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Article ; Online: Scientific Opinion on the safety and efficacy of L-valine (L-valine, feed grade) produced by Escherichia coli NITE BP-01755 for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

2015

Abstract: The product L-valine is a feed additive produced by fermentation with a genetically modified strain ... with the genetic modification of the production strain. L-Valine, feed grade, is safe for all target species ... purity, no risks are expected for the consumer from the use of the product as a feed additive. L-Valine ...

Abstract	The product L-valine is a feed additive produced by fermentation with a genetically modified strain of Escherichia coli (NITE BP-01755). Neither the production strain E. coli NITE BP-01755 nor its recombinant DNA was detected in the final product. The product does not give rise to any safety concern associated with the genetic modification of the production strain. L-Valine, feed grade, is safe for all target species when used to meet the animals’ nutritional requirements. As the composition of tissues and products of animal origin will not be changed by the use of the product in animal nutrition, and considering its high purity, no risks are expected for the consumer from the use of the product as a feed additive. L-Valine produced by E. coli NITE BP-01755 is not considered irritating to the skin or eyes and is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, acute toxicity by this route is not expected. Since the estimated total exposure to endotoxins by inhalation is below the provisional occupational exposure limits, no risk from the exposure to endotoxins for people handling the additive is expected. The amino acid L-valine is a natural component of the proteins of living organisms. Therefore, the use of the product does not pose a risk to the environment. The product is considered an efficacious source of the amino acid L-valine for all animal species. For the supplemental L-valine to be as efficacious in ruminant as in non-ruminant species, it requires protection against degradation in the rumen.
Keywords	Text ; ddc:630 ; nutritional additives ; amino acids and their salts and analogues ; L-valine ; genetically modified microorganisms ; safety ; efficacy
Subject code	660
Language	English
Publishing date	2015-05-21
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Scientific Opinion on the safety and efficacy of formaldehyde for all animal species based on a dossier submitted by Adiveter S.L.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

2014

Abstract: The additive formaldehyde is an aqueous solution containing 37 % formaldehyde and 14 % methanol. It is intended for use in all animal species at concentrations between 68 and 680 mg active substance/kg complete feed. Free and reversibly bound ... ...

Abstract	The additive formaldehyde is an aqueous solution containing 37 % formaldehyde and 14 % methanol. It is intended for use in all animal species at concentrations between 68 and 680 mg active substance/kg complete feed. Free and reversibly bound formaldehyde is readily absorbed in the gastrointestinal tract and joins the pool of endogenous formaldehyde. It is rapidly oxidised to formic acid further on to carbon dioxide and water. Formaldehyde is a carcinogen by inhalation. While local irritation is expected to strongly promote carcinogenesis, lower local concentrations of formaldehyde are known to produce DNA adducts. Therefore, the FEEDAP Panel deems it prudent not to consider the exposure to non-irritant concentration as totally riskless. Moreover, on the basis of the present knowledge, a causal association between formaldehyde exposure and leukaemia cannot be ruled out. The FEEDAP Panel estimated the oral intake of formaldehyde of consumers from food of animal origin to be 4 mg per person per day. A reliable additional exposure of consumers to formaldehyde from supplementing feedingstuffs cannot be calculated. However, the FEEDAP Panel considers that the proposed use of formaldehyde as a feed additive would not increase consumer exposure and consequently would not pose an additional risk for the consumer. A safe feed concentration for all animal species and categories could not be determined. Formaldehyde is a strong irritant, a potent skin and respiratory sensitiser. Measures should be taken to ensure that the respiratory tract, skin and eyes of any person handling the product are not exposed to any dust, mist or vapour generated by the use of formaldehyde. The use of formaldehyde in animal nutrition is not expected to pose a risk for the environment. Formaldehyde in concentrations between 340 and 680 mg/kg feed (compound feed and/or feed material) has the potential to be an efficacious preservative.
Keywords	Text ; ddc:630 ; technological additive ; preservative ; formaldehyde ; safety ; efficacy
Subject code	333
Language	English
Publishing date	2014-02-18
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Scientific Opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride technically pure produced using Escherichia coli (FERM BP-11355) for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

2014

Abstract: L-Lysine is an essential amino acid for all animal species. The products, concentrated liquid L ... lysine (base), concentrated liquid L-lysine monohydrochloride (HCl) and L-lysine HCl technically pure ... as sources of the amino acid L-lysine, are produced by fermentation with a genetically modified strain ...

Abstract	L-Lysine is an essential amino acid for all animal species. The products, concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride (HCl) and L-lysine HCl technically pure, as sources of the amino acid L-lysine, are produced by fermentation with a genetically modified strain of Escherichia coli (FERM BP-11355). Neither the production strain nor its recombinant DNA was detected in the final products. Concentrated liquid L-lysine (base), concentrated liquid L-lysine HCl and L-lysine HCl technically pure, manufactured by fermentation with E. coli FERM BP-11355, do not give rise to any safety concern with regard to the genetic modification of the production strain. The additives under assessment are considered safe for target species when supplemented in appropriate amounts. The use of concentrated liquid L-lysine (base), concentrated liquid L-lysine HCl and L-lysine HCl technically pure, produced by E. coli FERM BP-11355, in animal feed does not give rise to safety concerns for the consumer. The products under application are not considered to have the potential to cause respiratory toxicity, skin or eye irritation or skin sensitisation, but respiratory sensitisation cannot be excluded. L-Lysine is a substance naturally occurring in bacteria, plants and animals. The use of the products under application as feed additives does not represent a risk to the environment. The products concentrated liquid L-lysine (base), concentrated liquid L-lysine HCl and L-lysine HCl technically pure produced by E. coli FERM BP-11355 are regarded as efficacious sources of the essential amino acid L-lysine for all non-ruminant species. Supplemental free amino acid L-lysine is degraded by ruminal microorganisms, if not given in a protected form.
Keywords	Text ; ddc:630 ; nutritional additive ; amino acids ; concentrated liquid L-lysine base ; concentrated liquid L-lysine HCl ; L-lysine HCl technically pure ; safety
Subject code	660
Language	English
Publishing date	2014-11-18
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Scientific Opinion on the safety and efficacy of L-tryptophan produced by Escherichia coli (FERM BP-11354) for all animal species, based on a dossier submitted by Ajinomoto Eurolysine S.A.S.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

2014

Abstract: L-Tryptophan, technically pure, is a feed additive produced by a genetically modified ... in the final product. L-Tryptophan manufactured by fermentation with E. coli FERM BP-11354 does not give rise ... to any safety concern for the genetic modifications of the production strain. The L-tryptophan product produced ...

Abstract	L-Tryptophan, technically pure, is a feed additive produced by a genetically modified Escherichia coli strain (FERM BP-11354). Neither the production strain nor its recombinant DNA were detected in the final product. L-Tryptophan manufactured by fermentation with E. coli FERM BP-11354 does not give rise to any safety concern for the genetic modifications of the production strain. The L-tryptophan product produced by E. coli (FERM BP-11354) is considered safe for non-ruminant target species when used to supplement the diet in appropriate amounts. The use of unprotected L-tryptophan in ruminants’ feed should be avoided. L-Tryptophan will be incorporated into proteins of the body of the target animal and any potential excess will be metabolised and excreted. Considering the high purity of the product under assessment, no risks are expected for the consumer from the use of L-tryptophan produced by E. coli (FERM BP-11354) as a feed additive. Safety is further ensured by the low levels (less than 10 mg/kg additive each) of 1,1-ethylidene-bis-L-tryptophan (EBT) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA), previously seen to cause eosinophilia–myalgia syndrome in humans. The FEEDAP Panel considers that the product is not an irritant to the skin or eyes and it is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, there is no evidence of acute toxicity by the inhalation route. L-Tryptophan is a naturally occurring amino acid and its use in animal nutrition is not expected to be of concern to the environment. The additive L-tryptophan is regarded as an effective source of the amino acid L-tryptophan. Supplemental L-tryptophan is degraded by ruminal microorganisms if not given in a protected form.
Keywords	Text ; ddc:630 ; nutritional additive ; amino acids and their salts and analogues ; L-tryptophan ; safety ; efficacy ; genetically modified microorganisms
Subject code	660
Language	English
Publishing date	2014-10-03
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli (FERM BP-11383) for all animal species, based on a dossier submitted by Ajinomoto Eurolysine S.A.S.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

2014

Abstract: The product L-threonine, intended for use as a feed additive, is produced by fermentation ... to the genetic modification. L-Threonine, technically pure, produced by E. coli (FERM BP-11383) is considered ... to the environment. The product is considered as an efficacious source of the amino acid L-threonine ...

Abstract	The product L-threonine, intended for use as a feed additive, is produced by fermentation with a genetically modified strain of Escherichia coli (FERM BP 11383). Neither the production strain nor its recombinant DNA were detected in the product. The product does not raise safety concerns with regard to the genetic modification. L-Threonine, technically pure, produced by E. coli (FERM BP-11383) is considered safe for the target species when used to meet the animals’ nutritional requirements. As the composition of tissues and products of animal origin will not be changed by the use of the product in animal nutrition, and considering its high purity, no risks are expected for the consumer from the use of the product as a feed additive. The product is considered not irritating to the skin or eyes and is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, there is no evidence of acute toxicity by the inhalation route. The use of the product as a feed additive does not represent a risk to the environment. The product is considered as an efficacious source of the amino acid L-threonine for all animal species. Supplemental L-threonine is degraded by ruminal microorganisms if not given in a protected form.
Keywords	Text ; ddc:630 ; nutritional additives ; amino acids and their salts and analogues ; L-threonine ; safety ; efficacy ; genetically modified microorganisms
Subject code	660
Language	English
Publishing date	2014-10-03
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Positive Surgical Margins Increase Risk of Recurrence after Partial Nephrectomy for High Risk Renal Tumors. Shah PH, Moreira DM, Okhunov Z, Patel VR, Chopra S, Razmaria AA, Alom M, George AK, Yaskiv O, Schwartz MJ, Desai M, Vira MA, Richstone L, Landman J, Shalhav AL, Gill I, Kavoussi LR. J Urol. 2016 Aug;196(2):327-34.

Kryvenko, Oleksandr N

Urologic oncology

2017 Volume 35, Issue 6, Page(s) 449–450

Abstract: Purpose: The clinical significance of a positive surgical margin after partial nephrectomy remains controversial. The association between positive margin and risk of disease recurrence in patients with clinically localized renal neoplasms undergoing ... ...

Abstract	Purpose: The clinical significance of a positive surgical margin after partial nephrectomy remains controversial. The association between positive margin and risk of disease recurrence in patients with clinically localized renal neoplasms undergoing partial nephrectomy was evaluated. Materials and methods: A retrospective multi-institutional review of 1,240 patients undergoing partial nephrectomy for clinically localized renal cell carcinoma between 2006 and 2013 was performed. Recurrence-free survival was estimated using the Kaplan-Meier method and evaluated as a function of positive surgical margin with the log rank test and Cox models adjusting for tumor size, grade, histology, pathological stage, focality and laterality. The relationship between positive margin and risk of relapse was evaluated independently for pathological high risk (pT2-3a or Fuhrman grades III-IV) and low risk (pT1 and Fuhrman grades I-II) groups. Results: A positive surgical margin was encountered in 97 (7.8%) patients. Recurrence developed in 69 (5.6%) patients during a median followup of 33 months, including 37 (10.3%) with high risk disease (eg pT2-pT3a or Fuhrman grade III-IV). A positive margin was associated with an increased risk of relapse on multivariable analysis (HR 2.08, 95% CI 1.09-3.97, p=0.03) but not with site of recurrence. In a stratified analysis based on pathological features, a positive surgical margin was significantly associated with a higher risk of recurrence in cases considered high risk (HR 7.48, 95% CI 2.75-20.34, p <0.001) but not low risk (HR 0.62, 95% CI 0.08-4.75, p=0.647). Conclusions: Positive surgical margins after partial nephrectomy increase the risk of disease recurrence, primarily in patients with adverse pathological features.
MeSH term(s)	Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Female ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Nephrectomy/methods ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2017.03.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Adsorption of enantiomeric poly(lactide)s on surface-grafted poly(L-lactide).

Tretinnikov, O N / Kato, K / Iwata, H

Langmuir : the ACS journal of surfaces and colloids

2004 Volume 20, Issue 16, Page(s) 6748–6753

Abstract: ... we study adsorption of poly(L-lactide) (PLLA) and its enantiomer poly(D-lactide) (PDLA) onto layers ... with thicknesses ranging from 7 to 35 nm are produced by ring-opening polymerization of L-lactide from hydroxyl end ... surface is the same for the L- and D-form of the polymer. However, covering the gold with the surface ...

Abstract	We show that resistance of densely grafted polymer layers to adsorption of chemically identical free chains, which is known to be caused by entropic expulsion of free chains from the grafted layer, can be suppressed using the grafted and free chains of opposite stereoconfiguration. Specifically, we study adsorption of poly(L-lactide) (PLLA) and its enantiomer poly(D-lactide) (PDLA) onto layers of surface-grafted PLLA in acetonitrile and chloroform by infrared spectroscopy (IR). The grafted layers with thicknesses ranging from 7 to 35 nm are produced by ring-opening polymerization of L-lactide from hydroxyl end-groups of a self-assembled monolayer on gold. The IR data indicate that adsorption on the bare gold surface is the same for the L- and D-form of the polymer. However, covering the gold with the surface-grafted PLLA produces a significant decline in the adsorption of free PLLA and, by contrast, a strong enhancement in the adsorption of free PDLA. In addition, the IR data indicate that the adsorbed PDLA chains are stereocomplexed with the grafted PLLA chains. Thus, entropic expulsion of free chains from the grafted layer, which is responsible for the resistance of surface-grafted PLLA to adsorption of free PLLA, is suppressed in the case of free PDLA by stereocomplexation between the grafted and free chains.
Language	English
Publishing date	2004-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/la049277t
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Article: Response to Dr. Roger’s letter: further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of metabolic syndrome in the rural Thai population

Insawang, Tonkla / Selmi, Carlo / Cha’on, Ubon / Gershwin, M Eric / Yongvanit, Puangrat / Prasongwattana, Vitoon

Nutrition and metabolism. 2013 Dec., v. 10, no. 1

2013

Abstract: See related article: http://www.nutritionandmetabolism.com/content/10/1/ ... ...

Abstract	See related article: http://www.nutritionandmetabolism.com/content/10/1/14
Keywords	metabolic syndrome ; monosodium glutamate ; rural population ; Thailand
Language	English
Dates of publication	2013-12
Size	p. 527.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2160376-5
ISSN	1743-7075
ISSN	1743-7075
DOI	10.1186/1743-7075-10-10
Database	NAL-Catalogue (AGRICOLA)

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Article: Vliianie N-ftalamoil-L-glutaminovoĭ kisloty, selektivnogo agonista retseptorov NMDA, na sviazyvanie 3H-L-glutamata s sinapticheskimi membranami gippokampa.

Koreshonkov, O N / Perestenko, P V / Dumpis, M A / Piotrovskiĭ, L B

Biulleten' eksperimental'noi biologii i meditsiny

1992 Volume 113, Issue 6, Page(s) 563–565

Abstract: ... phthalamoyl-L-glutamic acid (PhGA), with the synaptic membranes preparation of human hippocampus was examined ... against NMDA. It was established that there are two binding sites of 3H-L-Glu, Kd1 = 0.35 +/- 0.11 nM ...

Title translation	Effects of N-phthalamoyl-L-glutaminic acid, a selective agonist of NMDA receptor, on binding of 3H-L-glutamate with synaptic membranes of the hippocampus.
Abstract	In the present investigation the interaction of a novel selective NMDA receptors agonist, N-phthalamoyl-L-glutamic acid (PhGA), with the synaptic membranes preparation of human hippocampus was examined against NMDA. It was established that there are two binding sites of 3H-L-Glu, Kd1 = 0.35 +/- 0.11 nM, Bmax1 = 6.5 +/- 2.3 pmol/mg and Kd2 = 51 +/- 12 nM, Bmax2 = 98 +/- 17 pmol/mg. The inhibition constants (Ki) were calculated for NMDA and PhGA and were equal: Ki(NMDA) = 19 microM, Ki (PhGA) = 13 microM, respectively. It was concluded that PhGA is the partial agonist of the NMDA receptors.
MeSH term(s)	Binding Sites ; Glutamates/metabolism ; Glutamates/pharmacology ; Hippocampus/metabolism ; Humans ; In Vitro Techniques ; N-Methylaspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/drug effects ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/physiology ; Synaptic Membranes/metabolism
Chemical Substances	Glutamates ; Receptors, N-Methyl-D-Aspartate ; N-phthaloylglutamic acid (3ULW2C76OT) ; N-Methylaspartate (6384-92-5)
Language	Russian
Publishing date	1992-06
Publishing country	Russia (Federation)
Document type	Comparative Study ; Journal Article
ZDB-ID	127365-6
ISSN	0365-9615 ; 0006-4041
ISSN	0365-9615 ; 0006-4041
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Zs.B 964: Show issues

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Article: Lechenie iazvennoĭ bolezni s pomoshch'iu L-dopa

Zavodskaia, I S / Sibirkin, N V / Egorova, G I / Zabrodin, O N

Terapevticheskii arkhiv

1976 Volume 48, Issue 5, Page(s) 79–82

Title translation	Treatment of ulcer disease with L-dopa.
MeSH term(s)	Adult ; Drug Evaluation ; Female ; Follow-Up Studies ; Humans ; Levodopa/administration & dosage ; Levodopa/therapeutic use ; Male ; Middle Aged ; Peptic Ulcer/drug therapy
Chemical Substances	Levodopa (46627O600J)
Language	Russian
Publishing date	1976
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
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