immune response. Recent data have shown that toll-like receptor 2 (TLR2) is ... ...

Abstract	Objective: According to modern views, the differences in the clinical course of chronic obstructive pulmonary disease (COPD) are associated with certain types of T-helper (Th) immune response. Recent data have shown that toll-like receptor 2 (TLR2) is involved in the development of Th immune response. However, TLR2-mediated regulation of Th subpopulation balance in COPD needs to be elucidated. The aim of our work is to determine the mechanisms of TLR2-mediated regulation of Th immune response in COPD of varying severity. Methods: The study included 323 smokers/ex-smokers with stable COPD (GOLD I, GOLD II, and GOLD III) and 97 healthy nonsmokers (control group). Serum levels of Th1 (TNF- Results: Patients with COPD GOLD II and III with Th1 and Th17 cytokine profiles exhibited an increase in the percentage of CD4 Conclusions: Enhanced TLR2 expression on CD4
MeSH term(s)	Cytokines/blood ; Disease Progression ; Humans ; Immunity ; Interleukin-17 ; Interleukin-6 ; Pulmonary Disease, Chronic Obstructive/immunology ; Toll-Like Receptor 2
Chemical Substances	Cytokines ; Interleukin-17 ; Interleukin-6 ; Toll-Like Receptor 2
Language	English
Publishing date	2021-08-13
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1213103-9
ISSN	1916-7245 ; 1198-2241
ISSN (online)	1916-7245
ISSN	1198-2241
DOI	10.1155/2021/5596095
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Article ; Online: Fatty Acids from a Glass Sponge Aulosaccus sp. Occurrence of New Cyclopropane-Containing and Methyl-Branched Acids.

Santalova, Elena A / Denisenko, Vladimir A

Lipids

2017 Volume 52, Issue 1, Page(s) 73–82

Abstract: In order to identify new structures, the free fatty acids from an extract of a glass sponge Aulosaccus sp. (from the north-west Pacific) belonging to one of the least chemically investigated classes (Hexactinellida), were fractionated by RP-HPLC and ... ...

Abstract	In order to identify new structures, the free fatty acids from an extract of a glass sponge Aulosaccus sp. (from the north-west Pacific) belonging to one of the least chemically investigated classes (Hexactinellida), were fractionated by RP-HPLC and analyzed by NMR spectroscopy and GC-MS of their pyrrolidine derivatives, methyl(ethyl) esters and their dimethyl disulfide adducts. One hundred and twenty-three C
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid ; Cyclopropanes/chemistry ; Fatty Acids/analysis ; Fatty Acids/chemistry ; Gas Chromatography-Mass Spectrometry ; Magnetic Resonance Spectroscopy ; Porifera/chemistry
Chemical Substances	Cyclopropanes ; Fatty Acids ; cyclopropane fatty acids
Language	English
Publishing date	2017-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	241539-2
ISSN	1558-9307 ; 0024-4201
ISSN (online)	1558-9307
ISSN	0024-4201
DOI	10.1007/s11745-016-4214-1
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Zs.A 645: Show issues

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Article ; Online: scMatch: a single-cell gene expression profile annotation tool using reference datasets.

Hou, Rui / Denisenko, Elena / Forrest, Alistair R R

Bioinformatics (Oxford, England)

2019 Volume 35, Issue 22, Page(s) 4688–4695

Abstract: Motivation: Single-cell RNA sequencing (scRNA-seq) measures gene expression at the resolution of individual cells. Massively multiplexed single-cell profiling has enabled large-scale transcriptional analyses of thousands of cells in complex tissues. In ... ...

Abstract	Motivation: Single-cell RNA sequencing (scRNA-seq) measures gene expression at the resolution of individual cells. Massively multiplexed single-cell profiling has enabled large-scale transcriptional analyses of thousands of cells in complex tissues. In most cases, the true identity of individual cells is unknown and needs to be inferred from the transcriptomic data. Existing methods typically cluster (group) cells based on similarities of their gene expression profiles and assign the same identity to all cells within each cluster using the averaged expression levels. However, scRNA-seq experiments typically produce low-coverage sequencing data for each cell, which hinders the clustering process. Results: We introduce scMatch, which directly annotates single cells by identifying their closest match in large reference datasets. We used this strategy to annotate various single-cell datasets and evaluated the impacts of sequencing depth, similarity metric and reference datasets. We found that scMatch can rapidly and robustly annotate single cells with comparable accuracy to another recent cell annotation tool (SingleR), but that it is quicker and can handle larger reference datasets. We demonstrate how scMatch can handle large customized reference gene expression profiles that combine data from multiple sources, thus empowering researchers to identify cell populations in any complex tissue with the desired precision. Availability and implementation: scMatch (Python code) and the FANTOM5 reference dataset are freely available to the research community here https://github.com/forrest-lab/scMatch. Supplementary information: Supplementary data are available at Bioinformatics online.
MeSH term(s)	Algorithms ; Gene Expression Profiling ; Single-Cell Analysis ; Software ; Transcriptome
Language	English
Publishing date	2019-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btz292
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Zs.A 2374: Show issues

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Article ; Online: Structural Analysis of Oxidized Cerebrosides from the Extract of Deep-Sea Sponge Aulosaccus sp.

Elena A. Santalova / Vladimir A. Denisenko / Pavel S. Dmitrenok

Molecules, Vol 25, Iss 6047, p

Occurrence of Amide-Linked Allylically Oxygenated Fatty Acids

2020 Volume 6047

Abstract	The structural elucidation of primary and secondary peroxidation products, formed from complex lipids, is a challenge in lipid analysis. In the present study, rare minor oxidized cerebrosides, isolated from the extract of a far eastern deep-sea glass sponge, Aulosaccus sp., were analyzed as constituents of a multi-component RP-HPLC (high-performance liquid chromatography on reversed-phase column) fraction using NMR (nuclear magnetic resonance) spectroscopy, mass spectrometry, GC (gas chromatography), and chemical transformations (including hydrogenation or derivatization with dimethyl disulfide before hydrolysis). Eighteen previously unknown β-D-glucopyranosyl-(1→1)-ceramides ( 1a – a // , 1b – b // , 2a – a // , 2b – b // , 3c – c // , 3d – d // ) were shown to contain phytosphingosine-type backbones (2 S ,3 S ,4 R ,11 Z )-2-aminoeicos-11-ene-1,3,4-triol (in 1 ), (2 S ,3 S ,4 R ,13 Z )-2-aminoeicos-13-ene-1,3,4-triol (in 2 ), and (13 S ,14 R )-2-amino-13,14-methylene-eicosane-1,3,4-triol (in 3 ). These backbones were N -acylated with straight-chain monoenoic (2 R )-2-hydroxy acids that had allylic hydroperoxy/hydroxy/keto groups on C-17 / in the 15 / E -23:1 chain ( a – a // ), C-16 / in the 17 / E -23:1 ( b – b // ) and 14 / E -22:1 ( c – c // ) chains, and C-15 / in the 16 / E -22:1 chain ( d – d // ). Utilizing complementary instrumental and chemical methods allowed for the first detailed structural analysis of a complex mixture of glycosphingolipids, containing allylically oxygenated monoenoic acyl chains.
Keywords	glycosphingolipids ; cerebrosides ; peroxidation products ; structure elucidation ; allylic thioether ; NMR ; Organic chemistry ; QD241-441
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Predicting cell-to-cell communication networks using NATMI.

Hou, Rui / Denisenko, Elena / Ong, Huan Ting / Ramilowski, Jordan A / Forrest, Alistair R R

Nature communications

2020 Volume 11, Issue 1, Page(s) 5011

Abstract: Development of high throughput single-cell sequencing technologies has made it cost-effective to profile thousands of cells from diverse samples containing multiple cell types. To study how these different cell types work together, here we develop NATMI ( ...

Abstract	Development of high throughput single-cell sequencing technologies has made it cost-effective to profile thousands of cells from diverse samples containing multiple cell types. To study how these different cell types work together, here we develop NATMI (Network Analysis Toolkit for Multicellular Interactions). NATMI uses connectomeDB2020 (a database of 2293 manually curated ligand-receptor pairs with literature support) to predict and visualise cell-to-cell communication networks from single-cell (or bulk) expression data. Using multiple published single-cell datasets we demonstrate how NATMI can be used to identify (i) the cell-type pairs that are communicating the most (or most specifically) within a network, (ii) the most active (or specific) ligand-receptor pairs active within a network, (iii) putative highly-communicating cellular communities and (iv) differences in intercellular communication when profiling given cell types under different conditions. Furthermore, analysis of the Tabula Muris (organism-wide) atlas confirms our previous prediction that autocrine signalling is a major feature of cell-to-cell communication networks, while also revealing that hundreds of ligands and their cognate receptors are co-expressed in individual cells suggesting a substantial potential for self-signalling.
MeSH term(s)	Age Factors ; Animals ; Autocrine Communication ; Cell Communication ; Computational Biology/methods ; Data Visualization ; Databases, Factual ; Female ; Ligands ; Mammary Glands, Animal ; Mice ; Proteins/metabolism ; Single-Cell Analysis ; Software ; User-Computer Interface
Chemical Substances	Ligands ; Proteins
Language	English
Publishing date	2020-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18873-z
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Article ; Online: Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones.

Nature communications

2024 Volume 15, Issue 1, Page(s) 2860

Abstract: High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Here, we use ... ...

Abstract	High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Here, we use spatial transcriptomics to identify HGSOC subclones and study their association with infiltrating cell populations. Visium spatial transcriptomics reveals multiple tumour subclones with different copy number alterations present within individual tumour sections. These subclones differentially express various ligands and receptors and are predicted to differentially associate with different stromal and immune cell populations. In one sample, CosMx single molecule imaging reveals subclones differentially associating with immune cell populations, fibroblasts, and endothelial cells. Cell-to-cell communication analysis identifies subclone-specific signalling to stromal and immune cells and multiple subclone-specific autocrine loops. Our study highlights the high degree of subclonal heterogeneity in HGSOC and suggests that subclone-specific ligand and receptor expression patterns likely modulate how HGSOC cells interact with their local microenvironment.
MeSH term(s)	Humans ; Female ; Tumor Microenvironment/genetics ; Endothelial Cells/metabolism ; Ovarian Neoplasms/pathology ; Gene Expression Profiling ; DNA Copy Number Variations
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47271-y
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