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Article: Complete denture fracture - A proposed classification system and its incidence in National Capital Region population: A survey.

Choudhary, Shweta

Journal of Indian Prosthodontic Society

2019 Volume 19, Issue 4, Page(s) 307–312

Abstract: Aim: The complete denture fracture of denture may ruin the routine life of an edentulous patient. The aim of the present study was to propose and evaluate a new classification system for denture fractures.: Settings and design: Cross sectional - ... ...

Abstract	Aim: The complete denture fracture of denture may ruin the routine life of an edentulous patient. The aim of the present study was to propose and evaluate a new classification system for denture fractures. Settings and design: Cross sectional -Survey. Materials and methods: Ten dental laboratories in Delhi and the National Capital Region participated in the study for 2 years. The accurate assessment of fractured dentures received in the laboratories for repairs was done. A questionnaire with complete information along with photographs was used to classify the denture fracture. Statistical analysis used: Percentage (proportion) statistical test. Results: Out of 620 dentures, 164 (94 maxillary and 70 mandibular) were found with previous repair, soft liners, metal frame, or wire reinforcements which were excluded from the study. In the present study, 456 dentures were considered (256 maxillary and 200 mandibular). Class I fracture (midline) was the most common in both maxillary and mandibular dentures (46.87% in maxillary and 61% in mandibular) with high significance ( Conclusions: This study encourages further clinical studies for validation and reliability evaluation of proposed new classification system.
Language	English
Publishing date	2019-10-10
Publishing country	India
Document type	Journal Article
ISSN	0972-4052
ISSN	0972-4052
DOI	10.4103/jips.jips_312_18
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Article ; Online: Silver-Catalyzed Asymmetric Double Desymmetrization via Vinylogous Michael Addition of Prochiral α,α-Dicyanoalkenes to Cyclopentendiones.

Choudhary, Kavita / Joshi, Harshit / Rohilla, Shweta / Singh, Vinod K

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 20, Page(s) e202304078

Abstract: An asymmetric double desymmetrization methodology has been developed for synthesizing densely functionalized chiral cyclopentylcyclohexane scaffolds. We have constructed four chiral centers, including an all-carbon quaternary stereocenter in a single C-C ...

Abstract	An asymmetric double desymmetrization methodology has been developed for synthesizing densely functionalized chiral cyclopentylcyclohexane scaffolds. We have constructed four chiral centers, including an all-carbon quaternary stereocenter in a single C-C bond formation event. The methodology has high functional-group tolerance and delivers a broad range of enantioenriched products. This vinylogous Michael addition reaction of prochiral α,α-dicyanocyclohexane to 2,2-disubstituted cyclopentene-1,3-dione is catalyzed by a chiral Ag-(R)-DTBM-SEGPHOS catalyst.
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202304078
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Article: A manganese(i)tricarbonyl-catalyst for near room temperature alkene and alkyne hydroarylation.

Choudhary, Shweta / Cannas, Diego M / Wheatley, Matthew / Larrosa, Igor

Chemical science

2022 Volume 13, Issue 44, Page(s) 13225–13230

Abstract: Developing more efficient catalytic processes using abundant and low toxicity transition metals is key to enable their mainstream use in synthetic chemistry. We have rationally designed a new Mn(i)-catalyst for hydroarylation reactions that displays much ...

Abstract	Developing more efficient catalytic processes using abundant and low toxicity transition metals is key to enable their mainstream use in synthetic chemistry. We have rationally designed a new Mn(i)-catalyst for hydroarylation reactions that displays much improved catalytic activity over the commonly used MnBr(CO)
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc04295a
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Article ; Online: Outcome of allogeneic stem cell transplant for Fanconi anemia in India.

Yadav, Satya Prakash / Raj, Revathi / Uppuluri, Ramya / Choudhary, Dharma / Doval, Divya / Dua, Vikas / Bhat, Sunil / Kharya, Gaurav / Patil, Rajesh / Bansal, Shweta / M, Deendayalan / Mehdi, Intezar / Mathews, Vikram / Abraham, Aby / George, Biju

Pediatric hematology and oncology

2024 Volume 41, Issue 2, Page(s) 169–171

MeSH term(s)	Humans ; Fanconi Anemia/therapy ; Stem Cell Transplantation ; Bone Marrow Transplantation ; Hematopoietic Stem Cell Transplantation ; India/epidemiology
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	632914-7
ISSN	1521-0669 ; 0888-0018
ISSN (online)	1521-0669
ISSN	0888-0018
DOI	10.1080/08880018.2023.2286971
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Article ; Online: Probiotics- its functions and influence on the ageing process: A comprehensive review

Choudhary, Pintu / Kathuria, Deepika / Suri, Shweta / Bahndral, Adity / Kanthi Naveen, A.

Food Bioscience. 2023 Apr., v. 52 p.102389-

2023

Abstract: The microbiota of the gastrointestinal tract is one of the most intricate ecosystems found in nature. More than a thousand different bacterial species have been identified in the gut microbiome, the majority of which belong to the phyla of Firmicutes (31. ...

Abstract	The microbiota of the gastrointestinal tract is one of the most intricate ecosystems found in nature. More than a thousand different bacterial species have been identified in the gut microbiome, the majority of which belong to the phyla of Firmicutes (31.1%), Proteobacteria (29.5%), Actinobacteria (25.9%), or Bacteroidetes (7.1%). There is a symbiotic link between the intestinal microflora and its host, this association plays an important role in the health of the host. The microbiota in the gut can become dysbiosis as a natural consequence of ageing, which raises the risk of several disorders. Probiotics are “live bacteria that confer a health benefit on the host when provided in suitable proportions.” They play important roles in preventing and treating digestive tract diseases in people of all ages, especially the elderly. One of the most complicated ecosystems in nature, the intestinal microbiota is home to approximately 10¹³ and 10¹⁴ different kinds of microorganisms. Through the gut-brain axis, it has been hypothesized that the use of probiotics can alleviate cognitive impairment and mental disturbance in individuals as well as in animal models used in experiments. Considering the most recent clinical trials, this article discusses the positive impact of probiotics in slowing down the ageing process, curing disorders associated with ageing, and enhancing the overall quality of life.
Keywords	Actinobacteria ; Bacteroidetes ; Firmicutes ; Proteobacteria ; animals ; cognitive disorders ; digestive tract ; dysbiosis ; elderly ; intestinal microorganisms ; people ; probiotics ; quality of life ; risk ; Ageing ; Immune function ; Immunomodulation
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2212-4292
DOI	10.1016/j.fbio.2023.102389
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Article ; Online: A randomized controlled pilot study of autoinoculation versus 35% trichloroacetic acid for the treatment of molluscum contagiosum.

Kachhawa, Dilip / Choudhary, Paras / Saraswat, Shweta / Lamoria, Aanand / Joshi, Yogi Raj / Yadav, Chinmai

Journal of the American Academy of Dermatology

2022 Volume 87, Issue 5, Page(s) 1207–1209

MeSH term(s)	Humans ; Molluscum Contagiosum/drug therapy ; Pilot Projects ; Trichloroacetic Acid/therapeutic use
Chemical Substances	Trichloroacetic Acid (5V2JDO056X)
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Comment
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2022.02.066
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Article ; Online: Emerging SARS-CoV-2 Variants: Genetic Variability and Clinical Implications.

Dubey, Aakriti / Choudhary, Shweta / Kumar, Pravindra / Tomar, Shailly

Current microbiology

2021 Volume 79, Issue 1, Page(s) 20

Abstract: The sudden rise in COVID-19 cases in 2020 and the incessant emergence of fast-spreading variants have created an alarming situation worldwide. Besides the continuous advancements in the design and development of vaccines to combat this deadly pandemic, ... ...

Abstract	The sudden rise in COVID-19 cases in 2020 and the incessant emergence of fast-spreading variants have created an alarming situation worldwide. Besides the continuous advancements in the design and development of vaccines to combat this deadly pandemic, new variants are frequently reported, possessing mutations that rapidly outcompeted an existing population of circulating variants. As concerns grow about the effects of mutations on the efficacy of vaccines, increased transmissibility, immune escape, and diagnostic failures are few other apprehensions liable for more deadly waves of COVID-19. Although the phenomenon of antigenic drift in new variants of SARS-CoV-2 is still not validated, it is conceived that the virus is acquiring new mutations as a fitness advantage for rapid transmission or to overcome immunological resistance of the host cell. Considerable evolution of SARS-CoV-2 has been observed since its first appearance in 2019, and despite the progress in sequencing efforts to characterize the mutations, their impacts in many variants have not been analyzed. The present article provides a substantial review of literature explaining the emerging variants of SARS-CoV-2 circulating globally, key mutations in viral genome, and the possible impacts of these new mutations on prevention and therapeutic strategies currently administered to combat this pandemic. Rising infections, mortalities, and hospitalizations can possibly be tackled through mass vaccination, social distancing, better management of available healthcare infrastructure, and by prioritizing genome sequencing for better serosurveillance studies and community tracking.
MeSH term(s)	Antigenic Drift and Shift ; COVID-19 ; Genome, Viral ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-021-02724-1
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Article ; Online: Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens.

Mahajan, Supreeti / Choudhary, Shweta / Kumar, Pravindra / Tomar, Shailly

Bioorganic & medicinal chemistry

2021 Volume 46, Page(s) 116356

Abstract: The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the emergence of challenging variants has created an urgent need of alternative therapeutic approaches to combat the spread of viral infections, failing to which may pose a ... ...

Abstract	The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the emergence of challenging variants has created an urgent need of alternative therapeutic approaches to combat the spread of viral infections, failing to which may pose a greater risk to mankind in future. Resilience against antiviral drugs or fast evolutionary rate of viruses is stressing the scientific community to identify new therapeutic approaches for timely control of disease. Host metabolic pathways are exquisite reservoir of energy to viruses and contribute a diverse array of functions for successful replication and pathogenesis of virus. Targeting the host factors rather than viral enzymes to cease viral infection, has emerged as an alternative antiviral strategy. This approach offers advantage in terms of increased threshold to viral resistance and can provide broad-spectrum antiviral action against different viruses. The article here provides substantial review of literature illuminating the host factors and molecular mechanisms involved in innate/adaptive responses to viral infection, hijacking of signalling pathways by viruses and the intracellular metabolic pathways required for viral replication. Host-targeted drugs acting on the pathways usurped by viruses are also addressed in this study. Host-directed antiviral therapeutics might prove to be a rewarding approach in controlling the unprecedented spread of viral infection, however the probability of cellular side effects or cytotoxicity on host cell should not be ignored at the time of clinical investigations.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Cytokines/metabolism ; Frameshifting, Ribosomal/drug effects ; Frameshifting, Ribosomal/physiology ; Glycosylation/drug effects ; Humans ; Immunity/drug effects ; Immunity/physiology ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Metabolic Networks and Pathways/drug effects ; Metabolic Networks and Pathways/physiology ; Polyamines/metabolism ; Positive-Strand RNA Viruses/drug effects ; Positive-Strand RNA Viruses/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Ubiquitination/drug effects ; Ubiquitination/physiology
Chemical Substances	Antiviral Agents ; Cytokines ; Polyamines
Language	English
Publishing date	2021-08-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2021.116356
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Article: Emerging SARS-CoV-2 Variants: Genetic Variability and Clinical Implications

Dubey, Aakriti / Choudhary, Shweta / Kumar, Pravindra / Tomar, Shailly

Current microbiology. 2022 Jan., v. 79, no. 1

2022

Abstract	The sudden rise in COVID-19 cases in 2020 and the incessant emergence of fast-spreading variants have created an alarming situation worldwide. Besides the continuous advancements in the design and development of vaccines to combat this deadly pandemic, new variants are frequently reported, possessing mutations that rapidly outcompeted an existing population of circulating variants. As concerns grow about the effects of mutations on the efficacy of vaccines, increased transmissibility, immune escape, and diagnostic failures are few other apprehensions liable for more deadly waves of COVID-19. Although the phenomenon of antigenic drift in new variants of SARS-CoV-2 is still not validated, it is conceived that the virus is acquiring new mutations as a fitness advantage for rapid transmission or to overcome immunological resistance of the host cell. Considerable evolution of SARS-CoV-2 has been observed since its first appearance in 2019, and despite the progress in sequencing efforts to characterize the mutations, their impacts in many variants have not been analyzed. The present article provides a substantial review of literature explaining the emerging variants of SARS-CoV-2 circulating globally, key mutations in viral genome, and the possible impacts of these new mutations on prevention and therapeutic strategies currently administered to combat this pandemic. Rising infections, mortalities, and hospitalizations can possibly be tackled through mass vaccination, social distancing, better management of available healthcare infrastructure, and by prioritizing genome sequencing for better serosurveillance studies and community tracking.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antigenic variation ; evolution ; health services ; infrastructure ; pandemic ; vaccination ; viral genome ; viruses
Language	English
Dates of publication	2022-01
Size	p. 20.
Publishing place	Springer US
Document type	Article
Note	Review
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-021-02724-1
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Article ; Online: Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2.

Dhaka, Preeti / Singh, Ankur / Choudhary, Shweta / Peddinti, Rama Krishna / Kumar, Pravindra / Sharma, Gaurav Kumar / Tomar, Shailly

Archives of biochemistry and biophysics

2023 Volume 750, Page(s) 109820

Abstract: The nucleocapsid (N) protein of SARS-CoV-2 plays a pivotal role in encapsulating the viral genome. Developing antiviral treatments for SARS-CoV-2 is imperative due to the diminishing immunity of the available vaccines. This study targets the RNA-binding ... ...

Abstract	The nucleocapsid (N) protein of SARS-CoV-2 plays a pivotal role in encapsulating the viral genome. Developing antiviral treatments for SARS-CoV-2 is imperative due to the diminishing immunity of the available vaccines. This study targets the RNA-binding site located in the N-terminal domain (NTD) of the N-protein to identify the potential antiviral molecules against SARS-CoV-2. A structure-based repurposing approach identified the twelve high-affinity molecules from FDA-approved drugs, natural products, and the LOPAC
MeSH term(s)	Humans ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Nucleocapsid/metabolism ; Thermodynamics ; RNA ; Molecular Docking Simulation
Chemical Substances	Antiviral Agents ; RNA (63231-63-0)
Language	English
Publishing date	2023-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2023.109820
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