LIVIVO - Search results -

Search results

Result 1 - 10 of total 44

Search options

Article: Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents.

Othman, Essam R / Al-Hendy, Ayman / Mostafa, Radwa / Lambalk, Cornelis B / Mijatovic, Velja

2024 Volume 16, Page(s) 309–321

Abstract: Current medical treatment options for endometriosis associated pains are inadequate. Evidence on effects of nonsteroidal anti-inflammatory drugs is scarce. Around one third of patients are not responsive to oral contraceptives or progestins due to ... ...

Abstract	Current medical treatment options for endometriosis associated pains are inadequate. Evidence on effects of nonsteroidal anti-inflammatory drugs is scarce. Around one third of patients are not responsive to oral contraceptives or progestins due to progesterone resistance. Gonadotropin-releasing hormone (GnRH) agonists can only be used for a short duration because of associated side effects. Oral GnRH antagonists, including elagolix, relugolix, and linzagolix allow oral administration, induce dose dependent reduction of estradiol levels, do not cause initial flare up of endometriosis symptoms, and allow the fast return of ovarian function and menstruation after discontinuation. Elagolix at a low dose of 150 mg once daily, or the higher dose of 200 mg twice daily, significantly increased the proportion of women achieving clinically meaningful decline of dysmenorrhea, noncyclic pelvic pain, and dyspareunia. Relugolix at an oral dose of 40 mg/day results in improvement in different forms of endometriosis related pelvic pain, with an efficacy and side effect profile similar to that of GnRH agonists. Adding 1 mg of estradiol and 0.5 mg of norethindrone to 40 mg of relugolix (relugolix combination therapy) allows extension of treatment to 24 weeks with maintained efficacy and an improved side effect profile. Linzagolix, in a dose of 75 mg/day, can be used alone to treat endometriosis associated pain. For severe pelvic pain and dyspareunia, linzagolix can be used in a high dose of 200 mg/day with hormonal add-back therapy to preserve bone health.
Language	English
Publishing date	2024-02-27
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2508161-5
ISSN	1179-1411
ISSN	1179-1411
DOI	10.2147/IJWH.S442357
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant.

Mahgoub, Samar M / Essam, Doaa / Eldin, Zienab E / Moaty, S A Abdel / Shehata, Mohamed R / Farghali, Ahmed / Abdalla, Saif Elden B / Othman, Sarah I / Allam, Ahmed A / El-Ela, Fatma I Abo / Mahmoud, Rehab

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3990

Abstract: Fluoxetine (FLX) is one of the most persistent pharmaceuticals found in wastewater due to increased use of antidepressant drugs in recent decades. In this study, a nanocomposite of ternary ZnCoAl layered double hydroxide supported on activated carbon ( ... ...

Abstract	Fluoxetine (FLX) is one of the most persistent pharmaceuticals found in wastewater due to increased use of antidepressant drugs in recent decades. In this study, a nanocomposite of ternary ZnCoAl layered double hydroxide supported on activated carbon (LAC) was used as an adsorbent for FLX in wastewater effluents. The nanocomposite was characterized using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), and surface area analysis (BET). The adsorption investigations showed that the maximum removal capacity was achieved at pH 10, with a 0.1 g/L adsorbent dose, 50 mL volume of solution, and at a temperature of 25 °C. The FLX adsorption process followed the Langmuir-Freundlich model with a maximum adsorption capacity of 450.92 mg/g at FLX concentration of 50 µg/mL. Density functional theory (DFT) computations were used to study the adsorption mechanism of FLX and its protonated species. The safety and toxicity of the nanocomposite formed from the adsorption of FLX onto LAC (FLX-LAC) was investigated in male albino rats. Acute toxicity was evaluated using probit analysis after 2, 6, and 24 h to determine LD
MeSH term(s)	Humans ; Male ; Animals ; Rats ; Fluoxetine ; Wastewater ; Hydroxides/chemistry ; Antidepressive Agents ; Nanocomposites/chemistry ; Adsorption ; Kinetics ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/chemistry ; Spectroscopy, Fourier Transform Infrared ; Hydrogen-Ion Concentration
Chemical Substances	Fluoxetine (01K63SUP8D) ; Wastewater ; hydroxide ion (9159UV381P) ; Hydroxides ; Antidepressive Agents ; Water Pollutants, Chemical
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53781-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reliability of Magnetic Resonance Imaging in diagnosis and assessment the depth of invasion of placental accreta in high risk gravid women.

Khalaf, Lamiaa M R / Zeid, Hazem Abou / Othman, Essam Rashad

Clinical imaging

2019 Volume 58, Page(s) 5–11

Abstract: Objectives: To evaluate sensitivity, specificity and accuracy of Magnetic Resonance Imaging (MRI) in diagnosis and assessment the depth of invasion of placenta accreta (PA) in high risk gravid women.: Materials & methods: The study included 58 ... ...

Abstract	Objectives: To evaluate sensitivity, specificity and accuracy of Magnetic Resonance Imaging (MRI) in diagnosis and assessment the depth of invasion of placenta accreta (PA) in high risk gravid women. Materials & methods: The study included 58 pregnant women with multiple risk factors for PA. Placental mapping by ultrasound was followed by MRI when the patients were diagnosed or suspicious by ultrasound to have PA. Focal myometrial interruption, dark intra-placental band, heterogeneous placenta, focal uterine bulge and invasion to the surrounding organs were used as a sign of diagnosis of PA. The results of the MRI were compared with intraoperative findings and/or histopathological diagnosis. Results: Placenta Previa was detected at MRI in 58 cases and PA in 49 cases. The sensitivity, specificity and accuracy of MRI in the diagnosis of PA were (100%, 75%, and 94.8% respectively) and (100%, 42.8%, and 79.3% respectively) in assessing the depth of invasion. Invasion to the surrounding organs sign was the most reliable sign in diagnosis of placenta percreta. Conclusion: MRI is a reliable method in the diagnosis of PAbut less reliable in assessing the depth of invasion of placenta accreta and increta making the task of differentiating between them difficult. Placenta percreta diagnosed accurately by invasion to the surrounding organs.
MeSH term(s)	Adult ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Placenta Accreta/diagnostic imaging ; Pregnancy ; Prenatal Diagnosis ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Young Adult
Language	English
Publishing date	2019-05-15
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2019.05.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1469: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Arabincosides A-D, pregnane glycosides isolated from Caralluma arabica

Abdel-Sattar, Essam A. / Al-Hawshabi, Othman S.S. / Shalabi, Akram A. / El Halawany, Ali M. / Meselhy, Meselhy R.

Tetrahedron. 2022 July 30, v. 119

2022

Abstract: The aqueous remained fraction after partitioning the crude ethanol extract with ether and methylene chloride of the aerial parts of Caralluma arabica yielded six pregnane glycosides, four of them were found to be new pregnane glycosides and were ... ...

Abstract	The aqueous remained fraction after partitioning the crude ethanol extract with ether and methylene chloride of the aerial parts of Caralluma arabica yielded six pregnane glycosides, four of them were found to be new pregnane glycosides and were identified using spectral analysis (MS, 1D and 2DNMR) as 3β,14β, dihydroxypregn-5-en-20-one-3-O-β-d-glucopyranosyl-(1 → 4)-O-β-d-digitalopyranoside (arabincoside A), 3β,14β-dihydroxypregn-5-en-20-one-3-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-glucopyranosyl-(1 → 4)-O-β-d-digitalopyranoside (arabincoside B), 12-β-O-benzoyl-3β, 12β, 14β, 20-tetrahydroxy-(20R)-pregn-5-ene-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-cymaropyranoside (arabincoside C) and 12-β-O-benzoyl-3β, 12β, 14β, 20-tetrahydroxy-(20R)-pregn-5-ene-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-cymaropyranoside (arabincoside D). In addition, two known pregnane glycosides were also isolated and identified as russelioside D and russelioside C, previously isolated from C. russelliana.
Keywords	Caralluma ; ethanol ; glycosides ; methylene chloride ; pregnanes ; spectral analysis
Language	English
Dates of publication	2022-0730
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2022.132858
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.B 1076: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Evidence of the Extrahepatic Replication of Hepatitis E Virus in Human Endometrial Stromal Cells.

El-Mokhtar, Mohamed A / Othman, Essam R / Khashbah, Maha Y / Ismael, Ali / Ghaliony, Mohamed Aa / Seddik, Mohamed Ismail / Sayed, Ibrahim M

Pathogens (Basel, Switzerland)

2020 Volume 9, Issue 4

Abstract: Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The tropism of HEV is not restricted to the liver, and the virus replicates in other organs. Not all the extrahepatic targets for HEV are identified. Herein, we found ... ...

Abstract	Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The tropism of HEV is not restricted to the liver, and the virus replicates in other organs. Not all the extrahepatic targets for HEV are identified. Herein, we found that non-decidualized primary human endometrial stromal cells (PHESCs), which are precursors for the decidua and placenta, are susceptible to HEV infection. PHESCs, isolated from healthy non-pregnant women (n = 5), were challenged with stool-derived HEV-1 and HEV-3. HEV RNA was measured by qPCR, and HEV capsid protein was assessed by flow cytometry, immunofluorescence (IF), and ELISA. HEV infection was successfully established in PHESCs. Intracellular and extracellular HEV RNA loads were increased over time, indicating efficient replication in vitro. In addition, HEV capsid protein was detected intracellularly in the HEV-infected PHESCs and accumulated extracellularly over time, confirming the viral assembly and release from the infected cells. HEV-1 replicated more efficiently in PHESCs than HEV-3 and induced more inflammatory responses. Ribavirin (RBV) treatment abolished the replication of HEV in PHESCs. In conclusion, PHESCs are permissive to HEV infection and these cells could be an endogenous source of HEV infection during pregnancy and mediate HEV vertical transmission.
Language	English
Publishing date	2020-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9040295
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Adipose tissue-derived mesenchymal stem cells reduce endometriosis cellular proliferation through their anti-inflammatory effects.

Meligy, Fatma Y / Elgamal, Dalia A / Abdelzaher, Lobna A / Khashbah, Maha Y / El-Mokhtar, Mohamed A / Sayed, Ayat A / Refaiy, Abeer M / Othman, Essam R

Clinical and experimental reproductive medicine

2021 Volume 48, Issue 4, Page(s) 322–336

Abstract: Objective: Endometriosis is a chronic debilitating inflammatory condition characterized by the presence of endometrial tissues outside the uterine cavity. Pelvic soreness and infertility are the usual association. Due to the poor effectiveness of the ... ...

Abstract	Objective: Endometriosis is a chronic debilitating inflammatory condition characterized by the presence of endometrial tissues outside the uterine cavity. Pelvic soreness and infertility are the usual association. Due to the poor effectiveness of the hormone therapy and the high incidence of recurrence following surgical excision, there is no single effective option for management of endometriosis. Mesenchymal stem cells (MSCs) are multipotent stromal cells studied for their broad immunoregulatory and anti-inflammatory properties; however, their efficiency in endometriosis cases is still a controversial issue. Our study aim was to evaluate whether adipose tissue-derived MSCs (AD-MSCs) could help with endometriosis through their studied anti-inflammatory role. Methods: Female Wistar rats weighting 180 to 250 g were randomly divided into two groups: group 1, endometriosis group; established by transplanting autologous uterine tissue into rats' peritoneal cavities and group 2, stem cell treated group; treated with AD-MSCs on the 5th day after induction of endometriosis. The proliferative activity of the endometriosis lesions was evaluated through Ki67 staining. Quantitative estimation of interferon γ, tumor necrosis factor-α, interleukin (IL)-6, IL-1β, IL-10, and transforming growth factor β expression, as well as immunohistochemical detection of CD68 positive macrophages, were used to assess the inflammatory status. Results: The size and proliferative activity of endometriosis lesions were significantly reduced in the stem cell treated group. Stem cells efficiently mitigated endometriosis associated chronic inflammatory reactions estimated through reduction of CD68 positive macrophages and the expression of the proinflammatory cytokines. Conclusion: Stem cell therapy can be considered a novel remedy in endometriosis possibly through its anti-inflammatory and antiproliferative properties.
Language	English
Publishing date	2021-12-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2653899-4
ISSN	2233-8241 ; 2233-8233
ISSN (online)	2233-8241
ISSN	2233-8233
DOI	10.5653/cerm.2021.04357
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Markers of Local and Systemic Estrogen Metabolism in Endometriosis.

Othman, Essam R / Markeb, Ahmad Abo / Khashbah, Maha Y / Abdelaal, Ibrahim I / ElMelegy, Tarek T / Fetih, Ahmed N / Van der Houwen, Lisette E / Lambalk, Cornelis B / Mijatovic, Velja

Reproductive sciences (Thousand Oaks, Calif.)

2020 Volume 28, Issue 4, Page(s) 1001–1011

Abstract: Estrogen metabolites (EMs) can work independently from their parent hormones. We hypothesize that in endometriosis, estrogen is metabolized preferentially along hormonally active pathways. We recruited 62 women with endometriosis (proven laparoscopically ...

Abstract	Estrogen metabolites (EMs) can work independently from their parent hormones. We hypothesize that in endometriosis, estrogen is metabolized preferentially along hormonally active pathways. We recruited 62 women with endometriosis (proven laparoscopically and histologically) and 52 control women (normal findings with laparoscopy) among patients undergoing surgery for pelvic pain and/or infertility during the proliferative phase of the menstrual cycle. Urinary samples were collected preoperatively. Biopsies from eutopic endometrium of control women and women with endometriosis were collected during surgery. EMs in urine and endometrial tissues were extracted and determined using Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS). These included: 2-hydroxyestrone (2OHE1), 16-α hydroxyestrone (16α-OHE1), 2OHE1/16α-OHE1 ratio, 4-hydroxyestrone (4OHE1), 2-hydroxyestradiol (2OHE2), and 4-hydroxyestradiol (4OHE2). Eutopic endometrium of endometriosis patients, as compared to control endometrium, contained significantly higher level of 4OHE1 (0.03 (IQR: 0.03-0.265) versus 0.03 (IQR: 0.03-0.03) μg/g, respectively, P = 0.005), 2-OHE2 (0.241 (IQR: 0.1-0.960) versus 0.1 (IQR: 0.1-0.1) μg/g, respectively, P < 0.001), and 4-OHE2 (0.225 (IQR: 0.22-1.29) versus 0.0.2 (IQR: 0.2-0.2) μg/g, respectively, P < 0.001). Only 2OHE1 showed higher concentration in urine of women with endometriosis than controls (9.9 (IQR: 3.64-14.88) versus 4.5 (IQR: 1.37-17.00) μg/mg creatinine, respectively, P = 0.042). Eutopic endometrium of women with endometriosis metabolizes estrogen preferentially to the biologically active 2OHE2, and potentially genotoxic 4OHE1 and 4OHE2 metabolites. This contributes to further understanding of endometriosis etiology, its link to ovarian cancer, and could help identifying an endometrial biomarker of the disease.
MeSH term(s)	Biomarkers/metabolism ; Chromatography, Liquid ; Endometriosis/metabolism ; Endometrium/metabolism ; Estrogens/metabolism ; Female ; Humans ; Hydroxyestrones/metabolism ; Tandem Mass Spectrometry
Chemical Substances	Biomarkers ; Estrogens ; Hydroxyestrones
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-020-00383-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4113: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Evidence of the Extrahepatic Replication of Hepatitis E Virus in Human Endometrial Stromal Cells

Mohamed A. El-Mokhtar / Essam R. Othman / Maha Y. Khashbah / Ali Ismael / Mohamed AA Ghaliony / Mohamed Ismail Seddik / Ibrahim M. Sayed

Pathogens, Vol 9, Iss 295, p

2020 Volume 295

Abstract	Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The tropism of HEV is not restricted to the liver, and the virus replicates in other organs. Not all the extrahepatic targets for HEV are identified. Herein, we found that non-decidualized primary human endometrial stromal cells (PHESCs), which are precursors for the decidua and placenta, are susceptible to HEV infection. PHESCs, isolated from healthy non-pregnant women (n = 5), were challenged with stool-derived HEV-1 and HEV-3. HEV RNA was measured by qPCR, and HEV capsid protein was assessed by flow cytometry, immunofluorescence (IF), and ELISA. HEV infection was successfully established in PHESCs. Intracellular and extracellular HEV RNA loads were increased over time, indicating efficient replication in vitro. In addition, HEV capsid protein was detected intracellularly in the HEV-infected PHESCs and accumulated extracellularly over time, confirming the viral assembly and release from the infected cells. HEV-1 replicated more efficiently in PHESCs than HEV-3 and induced more inflammatory responses. Ribavirin (RBV) treatment abolished the replication of HEV in PHESCs. In conclusion, PHESCs are permissive to HEV infection and these cells could be an endogenous source of HEV infection during pregnancy and mediate HEV vertical transmission.
Keywords	HEV ; endometrial stromal cells ; pathogenesis ; extrahepatic replication ; female genital system ; pregnancy ; Medicine ; R
Subject code	570
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Bisphenol A Concentrates Preferentially in Human Uterine Leiomyoma and Induces Proliferation in Rat Myometrium.

Othman, Essam R / Al-Adly, Dina M M / Elgamal, Dalia A / Ghandour, Nagwa / El-Sharkawy, Sawsan

Reproductive sciences (Thousand Oaks, Calif.)

2016 Volume 23, Issue 4, Page(s) 508–514

Abstract: Objectives: To measure tissue levels of bisphenol A (BPA) in uterine leiomyoma (ULM), adjacent myometrium (Myo-F), and normal myometrium (Myo-N). Also, we tested the effect of BPA treatment on rat myometrium.: Methods: Uterine leiomyomas and Myo-F ... ...

Abstract	Objectives: To measure tissue levels of bisphenol A (BPA) in uterine leiomyoma (ULM), adjacent myometrium (Myo-F), and normal myometrium (Myo-N). Also, we tested the effect of BPA treatment on rat myometrium. Methods: Uterine leiomyomas and Myo-F tissues were isolated from hysterectomy specimens done to treat symptomatic ULMs (N = 30). Normal myometrium is isolated from hysterectomies done on ULM-free uteri for other benign indications (N = 25). Bisphenol A was measured in 1 g of tissue using solid-phase extraction and high-performance liquid chromatography, with fluorescence detectors. Experimentally, adult female rats were fed BPA orally at a dose of 50 mg/kg/d for 90 days. Animals were killed, and their myometrial thickness and proliferating cell nuclear antigen (PCNA) immunostaining were evaluated. Results: Tissue concentration of BPA in each of ULM (12.3 ± 2.8 µg/g) and Myo-F (10.1 ± 0.2 µg/g) was significantly higher than that of Myo-N (0.58 ± 0.2 µg/g). There was no statistically significant difference in BPA level between ULM and Myo-F within submucous or interstitial/subserous fibroid groups. Compared to control rats, BPA-treated animals showed significantly higher myometrial thickness (168.67 ± 5.7 µm and 281.6 ± 20.32 µm, respectively, P = .003) and increased myometrial PCNA immunoscores (1.5 ± 0.37 and 10.38 ± 0.67, respectively, P ≤ .001). Conclusion: Bisphenol A concentrates in human ULM tissue and its adjacent Myo-F compared to Myo-N. No significant difference is detected in BPA content of ULM tissue of different subtypes. Bisphenol A increases thickness and induces cellular proliferation in rat myometrium. Taken together, our results support a role of BPA in ULM development/growth.
MeSH term(s)	Administration, Oral ; Adult ; Animals ; Benzhydryl Compounds/administration & dosage ; Benzhydryl Compounds/metabolism ; Benzhydryl Compounds/toxicity ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Female ; Humans ; Leiomyoma/metabolism ; Leiomyoma/pathology ; Middle Aged ; Myometrium/drug effects ; Myometrium/metabolism ; Myometrium/pathology ; Phenols/administration & dosage ; Phenols/metabolism ; Phenols/toxicity ; Proliferating Cell Nuclear Antigen/metabolism ; Rats ; Uterine Neoplasms/metabolism ; Uterine Neoplasms/pathology
Chemical Substances	Benzhydryl Compounds ; Phenols ; Proliferating Cell Nuclear Antigen ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1177/1933719115608001
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4113: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Evaluation of endometrial and subendometrial vascularity in obese women with polycystic ovarian disease

Essam R. Othman / Karim S. Abdullah / Ahmed M. Abbas / Mostafa Hussein / Elwany Elsnosy / Ihab H. El-Nashar

Middle East Fertility Society Journal, Vol 23, Iss 4, Pp 324-

2018 Volume 330

Abstract: Introduction: The study aims to evaluate the effect of obesity on the endometrium in women with polycystic ovarian disease (PCOD) through evaluation of endometrial and subendometrial vascularity by two-dimensional (2D) ultrasound, Doppler and three ... ...

Abstract	Introduction: The study aims to evaluate the effect of obesity on the endometrium in women with polycystic ovarian disease (PCOD) through evaluation of endometrial and subendometrial vascularity by two-dimensional (2D) ultrasound, Doppler and three dimensional power Doppler (3DPD). Methods: A prospective case-control study, conducted in a tertiary University hospital between February 2016 and December 2016. The study included 50 women with PCOD and 50 fertile regular menstruating women divided according to their body mass index (BMI) into normal weight and overweight/obese groups. Endometrial thickness and pattern combined with Doppler examination of the uterine vessels for measurement of Resistance index (RI) and pulsatility index (PI) were assessed. Evaluation of endometrial and subendometrial blood flow was performed by 3DPD using Virtual organ computer-aided analysis program. Results: No significant difference in the endometrial pattern or thickness between all study groups. Endometrial volume was significantly lower in the overweight/obese PCOD women and overall in the PCOD women compared to the control group (p < 0.01). Uterine artery RI was significantly higher in the PCOD women compared to the control group (p = 0.004), but no difference in uterine PI. Vascular indices of endometrial and subendometrial blood flow were significantly lower in the overweight/obese PCOD women than the normal weight PCOD women. Conclusions: The endometrium is negatively affected by obesity in women with PCOD. Additionally, PCOD women had lower endometrial and subendometrial blood flow than non-PCOD women. Therefore, overweight/obese PCOD women should be encouraged to reduce their body weight in order to improve the endometrial receptivity. Keywords: Obesity, Polycystic ovarian disease, Endometrium, Doppler, VOCAL, Infertility
Keywords	Medicine (General) ; R5-920 ; Reproduction ; QH471-489
Subject code	610
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED