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  1. Article ; Online: Genetic control of a sex-specific piRNA program.

    Chen, Peiwei / Aravin, Alexei A

    Current biology : CB

    2023  Volume 33, Issue 9, Page(s) 1825–1835.e3

    Abstract: Sexually dimorphic traits in morphologies are widely studied, ...

    Abstract Sexually dimorphic traits in morphologies are widely studied,
    MeSH term(s) Animals ; Female ; Male ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Piwi-Interacting RNA ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Drosophila/genetics ; Germ Cells/metabolism ; Argonaute Proteins/genetics ; RNA-Binding Proteins/metabolism ; Homeodomain Proteins/metabolism
    Chemical Substances Piwi-Interacting RNA ; Drosophila Proteins ; RNA, Small Interfering ; Argonaute Proteins ; Sxl protein, Drosophila ; RNA-Binding Proteins ; PHF7 protein, Drosophila ; Homeodomain Proteins
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.03.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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  2. Article ; Online: Pachytene piRNAs as beneficial regulators or a defense system gone rogue.

    Aravin, Alexei A

    Nature genetics

    2020  Volume 52, Issue 7, Page(s) 644–645

    MeSH term(s) Animals ; Fertility ; Male ; Mice ; RNA, Small Interfering ; Testis
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-020-0656-8
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  3. Article ; Online: Transposon-taming piRNAs in the germline: Where do they come from?

    Chen, Peiwei / Aravin, Alexei A

    Molecular cell

    2021  Volume 81, Issue 19, Page(s) 3884–3885

    Abstract: Mutations in the piRNA pathway protein components lead to transposon activation and fertility defects. In contrast, Gebert et al., (2021) saw no defects in transposon silencing or fertility when they deleted three large germline piRNA clusters in D. ... ...

    Abstract Mutations in the piRNA pathway protein components lead to transposon activation and fertility defects. In contrast, Gebert et al., (2021) saw no defects in transposon silencing or fertility when they deleted three large germline piRNA clusters in D. melanogaster.
    MeSH term(s) Animals ; Drosophila melanogaster/genetics ; Fertility ; Germ Cells ; RNA, Small Interfering
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2021-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.09.017
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  4. Article: SUMOylation of Bonus, the

    Godneeva, Baira / Ninova, Maria / Fejes Tóth, Katalin / Aravin, Alexei A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, ...

    Abstract The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members,
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.14.536936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: SUMOylation of Bonus, the

    Godneeva, Baira / Ninova, Maria / Fejes-Toth, Katalin / Aravin, Alexei

    eLife

    2023  Volume 12

    Abstract: The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members, ...

    Abstract The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. Unlike mammals that have four TIF1 members,
    MeSH term(s) Animals ; Female ; Chromatin/metabolism ; Drosophila/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Germ Cells/metabolism ; Mammals/genetics ; Mediation Analysis ; Sumoylation
    Chemical Substances Chromatin ; Drosophila Proteins ; transcriptional intermediary factor 1 ; Bon protein, Drosophila
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pervasive SUMOylation of heterochromatin and piRNA pathway proteins.

    Ninova, Maria / Holmes, Hannah / Lomenick, Brett / Fejes Tóth, Katalin / Aravin, Alexei A

    Cell genomics

    2023  Volume 3, Issue 7, Page(s) 100329

    Abstract: Genome regulation involves complex protein interactions that are often mediated through post-translational modifications (PTMs). SUMOylation-modification by the small ubiquitin-like modifier (SUMO)-has been implicated in numerous essential processes in ... ...

    Abstract Genome regulation involves complex protein interactions that are often mediated through post-translational modifications (PTMs). SUMOylation-modification by the small ubiquitin-like modifier (SUMO)-has been implicated in numerous essential processes in eukaryotes. In
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2023.100329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of Germline Depletion of Bonus on Chromatin State in

    Godneeva, Baira / Fejes Tóth, Katalin / Quan, Baiyi / Chou, Tsui-Fen / Aravin, Alexei A

    Cells

    2023  Volume 12, Issue 22

    Abstract: Gene expression is controlled via complex regulatory mechanisms involving transcription factors, chromatin modifications, and chromatin regulatory factors. Histone modifications, such as H3K27me3, H3K9ac, and H3K27ac, play an important role in ... ...

    Abstract Gene expression is controlled via complex regulatory mechanisms involving transcription factors, chromatin modifications, and chromatin regulatory factors. Histone modifications, such as H3K27me3, H3K9ac, and H3K27ac, play an important role in controlling chromatin accessibility and transcriptional output. In vertebrates, the Transcriptional Intermediary Factor 1 (TIF1) family of proteins play essential roles in transcription, cell differentiation, DNA repair, and mitosis. Our study focused on Bonus, the sole member of the TIF1 family in
    MeSH term(s) Animals ; Female ; Chromatin ; Drosophila/metabolism ; Histone Code ; Histones/metabolism ; Ovary/metabolism
    Chemical Substances Chromatin ; Histones ; Bon protein, Drosophila
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12222629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Maternally inherited siRNAs initiate piRNA cluster formation.

    Luo, Yicheng / He, Peng / Kanrar, Nivedita / Fejes Toth, Katalin / Aravin, Alexei A

    Molecular cell

    2023  Volume 83, Issue 21, Page(s) 3835–3851.e7

    Abstract: PIWI-interacting RNAs (piRNAs) guide transposable element repression in animal germ lines. In Drosophila, piRNAs are produced from heterochromatic loci, called piRNA clusters, which act as information repositories about genome invaders. piRNA generation ... ...

    Abstract PIWI-interacting RNAs (piRNAs) guide transposable element repression in animal germ lines. In Drosophila, piRNAs are produced from heterochromatic loci, called piRNA clusters, which act as information repositories about genome invaders. piRNA generation by dual-strand clusters depends on the chromatin-bound Rhino-Deadlock-Cutoff (RDC) complex, which is deposited on clusters guided by piRNAs, forming a positive feedback loop in which piRNAs promote their own biogenesis. However, how piRNA clusters are formed before cognate piRNAs are present remains unknown. Here, we report spontaneous de novo piRNA cluster formation from repetitive transgenic sequences. Cluster formation occurs over several generations and requires continuous trans-generational maternal transmission of small RNAs. We discovered that maternally supplied small interfering RNAs (siRNAs) trigger de novo cluster activation in progeny. In contrast, siRNAs are dispensable for cluster function after its establishment. These results reveal an unexpected interplay between the siRNA and piRNA pathways and suggest a mechanism for de novo piRNA cluster formation triggered by siRNAs.
    MeSH term(s) Animals ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Piwi-Interacting RNA ; Maternal Inheritance ; Drosophila/genetics ; Chromatin/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; DNA Transposable Elements/genetics ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism
    Chemical Substances RNA, Small Interfering ; Piwi-Interacting RNA ; Chromatin ; Drosophila Proteins ; DNA Transposable Elements
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.09.033
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    In stock of ZB MED Cologne/Königswinter

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  9. Article: Transposon-taming piRNAs in the germline: Where do they come from?

    Chen, Peiwei / Aravin, Alexei A.

    Molecular cell. 2021 Oct. 07, v. 81, no. 19

    2021  

    Abstract: Mutations in the piRNA pathway protein components lead to transposon activation and fertility defects. In contrast, Gebert et al., (2021) saw no defects in transposon silencing or fertility when they deleted three large germline piRNA clusters in D. ... ...

    Abstract Mutations in the piRNA pathway protein components lead to transposon activation and fertility defects. In contrast, Gebert et al., (2021) saw no defects in transposon silencing or fertility when they deleted three large germline piRNA clusters in D. melanogaster.
    Keywords Drosophila melanogaster ; germ cells ; transposons
    Language English
    Dates of publication 2021-1007
    Size p. 3884-3885.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.09.017
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  10. Article ; Online: RDC complex executes a dynamic piRNA program during Drosophila spermatogenesis to safeguard male fertility.

    Chen, Peiwei / Luo, Yicheng / Aravin, Alexei A

    PLoS genetics

    2021  Volume 17, Issue 9, Page(s) e1009591

    Abstract: piRNAs are small non-coding RNAs that guide the silencing of transposons and other targets in animal gonads. In Drosophila female germline, many piRNA source loci dubbed "piRNA clusters" lack hallmarks of active genes and exploit an alternative path for ... ...

    Abstract piRNAs are small non-coding RNAs that guide the silencing of transposons and other targets in animal gonads. In Drosophila female germline, many piRNA source loci dubbed "piRNA clusters" lack hallmarks of active genes and exploit an alternative path for transcription, which relies on the Rhino-Deadlock-Cutoff (RDC) complex. RDC was thought to be absent in testis, so it remains to date unknown how piRNA cluster transcription is regulated in the male germline. We found that components of RDC complex are expressed in male germ cells during early spermatogenesis, from germline stem cells (GSCs) to early spermatocytes. RDC is essential for expression of dual-strand piRNA clusters and transposon silencing in testis; however, it is dispensable for expression of Y-linked Suppressor of Stellate piRNAs and therefore Stellate silencing. Despite intact Stellate repression, males lacking RDC exhibited compromised fertility accompanied by germline DNA damage and GSC loss. Thus, piRNA-guided repression is essential for normal spermatogenesis beyond Stellate silencing. While RDC associates with multiple piRNA clusters in GSCs and early spermatogonia, its localization changes in later stages as RDC concentrates on a single X-linked locus, AT-chX. Dynamic RDC localization is paralleled by changes in piRNA cluster expression, indicating that RDC executes a fluid piRNA program during different stages of spermatogenesis. These results disprove the common belief that RDC is dispensable for piRNA biogenesis in testis and uncover the unexpected, sexually dimorphic and dynamic behavior of a core piRNA pathway machinery.
    MeSH term(s) Animals ; Cell Death/genetics ; DNA Damage ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/physiology ; Fertility/genetics ; Gene Expression Regulation, Developmental ; Gene Silencing ; Male ; RNA, Small Interfering/genetics ; Sex Characteristics ; Spermatocytes/metabolism ; Spermatogenesis/genetics ; Testis/cytology ; Testis/metabolism
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1009591
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