Article ; Online: Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069.
2021 Volume 18, Issue 11, Page(s) e2100674
Abstract: ... collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1 ...
Abstract | Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 μg/mL. |
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MeSH term(s) | Alkaloids/chemistry ; Alkaloids/metabolism ; Alkaloids/pharmacology ; Alkaloids/therapeutic use ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Binding Sites ; COVID-19/drug therapy ; COVID-19/virology ; Fungi/drug effects ; Geologic Sediments/microbiology ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; Isoindoles/chemistry ; Isoindoles/isolation & purification ; Isoindoles/metabolism ; Isoindoles/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; Molecular Docking Simulation ; SARS-CoV-2/isolation & purification ; Streptomyces/chemistry ; Streptomyces/isolation & purification ; Streptomyces/metabolism |
Chemical Substances | Alkaloids ; Isoindoles ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) |
Language | English |
Publishing date | 2021-10-27 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2139001-0 |
ISSN | 1612-1880 ; 1612-1872 |
ISSN (online) | 1612-1880 |
ISSN | 1612-1872 |
DOI | 10.1002/cbdv.202100674 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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