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  1. Article: (Thyroid) Hormonal regulation of breast cancer cells.

    Hercbergs, Aleck / Lin, Hung-Yun / Mousa, Shaker A / Davis, Paul J

    Frontiers in endocrinology

    2023  Volume 13, Page(s) 1109555

    Abstract: Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 ('thyrointegrin') to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive breast ... ...

    Abstract Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 ('thyrointegrin') to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive breast cancer cells, T4
    MeSH term(s) Humans ; Female ; Thyroid Gland/metabolism ; Breast Neoplasms/drug therapy ; Estrogen Receptor alpha/metabolism ; Thyroid Hormones/metabolism ; Thyroxine/pharmacology
    Chemical Substances Estrogen Receptor alpha ; Thyroid Hormones ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1109555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: What is thyroid function in your just-diagnosed cancer patient?

    Hercbergs, Aleck / Mousa, Shaker A / Lin, Hung-Yun / Davis, Paul J

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1109528

    Abstract: The principal hormonal product of the thyroid gland, L-thyroxine (T4), is a prohormone for 3,3',5-triiodo-L-thyronine, T3, the major ligand of nuclear thyroid hormone receptors (TRs). At a cell surface thyroid hormone analogue receptor on cancer cell and ...

    Abstract The principal hormonal product of the thyroid gland, L-thyroxine (T4), is a prohormone for 3,3',5-triiodo-L-thyronine, T3, the major ligand of nuclear thyroid hormone receptors (TRs). At a cell surface thyroid hormone analogue receptor on cancer cell and endothelial cell plasma membrane integrin αvβ3, however, T4 at physiological concentrations is biologically active and is the major ligand. At this site in solid tumor cells, T4 nongenomically initiates cell proliferation, is anti-apoptotic by multiple mechanisms, supports radioresistance and enhances cancer-related angiogenesis. In contrast, hypothyroidism has been reported clinically to slow tumor growth. At physiological levels, T3 is not biologically active at the integrin and maintenance of euthyroidism with T3 in cancer patients may be associated with slowed tumor proliferation. Against this background, we raise the possibility that host serum T4 levels that are spontaneously in the upper tertile or quartile of the normal range in cancer patients may be a factor that contributes to aggressive tumor behavior. Recent observations on tumor metastasis and tumor-associated propensity for thrombosis due to T4 also justify clinical statistical analysis for a relationship to upper tertile hormone levels. That reverse T3 (rT3) may stimulate tumor growth has recently been reported and thus the utility of adding this measurement to thyroid function testing in cancer patients requires assessment. In summary, T4 at physiological concentrations promotes tumor cell division and aggressiveness and euthyroid hypothyroxinemia arrests clinically advanced solid tumors. These findings support the clinical possibility that T4 levels in the upper tertile of the normal range require examination as a tumor supporting factor.
    MeSH term(s) Humans ; Thyroid Gland ; Ligands ; Neoplasms ; Neoplasms, Second Primary ; Thyroxine ; Receptors, Thyroid Hormone
    Chemical Substances Ligands ; Thyroxine (Q51BO43MG4) ; Receptors, Thyroid Hormone
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1109528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Rapid Detection of

    Ndraha, Nodali / Lin, Hung-Yun / Tsai, Shou-Kuan / Hsiao, Hsin-I / Lin, Han-Jia

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 21

    Abstract: Food safety concerns regarding foodborne pathogen contamination have gained global attention due to its significant implications. In this study, we developed a detection system utilizing a PCR array combined with an automated magnetic bead-based system ... ...

    Abstract Food safety concerns regarding foodborne pathogen contamination have gained global attention due to its significant implications. In this study, we developed a detection system utilizing a PCR array combined with an automated magnetic bead-based system and CE technology to enable the detection of three foodborne pathogens, namely
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12213895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rapid detection methods for foodborne pathogens based on nucleic acid amplification: Recent advances, remaining challenges, and possible opportunities.

    Ndraha, Nodali / Lin, Hung-Yun / Wang, Chen-Yow / Hsiao, Hsin-I / Lin, Han-Jia

    Food chemistry. Molecular sciences

    2023  Volume 7, Page(s) 100183

    Abstract: This article presents a review of recent advancements in the utilization of NAA-based techniques for detecting foodborne pathogens in food products, focusing on studies conducted within the past five years. This review revealed that recent research ... ...

    Abstract This article presents a review of recent advancements in the utilization of NAA-based techniques for detecting foodborne pathogens in food products, focusing on studies conducted within the past five years. This review revealed that recent research efforts have primarily aimed at enhancing sensitivity and specificity by improving sample pre-treatment/preparation, DNA isolation, and readout methods. Isothermal-based amplification methods, such as LAMP, RPA, RAA, and RCA, have emerged as promising approaches, providing rapid results within one h and often demonstrating comparable or superior sensitivity to conventional or qPCR methods. However, the attention paid to specific pathogens varies, with
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-5662
    ISSN (online) 2666-5662
    DOI 10.1016/j.fochms.2023.100183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modeling the Risk of Vibrio parahaemolyticus in Oysters in Taiwan by Considering Seasonal Variations, Time Periods, Climate Change Scenarios, and Post-Harvest Interventions

    Ndraha, Nodali / Lin, Hung-Yun / Lin, Han-Jia / Xiao, Xinyi

    Microbial Risk Analysis. 2023 July 25, p.100275-

    2023  , Page(s) 100275–

    Abstract: Vibrio parahaemolyticus is a halophilic gram-negative bacterium commonly found in marine environments, particularly in warm coastal waters. This pathogen has been reported as a common cause of foodborne illness associated with the consumption of raw or ... ...

    Abstract Vibrio parahaemolyticus is a halophilic gram-negative bacterium commonly found in marine environments, particularly in warm coastal waters. This pathogen has been reported as a common cause of foodborne illness associated with the consumption of raw or undercooked seafood. The presence and density of this bacterium in seafood are often associated with the climatological conditions of the marine environment. Herein, we developed the quantitative risk assessment model for Vibrio parahaemolyticus in oysters in Taiwan by considering seasonal variations, time periods, climate change scenarios, and post-harvest interventions. This study showed that season, time period, shared socioeconomic pathway (SSP), and post-harvest intervention significantly influenced the risk level of becoming ill from consuming oysters. The mean estimates of risk in winter, spring, summer, and fall were estimated to be 9.1 × 10⁻⁵, 2.0 × 10⁻³, 2.0 × 10⁻², 6.9 × 10⁻³ per serving, respectively. Our models predict that, if global temperatures continue to increase in the coming decades due to climate change, the risk per serving of oysters is likely to increase by 18-145% by 2041-2060 and by 18-718% by 2081-2100, depending on the season and SSP. The application of thermal processing or high hydrostatic pressure processing was found to be the most effective approach in reducing risk, even under the threat of increasing global temperatures.
    Keywords Gram-negative bacteria ; Vibrio parahaemolyticus ; climate change ; foodborne illness ; high pressure treatment ; marine environment ; microbiological risk assessment ; models ; pathogens ; quantitative risk assessment ; risk ; seafoods ; spring ; summer ; winter ; Taiwan ; machine learning ; Elastic-net ; representative concentration pathways ; Vibrio parahaemolyticus infection ; time-horizon
    Language English
    Dates of publication 2023-0725
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ISSN 2352-3522
    DOI 10.1016/j.mran.2023.100275
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: An Overview of the Potential of Food-Based Carbon Dots for Biomedical Applications

    Chen-Yow Wang / Nodali Ndraha / Ren-Siang Wu / Hsin-Yun Liu / Sin-Wei Lin / Kuang-Min Yang / Hung-Yun Lin

    International Journal of Molecular Sciences, Vol 24, Iss 23, p

    2023  Volume 16579

    Abstract: Food-based carbon dots (CDs) hold significant importance across various fields, ranging from biomedical applications to environmental and food industries. These CDs offer unique advantages over traditional carbon nanomaterials, including affordability, ... ...

    Abstract Food-based carbon dots (CDs) hold significant importance across various fields, ranging from biomedical applications to environmental and food industries. These CDs offer unique advantages over traditional carbon nanomaterials, including affordability, biodegradability, ease of operation, and multiple bioactivities. This work aims to provide a comprehensive overview of recent developments in food-based CDs, focusing on their characteristics, properties, therapeutic applications in biomedicine, and safety assessment methods. The review highlights the potential of food-based CDs in biomedical applications, including antibacterial, antifungal, antivirus, anticancer, and anti-immune hyperactivity. Furthermore, current strategies employed for evaluating the safety of food-based CDs have also been reported. In conclusion, this review offers valuable insights into their potential across diverse sectors and underscores the significance of safety assessment measures to facilitate their continued advancement and application.
    Keywords food-based carbon dots ; therapeutic activities ; human healthcare ; biosafety assessment ; carbon dots family ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 360
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: An Overview of the Potential of Food-Based Carbon Dots for Biomedical Applications.

    Wang, Chen-Yow / Ndraha, Nodali / Wu, Ren-Siang / Liu, Hsin-Yun / Lin, Sin-Wei / Yang, Kuang-Min / Lin, Hung-Yun

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Food-based carbon dots (CDs) hold significant importance across various fields, ranging from biomedical applications to environmental and food industries. These CDs offer unique advantages over traditional carbon nanomaterials, including affordability, ... ...

    Abstract Food-based carbon dots (CDs) hold significant importance across various fields, ranging from biomedical applications to environmental and food industries. These CDs offer unique advantages over traditional carbon nanomaterials, including affordability, biodegradability, ease of operation, and multiple bioactivities. This work aims to provide a comprehensive overview of recent developments in food-based CDs, focusing on their characteristics, properties, therapeutic applications in biomedicine, and safety assessment methods. The review highlights the potential of food-based CDs in biomedical applications, including antibacterial, antifungal, antivirus, anticancer, and anti-immune hyperactivity. Furthermore, current strategies employed for evaluating the safety of food-based CDs have also been reported. In conclusion, this review offers valuable insights into their potential across diverse sectors and underscores the significance of safety assessment measures to facilitate their continued advancement and application.
    MeSH term(s) Quantum Dots/therapeutic use ; Carbon ; Nanostructures/therapeutic use ; Antifungal Agents ; Anti-Bacterial Agents
    Chemical Substances Carbon (7440-44-0) ; Antifungal Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enhancing the Spermidine Synthase-Based Polyamine Biosynthetic Pathway to Boost Rapid Growth in Marine Diatom

    Lin, Hung-Yun / Liu, Chung-Hsiao / Kang, Yong-Ting / Lin, Sin-Wei / Liu, Hsin-Yun / Lee, Chun-Ting / Liu, Yu-Chen / Hsu, Man-Chun / Chien, Ya-Yun / Hong, Shao-Ming / Cheng, Yun-Hsuan / Hsieh, Bing-You / Lin, Han-Jia

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: Diatoms, efficient carbon capture organisms, contribute to 20% of global carbon fixation and 40% of ocean primary productivity, garnering significant attention to their growth. Despite their significance, the synthesis mechanism of polyamines (PAs), ... ...

    Abstract Diatoms, efficient carbon capture organisms, contribute to 20% of global carbon fixation and 40% of ocean primary productivity, garnering significant attention to their growth. Despite their significance, the synthesis mechanism of polyamines (PAs), especially spermidine (Spd), which are crucial for growth in various organisms, remains unexplored in diatoms. This study reveals the vital role of Spd, synthesized through the spermidine synthase (SDS)-based pathway, in the growth of the diatom
    MeSH term(s) Diatoms/genetics ; Diatoms/metabolism ; Spermidine Synthase/genetics ; Spermidine Synthase/metabolism ; Polyamines/metabolism ; Biosynthetic Pathways ; Genome
    Chemical Substances Spermidine Synthase (EC 2.5.1.16) ; Polyamines
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Inhibition of White Spot Syndrome Virus (WSSV) in Pacific White Shrimp (Litopenaeus vannamei) Using Polyamine-Modified Carbon Quantum Dots.

    Lin, Hung-Yun / Lin, John Han-You / Lin, Han-Jia / Chen, Li-Li

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2610, Page(s) 67–73

    Abstract: White spot syndrome virus (WSSV), an enveloped double-stranded DNA virus, is the causative agent of white spot syndrome (WSS), which has been linked to cultured shrimp mass mortality in many countries. Therefore, the development of anti-WSSV agents is ... ...

    Abstract White spot syndrome virus (WSSV), an enveloped double-stranded DNA virus, is the causative agent of white spot syndrome (WSS), which has been linked to cultured shrimp mass mortality in many countries. Therefore, the development of anti-WSSV agents is among the top priorities of the aquaculture sector. Here, we describe the preparation of polyamine-modified carbon quantum dots (polyamine CQDs) for the treatment of WSSV. Moreover, in vivo experiments were conducted in shrimp to confirm the anti-WSSV effect of the proposed CQD-based strategy.
    MeSH term(s) Animals ; White spot syndrome virus 1/genetics ; Carbon ; Polyamines/pharmacology ; Quantum Dots ; Penaeidae
    Chemical Substances Carbon (7440-44-0) ; Polyamines
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2895-9_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retraction notice to "Thyroid hormone is a MAPK-dependent growth factor for thyroid cancer cells and is anti-apoptotic" [Steroids 72(2) 2007 180-187].

    Lin, Hung-Yun / Tang, Heng-Yuan / Shih, Ai / Keating, Travis / Cao, Gary / Davis, Paul J / Davis, Faith B

    Steroids

    2023  Volume 195, Page(s) 109237

    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 80312-1
    ISSN 1878-5867 ; 0039-128X
    ISSN (online) 1878-5867
    ISSN 0039-128X
    DOI 10.1016/j.steroids.2023.109237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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