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  1. Article: Special Issue: Vaccines against Antibiotic-Resistant Bacteria: From Bench to Bedside.

    López-Siles, Mireia / Corral-Lugo, Andrés / McConnell, Michael J

    Vaccines

    2024  Volume 12, Issue 1

    Abstract: The emergence and global dissemination of bacterial strains from numerous species with resistance to multiple antibiotic classes has increased in recent years, both in the healthcare and the community setting [ ... ]. ...

    Abstract The emergence and global dissemination of bacterial strains from numerous species with resistance to multiple antibiotic classes has increased in recent years, both in the healthcare and the community setting [...].
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12010068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of Subinhibitory Concentrations of Antibiotics and Disinfectants on IS

    Olmeda-López, Héctor / Corral-Lugo, Andrés / McConnell, Michael J

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 10

    Abstract: Inactivation of the lipooligosaccharide (LOS) biosynthesis ... ...

    Abstract Inactivation of the lipooligosaccharide (LOS) biosynthesis genes
    Language English
    Publishing date 2021-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10101259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vaccines for multidrug resistant Gram negative bacteria: lessons from the past for guiding future success.

    López-Siles, Mireia / Corral-Lugo, Andrés / McConnell, Michael J

    FEMS microbiology reviews

    2021  Volume 45, Issue 3

    Abstract: Antimicrobial resistance is a major threat to global public health. Vaccination is an effective approach for preventing bacterial infections, however it has not been successfully applied to infections caused by some of the most problematic multidrug ... ...

    Abstract Antimicrobial resistance is a major threat to global public health. Vaccination is an effective approach for preventing bacterial infections, however it has not been successfully applied to infections caused by some of the most problematic multidrug resistant pathogens. In this review, the potential for vaccines to contribute to reducing the burden of disease of infections caused by multidrug resistant Gram negative bacteria is presented. Technical, logistical and societal hurdles that have limited successful vaccine development for these infections in the past are identified, and recent advances that can contribute to overcoming these challenges are assessed. A synthesis of vaccine technologies that have been employed in the development of vaccines for key multidrug resistant Gram negative bacteria is included, and emerging technologies that may contribute to future successes are discussed. Finally, a comprehensive review of vaccine development efforts over the last 40 years for three of the most worrisome multidrug resistant Gram negative pathogens, Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa is presented, with a focus on recent and ongoing studies. Finally, future directions for the vaccine development field are highlighted.
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1093/femsre/fuaa054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vaccines for multidrug resistant Gram negative bacteria: lessons from the past for guiding future success.

    López-Siles, Mireia / Corral-Lugo, Andrés / McConnell, Michael J

    FEMS microbiology reviews

    2020  Volume 45, Issue 3

    Abstract: Antimicrobial resistance is a major threat to global public health. Vaccination is an effective approach for preventing bacterial infections, however it has not been successfully applied to infections caused by some of the most problematic multidrug ... ...

    Abstract Antimicrobial resistance is a major threat to global public health. Vaccination is an effective approach for preventing bacterial infections, however it has not been successfully applied to infections caused by some of the most problematic multidrug resistant pathogens. In this review, the potential for vaccines to contribute to reducing the burden of disease of infections caused by multidrug resistant Gram negative bacteria is presented. Technical, logistical and societal hurdles that have limited successful vaccine development for these infections in the past are identified, and recent advances that can contribute to overcoming these challenges are assessed. A synthesis of vaccine technologies that have been employed in the development of vaccines for key multidrug resistant Gram negative bacteria is included, and emerging technologies that may contribute to future successes are discussed. Finally, a comprehensive review of vaccine development efforts over the last 40 years for three of the most worrisome multidrug resistant Gram negative pathogens, Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa is presented, with a focus on recent and ongoing studies. Finally, future directions for the vaccine development field are highlighted.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Vaccines ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacterial Infections/prevention & control ; Humans
    Chemical Substances Anti-Bacterial Agents ; Bacterial Vaccines
    Language English
    Publishing date 2020-12-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1093/femsre/fuaa054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The plant compound rosmarinic acid induces a broad quorum sensing response in Pseudomonas aeruginosa PAO1.

    Fernández, Matilde / Corral-Lugo, Andrés / Krell, Tino

    Environmental microbiology

    2018  Volume 20, Issue 12, Page(s) 4230–4244

    Abstract: The interference of plant compounds with bacterial quorum sensing (QS) is a major mechanism through which plants and bacteria communicate. However, little is known about the modes of action and effects on signal integrity during this type of ... ...

    Abstract The interference of plant compounds with bacterial quorum sensing (QS) is a major mechanism through which plants and bacteria communicate. However, little is known about the modes of action and effects on signal integrity during this type of communication. We have recently shown that the plant compound rosmarinic acid (RA) specifically binds to the Pseudomonas aeruginosa RhlR QS receptor. To determine the effect of RA on expression patterns, we carried out global RNA-seq analysis. The results show that RA induces the expression of 128 genes, amongst which many virulence factor genes. RA triggers a broad QS response because 88% of the induced genes are known to be controlled by QS, and because RA stimulated genes were found to be involved in all four QS signalling systems within P. aeruginosa. This finding was confirmed through the analysis of transcriptional fusions transferred to wt and a rhlI/lasI double mutant. RA did not induce gene expression in the rhlI/lasI/rhlR triple mutant indicating that the effects observed are due to the RA-RhlR interaction. Furthermore, RA induced seven sRNAs that were all encoded in regions close to QS and/or RA induced genes. This work significantly enhances our understanding of plant bacteria interaction.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Carrier Proteins/metabolism ; Cinnamates/metabolism ; Cinnamates/pharmacology ; Depsides/metabolism ; Depsides/pharmacology ; Gene Expression Regulation, Bacterial/drug effects ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/metabolism ; Quorum Sensing/drug effects ; Quorum Sensing/genetics ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Rosmarinic Acid
    Chemical Substances Bacterial Proteins ; Carrier Proteins ; Cinnamates ; Depsides ; Virulence Factors
    Language English
    Publishing date 2018-09-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.14301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000

    Pérez-Vázquez, María / López-Causapé, Carla / Corral-Lugo, Andrés / McConnell, Michael J / Oteo-Iglesias, Jesús / Oliver, Antonio / Martín-Galiano, Antonio J

    Microorganisms

    2023  Volume 11, Issue 10

    Abstract: Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the ... ...

    Abstract Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102486
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  7. Article: Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine Development.

    Corral-Lugo, Andrés / López-Siles, Mireia / López, Daniel / McConnell, Michael J / Martin-Galiano, Antonio J

    Vaccines

    2020  Volume 8, Issue 3

    Abstract: The efficacy of SARS-CoV-2 nucleic acid-based vaccines may be limited by proteolysis of the translated product due to anomalous protein folding. This may be the case for vaccines employing linear SARS-CoV-2 B-cell epitopes identified in previous studies ... ...

    Abstract The efficacy of SARS-CoV-2 nucleic acid-based vaccines may be limited by proteolysis of the translated product due to anomalous protein folding. This may be the case for vaccines employing linear SARS-CoV-2 B-cell epitopes identified in previous studies since most of them participate in secondary structure formation. In contrast, we have employed a consensus of predictors for epitopic zones plus a structural filter for identifying 20 unstructured B-cell epitope-containing loops (uBCELs) in S, M, and N proteins. Phylogenetic comparison suggests epitope switching with respect to SARS-CoV in some of the identified uBCELs. Such events may be associated with the reported lack of serum cross-protection between the 2003 and 2019 pandemic strains. Incipient variability within a sample of 1639 SARS-CoV-2 isolates was also detected for 10 uBCELs which could cause vaccine failure. Intermediate stages of the putative epitope switch events were observed in bat coronaviruses in which additive mutational processes possibly facilitating evasion of the bat immune system appear to have taken place prior to transfer to humans. While there was some overlap between uBCELs and previously validated SARS-CoV B-cell epitopes, multiple uBCELs had not been identified in prior studies. Overall, these uBCELs may facilitate the development of biomedical products for SARS-CoV-2.
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines8030397
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  8. Article: The plant compound rosmarinic acid induces a broad quorum sensing response in Pseudomonas aeruginosa PAO1

    Fernández, Matilde / Andrés Corral‐Lugo / Tino Krell

    Environmental microbiology. 2018 Dec., v. 20, no. 12

    2018  

    Abstract: The interference of plant compounds with bacterial quorum sensing (QS) is a major mechanism through which plants and bacteria communicate. However, little is known about the modes of action and effects on signal integrity during this type of ... ...

    Abstract The interference of plant compounds with bacterial quorum sensing (QS) is a major mechanism through which plants and bacteria communicate. However, little is known about the modes of action and effects on signal integrity during this type of communication. We have recently shown that the plant compound rosmarinic acid (RA) specifically binds to the Pseudomonas aeruginosa RhlR QS receptor. To determine the effect of RA on expression patterns, we carried out global RNA‐seq analysis. The results show that RA induces the expression of 128 genes, amongst which many virulence factor genes. RA triggers a broad QS response because 88% of the induced genes are known to be controlled by QS, and because RA stimulated genes were found to be involved in all four QS signalling systems within P. aeruginosa. This finding was confirmed through the analysis of transcriptional fusions transferred to wt and a rhlI/lasI double mutant. RA did not induce gene expression in the rhlI/lasI/rhlR triple mutant indicating that the effects observed are due to the RA‐RhlR interaction. Furthermore, RA induced seven sRNAs that were all encoded in regions close to QS and/or RA induced genes. This work significantly enhances our understanding of plant bacteria interaction.
    Keywords bacteria ; gene expression ; genes ; mechanism of action ; mutants ; plants (botany) ; Pseudomonas aeruginosa ; quorum sensing ; rosmarinic acid ; sequence analysis ; transcription (genetics) ; virulence
    Language English
    Dates of publication 2018-12
    Size p. 4230-4244.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.14301
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Identification of a chemoreceptor that specifically mediates chemotaxis toward metabolizable purine derivatives.

    Fernández, Matilde / Morel, Bertrand / Corral-Lugo, Andrés / Krell, Tino

    Molecular microbiology

    2016  Volume 99, Issue 1, Page(s) 34–42

    Abstract: Chemotaxis is an essential mechanism that enables bacteria to move toward favorable ecological niches. Escherichia coli, the historical model organism for studying chemotaxis, has five well-studied chemoreceptors. However, many bacteria with different ... ...

    Abstract Chemotaxis is an essential mechanism that enables bacteria to move toward favorable ecological niches. Escherichia coli, the historical model organism for studying chemotaxis, has five well-studied chemoreceptors. However, many bacteria with different lifestyle have more chemoreceptors, most of unknown function. Using a high throughput screening approach, we identified a chemoreceptor from Pseudomonas putida KT2440, named McpH, which specifically recognizes purine and its derivatives, adenine, guanine, xanthine, hypoxanthine and uric acid. The latter five compounds form part of the purine degradation pathway, permitting their use as sole nitrogen sources. Isothermal titration calorimetry studies show that these six compounds bind McpH-Ligand Binding Domain (LBD) with very similar affinity. In contrast, non-metabolizable purine derivatives (caffeine, theophylline, theobromine), nucleotides, nucleosides or pyrimidines are unable to bind McpH-LBD. Mutation of mcpH abolished chemotaxis toward the McpH ligands identified - a phenotype that is restored by complementation. This is the first report on bacterial chemotaxis to purine derivatives and McpH the first chemoreceptor described that responds exclusively to intermediates of a catabolic pathway, illustrating a clear link between metabolism and chemotaxis. The evolution of McpH may reflect a saprophytic lifestyle, which would have exposed the studied bacterium to high concentrations of purines produced by nucleic acid degradation.
    MeSH term(s) Chemotaxis ; Gene Deletion ; Genetic Complementation Test ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Protein Binding ; Pseudomonas putida/drug effects ; Pseudomonas putida/genetics ; Pseudomonas putida/physiology ; Purines/metabolism
    Chemical Substances Membrane Proteins ; Purines
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.13215
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    Zs.A 2502: Show issues Location:
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  10. Article: Towards Control and Oversight of SARS-CoV-2 Diagnosis and Monitoring through Multiplexed Quantitative Electroanalytical Immune Response Biosensors.

    Torrente-Rodríguez, Rebeca M / Montero-Calle, Ana / San Bartolomé, Clara / Cano, Olga / Vázquez, Mónica / Iglesias-Caballero, María / Corral-Lugo, Andrés / McConnell, Michael J / Pascal, Mariona / Mas, Vicente / Pingarrón, José M / Barderas, Rodrigo / Campuzano, Susana

    Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

    2022  Volume 134, Issue 28, Page(s) e202203662

    Abstract: The development of versatile and sensitive biotools to quantify specific SARS-CoV-2 immunoglobulins in SARS-CoV-2 infected and non-infected individuals, built on the surface of magnetic microbeads functionalized with nucleocapsid (N) and in-house ... ...

    Abstract The development of versatile and sensitive biotools to quantify specific SARS-CoV-2 immunoglobulins in SARS-CoV-2 infected and non-infected individuals, built on the surface of magnetic microbeads functionalized with nucleocapsid (N) and in-house expressed recombinant spike (S) proteins is reported. Amperometric interrogation of captured N- and S-specific circulating total or individual immunoglobulin (Ig) isotypes (IgG, IgM, and IgA), subsequently labelled with HRP-conjugated secondary antibodies, was performed at disposable single or multiplexed (8×) screen-printed electrodes using the HQ/HRP/H
    Language English
    Publishing date 2022-05-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 506609-8
    ISSN 1521-3757 ; 0044-8249 ; 0932-2140
    ISSN (online) 1521-3757
    ISSN 0044-8249 ; 0932-2140
    DOI 10.1002/ange.202203662
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