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  1. Article: Ideal anesthetic agents for day-care gynecological procedures: A clinical trial comparing thiopentone with ketamine as adjuncts to propofol.

    Ahuja, Hemani / Abraham, Valsamma / Abraham, John / Liddle, Dootika

    Advanced biomedical research

    2015  Volume 4, Page(s) 81

    Abstract: ... in terms of hemodynamic stability and requirement of a lesser total dose of propofol. However, the patients ...

    Abstract Background: Day-care gynecological procedures require the use of anesthetic agents, which ensure rapid induction and recovery. Although propofol is the gold standard drug in day-care procedures, it has its own side effects like apnea, cardiovascular instability, pain on injection, as well as its cost. The ideal drug combination to achieve this end remains elusive. Therefore, a combination of propofol, thiopentone, and ketamine may be a better alternative.
    Materials and methods: This prospective, double-blind, randomized study was conducted on 60 women, aged 18-50 years, American Society of Anesthesiologists (ASA) physical status 1 and 2, undergoing day-care gynecological surgeries. The patients were allocated to two groups. Group T received an admixture containing 10 ml of 1% propofol and 10 ml of 1.25% thiopentone. Group K received an admixture containing 10 ml of 1% propofol and 10 ml of 0.5% ketamine.
    Results: There was less variation in the mean systolic blood pressure of patients in Group K as compared to patients in Group T. The mean total dose of propofol required in Group K (0.85 mg/kg) was significantly less than that required in Group T (1.12 mg/kg) (P = 0.0004). The mean recovery time in Group T (3.67 minutes) was significantly less than in Group K (6.27 minutes; P = 0.0001). However, the mean discharge time in both the groups was similar. (P = 0.7392). The results were analyzed statistically using the Student's t-test and the Fisher's exact test.
    Conclusions: Both the propofol-thiopentone and propofol-ketamine admixtures provided adequate anesthesia. Propofol-ketamine proved superior to propofol-thiopentone in terms of hemodynamic stability and requirement of a lesser total dose of propofol. However, the patients in the propofol-thiopentone group had faster recovery.
    Language English
    Publishing date 2015-05-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/2277-9175.156639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ideal anesthetic agents for day-care gynecological procedures

    Hemani Ahuja / Valsamma Abraham / John Abraham / Dootika Liddle

    Advanced Biomedical Research, Vol 4, Iss 1, Pp 81-

    A clinical trial comparing thiopentone with ketamine as adjuncts to propofol

    2015  Volume 81

    Abstract: ... adequate anesthesia. Propofol-ketamine proved superior to propofol-thiopentone in terms of hemodynamic ...

    Abstract Background: Day-care gynecological procedures require the use of anesthetic agents, which ensure rapid induction and recovery. Although propofol is the gold standard drug in day-care procedures, it has its own side effects like apnea, cardiovascular instability, pain on injection, as well as its cost. The ideal drug combination to achieve this end remains elusive. Therefore, a combination of propofol, thiopentone, and ketamine may be a better alternative. Materials and Methods: This prospective, double-blind, randomized study was conducted on 60 women, aged 18-50 years, American Society of Anesthesiologists (ASA) physical status 1 and 2, undergoing day-care gynecological surgeries. The patients were allocated to two groups. Group T received an admixture containing 10 ml of 1% propofol and 10 ml of 1.25% thiopentone. Group K received an admixture containing 10 ml of 1% propofol and 10 ml of 0.5% ketamine. Results: There was less variation in the mean systolic blood pressure of patients in Group K as compared to patients in Group T. The mean total dose of propofol required in Group K (0.85 mg/kg) was significantly less than that required in Group T (1.12 mg/kg) (P = 0.0004). The mean recovery time in Group T (3.67 minutes) was significantly less than in Group K (6.27 minutes; P = 0.0001). However, the mean discharge time in both the groups was similar. (P = 0.7392). The results were analyzed statistically using the Student′s t-test and the Fisher′s exact test. Conclusions: Both the propofol-thiopentone and propofol-ketamine admixtures provided adequate anesthesia. Propofol-ketamine proved superior to propofol-thiopentone in terms of hemodynamic stability and requirement of a lesser total dose of propofol. However, the patients in the propofol-thiopentone group had faster recovery.
    Keywords Day care ; gynecological surgeries ; ketamine ; propofol ; thiopentone ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Case of difficult tracheostomy tube insertion: A novel yet simple solution to the dilemma.

    Ahuja, Hemani / Mathai, Ashu S / Chander, Reetika / Mathew, Amy E

    Anesthesia, essays and researches

    2015  Volume 7, Issue 3, Page(s) 402–404

    Abstract: Difficulties arising during tracheostomy tube insertion can be rapidly fatal if the airway is not adequately controlled. We report a case of difficult tracheostomy in a gentleman with severe subcutaneous emphysema following a previously failed ... ...

    Abstract Difficulties arising during tracheostomy tube insertion can be rapidly fatal if the airway is not adequately controlled. We report a case of difficult tracheostomy in a gentleman with severe subcutaneous emphysema following a previously failed tracheostomy attempt. Tracheostomy tube insertion through the pre-existing stoma failed repeatedly due to rapidly increasing distance of trachea from the skin and unexpected false passages; however, the trachea was eventually cannulated using a regular endotracheal tube.
    Language English
    Publishing date 2015-04-17
    Publishing country India
    Document type Case Reports
    ZDB-ID 2626233-2
    ISSN 2229-7685 ; 0259-1162
    ISSN (online) 2229-7685
    ISSN 0259-1162
    DOI 10.4103/0259-1162.123272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hairy Cell Leukemia: Hematological and Immunophenotypic Profile of 13 Patients.

    Bhatti, Vandana / Kaur, Gurpreet / Ahuja, Aarzoo / Isaacs, Roma

    Cureus

    2023  Volume 15, Issue 9, Page(s) e44876

    Abstract: ... CD25 in most cases.: Aim: The aim was to study the hematological and IPT of classical HCL and HCL ...

    Abstract Introduction: Hairy cell leukemia (HCL) is a rare lymphoproliferative disorder of the mature B-cells, mostly seen in men, and is characterized by cytopenia, splenomegaly, myelofibrosis, and the presence of atypical lymphoid cells showing the cytoplasmic hairy projection in the peripheral blood, bone marrow, and spleen. The immunophenotypic (IPT) profile shows the clonal expansion of B-cells with CD19, CD20, and CD22 showing bright expression. The diagnosis requires two hairy cell markers out of CD103, CD123, CD25, and CD11c to be positive. The HCL variant (HCL-v) has a different IPT profile with negative CD25 in most cases.
    Aim: The aim was to study the hematological and IPT of classical HCL and HCL variants.
    Methods: This cross-sectional study included all the cases of HCL diagnosed over a retrospective period of eight years from 1st January 2015 to 31st December 2022 in a tertiary care hospital in north India. The patients included in the study were those for whom immunophenotyping; that is, flow cytometry and/or immunohistochemistry (IHC) were done for diagnosis. Bone marrow slides, IHC slides, and flow cytometric IPTs were reviewed.
    Results: The study included 13 patients who were diagnosed to have HCL, of which 12 were classical HCL and one was HCL-variant (HCL-v). Among classical HCL, IPT was done by flow cytometry in 10 patients, while in two patients, it was done by IHC. CD19, CD20, and CD22 were positive in all patients of classical HCL (10/10, 10/10, and 5/5, respectively), while CD123, CD103, CD25, and CD11C were positive in 100%, 89%, 80%, and 100% cases, respectively. One patient of HCL-v had CD103 and CD123 positive, while CD25 and CD123 were negative.
    Conclusion: The diagnosis of HCL requires a multipronged approach. The use of clinical features, morphology, and immunophenotyping combined with ancillary techniques provides higher diagnostic accuracy and enables its distinction from other B-cell lymphoproliferative disorders (BCLPDs), leading to better patient management and treatment.
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.44876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute Poisonings Admitted to a Tertiary Level Intensive Care Unit in Northern India: Patient Profile and Outcomes.

    Ahuja, Hemani / Mathai, Ashu Sara / Pannu, Aman / Arora, Rohit

    Journal of clinical and diagnostic research : JCDR

    2015  Volume 9, Issue 10, Page(s) UC01–4

    Abstract: Background: Poisoning is becoming a real health care burden for developing countries like India. An improved knowledge of the patterns of poisonings, as well as the clinical course and outcomes of these cases can help to formulate better preventive and ... ...

    Abstract Background: Poisoning is becoming a real health care burden for developing countries like India. An improved knowledge of the patterns of poisonings, as well as the clinical course and outcomes of these cases can help to formulate better preventive and management strategies.
    Aim: To study the demographic and clinical profiles of patients admitted to the ICU with acute poisoning and to study the factors that predict their mortality.
    Materials and methods: Retrospective two years (September 1, 2010 to August 31, 2012) study of all consecutive patients admitted to the Intensive Care Unit (ICU) with acute poisoning at a tertiary care hospital in Northern India.
    Results: Out of the 67 patients admitted to the ICU during the study period, the majority were young (median age 29 years) males (69%) who had consumed poison intentionally. Pesticides were the most commonly employed poison, notably organophosphorus compounds (22 patients, 32.8%) and aluminium phosphide (14 patients, 20.9%). While the overall mortality from all poisonings was low (18%), aluminium phosphide was highly toxic, with a mortality rate of 35%. The factors at ICU admission that were found to be associated with a significant risk of death were, high APACHE II and SOFA scores (p =0.0001 and p=0.006, respectively), as well as the need for mechanical ventilation and drugs for vasoactive support (p=0.012 and p= 0.0001, respectively).
    Conclusion: Use of pesticides for intentional poisoning continues to be rampant in Northern India, with many patients presenting in a critical condition to tertiary level hospitals. Pesticide regulations laws, educational awareness, counseling and poison information centers will help to curtail this public health problem.
    Language English
    Publishing date 2015-10-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2015/16008.6632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acute Poisonings Admitted to a Tertiary Level Intensive Care Unit in Northern India

    Hemani Ahuja / Ashu Sara Mathai / Aman Pannu / Rohit Arora

    Journal of Clinical and Diagnostic Research, Vol 9, Iss 10, Pp UC01-UC

    Patient Profile and Outcomes

    2015  Volume 04

    Abstract: Background: Poisoning is becoming a real health care burden for developing countries like India. An improved knowledge of the patterns of poisonings, as well as the clinical course and outcomes of these cases can help to formulate better preventive and ... ...

    Abstract Background: Poisoning is becoming a real health care burden for developing countries like India. An improved knowledge of the patterns of poisonings, as well as the clinical course and outcomes of these cases can help to formulate better preventive and management strategies. Aim: To study the demographic and clinical profiles of patients admitted to the ICU with acute poisoning and to study the factors that predict their mortality. Materials and Methods: Retrospective two years (September 1, 2010 to August 31, 2012) study of all consecutive patients admitted to the Intensive Care Unit (ICU) with acute poisoning at a tertiary care hospital in Northern India. Results: Out of the 67 patients admitted to the ICU during the study period, the majority were young (median age 29 years) males (69%) who had consumed poison intentionally. Pesticides were the most commonly employed poison, notably organophosphorus compounds (22 patients, 32.8%) and aluminium phosphide (14 patients, 20.9%). While the overall mortality from all poisonings was low (18%), aluminium phosphide was highly toxic, with a mortality rate of 35%. The factors at ICU admission that were found to be associated with a significant risk of death were, high APACHE II and SOFA scores (p =0.0001 and p=0.006, respectively), as well as the need for mechanical ventilation and drugs for vasoactive support (p=0.012 and p= 0.0001, respectively). Conclusion: Use of pesticides for intentional poisoning continues to be rampant in Northern India, with many patients presenting in a critical condition to tertiary level hospitals. Pesticide regulations laws, educational awareness, counseling and poison information centers will help to curtail this public health problem.
    Keywords phosphide ; mortality ; organophosphate poisonings ; poisoning agents ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-10-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Methylcobalamin Deficiency Presenting as Thalamic Syndrome in the Elderly: Association or Chance?

    Daiya, Varun / Ahuja, Abhinav / Kumar, Sunil / Acharya, Sourya

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52761

    Abstract: ... hematological, neurological, and neuropsychiatric functioning. Methylcobalamin deficiency or vitamin B ...

    Abstract Vitamin deficiency is common in the geriatric population and is responsible for majorly imbalanced hematological, neurological, and neuropsychiatric functioning. Methylcobalamin deficiency or vitamin B
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Narrative Review of Maternal and Perinatal Outcomes of Dengue in Pregnancy.

    Ahuja, Shivani / Muntode Gharde, Pramita

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48640

    Abstract: ... anemia, maternal death and hemolysis, organ dysfunction, and even death. Concerns about perinatal ...

    Abstract Dengue is one of the most prevalent mosquito-borne diseases in today's world, especially in India. It is an important health problem and it is very important to address it promptly. Acquiring dengue during pregnancy can have a considerable influence on the health of the mother and baby. In dengue fever, moderate to severe consequences can occur in the mother. Severe dengue poses additional risks to pregnant women due to the likelihood of sequelae such as severe dengue, preeclampsia, gestational hypertension, anemia, maternal death and hemolysis, organ dysfunction, and even death. Concerns about perinatal outcomes in dengue-affected pregnancies have significantly increased. Compared to uninfected mothers, babies born to mothers with dengue are likely to have worse outcomes. Preterm birth and low birth weight are frequently observed in dengue-affected pregnancies, which can have serious effects on the health and development of the child. Complications such as respiratory distress, thrombocytopenia, and jaundice have also been created in the report. Another important consideration is the vertical transmission of dengue virus from mother to fetus. While infection rates can vary, it increases the chances of the virus crossing the placental barrier and harming a developing baby. Early diagnosis, accurate diagnosis, and care are needed to improve maternal and perinatal outcomes in dengue-infected pregnancies. This article discusses early interventions that can help reduce risks.
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Epithelioid Hemangioma of the Nasal Cavity: a Diagnostic Challenge.

    Khan, Adil Aziz / Ahuja, Sana / Zaheer, Sufian / Das, Sumanta

    Indian journal of surgical oncology

    2024  Volume 15, Issue 1, Page(s) 181–184

    Abstract: Epithelioid hemangioma also known as angio-lymphoid hyperplasia with eosinophilia is a rare benign ... vascular tumors. The present case report describes an extremely rare presentation of epithelioid hemangioma ... presentation of epithelioid hemangioma and the importance of histomorphological features in diagnosing ...

    Abstract Epithelioid hemangioma also known as angio-lymphoid hyperplasia with eosinophilia is a rare benign vascular neoplasm of unknown etiology. It very rarely involves the nasal cavity. It always poses a diagnostic challenge for clinicians and is usually misdiagnosed as Kimura's, IgG4-related disease, or malignant vascular tumors. The present case report describes an extremely rare presentation of epithelioid hemangioma inside the left nasal cavity causing complete obstruction and nasal septal deviation towards the right side in a young male. Hematoxylin and eosin-stained sections depicted a lobular proliferation of small capillary-sized vessels lined by plump epithelioid endothelial cells surrounding central vessels and scattered around them. These cells had abundant eosinophilic to amphophilic cytoplasm and enlarged nuclei with fine chromatin and central nucleoli. On immunohistochemistry, CD34 and CD31 highlighted the vascular proliferation and epithelioid endothelial cells. Erythroblast transformation-specific (ETS)-related gene (ERG) showed strong nuclear positivity in neoplastic plump epithelioid endothelial cells. EH is a benign vascular proliferation, but a high chance of recurrence is seen if complete resection is not done. As a result, the treatment of choice is complete surgical excision with clear margins. The case highlights a non-conventional presentation of epithelioid hemangioma and the importance of histomorphological features in diagnosing this entity.
    Language English
    Publishing date 2024-01-10
    Publishing country India
    Document type Case Reports
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-024-01875-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cavernous hemangioma of the parotid gland.

    Phulware, Ravi Hari / Talwar, Amrita / Ahuja, Arvind

    Autopsy & case reports

    2023  Volume 13, Page(s) e2023436

    Language English
    Publishing date 2023-06-12
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2023.436
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