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  1. Article ; Online: Safety of Health Care in the Inpatient Setting.

    Dietz, Donald E / Ranard, Benjamin L / Adelman, Jason S

    The New England journal of medicine

    2023  Volume 388, Issue 16, Page(s) 1535

    MeSH term(s) Humans ; Inpatients ; Hospitalization ; Patient Safety ; Health Facilities ; Delivery of Health Care
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2301651
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  2. Article ; Online: Minimizing bias when using artificial intelligence in critical care medicine.

    Ranard, Benjamin L / Park, Soojin / Jia, Yugang / Zhang, Yiye / Alwan, Fatima / Celi, Leo Anthony / Lusczek, Elizabeth R

    Journal of critical care

    2024  Volume 82, Page(s) 154796

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2024.154796
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    Zs.A 2152: Show issues Location:
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  3. Article ; Online: A mathematical model of SARS-CoV-2 immunity predicts paxlovid rebound.

    Ranard, Benjamin L / Chow, Carson C / Megjhani, Murad / Asgari, Shadnaz / Park, Soojin / Vodovotz, Yoram

    Journal of medical virology

    2023  Volume 95, Issue 6, Page(s) e28854

    Abstract: Nirmatrelvir/ritonavir (Paxlovid), an oral antiviral medication targeting SARS-CoV-2, remains an important treatment for COVID-19. Initial studies of nirmatrelvir/ritonavir were performed in SARS-CoV-2 unvaccinated patients without prior confirmed SARS- ... ...

    Abstract Nirmatrelvir/ritonavir (Paxlovid), an oral antiviral medication targeting SARS-CoV-2, remains an important treatment for COVID-19. Initial studies of nirmatrelvir/ritonavir were performed in SARS-CoV-2 unvaccinated patients without prior confirmed SARS-CoV-2 infection; however, most individuals have now either been vaccinated and/or have experienced SARS-CoV-2 infection. After nirmatrelvir/ritonavir became widely available, reports surfaced of "Paxlovid rebound," a phenomenon in which symptoms (and SARS-CoV-2 test positivity) would initially resolve, but after finishing treatment, symptoms and test positivity would return. We used a previously described parsimonious mathematical model of immunity to SARS-CoV-2 infection to model the effect of nirmatrelvir/ritonavir treatment in unvaccinated and vaccinated patients. Model simulations show that viral rebound after treatment occurs only in vaccinated patients, while unvaccinated (SARS-COV-2 naïve) patients treated with nirmatrelvir/ritonavir do not experience any rebound in viral load. This work suggests that an approach combining parsimonious models of the immune system could be used to gain important insights in the context of emerging pathogens.
    MeSH term(s) Humans ; SARS-CoV-2 ; Ritonavir/therapeutic use ; COVID-19/diagnosis ; Antiviral Agents/therapeutic use
    Chemical Substances nirmatrelvir and ritonavir drug combination ; Ritonavir (O3J8G9O825) ; nirmatrelvir (7R9A5P7H32) ; Antiviral Agents
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Intramural
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28854
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  4. Article ; Online: Harnessing Digital Media to Promote Health and Research.

    Ranard, Benjamin L / Merchant, Raina M

    Circulation

    2018  Volume 137, Issue 21, Page(s) 2197–2199

    MeSH term(s) Cardiovascular Diseases/mortality ; Cardiovascular Diseases/pathology ; Crowdsourcing ; Health Behavior ; Health Promotion ; Humans ; Research ; Social Media
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.031906
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  5. Article ; Online: Heart rate variability and adrenal size provide clues to sudden cardiac death in hospitalized COVID-19 patients.

    Ranard, Benjamin L / Megjhani, Murad / Terilli, Kalijah / Yarmohammadi, Hirad / Ausiello, John / Park, Soojin

    Journal of critical care

    2022  Volume 71, Page(s) 154114

    Abstract: Purpose: To examine the association between a measure of heart rate variability and sudden cardiac death (SCD) in COVID-19 patients.: Methods: Patients with SARS-COV-2 infection admitted to Columbia University Irving Medical Center who died between 4/ ...

    Abstract Purpose: To examine the association between a measure of heart rate variability and sudden cardiac death (SCD) in COVID-19 patients.
    Methods: Patients with SARS-COV-2 infection admitted to Columbia University Irving Medical Center who died between 4/25/2020 and 7/14/2020 and had an autopsy were examined for root mean square of successive differences (RMSSD), organ weights, and evidence of SCD.
    Results: Thirty COVID-19 patients were included and 12 had SCD. The RMSSD over 7 days without vs with SCD was median 0.0129 (IQR 0.0074-0.026) versus 0.0098 (IQR 0.0056-0.0197), p < 0.0001. The total adjusted adrenal weight of the non-SCD group was 0.40 g/kg (IQR 0.35-0.55) versus 0.25 g/kg (IQR 0.21-0.31) in the SCD group, p = 0.0007.
    Conclusions: Hospitalized patients with COVID-19 who experienced SCD had lower parasympathetic activity (RMSSD) and smaller sized adrenal glands. Further research is required to replicate these findings.
    MeSH term(s) Autopsy ; COVID-19 ; Death, Sudden, Cardiac/epidemiology ; Heart Rate ; Humans ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.154114
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  6. Article ; Online: No Quick Fixes: Integrating Population Health Education and Quality Improvement in a Large Residency Program.

    Shoup, John Paul / Kim, Azalea / Wilson, Jonathan / Pendergast, Jane / Ranard, Benjamin L / Boggan, Joel C

    Journal for healthcare quality : official publication of the National Association for Healthcare Quality

    2022  Volume 44, Issue 5, Page(s) 286–293

    Abstract: Abstract: The intersection of population health (PH), quality improvement (QI), and health disparities is increasingly a focus in graduate medical education. However, it remains unclear how trainees may best improve disparities within clinical training ... ...

    Abstract Abstract: The intersection of population health (PH), quality improvement (QI), and health disparities is increasingly a focus in graduate medical education. However, it remains unclear how trainees may best improve disparities within clinical training environments. We integrated PH education for residents participating in a practical QI experience in a continuity clinic serving an underserved population. We analyzed whether PH education increased confidence in creating care plans and implementing team-based care strategies after selection of one of three QI metrics with known health disparities led to improvement. Posteducational session, attendees had odds of confidence in creating care plans 10.0 (95% confidence interval [CI] 4.6-21.7) times the presession period, whereas nonattendees' confidence was unchanged (OR 1.63, 95% CI 0.78-3.4). Residents participating in the QI project did not have higher confidence in creating a care plan at baseline (20% vs. 9.6%, p = .09) nor any additional shift in confidence versus other residents (p = .57). There were no differences in QI metric performance rate trends for residents choosing a specific QI metric versus those that did not (p > .33 for all comparisons). PH didactics can increase resident confidence around PH topics. However, translating such learning into outcomes and improved health equity may require dedicated efforts across residency training.
    MeSH term(s) Curriculum ; Education, Medical, Graduate ; Humans ; Internship and Residency ; Population Health ; Quality Improvement
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472097-8
    ISSN 1945-1474 ; 1062-2551
    ISSN (online) 1945-1474
    ISSN 1062-2551
    DOI 10.1097/JHQ.0000000000000352
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    Zs.A 5029: Show issues Location:
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  7. Article ; Online: Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure.

    Thompson, Alison E / Ranard, Benjamin L / Wei, Ying / Jelic, Sanja

    JAMA internal medicine

    2020  Volume 180, Issue 11, Page(s) 1537–1539

    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Cohort Studies ; Female ; Humans ; Male ; New York City/epidemiology ; Outcome and Process Assessment, Health Care ; Oximetry/methods ; Oximetry/statistics & numerical data ; Oxygen Inhalation Therapy/methods ; Oxygen Inhalation Therapy/statistics & numerical data ; Oxyhemoglobins/analysis ; Patient Positioning/methods ; Prone Position/physiology ; Respiration, Artificial/methods ; Respiration, Artificial/statistics & numerical data ; Respiratory Insufficiency/blood ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/physiopathology ; Respiratory Insufficiency/therapy ; SARS-CoV-2 ; Wakefulness
    Chemical Substances Oxyhemoglobins
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.3030
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  8. Article ; Online: Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model.

    Day, Judy D / Park, Soojin / Ranard, Benjamin L / Singh, Harinder / Chow, Carson C / Vodovotz, Yoram

    Frontiers in immunology

    2021  Volume 12, Page(s) 754127

    Abstract: COVID-19 presentations range from mild to moderate through severe disease but also manifest with persistent illness or viral recrudescence. We hypothesized that the spectrum of COVID-19 disease manifestations was a consequence of SARS-CoV-2-mediated ... ...

    Abstract COVID-19 presentations range from mild to moderate through severe disease but also manifest with persistent illness or viral recrudescence. We hypothesized that the spectrum of COVID-19 disease manifestations was a consequence of SARS-CoV-2-mediated delay in the pathogen-associated molecular pattern (PAMP) response, including dampened type I interferon signaling, thereby shifting the balance of the immune response to be dominated by damage-associated molecular pattern (DAMP) signaling. To test the hypothesis, we constructed a parsimonious mechanistic mathematical model. After calibration of the model for initial viral load and then by varying a few key parameters, we show that the core model generates four distinct viral load, immune response and associated disease trajectories termed "patient archetypes", whose temporal dynamics are reflected in clinical data from hospitalized COVID-19 patients. The model also accounts for responses to corticosteroid therapy and predicts that vaccine-induced neutralizing antibodies and cellular memory will be protective, including from severe COVID-19 disease. This generalizable modeling framework could be used to analyze protective and pathogenic immune responses to diverse viral infections.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Alarmins/immunology ; Anti-Inflammatory Agents/therapeutic use ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines ; Humans ; Middle Aged ; Models, Biological ; Reproducibility of Results ; SARS-CoV-2 ; Viral Load
    Chemical Substances Adrenal Cortex Hormones ; Alarmins ; Anti-Inflammatory Agents ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2021-10-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.754127
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  9. Article: Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure

    Thompson, Alison E / Ranard, Benjamin L / Wei, Ying / Jelic, Sanja

    JAMA intern. med. (Print)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #609243
    Database COVID19

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  10. Article ; Online: Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure

    Thompson, Alison E. / Ranard, Benjamin L. / Wei, Ying / Jelic, Sanja

    JAMA Internal Medicine

    2020  Volume 180, Issue 11, Page(s) 1537

    Keywords Internal Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.3030
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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