LIVIVO - Search results -

Search results

Result 1 - 10 of total 35

Search options

Article: Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives.

Abouelela, Mohamed E / Helmy, Yosra A

2024 Volume 12, Issue 3

Abstract: Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs are designed not only for conventional use as foods or dietary supplements but are also tailored for ... ...

Abstract	Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs are designed not only for conventional use as foods or dietary supplements but are also tailored for pharmaceutical applications. Research indicates that NGPs show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over conventional probiotics, NGPs present opportunities for personalized probiotic therapies, involvement in synthetic biology and gene editing, participation in combination therapies, targeted delivery methods, and application in therapeutic settings. Our review discusses the potential therapeutic effect of the NGPs, covering diverse research trajectories for NGPs, including their identification, characterization, and targeted delivery. Furthermore, this review elucidates the influence of NGPs on critical aspects of human health, specifically, gut health, immune function, and broader health outcomes. Mechanistic insights encompass the production of bioactive compounds, competitive interactions with pathogenic bacteria, the modulation of immune cell activity, and the reinforcement of the gut barrier. What is noteworthy is that the current review points out the prevalent NGP strains and their diverse sources, providing a highlight for the comprehensive framework for understanding their potential applications and their future benefits in the domain of advanced therapeutics.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12030430
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Heliotropium ramosissimum metabolic profiling, in silico and in vitro evaluation with potent selective cytotoxicity against colorectal carcinoma.

Fayed, Marwa A A / Abouelela, Mohamed E / Refaey, Mohamed S

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12539

Abstract: Heliotropium is a genus of the Boraginaceae family. Its members are used in many traditional and folklore medicines to treat several ailments. Despite this widespread usage, only a few evidence-based scientific studies investigated and identified its ... ...

Abstract	Heliotropium is a genus of the Boraginaceae family. Its members are used in many traditional and folklore medicines to treat several ailments. Despite this widespread usage, only a few evidence-based scientific studies investigated and identified its phytoconstituents. Herein, we documented the chemical profile of the Heliotropium ramosissimum methanolic extract using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) and assessed its antioxidant and cytotoxic effects. The methanolic extract exhibited high phenolic content (179.74 ± 0.58 µg/mL) and high flavonoid content (53.18 ± 0.60 µg/mL). The GC-MS analysis of the lipoidal matter allowed us to identify 41 compounds with high percentages of 1,2-benzenedicarboxylic acid, bis(2-methoxyethyl) ester (23.91%), and 6,10,14-trimethylpentadecan-2-one (18.74%). Thirty-two phytomolecules were tentatively identified from the methanolic extract of H. ramosissimum using LC-MS/MS. These compounds belonged to several phytochemical classes such as phenolic acids, alkaloids, coumarins, and flavonoids. Furthermore, we assessed the antioxidant activity of the methanolic extract by DPPH assay and oxygen radical absorbance capacity assay, which yielded IC
MeSH term(s)	Antioxidants/chemistry ; Chromatography, Liquid/methods ; Colonic Neoplasms ; Colorectal Neoplasms/drug therapy ; Heliotropium ; Humans ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Tandem Mass Spectrometry/methods
Chemical Substances	Antioxidants ; Plant Extracts
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16552-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Identification of Potential

Orabi, Mohamed A A / Alshahrani, Mohammed Merae / Sayed, Ahmed M / Abouelela, Mohamed E / Shaaban, Khaled A / Abdel-Sattar, El-Shaymaa

Metabolites

2023 Volume 13, Issue 1

Abstract: Leishmaniasis is a group of infectious diseases caused ... ...

Abstract	Leishmaniasis is a group of infectious diseases caused by
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13010093
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Ceiba pentandra

Orabi, Mohamed A A / Abouelela, Mohamed E / Darwish, Faten M M / Abdelkader, Mohamed S A / Elsadek, Bakheet E M / Al Awadh, Ahmed Abdullah / Alshahrani, Mohammed Merae / Alhasaniah, Abdulaziz Hassan / Aldabaan, Nayef / Abdelhamid, Reda A

Frontiers in pharmacology

2024 Volume 15, Page(s) 1337910

Abstract: Hepatocellular carcinoma (HCC) is a prevalent cancer worldwide. Late-stage detection, ineffective treatments, and tumor recurrence contribute to the low survival rate of the HCC. Conventional chemotherapeutic drugs, like doxorubicin (DOX), are associated ...

Abstract	Hepatocellular carcinoma (HCC) is a prevalent cancer worldwide. Late-stage detection, ineffective treatments, and tumor recurrence contribute to the low survival rate of the HCC. Conventional chemotherapeutic drugs, like doxorubicin (DOX), are associated with severe side effects, limited effectiveness, and tumor resistance. To improve therapeutic outcomes and minimize these drawbacks, combination therapy with natural drugs is being researched. Herein, we assessed the antitumor efficacy of
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1337910
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Chemical constituents from

Hamed, Ashraf N E / Abouelela, Mohamed E / El Zowalaty, Ahmed E / Badr, Mohamed M / Abdelkader, Mohamed S A

RSC advances

2022 Volume 12, Issue 15, Page(s) 9154–9162

Abstract: The phytochemical investigation of the hydromethanolic extract ... ...

Abstract	The phytochemical investigation of the hydromethanolic extract of
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra07000b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: In vitro

Al Awadh, Ahmed Abdullah / Sakagami, Hiroshi / Amano, Shigeru / Sayed, Ahmed M / Abouelela, Mohamed E / Alhasaniah, Abdulaziz Hassan / Aldabaan, Nayef / Refaey, Mohamed S / Abdelhamid, Reda A / Khalil, Heba M A / Hamdan, Dalia I / Abdel-Sattar, El-Shaymaa / Orabi, Mohamed A A

Frontiers in pharmacology

2024 Volume 15, Page(s) 1325272

Abstract: Oral cancer is a severe health problem that accounts for an alarmingly high number of fatalities worldwide. ...

Abstract	Oral cancer is a severe health problem that accounts for an alarmingly high number of fatalities worldwide.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1325272
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Anti-Staphylococcal, Anti-Candida, and Free-Radical Scavenging Potential of Soil Fungal Metabolites: A Study Supported by Phenolic Characterization and Molecular Docking Analysis.

Al Mousa, Amal A / Abouelela, Mohamed E / Al Ghamidi, Nadaa S / Abo-Dahab, Youssef / Mohamed, Hassan / Abo-Dahab, Nageh F / Hassane, Abdallah M A

Current issues in molecular biology

2023 Volume 46, Issue 1, Page(s) 221–243

Abstract: ... ...

Abstract	Staphylococcus
Language	English
Publishing date	2023-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46010016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5122: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: In Vitro Anti-Inflammatory Activity of

Refaey, Mohamed S / Abouelela, Mohamed E / El-Shoura, Ehab A M / Alkhalidi, Hala M / Fadil, Sana A / Elhady, Sameh S / Abdelhameed, Reda F A

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 6

Abstract: ... The ... ...

Abstract	The genus
MeSH term(s)	Anti-Inflammatory Agents/analysis ; Anti-Inflammatory Agents/pharmacology ; Asteraceae/chemistry ; Flowers/chemistry ; Molecular Docking Simulation ; Oils, Volatile/chemistry
Chemical Substances	Anti-Inflammatory Agents ; Oils, Volatile
Language	English
Publishing date	2022-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27061994
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFRʷᵗ and aromatase (CYP19A) inhibitors; a study supported by molecular docking

Hamed, Ashraf N. E. / Abouelela, Mohamed E. / El Zowalaty, Ahmed E. / Badr, Mohamed M. / Abdelkader, Mohamed S. A.

RSC advances. 2022 Mar. 23, v. 12, no. 15

2022

Abstract: The phytochemical investigation of the hydromethanolic extract of Carica papaya Linn. leaves (Caricaceae) resulted in the isolation and characterization of ten compounds, namely; carpaine (1), methyl gallate (2), loliolide (3), rutin (4), clitorin (5), ... ...

Abstract	The phytochemical investigation of the hydromethanolic extract of Carica papaya Linn. leaves (Caricaceae) resulted in the isolation and characterization of ten compounds, namely; carpaine (1), methyl gallate (2), loliolide (3), rutin (4), clitorin (5), kaempferol-3-O-neohesperidoside (6), isoquercetin (7), nicotiflorin (8) and isorhamnetin-3-O-β-d-glucopyranoside (9). The compounds 2, 3, 5–7 and 9 were isolated for the first time from the genus Carica. An in vitro breast cancer cytotoxicity study was evaluated with an MCF-7 cell line using the MTT assay. Methyl gallate and clitorin demonstrated the most potent cytotoxic activities with an IC₅₀ of 1.11 ± 0.06 and 2.47 ± 0.14 μM, respectively. Moreover, methyl gallate and nicotiflorin exhibited potential EGFRʷᵗ kinase inhibition activities with an IC₅₀ of 37.3 ± 1.9 and 41.08 ± 2.1 nM, respectively, compared with the positive control erlotinib (IC₅₀ = 35.94 ± 1.8 nM). On the other hand, clitorin and nicotiflorin displayed the strongest aromatase kinase inhibition activities with an IC₅₀ of 77.41 ± 4.53 and 92.84 ± 5.44 nM, respectively. Clitorin was comparable to the efficacy of the standard drug letrozole (IC₅₀ = 77.72 ± 4.55). Additionally, molecular docking simulations of the isolated compounds to EGFR and human placental aromatase cytochrome P450 (CYP19A1) were evaluated. Methyl gallate linked with the EGFR receptor through hydrogen bonding with a pose score of −4.5287 kcal mol⁻¹ and RMSD value of 1.69 Å. Clitorin showed the strongest interaction with aromatase (CYP19A1) for the breast cancer receptor with a posing score of −14.2074 and RMSD value of 1.56 Å. Compounds (1–3) possessed a good bioavailability score with a 0.55 value.
Keywords	Carica papaya ; aromatase ; bioavailability ; breast neoplasms ; cytochrome P-450 ; cytotoxicity ; drugs ; human cell lines ; humans ; hydrogen ; methyl gallate ; rutin
Language	English
Dates of publication	2022-0323
Size	p. 9154-9162.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra07000b
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: In Vitro

Hassane, Abdallah M A / Hussien, Saleh M / Abouelela, Mohamed E / Taha, Taher M / Awad, Mohamed F / Mohamed, Hassan / Hassan, Mohammad M / Hassan, Mohammad H A / Abo-Dahab, Nageh F / El-Shanawany, Abdel-Rehim A

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 930161

Abstract: Oxidative stress is involved in the pathophysiology of multiple health complications, and it has become a major focus in targeted research fields. As known, black seeds are rich sources of bio-active compounds and widely used to promote human health due ... ...

Abstract	Oxidative stress is involved in the pathophysiology of multiple health complications, and it has become a major focus in targeted research fields. As known, black seeds are rich sources of bio-active compounds and widely used to promote human health due to their excellent medicinal and pharmaceutical properties. The present study investigated the antioxidant potency of various black seeds from plants and their derived mycoendophytes, and determined the total phenolic and flavonoid contents in different extracts, followed by characterization of major constituents by HPLC analysis. Finally,
Language	English
Publishing date	2022-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.930161
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito