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  1. Article ; Online: Effects of nasal aspiration by the Proetz® method in pediatric patients with sinusitis.

    Filgueira, Yaskara Amorim / Holanda, Vanderlan Nogueira / Fonseca, Fernando Luiz Affonso / Feder, David

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 11, Page(s) 1503–1508

    Abstract: Objective: To characterize the effects of nasal aspiration with Proetz® in peak nasal inspiratory flow (PNIF) in pediatric sinusitis (PS) patients with nasal obstruction.: Methods: This is a non-randomized descriptive-analytical clinical trial with a ...

    Abstract Objective: To characterize the effects of nasal aspiration with Proetz® in peak nasal inspiratory flow (PNIF) in pediatric sinusitis (PS) patients with nasal obstruction.
    Methods: This is a non-randomized descriptive-analytical clinical trial with a quantitative approach. The sample comprised 30 children. Initially, the PNIF was measured and the Visual Analogical Scale (VAS) was used for nasal obstruction, followed by the nasal aspiration procedure. The SNOT-22 questionnaire was applied to the legal guardian of each child, and one week later, it was reapplied for the sake of follow-up.
    Results: 16 (53.3%) patients were females and 14 (46.7%) were males, with an average age of 6.4±1.8 years (between 4 and 10 years of age). Analyses of the VAS for obstruction before the intervention revealed that 10 of the participants (33.3%) presented moderate levels, and 20 of them (66.7%) severe levels. However, after the Proetz® method was applied, all the samples (n=30) had mild levels. The PNIF significantly increased after the technique was used, with an improvement of 23.4% in mean values. There was no significant correlation between the VAS and the PNIF.
    Conclusion: Nasal aspiration with the Proetz® method significantly improved the clinical condition of sinusitis patients with nasal obstruction according to the visual analogical scale, the PNIF, and the SNOT-22 questionnaire. No correlation between the VAS and the PNIF could be found. The study confirms the importance of non-pharmacological interventions in the treatment of sinusitis in children, thus resulting in an improvement in their quality of life.
    MeSH term(s) Child ; Child, Preschool ; Female ; Humans ; Male ; Nasal Obstruction ; Quality of Life ; Sinusitis/therapy ; Surveys and Questionnaires ; Visual Analog Scale
    Language English
    Publishing date 2020-12-09
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.11.1503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Activity of poly(methacrylic acid)-silver nanoparticles on fluconazole-resistant Candida albicans strains: Synergistic and cytotoxic effects.

    Falcão, Cecília Maria Cruz / Andrade, Audrey / Holanda, Vanderlan Nogueira / de Figueiredo, Regina Celia Bressan Queiroz / Ximenes, Eulália Azevedo / Gomes, Anderson Stevens Leonidas

    Journal of applied microbiology

    2022  Volume 132, Issue 6, Page(s) 4300–4309

    Abstract: Aims: To synthesize and evaluate the antifungal activity of poly(methacrylic acid)-silver nanoparticles (PMAA-AgNPs) against nine Candida albicans isolated from clinical specimens.: Methods and results: The effects of PMAA-AgNPs-fluconazole ... ...

    Abstract Aims: To synthesize and evaluate the antifungal activity of poly(methacrylic acid)-silver nanoparticles (PMAA-AgNPs) against nine Candida albicans isolated from clinical specimens.
    Methods and results: The effects of PMAA-AgNPs-fluconazole combination was analysed by checkerboard methodology. The synergistic potential of PMAA-AgNPs-fluconazole was determined by the fractional inhibitory concentration index (FICI). The inhibition of germ tube formation and the determination of PMAA-AgNPs cytotoxicity were also performed. All C. albicans strains were susceptible to PMAA-AgNPs and resistant to fluconazole. PMAA-AgNPs at subinhibitory concentrations restored the susceptibility of resistant C. albicans to fluconazole, whose FICI ranged from 0.3 to 0.5. The synergistic interaction of the combination was observed in eight of nine strains. The PMAA-AgNPs-fluconazole combination was also able to inhibit the germ tube formation. PMAA-AgNPs showed a dose-dependent decrease in viability for cells tested, with 50% cytotoxic concentration (CC
    Conclusions: This study demonstrated that, in general, PMAA-AgNPs acts synergistically in combination with fluconazole, inhibiting fluconazole-resistant C. albicans strains. PMAA-AgNPs-fluconazole combination was also able to inhibit germ tube formation, an important virulence factor. Inhibitory effect of PMAA-AgNPs alone or in combination was higher in C. albicans than in mammalian cells.
    Significance and impact of study: This study shows the potential of PMAA-AgNPs combined with fluconazole to inhibit fluconazole-resistant C. albicans strains.
    MeSH term(s) Animals ; Antifungal Agents/pharmacology ; Candida albicans ; Chlorocebus aethiops ; Drug Resistance, Fungal ; Drug Synergism ; Fluconazole/pharmacology ; Mammals ; Metal Nanoparticles ; Methacrylates ; Microbial Sensitivity Tests ; Silver/pharmacology ; Vero Cells
    Chemical Substances Antifungal Agents ; Methacrylates ; methacrylic acid (1CS02G8656) ; Silver (3M4G523W1G) ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates.

    García-Estrada, Carlos / Pérez-Pertejo, Yolanda / Domínguez-Asenjo, Bárbara / Holanda, Vanderlan Nogueira / Murugesan, Sankaranarayanan / Martínez-Valladares, María / Balaña-Fouce, Rafael / Reguera, Rosa M

    Biomolecules

    2023  Volume 13, Issue 4

    Abstract: Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively on pharmacological treatments. Current drugs against them are scarce, old ... ...

    Abstract Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively on pharmacological treatments. Current drugs against them are scarce, old and exhibit disadvantages, such as adverse effects, parenteral administration, chemical instability and high costs which are often unaffordable for endemic low-income countries. Discoveries of new pharmacological entities for the treatment of these diseases are scarce, since most of the big pharmaceutical companies find this market unattractive. In order to fill the pipeline of compounds and replace existing ones, highly translatable drug screening platforms have been developed in the last two decades. Thousands of molecules have been tested, including nitroheterocyclic compounds, such as benznidazole and nifurtimox, which had already provided potent and effective effects against Chagas disease. More recently, fexinidazole has been added as a new drug against African trypanosomiasis. Despite the success of nitroheterocycles, they had been discarded from drug discovery campaigns due to their mutagenic potential, but now they represent a promising source of inspiration for oral drugs that can replace those currently on the market. The examples provided by the trypanocidal activity of fexinidazole and the promising efficacy of the derivative DNDi-0690 against leishmaniasis seem to open a new window of opportunity for these compounds that were discovered in the 1960s. In this review, we show the current uses of nitroheterocycles and the novel derived molecules that are being synthesized against these neglected diseases.
    MeSH term(s) Animals ; Humans ; Pharmaceutical Preparations ; Trypanosomiasis, African/drug therapy ; Chagas Disease/drug therapy ; Leishmaniasis/drug therapy
    Chemical Substances fexinidazole (306ERL82IR) ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13040637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of nasal aspiration by the Proetz® method in pediatric patients with sinusitis

    Yaskara Amorim Filgueira / Vanderlan Nogueira Holanda / Fernando Luiz Affonso Fonseca / David Feder

    Revista da Associação Médica Brasileira, Vol 66, Iss 11, Pp 1503-

    2020  Volume 1508

    Abstract: SUMMARY OBJECTIVE: To characterize the effects of nasal aspiration with Proetz® in peak nasal inspiratory flow (PNIF) in pediatric sinusitis (PS) patients with nasal obstruction. METHODS: This is a non-randomized descriptive-analytical clinical trial ... ...

    Abstract SUMMARY OBJECTIVE: To characterize the effects of nasal aspiration with Proetz® in peak nasal inspiratory flow (PNIF) in pediatric sinusitis (PS) patients with nasal obstruction. METHODS: This is a non-randomized descriptive-analytical clinical trial with a quantitative approach. The sample comprised 30 children. Initially, the PNIF was measured and the Visual Analogical Scale (VAS) was used for nasal obstruction, followed by the nasal aspiration procedure. The SNOT-22 questionnaire was applied to the legal guardian of each child, and one week later, it was reapplied for the sake of follow-up. RESULTS: 16 (53.3%) patients were females and 14 (46.7%) were males, with an average age of 6.4±1.8 years (between 4 and 10 years of age). Analyses of the VAS for obstruction before the intervention revealed that 10 of the participants (33.3%) presented moderate levels, and 20 of them (66.7%) severe levels. However, after the Proetz® method was applied, all the samples (n=30) had mild levels. The PNIF significantly increased after the technique was used, with an improvement of 23.4% in mean values. There was no significant correlation between the VAS and the PNIF. CONCLUSION: Nasal aspiration with the Proetz® method significantly improved the clinical condition of sinusitis patients with nasal obstruction according to the visual analogical scale, the PNIF, and the SNOT-22 questionnaire. No correlation between the VAS and the PNIF could be found. The study confirms the importance of non-pharmacological interventions in the treatment of sinusitis in children, thus resulting in an improvement in their quality of life.
    Keywords Sinusitis ; Respiratory Tract Infections ; Child ; Nasal Obstruction ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Identification of 1,2,3-triazole-phthalimide derivatives as potential drugs against COVID-19: a virtual screening, docking and molecular dynamic study.

    Holanda, Vanderlan Nogueira / Lima, Elton Marlon de Araújo / Silva, Welson Vicente da / Maia, Rafael Trindade / Medeiros, Rafael de Lima / Ghosh, Arabinda / Lima, Vera Lúcia de Menezes / Figueiredo, Regina Celia Bressan Queiroz de

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 12, Page(s) 5462–5480

    Abstract: In this work we aimed to perform ... ...

    Abstract In this work we aimed to perform an
    MeSH term(s) Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Phthalimides/pharmacology ; Protease Inhibitors/chemistry ; SARS-CoV-2 ; Triazoles/pharmacology ; COVID-19 Drug Treatment
    Chemical Substances Phthalimides ; Protease Inhibitors ; Triazoles
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1871073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Leishmanicidal and cytotoxic activity of essential oil from the fruit peel of

    Barbosa, Deyzi Caroline da Silva / Holanda, Vanderlan Nogueira / Ghosh, Arabinda / Maia, Rafael Trindade / da Silva, Welson Vicente / Lima, Vera Lúcia de Menezes / da Silva, Márcia Vanusa / Dos Santos Correia, Maria Tereza / de Figueiredo, Regina Celia Bressan Queiroz

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 23, Page(s) 13001–13016

    Abstract: Cutaneous Leishmaniasis (CL) is a neglected disease characterized by highest morbidity rates worldwide. The available treatment for CL has several limitations including serious side effects and resistance to the treatment. Herein we aimed to evaluate the ...

    Abstract Cutaneous Leishmaniasis (CL) is a neglected disease characterized by highest morbidity rates worldwide. The available treatment for CL has several limitations including serious side effects and resistance to the treatment. Herein we aimed to evaluate the activity of essential oil from the peel of
    MeSH term(s) Animals ; Chlorocebus aethiops ; Leishmania ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Fruit ; Vero Cells ; Antiprotozoal Agents/chemistry ; Mammals
    Chemical Substances delta-cadinene (7848KI47OS) ; Oils, Volatile ; Antiprotozoal Agents
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1978320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A new biocompatible silver/polypyrrole composite with in vitro antitumor activity.

    Araújo Lima, Elton Marlon de / Holanda, Vanderlan Nogueira / Ratkovski, Gabriela Plautz / Silva, Welson Vicente da / Nascimento, Pedro Henrique do / Figueiredo, Regina Celia Bressan Queiroz de / de Melo, Celso Pinto

    Materials science & engineering. C, Materials for biological applications

    2021  Volume 128, Page(s) 112314

    Abstract: We used an in situ chemical oxidation method to prepare a new composite of silver nanoparticles (AgNPs) with polypyrrole (PPy), whose properties were optimized through a ... ...

    Abstract We used an in situ chemical oxidation method to prepare a new composite of silver nanoparticles (AgNPs) with polypyrrole (PPy), whose properties were optimized through a 2
    MeSH term(s) Anti-Bacterial Agents ; HeLa Cells ; Humans ; Metal Nanoparticles ; Polymers ; Pyrroles/pharmacology ; Silver
    Chemical Substances Anti-Bacterial Agents ; Polymers ; Pyrroles ; polypyrrole (30604-81-0) ; Silver (3M4G523W1G)
    Language English
    Publishing date 2021-07-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2021.112314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico ADMET, in vitro activity, docking and molecular dynamic simulations.

    Holanda, Vanderlan Nogueira / Silva, Welson Vicente da / Nascimento, Pedro Henrique do / Silva, Sérgio Ruschi Bergamachi / Cabral Filho, Paulo Euzébio / Assis, Shalom Porto de Oliveira / Silva, César Augusto da / Oliveira, Ronaldo Nascimento de / Figueiredo, Regina Celia Bressan Queiroz de / Lima, Vera Lucia de Menezes

    Bioorganic chemistry

    2020  Volume 105, Page(s) 104437

    Abstract: Organic compounds obtained by click chemistry reactions have demonstrated a broad spectrum of biological activities being widely applied for the development of molecules against pathogens of medical and veterinary importance. Cutaneous leishmaniasis (CL), ...

    Abstract Organic compounds obtained by click chemistry reactions have demonstrated a broad spectrum of biological activities being widely applied for the development of molecules against pathogens of medical and veterinary importance. Cutaneous leishmaniasis (CL), caused by intracellular protozoa parasite of genus Leishmania, comprises a complex of clinical manifestations that affect the skin and mucous membranes. The available drugs for the treatment are toxic and costly, with long periods of treatment, and the emergence of resistant strains has been reported. In this study we investigated the in vitro effects of a phthalimide-1,2,3-triazole derivative, the 4-Phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3-triazole (PT4) obtained by click chemistry, on mammalian cells and on L. amazonensis and L. braziliensis, the causative agents of CL in Brazil. In silico ADMET evaluation of PT4 showed that this molecule has good pharmacokinetic properties with no violation of Lipinski's rules. The in vitro assays showed that PT4 was more selective for both Leishmania species than to mammalian cells. This compound also presented low cytotoxicity to mammalian cells with CC
    MeSH term(s) Animals ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/pharmacology ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Leishmania/drug effects ; Macrophages/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Molecular Structure ; Parasitic Sensitivity Tests ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacology
    Chemical Substances Antiprotozoal Agents ; Reactive Oxygen Species ; Triazoles
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2020.104437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hábitos alimentares e ocorrência de alterações no metabolismo lipídico em universitários residentes e não residentes com familiares

    Vanderlan Nogueira HOLANDA1 / Dayane Correia GOMES / Elton Marlon de Araújo LIMA / Sherida Brito de FREITAS / Wislayane Gomes MILFONT / Vivianne Cortez Sombra VANDESMET

    Infarma: Pharmaceutical Sciences, Vol 30, Iss 4, Pp 250-

    2018  Volume 260

    Abstract: A dislipidemia consiste numa alteração relacionada ao metabolismo lipídico e está entre as principais causas de doenças cardiovasculares no mundo, acometendo diferentes populações, sobretudo estudantes universitários. O ingresso na universidade é uma ... ...

    Abstract A dislipidemia consiste numa alteração relacionada ao metabolismo lipídico e está entre as principais causas de doenças cardiovasculares no mundo, acometendo diferentes populações, sobretudo estudantes universitários. O ingresso na universidade é uma etapa repleta de mudanças biopsicossociais e dentre elas, a saída da casa dos pais está diretamente relacionada a modificações nos hábitos alimentares e consequentemente alterações no metabolismo lipídico. Neste estudo, foram avaliados os hábitos alimentares e determinado o perfil lipídico de uma população de 86 estudantes universitários que viviam ou não com os pais, oriundos de uma instituição de ensino superior de Juazeiro do Norte, Ceará, Brasil. Dos 86 participantes do estudo, 55,8% eram do sexo feminino e 44,2% do masculino; 95,4% dos universitários apresentaram hábitos alimentares inadequados ou irregulares ao estilo de vida saudável; e apenas 4,6% apresentaram a alimentação saudável. As alterações mais prevalentes no perfil lipídico foram hipertrigliceridemia e diminuição do HDL-c. A partir dos resultados da presente pesquisa foi possível concluir que os estudantes universitários que vivem com os pais apresentam uma maior probabilidade de adoção de maus hábitos alimentares e desenvolvimento de dislipidemias. A participação mais ativa de Instituições de Ensino Superior em campanhas que promovam maior informação sobre as vantagens da adoção de um estilo de vida mais saudável se constituiria de uma importante ação preventiva para os universitários.
    Keywords dislipidemia ; comportamento alimentar ; estudantes ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Federal Council of Pharmacy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: GC-MS Analysis and Hemolytic, Antipyretic and Antidiarrheal Potential of Syzygium aromaticum (Clove) Essential Oil

    Cristiane Marinho Uchôa Lopes / João Ricardhis Saturnino de Oliveira / Vanderlan Nogueira Holanda / Antonio Yony Felipe Rodrigues / Caíque Silveira Martins da Fonseca / Fábio Fernandes Galvão Rodrigues / Cicera Janaine Camilo / Vera Lucia de Menezes Lima / Henrique Douglas Melo Coutinho / Radosław Kowalski / José Galberto Martins da Costa

    Separations, Vol 7, Iss 35, p

    2020  Volume 35

    Abstract: Clove ( Syzygium aromaticum ) is a spice widely used for its medical properties, though the species lacks scientific evidence regarding its toxicity and biologic effects. The aim of this study was the chemical identification by GC-MS analysis and ... ...

    Abstract Clove ( Syzygium aromaticum ) is a spice widely used for its medical properties, though the species lacks scientific evidence regarding its toxicity and biologic effects. The aim of this study was the chemical identification by GC-MS analysis and evaluation of the hemolytic, anticoagulant, antidiarrheal and antipyretic activities of the essential oil from S. aromaticum (EOSa) in adult male mice. Essential oil was obtained by hydrodistillation and provided 9.8% v/w yield. GC-MS analyses allowed the identification of nine constituents, with eugenol (84.63%) as the majority. EOSa was diluted in several concentrations (0.005–2 mg/mL) for hemolytic assays, showing hemolytic activity above 20% in concentrations higher than 0.625 mg/mL. Different concentrations of EOSa induced a coagulation time 100% higher than control blood. 50 and 100 mg/kg of EOSa caused additional intestinal motility induced by castor oil by 90–100%. Fever, induced by Saccharomyces cerevisae 15% (s.c.), was controlled by 50 and 100 mg/kg EOSa (p.o.), effects similar to 100 mg/kg dypirone. Results showed that when used orally, EOSa may have a certain degree of toxicity in high dosages, but with antipyretic and intestinal motility properties.
    Keywords essential oil ; GC-MS ; fever ; intestinal motility ; toxicity ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 590
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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