LIVIVO - Search results -

Search results

Result 1 - 10 of total 27

Search options

Article ; Online: A transdiagnostic network for psychiatric illness derived from atrophy and lesions.

Taylor, Joseph J / Lin, Christopher / Talmasov, Daniel / Ferguson, Michael A / Schaper, Frederic L W V J / Jiang, Jing / Goodkind, Madeleine / Grafman, Jordan / Etkin, Amit / Siddiqi, Shan H / Fox, Michael D

Nature human behaviour

2023 Volume 7, Issue 3, Page(s) 420–429

Abstract: Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used coordinate and lesion network mapping to test for a shared brain ... ...

Abstract	Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used coordinate and lesion network mapping to test for a shared brain network across psychiatric disorders. In our meta-analysis of 193 studies, atrophy coordinates across six psychiatric disorders mapped to a common brain network defined by positive connectivity to anterior cingulate and insula, and by negative connectivity to posterior parietal and lateral occipital cortex. This network was robust to leave-one-diagnosis-out cross-validation and specific to atrophy coordinates from psychiatric versus neurodegenerative disorders (72 studies). In 194 patients with penetrating head trauma, lesion damage to this network correlated with the number of post-lesion psychiatric diagnoses. Neurosurgical ablation targets for psychiatric illness (four targets) also aligned with the network. This convergent brain network for psychiatric illness may partially explain high rates of psychiatric comorbidity and could highlight neuromodulation targets for patients with more than one psychiatric disorder.
MeSH term(s)	Humans ; Mental Disorders/diagnosis ; Brain/diagnostic imaging ; Brain/pathology ; Atrophy/pathology ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/pathology ; Comorbidity
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2397-3374
ISSN (online)	2397-3374
DOI	10.1038/s41562-022-01501-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Stress Inoculation Training (SIT-NORCAL), Part 1: The Development and Preliminary Evaluation of a Psychological Performance Training Protocol.

Jackson, Sarah E / Baity, Matthew R / Thomas, Patrick R / Barba, Douglas / Jacobson, Daniel / Goodkind, Madeleine / Swick, Diane / Ivey, A Sarah

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

2021 Volume 21, Issue 4, Page(s) 37–45

Abstract: Background: Stress inoculation training (SIT) interventions have demonstrated promise within military contexts for human performance enhancement and psychological health applications. However, lack of manualized guidance on core content selection, ... ...

Abstract	Background: Stress inoculation training (SIT) interventions have demonstrated promise within military contexts for human performance enhancement and psychological health applications. However, lack of manualized guidance on core content selection, delivery, and measurement processes has limited their use. Purpose: The purpose of this study was to develop and evaluate a comprehensive SIT intervention protocol to enhance the performance and health of military personnel engaged in special warfare and first-response activities. Methods: Multidisciplinary teams of subject matter experts (n = 19) were consulted in protocol generation. The performance improvement/human performance technology (HPT) model was used in the selection, refinement, and measurement of core skills. The protocol was trialed and refined (44 cohorts, n = =300; 2013-2020) to generate the results. Results: Four primary aims were achieved: (1) The generation of a flexible, evidence-based/evidence-driven psychological performance and health sustainment hybrid, SIT-NORCAL. (2) Manualized content and process guidance. (3) The creation of multimedia materials using evidence-based methodologies. (4) The design of initial measurement systems. Preliminary quality improvement analysis demonstrated positive results using standard-of-care and performance enhancement assessments. Conclusion: Hybridized human performance and psychological health sustainment protocols represent a paradigm shift in the delivery of psychological performance training with the potential to overcome barriers to success in traditional care. Further study is needed to determine the effectiveness and reach of SIT-NORCAL.
MeSH term(s)	Humans ; Mental Disorders ; Military Personnel
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3006517-3
ISSN	1553-9768
ISSN	1553-9768
DOI	10.55460/HCUV-LP37
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7196: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Transdiagnostic impairment of cognitive control in mental illness.

McTeague, Lisa M / Goodkind, Madeleine S / Etkin, Amit

Journal of psychiatric research

2016 Volume 83, Page(s) 37–46

Abstract: Intact cognitive control or executive function has characteristic patterns in both behavior and functional neurocircuitry. Functional neuroimaging studies have shown that a frontal-cingulate-parietal-insular (i.e., "multiple demand") network forms a ... ...

Abstract	Intact cognitive control or executive function has characteristic patterns in both behavior and functional neurocircuitry. Functional neuroimaging studies have shown that a frontal-cingulate-parietal-insular (i.e., "multiple demand") network forms a common functional substrate undergirding successful adaptation to diverse cognitive processing demands. Separate work on intact neurocognitive performance implicates a higher order factor that largely explains performance across domains and may reflect trait cognitive control capacity. In the current review we highlight findings from respective psychiatric disorders (i.e., psychotic, bipolar and unipolar depressive, anxiety, and substance use disorders) suggesting that cognitive control perturbations amidst psychopathology are most pronounced within these common brain and behavioral indices of adaptive cognitive functioning and moreover, are evident across disorders (i.e., transdiagnostically). Specifically, within each of the disorder classes impairments are consistent in the multiple demand network across a wide range of cognitive tasks. While severity varies between disorders, broad as opposed to domain-specific impairments consistently emerge in neurocognitive performance. Accumulating findings have revealed that phenotypically diverse psychiatric disorders share a common factor or vulnerability to dysfunction that is in turn related to broad neurocognitive deficits. Furthermore, we have observed that regions of the multiple demand network, which overlap with the salience network (dorsal anterior cingulate and bilateral anterior insula) are characterized by reduced gray matter transdiagnostically and predict weaker neurocognitive performance. In summary, transdiagnostic (as opposed to disorder-specific) patterns of symptomatic distress and neurocognitive performance deficits, concurrent with parallel anomalies of brain structure and function may largely contribute to the real-world socio-occupational impairment common across disorders.
MeSH term(s)	Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Humans ; Mental Disorders/complications ; Mental Disorders/pathology
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2016.08.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.243: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Stress Inoculation Training (SIT-NORCAL), Part 2: A Pilot Study Among Explosive Ordnance Disposal Special Warfare Enablers.

Jackson, Sarah E / Baity, Matthew R / Thomas, Patrick R / Walker, Mark / Goodkind, Madeleine / Swick, Diane / Barba, Douglas / Jacobson, Daniel / Byrd, Eric / Ivey, A Sarah

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

2021 Volume 21, Issue 4, Page(s) 46–53

Abstract: Background: Despite being a well-supported strategy, Stress Inoculation Training (SIT) has not been fully incorporated in the advancement of human performance among most military personnel. The RAND Study recommendations for maximizing SIT's potential ... ...

Abstract	Background: Despite being a well-supported strategy, Stress Inoculation Training (SIT) has not been fully incorporated in the advancement of human performance among most military personnel. The RAND Study recommendations for maximizing SIT's potential within high-risk/ high-intensity occupational groups were used in designing the Core Training protocol targeting psychological performance, SIT-NORCAL (Part 1). Purpose: The current project (Part 2) sought to further develop the protocol as a health and human performance hybrid through quality improvement analysis of the content, process, and measurement elements for use in the human performance context. Methods: Evidence-based/evidence-driven methodologies were used in collaborative design tailored to the unique needs of special warfare enablers specializing in Explosive Ordnance Disposal (n = 17). The resultant three-phase training was conducted with a novice group (n = 10) using standardized measurements of collaboration, human performance, and adaptive capabilities on identified training targets. Results: Process elements demonstrated high feasibility, resulting in high collaboration and trainee satisfaction. Significant improvements in psychological performance targets were observed pre- to post-training, and during an Adaptive Environmental Simulation designed by unit members. Two weeks post-training, unit members (n = 5) responded to an actual crash of an F-16 aircraft; measurements indicated maintenance of skill set from training to real-world events. Conclusion: Deployment of the elements in the SIT-NORCAL protocol demonstrated early feasibility and positive training impact on occupationally relevant skills that carried over into real-world events.
MeSH term(s)	Explosive Agents ; Humans ; Military Personnel ; Pilot Projects ; Warfare
Chemical Substances	Explosive Agents
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3006517-3
ISSN	1553-9768
ISSN	1553-9768
DOI	10.55460/JKSD-4SEW
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7196: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Empathic Accuracy Deficits in Patients with Neurodegenerative Disease: Association with Caregiver Depression.

Brown, Casey L / Lwi, Sandy J / Goodkind, Madeleine S / Rankin, Katherine P / Merrilees, Jennifer / Miller, Bruce L / Levenson, Robert W

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2017 Volume 26, Issue 4, Page(s) 484–493

Abstract: Objectives: To investigate whether deficits in empathic accuracy (i.e., ability to recognize emotion in others) in patients with neurodegenerative disease are associated with greater depression in their caregivers.: Design: Two cross-sectional ... ...

Abstract	Objectives: To investigate whether deficits in empathic accuracy (i.e., ability to recognize emotion in others) in patients with neurodegenerative disease are associated with greater depression in their caregivers. Design: Two cross-sectional studies. Setting: Academic medical center and research university. Participants: Two independent samples (N = 172, N = 63) of patients with a variety of neurodegenerative diseases and their caregivers; comparison group of healthy couples. Measurement: Patients' empathic accuracy was assessed in the laboratory using a novel dynamic tracking task (rating another person's changing emotions over time) and more traditional measures (recognizing the emotion expressed in photographs of facial expressions and by characters in films). Caregivers completed self-report inventories of depression. Results: Lower empathic accuracy in patients was associated with greater depression in caregivers in both studies. In study 1, this association was found when empathic accuracy was measured using the dynamic tracking measure but not when measured using the more traditional photograph and film measures. In study 2, we found preliminary support for our theoretical model wherein lower empathic accuracy in patients is associated with increased caregiver stress (loneliness, strain, and burden), which in turn is associated with greater caregiver depression. Conclusions: Caring for a patient with deficits in empathic accuracy is associated with greater loneliness, strain, and burden for caregivers, and increased depression. Caregivers may benefit from interventions designed to compensate for the stress and interpersonal loss associated with patients' declining empathic accuracy.
MeSH term(s)	Aged ; Caregivers/psychology ; Cross-Sectional Studies ; Depression/complications ; Empathy ; Female ; Humans ; Interpersonal Relations ; Linear Models ; Male ; Middle Aged ; Neurodegenerative Diseases/psychology ; Psychiatric Status Rating Scales ; Self Report ; Stress, Psychological/complications ; United States
Language	English
Publishing date	2017-12-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1016/j.jagp.2017.10.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4443: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Aging and emotion recognition: not just a losing matter.

Sze, Jocelyn A / Goodkind, Madeleine S / Gyurak, Anett / Levenson, Robert W

Psychology and aging

2012 Volume 27, Issue 4, Page(s) 940–950

Abstract: Past studies on emotion recognition and aging have found evidence of age-related decline when emotion recognition was assessed by having participants detect single emotions depicted in static images of full or partial (e.g., eye region) faces. These ... ...

Abstract	Past studies on emotion recognition and aging have found evidence of age-related decline when emotion recognition was assessed by having participants detect single emotions depicted in static images of full or partial (e.g., eye region) faces. These tests afford good experimental control but do not capture the dynamic nature of real-world emotion recognition, which is often characterized by continuous emotional judgments and dynamic multimodal stimuli. Research suggests that older adults often perform better under conditions that better mimic real-world social contexts. We assessed emotion recognition in young, middle-aged, and older adults using two traditional methods (single emotion judgments of static images of faces and eyes) and an additional method in which participants made continuous emotion judgments of dynamic, multimodal stimuli (videotaped interactions between young, middle-aged, and older couples). Results revealed an Age × Test interaction. Largely consistent with prior research, we found some evidence that older adults performed worse than young adults when judging single emotions from images of faces (for sad and disgust faces only) and eyes (for older eyes only), with middle-aged adults falling in between. In contrast, older adults did better than young adults on the test involving continuous emotion judgments of dyadic interactions, with middle-aged adults falling in between. In tests in which target stimuli differed in age, emotion recognition was not facilitated by an age match between participant and target. These findings are discussed in terms of theoretical and methodological implications for the study of aging and emotional processing.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging/psychology ; Emotions ; Facial Expression ; Female ; Humans ; Judgment ; Male ; Middle Aged ; Photic Stimulation ; Recognition, Psychology ; Young Adult
Language	English
Publishing date	2012-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	635596-1
ISSN	1939-1498 ; 0882-7974
ISSN (online)	1939-1498
ISSN	0882-7974
DOI	10.1037/a0029367
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3194: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Amygdala and Insula Connectivity Changes Following Psychotherapy for Posttraumatic Stress Disorder: A Randomized Clinical Trial.

Fonzo, Gregory A / Goodkind, Madeleine S / Oathes, Desmond J / Zaiko, Yevgeniya V / Harvey, Meredith / Peng, Kathy K / Weiss, M Elizabeth / Thompson, Allison L / Zack, Sanno E / Lindley, Steven E / Arnow, Bruce A / Jo, Booil / Rothbaum, Barbara O / Etkin, Amit

Biological psychiatry

2020 Volume 89, Issue 9, Page(s) 857–867

Abstract: Background: Exposure-based psychotherapy is a first-line treatment for posttraumatic stress disorder (PTSD), but its mechanisms are poorly understood. Functional brain connectivity is a promising metric for identifying treatment mechanisms and ... ...

Abstract	Background: Exposure-based psychotherapy is a first-line treatment for posttraumatic stress disorder (PTSD), but its mechanisms are poorly understood. Functional brain connectivity is a promising metric for identifying treatment mechanisms and biosignatures of therapeutic response. To this end, we assessed amygdala and insula treatment-related connectivity changes and their relationship to PTSD symptom improvements. Methods: Individuals with a primary PTSD diagnosis (N = 66) participated in a randomized clinical trial of prolonged exposure therapy (n = 36) versus treatment waiting list (n = 30). Task-free functional magnetic resonance imaging was completed prior to randomization and 1 month following cessation of treatment/waiting list. Whole-brain blood oxygenation level-dependent responses were acquired. Intrinsic connectivity was assessed by subregion in the amygdala and insula, limbic structures key to the disorder pathophysiology. Dynamic causal modeling assessed evidence for effective connectivity changes in select nodes informed by intrinsic connectivity findings. Results: The amygdala and insula displayed widespread patterns of primarily subregion-uniform intrinsic connectivity change, including increased connectivity between the amygdala and insula; increased connectivity of both regions with the ventral prefrontal cortex and frontopolar and sensory cortices; and decreased connectivity of both regions with the left frontoparietal nodes of the executive control network. Larger decreases in amygdala-frontal connectivity and insula-parietal connectivity were associated with larger PTSD symptom reductions. Dynamic causal modeling evidence suggested that treatment decreased left frontal inhibition of the left amygdala, and larger decreases were associated with larger symptom reductions. Conclusions: PTSD psychotherapy adaptively attenuates functional interactions between frontoparietal and limbic brain circuitry at rest, which may reflect a potential mechanism or biosignature of recovery.
MeSH term(s)	Amygdala ; Brain ; Humans ; Implosive Therapy ; Magnetic Resonance Imaging ; Stress Disorders, Post-Traumatic/diagnostic imaging ; Stress Disorders, Post-Traumatic/therapy
Language	English
Publishing date	2020-12-08
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2020.11.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 720: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Greater emotional empathy and prosocial behavior in late life.

Sze, Jocelyn A / Gyurak, Anett / Goodkind, Madeleine S / Levenson, Robert W

Emotion (Washington, D.C.)

2011 Volume 12, Issue 5, Page(s) 1129–1140

Abstract: Emotional empathy and prosocial behavior were assessed in older, middle-aged, and young adults. Participants watched two films depicting individuals in need, one uplifting and the other distressing. Physiological responses were monitored during the films, ...

Abstract	Emotional empathy and prosocial behavior were assessed in older, middle-aged, and young adults. Participants watched two films depicting individuals in need, one uplifting and the other distressing. Physiological responses were monitored during the films, and participants rated their levels of emotional empathy following each film. As a measure of prosocial behavior, participants were given an additional payment they could contribute to charities supporting the individuals in the films. Age-related linear increases were found for both emotional empathy (self-reported empathic concern and cardiac and electrodermal responding) and prosocial behavior (size of contribution) across both films and in self-reported personal distress to the distressing film. Empathic concern and cardiac reactivity to both films, along with personal distress to the distressing film only, were associated with greater prosocial behavior. Empathic concern partially mediated the age-related differences in prosocial behavior. Results are discussed in terms of our understanding both of adult development and of the nature of these vital aspects of human emotion.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging/psychology ; Altruism ; Emotions/physiology ; Empathy/physiology ; Female ; Galvanic Skin Response ; Humans ; Male ; Middle Aged ; Photoplethysmography ; Regression Analysis ; Social Behavior
Language	English
Publishing date	2011-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2102391-8
ISSN	1931-1516 ; 1528-3542
ISSN (online)	1931-1516
ISSN	1528-3542
DOI	10.1037/a0025011
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Emotion recognition in frontotemporal dementia and Alzheimer's disease: A new film-based assessment.

Goodkind, Madeleine S / Sturm, Virginia E / Ascher, Elizabeth A / Shdo, Suzanne M / Miller, Bruce L / Rankin, Katherine P / Levenson, Robert W

Emotion (Washington, D.C.)

2015 Volume 15, Issue 4, Page(s) 416–427

Abstract: Deficits in recognizing others' emotions are reported in many psychiatric and neurological disorders, including autism, schizophrenia, behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). Most previous emotion recognition ... ...

Abstract	Deficits in recognizing others' emotions are reported in many psychiatric and neurological disorders, including autism, schizophrenia, behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). Most previous emotion recognition studies have required participants to identify emotional expressions in photographs. This type of assessment differs from real-world emotion recognition in important ways: Images are static rather than dynamic, include only 1 modality of emotional information (i.e., visual information), and are presented absent a social context. Additionally, existing emotion recognition batteries typically include multiple negative emotions, but only 1 positive emotion (i.e., happiness) and no self-conscious emotions (e.g., embarrassment). We present initial results using a new task for assessing emotion recognition that was developed to address these limitations. In this task, respondents view a series of short film clips and are asked to identify the main characters' emotions. The task assesses multiple negative, positive, and self-conscious emotions based on information that is multimodal, dynamic, and socially embedded. We evaluate this approach in a sample of patients with bvFTD, AD, and normal controls. Results indicate that patients with bvFTD have emotion recognition deficits in all 3 categories of emotion compared to the other groups. These deficits were especially pronounced for negative and self-conscious emotions. Emotion recognition in this sample of patients with AD was indistinguishable from controls. These findings underscore the utility of this approach to assessing emotion recognition and suggest that previous findings that recognition of positive emotion was preserved in dementia patients may have resulted from the limited sampling of positive emotion in traditional tests.
MeSH term(s)	Alzheimer Disease/psychology ; Emotions ; Female ; Frontotemporal Dementia/psychology ; Happiness ; Humans ; Male ; Motion Pictures ; Psychological Tests
Language	English
Publishing date	2015-05-25
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2102391-8
ISSN	1931-1516 ; 1528-3542
ISSN (online)	1931-1516
ISSN	1528-3542
DOI	10.1037/a0039261
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography.

Nature biomedical engineering

2020 Volume 5, Issue 4, Page(s) 309–323

Abstract: The understanding and treatment of psychiatric disorders, which are known to be neurobiologically and clinically heterogeneous, could benefit from the data-driven identification of disease subtypes. Here, we report the identification of two clinically ... ...

Abstract	The understanding and treatment of psychiatric disorders, which are known to be neurobiologically and clinically heterogeneous, could benefit from the data-driven identification of disease subtypes. Here, we report the identification of two clinically relevant subtypes of post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) on the basis of robust and distinct functional connectivity patterns, prominently within the frontoparietal control network and the default mode network. We identified the disease subtypes by analysing, via unsupervised and supervised machine learning, the power-envelope-based connectivity of signals reconstructed from high-density resting-state electroencephalography in four datasets of patients with PTSD and MDD, and show that the subtypes are transferable across independent datasets recorded under different conditions. The subtype whose functional connectivity differed most from those of healthy controls was less responsive to psychotherapy treatment for PTSD and failed to respond to an antidepressant medication for MDD. By contrast, both subtypes responded equally well to two different forms of repetitive transcranial magnetic stimulation therapy for MDD. Our data-driven approach may constitute a generalizable solution for connectome-based diagnosis.
MeSH term(s)	Adult ; Antidepressive Agents/therapeutic use ; Brain/physiopathology ; Case-Control Studies ; Cluster Analysis ; Connectome ; Databases, Factual ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/physiopathology ; Electroencephalography ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Psychotherapy ; Stress Disorders, Post-Traumatic/physiopathology ; Stress Disorders, Post-Traumatic/therapy ; Transcranial Magnetic Stimulation
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-020-00614-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED