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Article ; Online: High-Performance All-Small-Molecule Organic Solar Cells Fabricated via Halogen-Free Preparation Process.

Du, Bo / Ma, Mengyuan / Zhang, Panpan / Wu, Shangrong / Bin, Haijun / Li, Yongfang

ACS applied materials & interfaces

2024 Volume 16, Issue 2, Page(s) 2564–2572

Abstract: Small-molecule organic photovoltaic materials attract more attention attributing to their precisely defined structure, ease of synthesis, and reduced batch-to-batch variations. The majority of all-small-molecule organic solar cells (ASM-OSCs) have ... ...

Abstract	Small-molecule organic photovoltaic materials attract more attention attributing to their precisely defined structure, ease of synthesis, and reduced batch-to-batch variations. The majority of all-small-molecule organic solar cells (ASM-OSCs) have traditionally relied on halogenated solvents for dissolving photovoltaic materials as well as used for the additives or solvent vapor annealing. However, these halogen-based processes pose risks to the environment and human health, potentially impeding future commercial production. Herein, we conducted an investigation into the impact of various nonhalogen solvents on the performance of the devices. By selecting the high boiling point solvent toluene, we achieved a desirable phase separation and stable morphology characterized by fibrous crystals within the blend film. Consequently, the power conversion efficiencies of 14.4 and 11.7% were obtained from H31:Y6-based small-area (0.04 cm
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c14992
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Article ; Online: Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a

Yong Zheng / Shangrong Wu / Haiqiang Ke / Shanshan Peng / Chengjun Hu

Experimental Gerontology, Vol 172, Iss , Pp 112062- (2023)

2023

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms ...

Abstract	Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms that contribute to BMSC senescence is critical for the development of BMSC-based tissue engineering and regenerative medicine. In this study, senescent BMSCs were characterized with >80 % of BMSCs stained positive for SA-β-gal, increased expressions of senescence-related genes (p16INK4a and p21Waf1). These senescent characters were accompanied by elevated autophagic activity, up-regulation of interleukin 6 (IL-6), IL-8, and FoxO3a. Autophagic activity inhibition alleviated the senescent state with reduced levels of IL-6 and IL-8 during BMSC senescence. The enhanced autophagic activity upregulated the levels of IL-6 and IL-8 which is associated with up-regulation of FoxO3a, and knockdown of FoxO3a reduced IL-6 and IL-8 expression in senescent BMSCs. Therefore, this study indicated the pivotal role of autophagic activity in the expressions of IL-6 and IL-8 during BMSC senescence, which is regulated by FoxO3a.
Keywords	Bone marrow mesenchymal stem cells ; Senescence ; Autophagy ; Interleukin 6 ; Interleukin 8 ; FoxO3a ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preliminary characterization and probabilistic risk assessment of microplastics and potentially toxic elements (PTEs) in garri (cassava flake), a common staple food consumed in West Africa.

Enyoh, Christian Ebere / Wang, Qingyue / Rabin, Mominul Haque / Bakare, Rasheed Oluwafemi / Dadiel, Joseph Longji / Shangrong, Wu / Lu, Senlin / Ilechukwu, Ifenna

Environmental analysis, health and toxicology

2023 Volume 38, Issue 1, Page(s) e2023005–0

Abstract: Garri from cassava is one of the most consumed foods in West Africa, hence this research was conducted to examine microplastics (MPs) and potentially toxic elements (PTEs) in garri from Nigeria (West Africa) and Japan. This is the first investigation on ... ...

Abstract	Garri from cassava is one of the most consumed foods in West Africa, hence this research was conducted to examine microplastics (MPs) and potentially toxic elements (PTEs) in garri from Nigeria (West Africa) and Japan. This is the first investigation on MPs in garri samples that has been reported in the literature. The study analyzed both packaged and unpackaged vended garri samples using microscopic/spectroscopic and X-ray fluorescence techniques for MPs and PTEs respectively. Microplastic particles in the garri samples ranged from (or were between) 2.00±2.00 - 175.00±25.16 particles/50 with > 90 % as fragments and consisted of polyacrylamide, polyethylene terepthalate, polyvinyl alcohol, high density polyethylene, polyvinyl chloride acrylonitrile, polyethylene chlorinated, polypropylene with silicate mix, polychloroprene and polyethylene chlorosulphonated. The mean concentration of PTEs raged from ND to 0.07 mg/g for Cr and Mn, 0.73 to 5.63 mg/g for Fe, ND to 0.57mg/g for Co, 0.23 to 1.21 mg/g for Ni, 0.15 to 1.53 mg/g for Cu, and 0.12 to 0.63 mg/g for Zn. However, their daily intake was low for both adult and children as with the MPs. The sources of MPs and PTEs were mainly from the garri production processes, atmospheric dusts and during packaging. The non-carcinogenic risk for all samples was low for MPs while in openly vended garri, Ni and Cr in all sample poses carcinogenic risks. There is a need to improve indigenous garri processing techniques to minimize contamination. This research emphasizes the critical necessity to understand the consequences of MPs on human health.
Language	English
Publishing date	2023-03-20
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2671-9525
ISSN (online)	2671-9525
DOI	10.5620/eaht.2023005
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Article ; Online: Impact of Three Thiazolidinone Compounds with Piperine Skeletons on Trehalase Activity and Development of

Tang, Bin / Hu, Shangrong / Luo, Yujia / Shi, Dongmei / Liu, Xiangyu / Zhong, Fan / Jiang, Xinyi / Hu, Gao / Li, Can / Duan, Hongxia / Wu, Yan

Journal of agricultural and food chemistry

2024 Volume 72, Issue 15, Page(s) 8423–8433

Abstract: Trehalases (TREs) are pivotal enzymes involved in insect development and reproduction, making them prime targets for pest control. We investigated the inhibitory effect of three thiazolidinones with piperine skeletons (6a, 7b, and 7e) on TRE activity and ...

Abstract	Trehalases (TREs) are pivotal enzymes involved in insect development and reproduction, making them prime targets for pest control. We investigated the inhibitory effect of three thiazolidinones with piperine skeletons (6a, 7b, and 7e) on TRE activity and assessed their impact on the growth and development of the fall armyworm (FAW),
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08898
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Article ; Online: The influence of placenta microbiota of normal term pregnant women on immune regulation during pregnancy.

Yang, Ping / Lu, Tong / Liang, Xinyuan / Huang, Ting / Wu, Lulu / He, Zonglin / Xiao, Xiaomin / Fan, Shangrong

BMC pregnancy and childbirth

2024 Volume 24, Issue 1, Page(s) 171

Abstract: Background: The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta ... ...

Abstract	Background: The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta microbiota and immune regulation during pregnancy. Methods: Twenty-six healthy pregnant women scheduled for elective cesarean section in the First Affiliated Hospital of Jinan University who met the inclusion criteria were recruited. Placenta and peripheral venous blood samples were collected. Microbiota in placental tissue was detected using high-throughput sequencing. Flow cytometry was used to detect immune cells in placental tissue and peripheral venous blood. ELISA and Luminex liquid chip technology were used to detect the content of cytokines in placental tissue and peripheral venous blood, respectively. Results: The placental microbiota has stimulating effects on the local immunity of the placenta and mainly stimulates the placental balance ratio CD56 + CD16 + /CD56 + CD16 and the placental macrophages, that is, it plays the role of immune protection and supporting nutrition. The stimulating effect of placental microbiota on maternal systemic immunity mainly induces peripheral Treg cells and B lymphocytes. Conclusion: The placental microbiota may be an important factor mediating local immune regulation in the placenta, and placental microbiota participates in the regulatory function of the maternal immune system.
MeSH term(s)	Pregnancy ; Female ; Humans ; Placenta ; Pregnant Women ; Cesarean Section ; Cytokines ; Microbiota
Chemical Substances	Cytokines
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-024-06353-x
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Article ; Online: Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a.

Zheng, Yong / Wu, Shangrong / Ke, Haiqiang / Peng, Shanshan / Hu, Chengjun

Experimental gerontology

2022 Volume 172, Page(s) 112062

Abstract	Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms that contribute to BMSC senescence is critical for the development of BMSC-based tissue engineering and regenerative medicine. In this study, senescent BMSCs were characterized with >80 % of BMSCs stained positive for SA-β-gal, increased expressions of senescence-related genes (p16
MeSH term(s)	Autophagy/physiology ; Bone Marrow Cells/metabolism ; Cellular Senescence/physiology ; Interleukin-6/metabolism ; Interleukin-8 ; Mesenchymal Stem Cells/physiology ; Forkhead Transcription Factors
Chemical Substances	Interleukin-6 ; Interleukin-8 ; Forkhead Transcription Factors
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2022.112062
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Article ; Online: Is switching intravesical chemotherapeutic agents beneficial in short-term recurrent high-risk non-muscle-invasive bladder tumors? A 5-year retrospective study.

Chen, Shuaiqi / Sun, Guangyu / Chen, Xiaoxu / Salgado, Tiyara / Wu, Shangrong / Hu, Hailong / Liu, Ranlu / Qie, Yunkai

BMC urology

2024 Volume 24, Issue 1, Page(s) 25

Abstract: Objective: To explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive bladder cancer (NMIBC) following the failure of preceding intravesical therapy.: Materials and methods: ... ...

Abstract	Objective: To explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive bladder cancer (NMIBC) following the failure of preceding intravesical therapy. Materials and methods: From June 2010 to October 2015, 205 patients with NMIBC who experienced tumor recurrence within a year after receiving first-line intravesical chemotherapy (IVC) were classified into two groups. After a second complete transurethral resection (TUR) process, we immediately altered the intravesical instillation agent for 107 patients (group A). In contrast, the remaining 98 patients (group B) continued using their original intravesical instillation agent. After transurethral resection of the bladder tumor (TURBT), all patients received either an immediate instillation of epirubicin (EPI), gemcitabine (GEM), or hydroxycamptothecin (HCPT), followed by regular induction and maintenance instillations. Recurrence and progression rates were evaluated using the Chi-square test, and recurrence-free survival (RFS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Results: In this study, there was no significant difference in either the 5-year tumor recurrence or progression rates between the two groups (p > 0.05) The Kaplan-Meier plot showed no difference in progression-free or recurrence-free survival between the two groups. Conclusion: Switching IVC agents does not improve RFS and PFS for patients with short-term recurrent high-risk NMIBC.
MeSH term(s)	Humans ; Administration, Intravesical ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Non-Muscle Invasive Bladder Neoplasms/drug therapy ; Non-Muscle Invasive Bladder Neoplasms/surgery ; Retrospective Studies ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery ; Transurethral Resection of Bladder ; Epirubicin/therapeutic use ; Gemcitabine/therapeutic use ; Camptothecin/therapeutic use ; Antineoplastic Agents/therapeutic use
Chemical Substances	Epirubicin (3Z8479ZZ5X) ; Gemcitabine ; Camptothecin (XT3Z54Z28A) ; hydroxycamptothecinum ; Antineoplastic Agents
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-024-01410-1
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Article ; Online: Dynamic Harvest Index Estimation of Winter Wheat Based on UAV Hyperspectral Remote Sensing Considering Crop Aboveground Biomass Change and the Grain Filling Process

Jianqiang Ren / Ningdan Zhang / Xingren Liu / Shangrong Wu / Dandan Li

Remote Sensing, Vol 14, Iss 1955, p

2022 Volume 1955

Abstract: The crop harvest index (HI) is of great significance for research on the application of crop variety breeding, crop growth simulation, crop management in precision agriculture and crop yield estimation, among other topics. To obtain spatial information ... ...

Abstract	The crop harvest index (HI) is of great significance for research on the application of crop variety breeding, crop growth simulation, crop management in precision agriculture and crop yield estimation, among other topics. To obtain spatial information on the crop dynamic HI (D-HI), taking winter wheat as the research object and fully considering the changes in crop biomass and the grain filling process from the flowering period to the maturity period, the dynamic f G (D- f G ) parameter was estimated as the ratio between the aboveground biomass accumulated in different growth periods, from the flowering stage to the maturity stage, and the aboveground biomass in the corresponding periods. Based on the D- f G parameter estimation using unmanned aerial vehicle (UAV) hyperspectral remote sensing data, a technical method for obtaining spatial information on the winter wheat D-HI was proposed and the accuracy of the proposed method was verified. A correlation analysis was performed between the normalized difference spectral index (NDSI), which was calculated using pairs of any two bands of the UAV hyperspectral spectrum, and the measured D- f G . Based on this correlation analysis, the center of gravity of the local maximum region of R 2 was used to determine the sensitive band center to accurately estimate D- f G . On this basis, remote sensing estimation of the D- f G was realized by using the NDSI constructed by the sensitive hyperspectral band centers. Finally, based on the D- f G remote sensing parameters and the D-HI estimation model, spatial information on the D-HI of winter wheat was accurately obtained. The results revealed five pairs of sensitive hyperspectral band centers (i.e., λ (476 nm, 508 nm), λ (444 nm, 644 nm), λ (608 nm, 788 nm), λ (724 nm, 784 nm) and λ (816 nm, 908 nm)) for D- f G estimation, and the results of the D- f G remote sensing estimation showed high precision. The root mean square error (RMSE) was between 0.0436 and 0.0604, the normalized RMSE (NRMSE) was between 10.31% and 14.27% and ...
Keywords	winter wheat ; harvest index ; unmanned aerial vehicle ; hyperspectral remote sensing ; sensitive band selection ; NDSI ; Science ; Q
Subject code	333
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How Well Can Matching High Spatial Resolution Landsat Data with Flux Tower Footprints Improve Estimates of Vegetation Gross Primary Production

Xiaojuan Huang / Shangrong Lin / Xiangqian Li / Mingguo Ma / Chaoyang Wu / Wenping Yuan

Remote Sensing, Vol 14, Iss 6062, p

2022 Volume 6062

Abstract: Eddy-covariance (EC) measurements are widely used to optimize the terrestrial vegetation gross primary productivity (GPP) model because they provide standardized and high-quality flux data within their footprint areas. However, the extent of flux data ... ...

Abstract	Eddy-covariance (EC) measurements are widely used to optimize the terrestrial vegetation gross primary productivity (GPP) model because they provide standardized and high-quality flux data within their footprint areas. However, the extent of flux data taken from a tower site within the EC footprint, represented by the satellite-based grid cell between Landsat and Moderate Resolution Imaging Spectroradiometer (MODIS), and the performance of the model derived from the Normalized Difference Vegetation Index (NDVI) within the EC footprint at different spatial resolutions (e.g., Landsat and MODIS) remain unclear. Here, we first calculated the Landsat-footprint NDVI and MODIS-footprint NDVI and assessed their spatial representativeness at 78 FLUXNET sites at 30 m and 500 m scale, respectively. We then optimized the parameters of the revised Eddy Covariance-Light Use Efficiency (EC-LUE) model using NDVI within the EC-tower footprints that were calculated from the Landsat and MODIS sensor. Finally, we evaluated the performance of the optimized model at 30 m and 500 m scale. Our results showed that matching Landsat data with the flux tower footprint was able to improve the performance of the revised EC-LUE model by 18% for savannas, 14% for croplands, 9% for wetlands. The outperformance of the Landsat-footprint NDVI in driving model relied on the spatial heterogeneity of the flux sites. Our study assessed the advantages of remote sensing data with high spatial resolution in simulating GPP, especially for areas with high heterogeneity of landscapes. This could facilitate a more accurate estimation of global ecosystem carbon sink and a better understanding of plant productivity and carbon climate feedbacks.
Keywords	footprints ; light use efficiency ; gross primary production ; parameter optimization ; Science ; Q
Subject code	333
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adverse Effects of Prenatal Exposure to Oxidized Black Carbon Particles on the Reproductive System of Male Mice.

Jiang, Shuanglin / Chen, Li / Shen, Jianyun / Zhang, Di / Wu, Hai / Wang, Rong / Zhang, Shangrong / Jiang, Nan / Li, Wenyong

Toxics

2023 Volume 11, Issue 7

Abstract: Ambient black carbon (BC), a main constituent of atmospheric particulate matter (PM), is a primary particle that is mainly generated by the incomplete combustion of fossil fuel and biomass burning. BC has been identified as a potential health risk via ... ...

Abstract	Ambient black carbon (BC), a main constituent of atmospheric particulate matter (PM), is a primary particle that is mainly generated by the incomplete combustion of fossil fuel and biomass burning. BC has been identified as a potential health risk via exposure. However, the adverse effects of exposure to BC on the male reproductive system remain unclear. In the present study, we explored the effects of maternal exposure to oxidized black carbon (OBC) during pregnancy on testicular development and steroid synthesis in male offspring. Pregnant mice were exposed to OBC (467 μg/kg BW) or nanopure water (as control) by intratracheal instillation from gestation day (GD) 4 to GD 16.5 (every other day). We examined the testicular histology, daily sperm production, serum testosterone, and mRNA expression of hormone synthesis process-related factors of male offspring at postnatal day (PND) 35 and PND 84. Histological examinations exhibited abnormal seminiferous tubules with degenerative changes and low cellular adhesion in testes of OBC-exposed mice at PND 35 and PND 84. Consistent with the decrease in daily sperm production, the serum testosterone level of male offspring of OBC-exposed mice also decreased significantly. Correspondingly, mRNA expression levels of hormone-synthesis-related genes (i.e.,
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11070556
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