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Article ; Online: Sustainability and molecular biology: An interview with Dr. Andrea Bodnar.

Bodnar, Andrea

2023 Volume 83, Issue 18, Page(s) 3227–3228

Abstract: Here, Molecular Cell has a discussion with Dr. Andrea Bodnar about GMGI and its various efforts ...

Abstract	Here, Molecular Cell has a discussion with Dr. Andrea Bodnar about GMGI and its various efforts to minimize harm through research and implementing sustainable practices and efforts made at the institutional level to train budding scientists with diverse scientific skills and eco-conscious mindsets.
MeSH term(s)	Molecular Biology ; Cell Division
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Interview
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.08.013
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Article: Seasonal Effects on the Performance of Finishing Pigs' Carcass and Meat Quality in Indoor Environments.

Albert, Fruzsina / Kovács-Weber, Mária / Bodnár, Ákos / Pajor, Ferenc / Egerszegi, István

Animals : an open access journal from MDPI

2024 Volume 14, Issue 2

Abstract: Most retailers in EU countries pay pig breeders for their animals' lean meat percentage, which does not align fully with measures of pork quality (such as colour). In this study, we investigated the effects of season (summer vs. autumn) on finishing pigs' ...

Abstract	Most retailers in EU countries pay pig breeders for their animals' lean meat percentage, which does not align fully with measures of pork quality (such as colour). In this study, we investigated the effects of season (summer vs. autumn) on finishing pigs' performance, carcass characteristics, and meat quality parameters in 24 slaughter pigs. Growing performance traits (live weights, average daily weight gain), slaughter values (warm and cold carcass weights, trunk length, fat thickness) and meat quality parameters (pH at 45 min and 24 h postmortem, colour, drip loss, thawing loss, cooking loss, shear force, and meat composition) were recorded. Seasonal differences were more pronounced for the initial age, the number of days in the growing-finishing phase, and the average daily gain. There was also a significant difference in the trunk length between groups, the fat thickness on withers and loin, and also in mean fat thickness. A significant difference was found in the case of pH, total drip loss, and meat colour (L*). The intramuscular fat and collagen content of meat was significantly higher in summer; in contrast, the protein content of meat samples was considerably lower in summer. In conclusion, seasonal effects on finishers' performance, lean meat values, and several meat quality parameters highlight the importance of more profound seasonal settings of climate control to fulfil the progressively changing quantitative and qualitative requests of pork sector participants from farm to fork.
Language	English
Publishing date	2024-01-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14020259
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Article ; Online: Correction to "Perspectives on Genetically Engineered Microorganisms and Their Regulation in the United States".

Shams, Arik / Fischer, Alexandria / Bodnar, Anastasia / Kliegman, Melinda

ACS synthetic biology

2024

Language	English
Publishing date	2024-05-18
Publishing country	United States
Document type	Published Erratum
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.4c00325
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Article ; Online: Perspectives on Genetically Engineered Microorganisms and Their Regulation in the United States.

Shams, Arik / Fischer, Alexandria / Bodnar, Anastasia / Kliegman, Melinda

ACS synthetic biology

2024 Volume 13, Issue 5, Page(s) 1412–1423

Abstract: Genetically engineered microorganisms (GEMs) represent a new paradigm in our ability to address the needs of a growing, changing world. GEMs are being used in agriculture, food production and additives, manufacturing, commodity and noncommodity products, ...

Abstract	Genetically engineered microorganisms (GEMs) represent a new paradigm in our ability to address the needs of a growing, changing world. GEMs are being used in agriculture, food production and additives, manufacturing, commodity and noncommodity products, environmental remediation, etc., with even more applications in the pipeline. Along with modern advances in genome-manipulating technologies, new manufacturing processes, markets, and attitudes are driving a boom in more products that contain or are derived from GEMs. Consequentially, researchers and developers are poised to interact with biotechnology regulatory policies that have been in effect for decades, but which are out of pace with rapidly changing scientific advances and knowledge. In the United States, biotechnology is regulated by multiple agencies with overlapping responsibilities. This poses a challenge for both developers and regulators to simultaneously allow new innovation and products into the market while also ensuring their safety and efficacy for the public and environment. This article attempts to highlight the various factors that interact between regulatory policy and development of GEMs in the United States, with perspectives from both regulators and developers. We present insights from a 2022 workshop hosted at the University of California, Berkeley that convened regulators from U.S. regulatory agencies and industry developers of various GEMs and GEM-derived products. We highlight several new biotechnologies and applications that are driving innovation in this space, and how regulatory agencies evaluate and assess these products according to current policies. Additionally, we describe recent updates to regulations that incorporate new technology and knowledge and how they can adapt further to effectively continue regulating for the future.
MeSH term(s)	United States ; Biotechnology/methods ; Genetic Engineering/methods ; Genetic Engineering/legislation & jurisprudence ; Microorganisms, Genetically-Modified
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.4c00048
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Article: The Effect of Acetylsalicylic Acid, as a Representative Non-Steroidal Anti-Inflammatory Drug, on the Activity of Myeloperoxidase.

Gąsowska-Bajger, Beata / Sosnowska, Kinga / Gąsowska-Bodnar, Agnieszka / Bodnar, Lubomir

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 7

Abstract: Background: Acetylsalicylic acid (ASA or aspirin) is one of the world's most widely used non-steroidal anti-inflammatory drug (NSAID). Numerous studies have shown that the long-term use of aspirin may contribute to longer survival among patients with ... ...

Abstract	Background: Acetylsalicylic acid (ASA or aspirin) is one of the world's most widely used non-steroidal anti-inflammatory drug (NSAID). Numerous studies have shown that the long-term use of aspirin may contribute to longer survival among patients with various types of cancer, including ovarian cancer. Aim: The aim of this study was to investigate the effect of ASA on myeloperoxidase (MPO), which is found at an elevated level in women with ovarian cancer, among others. Methods: The influence of different concentrations of ASA on the chlorinating and peroxidase activity of MPO was analysed. The relationship between the concentration of ASA and the degree of inhibition of MPO activity was determined based on the results. Conclusions: Aspirin has a significant effect on MPO activity. The use of 50 mM ASA resulted in the enzyme activity being inhibited by more than 90%.
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16071012
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Article ; Online: Controlling the formation of halogenated byproducts in the chlorination of source waters by oxidative pre-treatment with the Fe(II)/Fe(III)-S(IV)-air system.

Truzsi, Alexandra / Kovács, Boglárka / Bodnár, Ildikó / Fábián, István

Ecotoxicology and environmental safety

2022 Volume 244, Page(s) 114036

Abstract: Breakpoint chlorination is a generally accepted method for removing ammonium ion from source waters in drinking water treatment technologies. This process is often accompanied by the formation of halogenated organic byproducts. The presence of these ... ...

Abstract	Breakpoint chlorination is a generally accepted method for removing ammonium ion from source waters in drinking water treatment technologies. This process is often accompanied by the formation of halogenated organic byproducts. The presence of these compounds in potable water is of primary concern. In this paper, we demonstrate that the concentration of the precursors of the halogenated species can sufficiently be decreased by oxidizing the organic pollutants with the Fe(II)/Fe(III) - S(IV) - air system. Pre-oxidative treatment of the source waters results in a substantial reduction of chemical oxygen demand, while the ammonium ion concentration remains unaffected. The breakpoint chlorination produces substantially less trihalomethanes (THMs) and adsorbable halogenated organic compounds (AOXs) in oxidatively pre-treated source waters than in raw waters. These results offer a possibility to improve drinking water treatment technologies for better controlling the formation of antagonistic byproducts. It is demonstrated that reaching the regulated concentration levels of THMs is feasible with this method even in source waters containing organic pollutants at relatively high concentration levels. The main advantage of the procedure is that the reagents used for the oxidative pre-treatment are converted into non-toxic products (Fe(III) and SO
MeSH term(s)	Ammonium Compounds ; Disinfectants ; Disinfection/methods ; Drinking Water ; Ferric Compounds ; Ferrous Compounds ; Halogenation ; Oxidation-Reduction ; Oxidative Stress ; Trihalomethanes/analysis ; Water Pollutants, Chemical/analysis ; Water Purification/methods
Chemical Substances	Ammonium Compounds ; Disinfectants ; Drinking Water ; Ferric Compounds ; Ferrous Compounds ; Trihalomethanes ; Water Pollutants, Chemical
Language	English
Publishing date	2022-08-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.114036
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Article ; Online: Are Detailed Behavioral, Psychosocial, and Environmental Variables Necessary to Control for Confounding in Pregnancy Weight Gain Research?

Bodnar, Lisa M / Hutcheon, Jennifer A

Epidemiology (Cambridge, Mass.)

2022 Volume 34, Issue 1, Page(s) 56–63

Abstract: Background: Associations between pregnancy weight gain and adverse outcomes may be spurious owing to confounding by factors not typically measured in cohort studies. We determined the extent to which the addition of detailed behavioral, psychosocial, ... ...

Abstract	Background: Associations between pregnancy weight gain and adverse outcomes may be spurious owing to confounding by factors not typically measured in cohort studies. We determined the extent to which the addition of detailed behavioral, psychosocial, and environmental measurements to commonly available covariates improved control of confounding. Methods: We used data from a prospective US pregnancy cohort study (2010-2013, n = 8978). We calculated two propensity scores for low and high pregnancy weight gain (vs. adequate gain) using 11 standard confounders (e.g., age and education). We examined the balance of characteristics between weight gain groups before and after propensity score matching. We used negative binomial regression to estimate the association between weight gain and small- and large-for-gestational-age birth, preterm birth, and unplanned cesarean delivery, controlling for propensity score. To this model, we then added 17 detailed behavioral, psychosocial, and environmental measurements ("fully adjusted"). We calculated the risk ratio owing to confounding as the ratio of the standard confounder-adjusted risk ratio to the fully adjusted risk ratio. Results: There were minimal imbalances between weight gain groups in detailed measures after matching for a propensity score of standard covariates. Accordingly, the inclusion of detailed covariates had minimal impact on estimated associations between low or high pregnancy weight gain and adverse pregnancy outcomes: risk ratios owing to confounding were null for all outcomes (e.g., 1.1 [95% CI = 1.0, 1.1] for low weight gain and preterm birth). Conclusions: Adjustment for detailed behavioral, psychosocial, and environmental measurements had minimal impact on estimated associations between pregnancy weight gain and adverse perinatal outcomes.
MeSH term(s)	Infant, Newborn ; Female ; Pregnancy ; Humans ; Gestational Weight Gain ; Cohort Studies ; Prospective Studies ; Premature Birth/epidemiology ; Weight Gain
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1053263-8
ISSN	1531-5487 ; 1044-3983
ISSN (online)	1531-5487
ISSN	1044-3983
DOI	10.1097/EDE.0000000000001556
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Article ; Online: Should gestational weight gain charts exclude individuals with excess postpartum weight retention?

Socha, Peter M / Johansson, Kari / Bodnar, Lisa M / Hutcheon, Jennifer A

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

2024

Abstract: Background: High gestational weight gain is associated with excess postpartum weight retention, yet excess postpartum weight retention is not an exclusion criterion for current gestational weight gain charts. We aimed to assess the impact of excluding ... ...

Abstract	Background: High gestational weight gain is associated with excess postpartum weight retention, yet excess postpartum weight retention is not an exclusion criterion for current gestational weight gain charts. We aimed to assess the impact of excluding individuals with high interpregnancy weight change (a proxy for excess postpartum weight retention) on gestational weight gain distributions. Methods: We included individuals with an index birth from 2008 to 2014 and a subsequent birth before 2019, in the population-based Stockholm-Gotland Perinatal Cohort. We estimated gestational weight gain (kg) at 25 and 37 weeks, using weight at first prenatal visit (<14 weeks) as the reference. We calculated high interpregnancy weight change (≥10 kg and ≥5 kg) using the difference between weight at the start of an index and subsequent pregnancy. We compared gestational weight gain distributions and percentiles (stratified by early-pregnancy body mass index) before and after excluding participants with high interpregnancy weight change. Results: Among 55,723 participants, 17% had ≥10 kg and 34% had ≥5 kg interpregnancy weight change. The third, tenth, 50th, 90th and 97th percentiles of gestational weight gain were similar (largely within 1 kg) before versus after excluding participants with high interpregnancy weight change, at both 25 and 37 weeks. For example, among normal weight participants at 37 weeks, the 50th and 97th percentiles were 14 kg and 23 kg including versus 13 kg and 23 kg excluding participants with ≥5 kg interpregnancy weight change. Conclusions: Excluding individuals with excess postpartum weight retention from normative gestational weight gain charts may not meaningfully impact the charts' percentiles.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	645183-4
ISSN	1365-277X ; 0952-3871 ; 1465-8178
ISSN (online)	1365-277X
ISSN	0952-3871 ; 1465-8178
DOI	10.1111/jhn.13310
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Article ; Online: Triggering antibacterial activity of a common plant by biosorption of selected heavy metals.

Kováčová, Mária / Bodnár Yankovych, Halyna / Augustyniak, Adrian / Casas-Luna, Mariano / Remešová, Michaela / Findoráková, Lenka / Stahorský, Martin / Čelko, Ladislav / Baláž, Matej

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

2024 Volume 29, Issue 2, Page(s) 201–216

Abstract: The presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. ... ...

Abstract	The presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. Apart from biochars that are commonly used for adsorption, here we report the direct use of native plant, which is potentially interesting also for soil remediation. The highest adsorption capacity for Cu(II) and Pb(II) ions (q
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/metabolism ; Escherichia coli/drug effects ; Staphylococcus aureus/drug effects ; Adsorption ; Metals, Heavy/chemistry ; Metals, Heavy/metabolism ; Metals, Heavy/pharmacology ; Thymus Plant/chemistry ; Lead/chemistry ; Lead/metabolism ; Copper/chemistry ; Copper/pharmacology ; Copper/metabolism ; Microbial Sensitivity Tests
Language	English
Publishing date	2024-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1464026-0
ISSN	1432-1327 ; 0949-8257
ISSN (online)	1432-1327
ISSN	0949-8257
DOI	10.1007/s00775-024-02045-1
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Article ; Online: Financial incentives and prescribing behavior in primary care.

Bodnar, Olivia / Gravelle, Hugh / Gutacker, Nils / Herr, Annika

Health economics

2023 Volume 33, Issue 4, Page(s) 696–713

Abstract: Many healthcare systems prohibit primary care physicians from dispensing the drugs they prescribe due to concerns that this encourages excessive, ineffective or unnecessarily costly prescribing. Using data from the English National Health Service for ... ...

Abstract	Many healthcare systems prohibit primary care physicians from dispensing the drugs they prescribe due to concerns that this encourages excessive, ineffective or unnecessarily costly prescribing. Using data from the English National Health Service for 2011-2018, we estimate the impact of physician dispensing rights on prescribing behavior at the extensive margin (comparing practices that dispense and those that do not) and the intensive margin (comparing practices with different proportions of patients to whom they dispense). We control for practices selecting into dispensing based on observable (OLS, entropy balancing) and unobservable practice characteristics (2SLS). We find that physician dispensing increases drug costs per patient by 3.1%, due to more, and more expensive, drugs being prescribed. Reimbursement is partly based on a fixed fee per package dispensed and we find that dispensing practices prescribe smaller packages. As the proportion of the practice population for whom they can dispense increases, dispensing practices behave more like non-dispensing practices.
MeSH term(s)	Humans ; Motivation ; State Medicine ; Drug Costs ; Physicians ; Primary Health Care
Language	English
Publishing date	2023-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1135838-5
ISSN	1099-1050 ; 1057-9230
ISSN (online)	1099-1050
ISSN	1057-9230
DOI	10.1002/hec.4793
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