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  1. Article ; Online: Noções básicas de R com dados tabulares

    Taryn Dewar

    The Programming Historian em Português, Vol

    2021  Volume 1

    Abstract: Esta lição ensina uma maneira de analisar rapidamente grandes volumes de dados tabulares, tornando a pesquisa mais rápida e eficaz. ...

    Abstract Esta lição ensina uma maneira de analisar rapidamente grandes volumes de dados tabulares, tornando a pesquisa mais rápida e eficaz.
    Keywords History of scholarship and learning. The humanities ; AZ20-999 ; Computer software ; QA76.75-76.765
    Language Portuguese
    Publishing date 2021-08-01T00:00:00Z
    Publisher Editorial Board of the Programming Historian
    Document type Article ; Online
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  2. Article ; Online: Automated detection of atrial fibrillation using R-R intervals and multivariate-based classification.

    Kennedy, Alan / Finlay, Dewar D / Guldenring, Daniel / Bond, Raymond R / Moran, Kieran / McLaughlin, James

    Journal of electrocardiology

    2016  Volume 49, Issue 6, Page(s) 871–876

    Abstract: ... from existing sources. R-R intervals were then analyzed using four previously described R-R irregularity ... outputs from all four R-R irregularity measurements, RF and k-nn models were trained. RF classification ...

    Abstract Automated detection of AF from the electrocardiogram (ECG) still remains a challenge. In this study, we investigated two multivariate-based classification techniques, Random Forests (RF) and k-nearest neighbor (k-nn), for improved automated detection of AF from the ECG. We have compiled a new database from ECG data taken from existing sources. R-R intervals were then analyzed using four previously described R-R irregularity measurements: (1) the coefficient of sample entropy (CoSEn), (2) the coefficient of variance (CV), (3) root mean square of the successive differences (RMSSD), and (4) median absolute deviation (MAD). Using outputs from all four R-R irregularity measurements, RF and k-nn models were trained. RF classification improved AF detection over CoSEn with overall specificity of 80.1% vs. 98.3% and positive predictive value of 51.8% vs. 92.1% with a reduction in sensitivity, 97.6% vs. 92.8%. k-nn also improved specificity and PPV over CoSEn; however, the sensitivity of this approach was considerably reduced (68.0%).
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410286-1
    ISSN 1532-8430 ; 0022-0736
    ISSN (online) 1532-8430
    ISSN 0022-0736
    DOI 10.1016/j.jelectrocard.2016.07.033
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  3. Article ; Online: Repression of Acetaminophen-Induced Hepatotoxicity in HepG2 Cells by Polyphenolic Compounds from Lauridia tetragona (L.f.) R.H. Archer

    Samuel Odeyemi / John Dewar

    Molecules, Vol 24, Iss 11, p

    2019  Volume 2118

    Abstract: Lauridia tetragona (L.f) R.H. Archer is routinely used in traditional medicine ...

    Abstract Lauridia tetragona (L.f) R.H. Archer is routinely used in traditional medicine; however, its hepatoprotective property is yet to be scientifically proven. To this effect, the hepatoprotective activity of the polyphenolic-rich fractions (PPRFs) was investigated against acetaminophen (APAP) injured HepG2 cells. The ability of the PPRF to scavenge free radicals was tested against 2,2-diphenyl-1-picrylhydrazyl (DPPH), and [2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonicacid)] (ABTS). The ferric ion reducing power (FRAP) was also evaluated as a cell-free antioxidant assay. The hepatoprotective activity was then investigated by observing the effect of PPRFs against APAP-induced reduction in cell viability of HepG2 cells. The concentrations of alanine aminotransferase (AST), aspartate aminotransferase (ALT) and lactate dehydrogenase (LDH) released into the medium were evaluated while the underlying mechanism was further explored through western blot analysis. Thereafter, the isolated PPRFs were identified using UHPLC-QToF-MS. All six fractions of the PPRFs isolated showed significant antioxidant properties that were evident by the effective scavenging of DPPH, ABTS, and higher FRAP. The results indicated that PPRF pretreatments ameliorated APAP-induced hepatocellular injury by significantly inhibiting the leakage of AST, ALT, and LDH into the medium. The most active fractions for hepatoprotection were PPRF4 and PPRF6 with IC 50 of 50.243 ± 8.03 and 154.59 ± 1.9 μg/mL, respectively. PPRFs markedly increased activities of liver superoxide dismutase, total antioxidant capacity, and liver glutathione concentration. Both PPRF4 and PPRF6 significantly increased the expression of Nrf2 and translocation. The LC-MS analysis revealed the presence of a wide variety of polyphenolics such as coumarin, ferulic acid, and caffeine among the dominant constituents. In conclusion, this study demonstrates that the isolated PPRFs have potential hepatoprotective activity that may be due to the increased expression of antioxidative genes ...
    Keywords Lauridia tetragona ; antioxidant ; hepatoprotective ; acetaminophen ; cell viability ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article ; Online: In Vitro Antidiabetic Activity Affecting Glucose Uptake in HepG2 Cells Following Their Exposure to Extracts of Lauridia tetragona (L.f.) R.H. Archer

    Samuel Odeyemi / John Dewar

    Processes, Vol 8, Iss 1, p

    2019  Volume 33

    Abstract: The incidence of diabetes is on the rise and one of the medically active plants used for the treatment of diabetes in South Africa is Lauridia tetragona . The aim of this study is to investigate the antidiabetic property of the polyphenolics (PP) ... ...

    Abstract The incidence of diabetes is on the rise and one of the medically active plants used for the treatment of diabetes in South Africa is Lauridia tetragona . The aim of this study is to investigate the antidiabetic property of the polyphenolics (PP) compounds isolated from the methanolic extract of Lauridia tetragona . The α-amylase, α-glucosidase, dipeptidyl peptidase IV (DPPIV), lipase inhibitory activities, and glucose uptake in HepG2 were investigated. The methanolic extract fractions of L. tetragona yielded six fractions (PP1−PP6) all of which showed weak inhibition against DPPIV and lipase compared to the standards. However, PP4 and PP6 showed the best inhibition against α-amylase (IC 50 of 359.3 ± 2.11 and 416.82 ± 2.58 μg/mL, respectively) and α-glucosidase (IC 50 of 95.93 ± 2.34 and 104.49 ± 2.21 μg/mL, respectively) and only PP4 (173.6%) resulted in enhanced glucose uptake in HepG2 cells compared to berberine (129.89%) and metformin (187.16%) used as positive controls. The previous investigation on PP4 and PP6 showed the presence of polyphenolics such as ferulic acid, coumaric acid, and caffeic acid. The results of this study suggest that L. tetragona could be suitable as an antidiabetic agent and justifies the folkloric use of the plant to treat diabetes.
    Keywords lauridia tetragona ; polyphenols ; diabetes ; α-amylase ; α-glucosidase ; lipase ; glucose uptake ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: The Duke Activity Status Index compared with cardiopulmonary exercise testing in patients undergoing pre-operative assessment for cancer surgery.

    Dewar, A / Tetlow, N / Stephens, R / Whittle, J

    Anaesthesia

    2023  Volume 78, Issue 12, Page(s) 1505–1506

    MeSH term(s) Humans ; Exercise Test ; Preoperative Care ; Risk Assessment ; Neoplasms/surgery
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.16118
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    Zs.A 388: Show issues Location:
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  6. Article: Surgical Decision-Making for Temporal Lobe Epilepsy: Patient Experiences of the Informed Consent Process.

    Dewar, Sandra R / Pieters, Huibrie C / Fried, Itzhak

    Frontiers in neurology

    2021  Volume 12, Page(s) 780306

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.780306
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  7. Article ; Online: Evaluating the effects of a brief motivational interviewing protocol on excessive acquisition.

    Wong, Shiu F / Dewar, Emily / Baldwin, Peter A / Grisham, Jessica R

    Journal of behavior therapy and experimental psychiatry

    2023  Volume 80, Page(s) 101790

    Abstract: Background and objectives: Individuals with hoarding disorder, especially those with problems around acquiring, typically demonstrate a lack of motivation and awareness of their problematic behaviours. Since acquiring behaviours are important targets in ...

    Abstract Background and objectives: Individuals with hoarding disorder, especially those with problems around acquiring, typically demonstrate a lack of motivation and awareness of their problematic behaviours. Since acquiring behaviours are important targets in interventions for hoarding, effective strategies for increasing motivation in this population are required to enhance the acceptability and efficacy of these interventions.
    Methods: The aim of the current study was to evaluate the ability of a brief online motivational intervention to reduce acquiring in a community sample of high acquirers (N = 159). Participants were randomly assigned to either a motivational interviewing protocol (n = 73) or progressive muscle relaxation control condition (n = 86). Readiness to change and motivation to acquire was measured via self-report, and acquiring behaviour was measured using a modified version of the Preston Acquisition Decision Making Task (to increase ecological validity).
    Results: In both conditions, participants' readiness and motivation to change increased over time. Contrary to hypotheses, the magnitude of this improvement did not significantly differ between conditions. Furthermore, conditions did not perform differently on the behavioural measure of acquiring.
    Limitations: Insufficient dose of the intervention may have precluded any differences being observed between conditions.
    Conclusions: Results underscore the need to better address the problem of lowered motivation in this population.
    MeSH term(s) Humans ; Motivational Interviewing/methods ; Motivation ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-03-13
    Publishing country Netherlands
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280250-8
    ISSN 1873-7943 ; 0005-7916
    ISSN (online) 1873-7943
    ISSN 0005-7916
    DOI 10.1016/j.jbtep.2022.101790
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  8. Article ; Online: A Multiregional Evaluation of Cycle Threshold Values in Severe Acute Respiratory Syndrome Coronavirus 2 VOC-20DEC-01 Variant.

    Hill, K J / Dewar, R / Templeton, K

    The Journal of infectious diseases

    2021  Volume 224, Issue 5, Page(s) 927–928

    MeSH term(s) COVID-19/epidemiology ; COVID-19/virology ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab303
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  9. Article ; Online: Erratum to 'Reciprocal burden: Adults with drug-resistant epilepsy reflect upon informal caregiver support [Seizure: European Journal of Epilepsy 89 (2021) 85-92).

    Dewar, Sandra R / Ranit, Lizza / Pieters, Huibrie C

    Seizure

    2021  Volume 91, Page(s) e1–e5

    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2021.06.018
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    Zs.A 3573: Show issues Location:
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  10. Article ; Online: Improved mRNA affinity chromatography binding capacity and throughput using an oligo-dT immobilized electrospun polymer nanofiber adsorbent.

    Dewar, Emily A / Guterstam, Peter / Holland, David / Lindman, Susanna / Lundbäck, Peter / Brito Dos Santos, Susana / Wang, Sheng-Ching / Swartz, Andrew R

    Journal of chromatography. A

    2024  Volume 1717, Page(s) 464670

    Abstract: Increased demand for mRNA-based therapeutics and improved in vitro transcription (IVT) yields have challenged the mRNA purification platform. Hybridization-affinity chromatography with an immobilized oligo-deoxythymidilic acid (oligodT) ligand is often ... ...

    Abstract Increased demand for mRNA-based therapeutics and improved in vitro transcription (IVT) yields have challenged the mRNA purification platform. Hybridization-affinity chromatography with an immobilized oligo-deoxythymidilic acid (oligodT) ligand is often used to capture mRNA through base pairing with the polyadenylated tail. Commercially available oligodT matrices include perfusive cross-linked poly(styrene-divinylbenzene) 50 µm POROS™ chromatography resin beads and convective polymethacrylate CIMmultus® monolithic columns consisting of 2 µm interconnected channels. POROS™ columns may be limited by poor mass transfer for larger mRNAs and slow flowrates, while monoliths can operate at higher flowrates but are limited by modest binding capacity. To enable both high flowrates and binding capacity for mRNA of all lengths, prototype chromatography media was developed by Cytiva using oligodT immobilized electrospun cellulose nanofibers (Fibro™) with a 0.3-0.4 µm pore size. In this work, four polyadenylated mRNAs ranging from ∼1900-4300 nucleotides were used to compare the dynamic binding capacity (DBC) of Fibro™, POROS® and CIMmultus® columns as a function of residence time and binding buffer compositions. Fibro™ improved the DBC ∼2-4-fold higher than CIMmultus® and ∼2-13-fold higher than POROS™ across all residence times, mRNA length, and binding matrix compositions tested. CIMmultus® DBC was least dependent on residence time and mRNA size, while both Fibro™ and POROS™ DBC increased at slower flowrates and with shorter mRNA. Surprisingly, inverse size exclusion (ISE) experiments showed that POROS™ was not limited by diffusion and POROS™ along with CIMmultus® demonstrate higher mRNA permeation however the Fibro™ prototype is not in the final configuration. Lastly, IVT reaction products were subjected to purification and oligodT elution product yield, quality, and purity were consistent across the three matrices investigated. These results highlight the benefits of high DBC and equivalent product profiles offered by the oligodT Fibro™ prototype compared to commercially available oligodT media.
    MeSH term(s) Polymers/chemistry ; Nanofibers ; RNA, Messenger ; Chromatography, Affinity/methods ; Cellulose
    Chemical Substances Polymers ; RNA, Messenger ; Cellulose (9004-34-6)
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2024.464670
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