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  1. Article ; Online: The value of bispecific antibodies in relapsed and refractory DLBCL.

    Lewis, Katharine Louise / Cheah, Chan Yoon

    Leukemia & lymphoma

    2024  , Page(s) 1–16

    Abstract: Diffuse large B-cell lymphoma (DLBCL) may be cured with anti-CD20 based chemoimmunotherapy in the majority of cases, however, relapsed/refractory disease occurs in 30-40% patients, and despite significant recent therapeutic advances, continues to ... ...

    Abstract Diffuse large B-cell lymphoma (DLBCL) may be cured with anti-CD20 based chemoimmunotherapy in the majority of cases, however, relapsed/refractory disease occurs in 30-40% patients, and despite significant recent therapeutic advances, continues to represent an unmet clinical need. Bispecific antibodies represent a novel class of therapy currently in development for relapsed/refractory B-cell lymphoma. This review discusses the background clinical need, mechanism of action, and clinical data including efficacy and toxicity for bispecific antibodies in DLBCL, focusing on the most advanced class in development; CD20 targeting T-cell engaging antibodies. Emerging possibilities for future use of bispecific antibodies is also discussed, including novel and cytotoxic combination regimens in relapsed and first-line settings.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2024.2323085
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    Zs.A 2997: Show issues Location:
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  2. Article ; Online: Time to omit interim CT imaging during frontline chemoimmunotherapy for patients with follicular lymphoma?

    Salvaris, Ross Thomas / Cheah, Chan Yoon

    Leukemia & lymphoma

    2022  Volume 63, Issue 14, Page(s) 3271–3273

    MeSH term(s) Humans ; Lymphoma, Follicular/pathology ; Rituximab/therapeutic use ; Tomography, X-Ray Computed ; Fluorodeoxyglucose F18 ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Rituximab (4F4X42SYQ6) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2142057
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  3. Article ; Online: About time: why central nervous system prophylaxis timing in diffuse large B-cell lymphoma matters and does the protocol need updating?

    Lewis, Katharine Louise / Cheah, Chan Yoon

    Expert review of hematology

    2022  Volume 15, Issue 11, Page(s) 959–962

    MeSH term(s) Humans ; Neoplasm Recurrence, Local/drug therapy ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Central Nervous System Neoplasms/prevention & control ; Central Nervous System/pathology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Methotrexate/therapeutic use ; Rituximab/therapeutic use ; Cyclophosphamide/therapeutic use ; Prednisone/therapeutic use
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Editorial
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2022.2140138
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    Zs.A 6943: Show issues Location:
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  4. Article ; Online: Event free survival at 12 months (EFS12) in stage 1 DLBCL - a reassuring milestone?

    Lewis, Katharine L / Cheah, Chan Yoon

    Leukemia & lymphoma

    2020  Volume 61, Issue 11, Page(s) 2542–2543

    MeSH term(s) Biomarkers ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Progression-Free Survival ; Registries ; Thailand
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1808214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Designing optimal prognostic models for diffuse large B-cell lymphoma.

    Keane, Colm / Yoon Cheah, Chan

    Leukemia & lymphoma

    2019  Volume 60, Issue 8, Page(s) 1848–1850

    MeSH term(s) Fluorodeoxyglucose F18 ; Humans ; Lymphoma, Large B-Cell, Diffuse ; Monocytes ; Positron Emission Tomography Computed Tomography ; Prognosis
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2019.1599117
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  6. Article ; Online: How I manage mantle cell lymphoma: indolent versus aggressive disease.

    Wilson, Matthew R / Barrett, Aisling / Cheah, Chan Yoon / Eyre, Toby A

    British journal of haematology

    2023  Volume 201, Issue 2, Page(s) 185–198

    Abstract: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma with a variable clinical course and historically poor prognosis. Management is challenging in part due to the heterogeneity of the disease course, with indolent and aggressive subtypes now well ... ...

    Abstract Mantle cell lymphoma (MCL) is a mature B-cell lymphoma with a variable clinical course and historically poor prognosis. Management is challenging in part due to the heterogeneity of the disease course, with indolent and aggressive subtypes now well recognised. Indolent MCL is often characterised by a leukaemic presentation, SOX11 negativity and low proliferation index (Ki-67). Aggressive MCL is characterised by rapid onset widespread lymphadenopathy, extra-nodal involvement, blastoid or pleomorphic histology and high Ki-67. Tumour protein p53 (TP53) aberrations in aggressive MCL are recognised with clear negative impact on survival. Until recently, trials have not addressed these specific subtypes separately. With the increasing availability of targeted novel agents and cellular therapies, the treatment landscape is constantly evolving. In this review, we describe the clinical presentation, biological factors, and specific management considerations of both indolent and aggressive MCL and discuss current and potential future evidence which may help move to a more personalised approach.
    MeSH term(s) Adult ; Humans ; Lymphoma, Mantle-Cell/therapy ; Lymphoma, Mantle-Cell/drug therapy ; Ki-67 Antigen ; Antineoplastic Agents/therapeutic use ; Lymphoma, B-Cell/drug therapy ; Disease Progression
    Chemical Substances Ki-67 Antigen ; Antineoplastic Agents
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18697
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  7. Article ; Online: Practical management of chronic lymphocytic leukemia with acalabrutinib.

    Kuss, Bryone / Nagarajan, Chandramouli / Hsieh, Wen Son / Cheah, Chan Yoon

    Leukemia & lymphoma

    2022  Volume 63, Issue 12, Page(s) 2785–2794

    Abstract: Treatment of chronic lymphocytic leukemia (CLL) has been transformed in the past two decades. The introduction of targeted therapies has improved patient outcomes and the deliverability of effective therapies. Making the best use of the next wave of ... ...

    Abstract Treatment of chronic lymphocytic leukemia (CLL) has been transformed in the past two decades. The introduction of targeted therapies has improved patient outcomes and the deliverability of effective therapies. Making the best use of the next wave of Bruton's tyrosine kinase (BTK) inhibitors requires an understanding of the nuances that separate the drugs in this class of agents. This paper reviews the newer BTK inhibitors and provides practical guidance on the management of CLL using acalabrutinib. Acalabrutinib is a safe and efficacious BTKi in the treatment of CLL. While some side effects appear to be an "on-target" effect of BTK inhibition, the selectivity of second-generation covalent BTK inhibitors such as acalabrutinib may result in a favorable safety profile due to less off-target kinase inhibition. Acalabrutinib represents a well-tolerated and effective alternative to ibrutinib in the management of CLL.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Agammaglobulinaemia Tyrosine Kinase ; Pyrimidines/adverse effects ; Pyrazoles/therapeutic use ; Protein Kinase Inhibitors/adverse effects
    Chemical Substances acalabrutinib (I42748ELQW) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; Pyrimidines ; Pyrazoles ; Protein Kinase Inhibitors
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2098289
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Durable Responses With Mosunetuzumab in Relapsed/Refractory Indolent and Aggressive B-Cell Non-Hodgkin Lymphomas: Extended Follow-Up of a Phase I/II Study.

    Budde, Lihua E / Assouline, Sarit / Sehn, Laurie H / Schuster, Stephen J / Yoon, Sung-Soo / Yoon, Dok Hyun / Matasar, Matthew J / Bosch, Francesc / Kim, Won Seog / Nastoupil, Loretta J / Flinn, Ian W / Shadman, Mazyar / Diefenbach, Catherine / Cheah, Chan Yoon / Ma, Connie Y / Huang, Huang / Kwan, Antonia / Wei, Michael C / Yin, Shen /
    Bartlett, Nancy L

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  , Page(s) JCO2302329

    Abstract: Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial ... ...

    Abstract Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.02329
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  9. Article ; Online: Routine imaging for disease surveillance in follicular lymphoma-To comfort the patients or their doctors?

    El-Galaly, Tarec Christoffer / Øvlisen, Andreas Kiesbye / Cheah, Chan Yoon

    Cancer

    2021  Volume 127, Issue 18, Page(s) 3298–3301

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Cyclophosphamide/therapeutic use ; Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/drug therapy ; Lymphoma, Follicular/epidemiology
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33659
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  10. Article ; Online: Mantle cell lymphoma - where precision medicine based on response-adapted treatment strategies could show its full worth.

    El-Galaly, Tarec Christoffer / Cheah, Chan Yoon

    British journal of haematology

    2020  Volume 189, Issue 4, Page(s) 600–602

    MeSH term(s) Adult ; Fluorodeoxyglucose F18 ; Humans ; Lymphoma, Mantle-Cell/drug therapy ; Positron-Emission Tomography ; Precision Medicine ; Prognosis
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-01-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16396
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