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  1. Article ; Online: SARS-CoV-2 learned the 'Alpha'bet of immune evasion.

    Liu, GuanQun / Gack, Michaela U

    Nature immunology

    2022  Volume 23, Issue 3, Page(s) 351–353

    MeSH term(s) COVID-19 ; Humans ; Immune Evasion ; SARS-CoV-2
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01148-8
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    Zs.A 5294: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 42: Show issues

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  2. Article ; Online: Association between dietary carbohydrate intake percentage and epilepsy prevalence in the NHANES 2013-2018: a cross-sectional study.

    Liu, Yanting / Hu, Guanqun / Zhang, Meiyun / Lin, Jingna

    Nutritional neuroscience

    2024  , Page(s) 1–9

    Abstract: Background: Epilepsy is a neurological disorder characterized by recurrent seizures. We aimed to investigate the association between the percentage of dietary carbohydrate intake (DCI) and epilepsy prevalence among American adults.: Methods: We ... ...

    Abstract Background: Epilepsy is a neurological disorder characterized by recurrent seizures. We aimed to investigate the association between the percentage of dietary carbohydrate intake (DCI) and epilepsy prevalence among American adults.
    Methods: We analyzed the data from 9,584 adults aged 20-80 years who participated in the National Health and Nutrition Examination Survey from 2013 to 2018. Logistic regression was applied to explore the association between the percentage of DCI and epilepsy prevalence.
    Results: A total of 146 (1.5%) individuals with epilepsy were enrolled in this study. The average age of the participants was 56.4 years, and 5,454 (56.9%) individuals were female. A high DCI was associated with an increased prevalence of epilepsy (odds ratio [OR], 4.56; 95% confidence interval [CI], 1.11-18.69;
    Conclusions: A high percentage of DCI was associated with an increased prevalence of epilepsy. The risk of epilepsy increased 3.5-fold with a 1% increase in DCI. These results suggest an important role of DCI in the dietary management of epilepsy.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1447449-9
    ISSN 1476-8305 ; 1028-415X
    ISSN (online) 1476-8305
    ISSN 1028-415X
    DOI 10.1080/1028415X.2024.2329481
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  3. Article ; Online: An optimized circular polymerase extension reaction-based method for functional analysis of SARS-CoV-2.

    Liu, GuanQun / Gack, Michaela U

    Virology journal

    2023  Volume 20, Issue 1, Page(s) 63

    Abstract: Background: Reverse genetics systems have been crucial for studying specific viral genes and their relevance in the virus lifecycle, and become important tools for the rational attenuation of viruses and thereby for vaccine design. Recent rapid progress ...

    Abstract Background: Reverse genetics systems have been crucial for studying specific viral genes and their relevance in the virus lifecycle, and become important tools for the rational attenuation of viruses and thereby for vaccine design. Recent rapid progress has been made in the establishment of reverse genetics systems for functional analysis of SARS-CoV-2, a coronavirus that causes the ongoing COVID-19 pandemic that has resulted in detrimental public health and economic burden. Among the different reverse genetics approaches, circular polymerase extension reaction (CPER) has become one of the leading methodologies to generate recombinant SARS-CoV-2 infectious clones. Although CPER has greatly facilitated SARS-CoV-2 analysis, it still has certain intrinsic limitations that impede the efficiency and robustness of virus rescue.
    Results: We developed an optimized CPER methodology which, through the use of a modified linker plasmid and by performing DNA nick ligation and direct transfection of permissive cells, overcomes certain intrinsic limitations of the 'traditional' CPER approaches for SARS-CoV-2, allowing for efficient virus rescue.
    Conclusions: The herein described optimized CPER system may facilitate research studies to assess the contribution of SARS-CoV-2 genes and individual motifs or residues to virus replication, pathogenesis and immune escape, and may also be adapted to other viruses.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Pandemics ; Virus Replication ; Nucleotidyltransferases
    Chemical Substances Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-023-02025-y
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  4. Article ; Online: Color-guided deformable convolution network for intestinal metaplasia severity classification using endoscopic images.

    Li, Zheng / Zheng, Xiangwei / Mu, Yijun / Zhang, Mingzhe / Liu, Guanqun

    Physics in medicine and biology

    2023  Volume 68, Issue 18

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Stomach Neoplasms ; Endoscopy ; Neural Networks, Computer ; Precancerous Conditions
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acf3ca
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    Zs.A 199: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus.

    Liu, GuanQun / Gack, Michaela U

    Current opinion in immunology

    2022  Volume 78, Page(s) 102252

    Abstract: The outbreak of the COVID-19 pandemic one year after the centennial of the 1918 influenza pandemic reaffirms the catastrophic impact respiratory viruses can have on global health and economy. A key feature of SARS-CoV-2 and influenza A viruses (IAV) is ... ...

    Abstract The outbreak of the COVID-19 pandemic one year after the centennial of the 1918 influenza pandemic reaffirms the catastrophic impact respiratory viruses can have on global health and economy. A key feature of SARS-CoV-2 and influenza A viruses (IAV) is their remarkable ability to suppress or dysregulate human immune responses. Here, we summarize the growing knowledge about the interplay of SARS-CoV-2 and antiviral innate immunity, with an emphasis on the regulation of type-I or -III interferon responses that are critically implicated in COVID-19 pathogenesis. Furthermore, we draw parallels to IAV infection and discuss shared innate immune sensing mechanisms and the respective viral countermeasures.
    MeSH term(s) Humans ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/virology ; Immunity, Innate ; Influenza A virus/immunology ; Influenza, Human/immunology ; Influenza, Human/metabolism ; Influenza, Human/virology ; Interferons/immunology ; Pandemics ; SARS-CoV-2/immunology
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2022.102252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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  6. Article ; Online: Inverted Meckel Diverticulum Diagnosed, Treated, and Followed Up by Enteroscopy.

    Jia, Xiaoqing / Ma, Tian / Liu, Guanqun / Zuo, Xiuli

    The American journal of gastroenterology

    2022  Volume 118, Issue 6, Page(s) 927

    MeSH term(s) Humans ; Meckel Diverticulum/diagnostic imaging ; Meckel Diverticulum/surgery ; Laparoscopy ; Endoscopy, Gastrointestinal ; Diverticulum
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002141
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  7. Article: An Optimized Circular Polymerase Extension Reaction-based Method for Functional Analysis of SARS-CoV-2.

    Liu, GuanQun / Gack, Michaela U

    bioRxiv : the preprint server for biology

    2022  

    Abstract: Reverse genetics systems have been crucial for studying specific viral genes and their relevance in the virus lifecycle, and become important tools for the rational attenuation of viruses and thereby for vaccine design. Recent rapid progress has been ... ...

    Abstract Reverse genetics systems have been crucial for studying specific viral genes and their relevance in the virus lifecycle, and become important tools for the rational attenuation of viruses and thereby for vaccine design. Recent rapid progress has been made in the establishment of reverse genetics systems for functional analysis of SARS-CoV-2, a coronavirus that causes the ongoing COVID-19 pandemic that has resulted in detrimental public health and economic burden. Among the different reverse genetics approaches, CPER (circular polymerase extension reaction) has become one of the leading methodologies to generate recombinant SARS-CoV-2 infectious clones due to its accuracy, efficiency, and flexibility. Here, we report an optimized CPER methodology which, through the use of a modified linker plasmid and by performing DNA nick ligation and direct transfection of permissive cells, overcomes certain intrinsic limitations of the 'traditional' CPER approaches for SARS-CoV-2, allowing for efficient virus rescue. This optimized CPER system may facilitate research studies to assess the contribution of SARS-CoV-2 genes and individual motifs or residues to virus replication, pathogenesis and immune escape, and may also be adapted to other viruses.
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2022.11.26.518005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: ISG15: its roles in SARS-CoV-2 and other viral infections.

    Sarkar, Lucky / Liu, GuanQun / Gack, Michaela U

    Trends in microbiology

    2023  Volume 31, Issue 12, Page(s) 1262–1275

    Abstract: Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated. Emerging ... ...

    Abstract Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated. Emerging evidence suggests that ISG15 - either in its conjugated or unconjugated 'free' form - acts both intracellularly and extracellularly, and exerts anti- or pro-viral effects. To counteract ISG15's antiviral roles, viruses have evolved sophisticated tactics. Here, we discuss recent advances in ISG15's physiological functions as a post-translational modifier or 'cytokine-like' molecule during SARS-CoV-2 and other viral infections. Furthermore, we highlight the detailed mechanisms viruses use to block ISG15-dependent antiviral defenses. A comprehensive understanding of ISG15 biology in the context of virus infection may spur new therapeutic approaches for a range of viral infectious diseases.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Cytokines/genetics ; Cytokines/metabolism ; Virus Diseases ; Ubiquitins/genetics ; Ubiquitins/metabolism ; Antiviral Agents
    Chemical Substances Cytokines ; Ubiquitins ; Antiviral Agents ; ISG15 protein, human (60267-61-0)
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2023.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Research on Multi-camera Multi-target Tracking Method Based on Hierarchical Relational Model of Trajectory Tree

    LIU Guanqun, LI Ting

    Jisuanji kexue yu tansuo, Vol 14, Iss 6, Pp 1036-

    2020  Volume 1044

    Abstract: To improve the accuracy of camera target tracking, a multi-camera multi-target tracking method based on multi-hypothesis tracking (MHT) framework using hierarchical relation model of trajectory tree is proposed. First of all, the unknown number of ... ...

    Abstract To improve the accuracy of camera target tracking, a multi-camera multi-target tracking method based on multi-hypothesis tracking (MHT) framework using hierarchical relation model of trajectory tree is proposed. First of all, the unknown number of trajectories can be found by spatiotemporal correlation between trajectories generated by multiple cameras, and the three-dimensional trajectory of the target can be estimated online by solving the maximum weight clique problem (MWCP) of each frame. Then, in order to solve the NP problem of multi-frame image processing, a new online scheme is proposed, which uses the feedback information of the results of the previous frame to establish a multi-frame image processing scheme, so as to find the best trajectory in each frame. This scheme can make multiple sub-problems constitute multi-objective and multi-objective control problems, and greatly reduces the amount of calculation. Experiments show that the algorithm has better performance than the most advanced batch processing algorithm.
    Keywords trajectory tree ; hierarchical relationship ; multi-camera ; multi-target ; tracking ; multi-frame image ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 004
    Language Chinese
    Publishing date 2020-06-01T00:00:00Z
    Publisher Journal of Computer Engineering and Applications Beijing Co., Ltd., Science Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: ISG15: Its Roles in SARS-CoV-2 and Other Viral Infections

    Sarkar, Lucky / Liu, Guanqun / Gack, Michaela U.

    Trends in Microbiology.

    2023  

    Abstract: Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated. Emerging ... ...

    Abstract Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have just begun to be elucidated. Emerging evidence suggests that ISG15 -either in its conjugated or unconjugated 'free' form- acts both intracellularly and extracellularly, and exerts anti- or pro-viral effects. To counteract ISG15's antiviral roles, viruses have evolved sophisticated tactics. Here, we discuss recent advances in ISG15's physiological functions as a post-translational modifier or 'cytokine-like' molecule during SARS-CoV-2 and other viral infections. Furthermore, we highlight the detailed mechanisms viruses use to block ISG15-dependent antiviral defenses. A comprehensive understanding of ISG15 biology in the context of virus infection may spur new therapeutic approaches for a range of viral infectious diseases.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; genes ; interferons ; therapeutics ; viruses ; ISG15 ; ISGylation ; innate immunity ; SARS-CoV-2 ; hyperinflammation ; viral evasion
    Language English
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2023.07.006
    Database NAL-Catalogue (AGRICOLA)

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