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  1. Article: IVIG Associated Aseptic Meningitis in a Renal Transplant Patient.

    Wanigasekera, Tamara / Grainger, Rachel J / Sexton, Donal J / Magee, Colm

    Case reports in transplantation

    2017  Volume 2017, Page(s) 6962150

    Abstract: The management of antibody-mediated rejection in renal transplant recipients involves plasmapheresis with IVIG. Aseptic meningitis is a rare adverse effect of IVIG therapy and is a diagnosis of exclusion. We report a case of a renal transplant patient ... ...

    Abstract The management of antibody-mediated rejection in renal transplant recipients involves plasmapheresis with IVIG. Aseptic meningitis is a rare adverse effect of IVIG therapy and is a diagnosis of exclusion. We report a case of a renal transplant patient who developed IVIG associated aseptic meningitis in the context of management of antibody-mediated rejection, four years after transplantation.
    Language English
    Publishing date 2017-05-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627657-4
    ISSN 2090-6951 ; 2090-6943
    ISSN (online) 2090-6951
    ISSN 2090-6943
    DOI 10.1155/2017/6962150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset.

    Scott, Jennifer / Havyarimana, Enock / Navarro-Gallinad, Albert / White, Arthur / Wyse, Jason / van Geffen, Jos / van Weele, Michiel / Buettner, Antonia / Wanigasekera, Tamara / Walsh, Cathal / Aslett, Louis / Kelleher, John D / Power, Julie / Ng, James / O'Sullivan, Declan / Hederman, Lucy / Basu, Neil / Little, Mark A / Zgaga, Lina

    Arthritis research & therapy

    2022  Volume 24, Issue 1, Page(s) 147

    Abstract: Background: The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non- ...

    Abstract Background: The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non-granulomatous AAV phenotypes. A narrow ultraviolet B spectrum induces vitD synthesis (vitD-UVB) via the skin. We hypothesised that prolonged periods of low ambient UVB (and by extension vitD deficiency) are associated with the granulomatous form of the disease and an increased risk of AAV relapse.
    Methods: Patients with AAV recruited to the Irish Rare Kidney Disease (RKD) (n = 439) and UKIVAS (n = 1961) registries were studied. Exposure variables comprised latitude and measures of ambient vitD-UVB, including cumulative weighted UVB dose (CW-D-UVB), a well-validated vitD proxy. An n-of-1 study design was used to examine the relapse risk using only the RKD dataset. Multi-level models and logistic regression were used to examine the effect of predictors on AAV relapse risk, phenotype and serotype.
    Results: Residential latitude was positively correlated (OR 1.41, 95% CI 1.14-1.74, p = 0.002) and average vitD-UVB negatively correlated (0.82, 0.70-0.99, p = 0.04) with relapse risk, with a stronger effect when restricting to winter measurements (0.71, 0.57-0.89, p = 0.002). However, these associations were not restricted to granulomatous phenotypes. We observed no clear relationship between latitude, vitD-UVB or CW-D-UVB and AAV phenotype or serotype.
    Conclusion: Our findings suggest that low winter ambient UVB and prolonged vitD status contribute to AAV relapse risk across all phenotypes. However, the development of a granulomatous phenotype does not appear to be directly vitD-mediated. Further research is needed to determine whether sufficient vitD status would reduce relapse propensity in AAV.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/epidemiology ; Chronic Disease ; Humans ; Recurrence ; Ultraviolet Rays/adverse effects ; Vitamin D ; Vitamin D Deficiency
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-06-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-022-02834-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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