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  1. Article: Adult-onset nevus lipomatosus cutaneous superficialis mimicking plane xanthoma.

    Hassab-El-Naby, Hussein M M / Rageh, Mahmoud A

    The Journal of clinical and aesthetic dermatology

    2022  Volume 15, Issue 7, Page(s) 10–11

    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2571623-2
    ISSN 1941-2789
    ISSN 1941-2789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Agminated Halo Nevus: A Novel Presentation.

    Hassab-El-Naby, Hussein M M / Rageh, Mahmoud A

    The American Journal of dermatopathology

    2023  Volume 45, Issue 6, Page(s) 388–390

    Abstract: Abstract: Halo nevus is a benign type of melanocytic nevi commonly found in children and manifests as a central pigmented part surrounded by a well-defined hypopigmented area. Halo nevi are commonly located on the trunk. The central nevus may show ... ...

    Abstract Abstract: Halo nevus is a benign type of melanocytic nevi commonly found in children and manifests as a central pigmented part surrounded by a well-defined hypopigmented area. Halo nevi are commonly located on the trunk. The central nevus may show partial or complete regression, whereas the associated halo may persist or enlarge. The term 'agminated nevus' refers to a cluster of melanocytic nevi restricted to an area of the body and commonly reported with acquired melanocytic nevi, blue nevi, and Spitz nevi. To the best of our knowledge, agminated halo nevus has not been previously described. We hereby report 2 cases with clinical and histopathologic findings consistent with the diagnosis of agminated halo nevus.
    MeSH term(s) Child ; Humans ; Nevus, Halo ; Skin Neoplasms/pathology ; Nevus, Pigmented/pathology ; Nevus, Epithelioid and Spindle Cell ; Nevus
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1518: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Berberine loaded thermosensitive lipid nanoparticles:

    Gad, Heba A / Abbas, Haidy / El Sayed, Nesrine S / Khattab, Mohamed A / El Hassab, Mahmoud A / Mansour, Mai

    Journal of liposome research

    2023  , Page(s) 1–13

    Abstract: Thermoresponsive drug delivery systems have been used to treat diseases that cause hyperthermia or elevated body tissue temperatures, ...

    Abstract Thermoresponsive drug delivery systems have been used to treat diseases that cause hyperthermia or elevated body tissue temperatures,
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 645173-1
    ISSN 1532-2394 ; 0898-2104
    ISSN (online) 1532-2394
    ISSN 0898-2104
    DOI 10.1080/08982104.2023.2273390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2539: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Chemical composition, seasonal variation and antiaging activities of essential oil from

    Rabie, Omyma / El-Nashar, Heba A S / Majrashi, Taghreed A / Al-Warhi, Tarfah / El Hassab, Mahmoud A / Eldehna, Wagdy M / Mostafa, Nada M

    Journal of enzyme inhibition and medicinal chemistry

    2023  Volume 38, Issue 1, Page(s) 2224944

    Abstract: ... ...

    Abstract Callistemon
    MeSH term(s) Oils, Volatile/pharmacology ; Oils, Volatile/analysis ; Oils, Volatile/chemistry ; Seasons ; Acetylcholinesterase ; Eucalyptol/pharmacology ; Eucalyptol/analysis ; Egypt ; Molecular Docking Simulation ; Plant Leaves/chemistry ; Myrtaceae/chemistry ; Pancreatic Elastase
    Chemical Substances Oils, Volatile ; Acetylcholinesterase (EC 3.1.1.7) ; Eucalyptol (RV6J6604TK) ; Pancreatic Elastase (EC 3.4.21.36)
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2023.2224944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Synergistic Effect of

    Aly, Shaza H / Elissawy, Ahmed M / Mahmoud, Abdulla M A / El-Tokhy, Fatma Sa'eed / Mageed, Sherif S Abdel / Almahli, Hadia / Al-Rashood, Sara T / Binjubair, Faizah A / Hassab, Mahmoud A El / Eldehna, Wagdy M / Singab, Abd El-Nasser B

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Glycyrrhiza ... ...

    Abstract Glycyrrhiza glabra
    MeSH term(s) Flavonoids/pharmacology ; Flavonoids/analysis ; Sophora japonica ; Molecular Docking Simulation ; Glycogen Synthase Kinase 3 ; Ointments ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Glycyrrhiza/chemistry ; Wound Healing
    Chemical Substances Flavonoids ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Ointments ; Plant Extracts
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28072994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Insights into targeting SARS-CoV-2: design, synthesis,

    Mohamed, Abdalla R / Mostafa, Ahmed / El Hassab, Mahmoud A / Hedeab, Gomaa M / Mahmoud, Sara H / George, Riham F / Georgey, Hanan H / Abdel Gawad, Nagwa M / El-Ashrey, Mohamed K

    RSC medicinal chemistry

    2023  Volume 14, Issue 5, Page(s) 899–920

    Abstract: Aiming to achieve efficient activity against severe acute respiratory syndrome coronavirus (SARS-CoV-2), the expansion of the structure- and ligand-based drug design approaches was adopted, which has been recently reported by our research group. Purine ... ...

    Abstract Aiming to achieve efficient activity against severe acute respiratory syndrome coronavirus (SARS-CoV-2), the expansion of the structure- and ligand-based drug design approaches was adopted, which has been recently reported by our research group. Purine ring is a corner stone in the development of SARS-CoV-2 main protease (M
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00056g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: DFT and molecular simulation validation of the binding activity of PDEδ inhibitors for repression of oncogenic k-Ras.

    Majrashi, Taghreed A / Sabt, Ahmed / Almahli, Hadia / El Hassab, Mahmoud A / Noamaan, Mahmoud A / Elkaeed, Eslam B / Hamissa, Mohamed Farouk / Maslamani, Abdalkareem Nael / Shaldam, Moataz A / Eldehna, Wagdy M

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300035

    Abstract: The development of effective drugs targeting the K-Ras oncogene product is a significant focus in anticancer drug development. Despite the lack of successful Ras signaling inhibitors, recent research has identified PDEδ, a KRAS transporter, as a ... ...

    Abstract The development of effective drugs targeting the K-Ras oncogene product is a significant focus in anticancer drug development. Despite the lack of successful Ras signaling inhibitors, recent research has identified PDEδ, a KRAS transporter, as a potential target for inhibiting the oncogenic KRAS signaling pathway. This study aims to investigate the interactions between eight K-Ras inhibitors (deltarazine, deltaflexin 1 and 2, and its analogues) and PDEδ to understand their binding modes. The research will utilize computational techniques such as density functional theory (DFT) and molecular electrostatic surface potential (MESP), molecular docking, binding site analyses, molecular dynamic (MD) simulations, electronic structure computations, and predictions of the binding free energy. Molecular dynamic simulations (MD) will be used to predict the binding conformations and pharmacophoric features in the active site of PDEδ for the examined structures. The binding free energies determined using the MMPB(GB)SA method will be compared with the observed potency values of the tested compounds. This computational approach aims to enhance understanding of the PDEδ selective mechanism, which could contribute to the development of novel selective inhibitors for K-Ras signaling.
    MeSH term(s) Molecular Docking Simulation ; Proto-Oncogene Proteins p21(ras)/genetics ; Molecular Dynamics Simulation ; Binding Sites ; Catalytic Domain
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2.

    Majrashi, Taghreed A / El Hassab, Mahmoud A / Mahmoud, Sara H / Mostafa, Ahmed / Wahsh, Engy A / Elkaeed, Eslam B / Hassan, Fatma E / Eldehna, Wagdy M / Abdelgawad, Shimaa M

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0301086

    Abstract: There is still a great global need for efficient treatments for the management of SARS-CoV-2 illness notwithstanding the availability and efficacy of COVID-19 vaccinations. Olive leaf is an herbal remedy with a potential antiviral activity that could ... ...

    Abstract There is still a great global need for efficient treatments for the management of SARS-CoV-2 illness notwithstanding the availability and efficacy of COVID-19 vaccinations. Olive leaf is an herbal remedy with a potential antiviral activity that could improve the recovery of COVID-19 patients. In this work, the olive leaves major metabolites were screened in silico for their activity against SARS-CoV-2 by molecular docking on several viral targets such as methyl transferase, helicase, Plpro, Mpro, and RdRp. The results of in silico docking study showed that olive leaves phytoconstituents exhibited strong potential antiviral activity against SARS-CoV-2 selected targets. Verbacoside demonstrated a strong inhibition against methyl transferase, helicase, Plpro, Mpro, and RdRp (docking scores = -17.2, -20, -18.2, -19.8, and -21.7 kcal/mol.) respectively. Oleuropein inhibited 5rmm, Mpro, and RdRp (docking scores = -15, -16.6 and -18.6 kcal/mol., respectively) respectively. Apigenin-7-O-glucoside exhibited activity against methyl transferase and RdRp (docking score = -16.1 and -19.4 kcal/mol., respectively) while Luteolin-7-O-glucoside inhibited Plpro and RdRp (docking score = -15.2 and -20 kcal/mol., respectively). The in vitro antiviral assay was carried out on standardized olive leaf extract (SOLE) containing 20% oleuropein and IC50 was calculated. The results revealed that 20% SOLE demonstrated a moderate antiviral activity against SARS-CoV-2 with IC50 of 118.3 μg /mL. Accordingly, olive leaf could be a potential herbal therapy against SARS-CoV-2 but more in vivo and clinical investigations are recommended.
    MeSH term(s) Olea/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; SARS-CoV-2/drug effects ; Plant Leaves/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Molecular Docking Simulation ; Iridoids/pharmacology ; Iridoids/chemistry ; Humans ; Iridoid Glucosides/pharmacology ; Iridoid Glucosides/chemistry ; Glucosides/pharmacology ; Glucosides/chemistry ; Methyltransferases/metabolism ; Methyltransferases/antagonists & inhibitors ; COVID-19/virology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Coronavirus 3C Proteases/chemistry ; Computer Simulation ; COVID-19 Drug Treatment ; Luteolin/pharmacology ; Luteolin/chemistry ; RNA Helicases/metabolism ; RNA Helicases/antagonists & inhibitors ; Apigenin/pharmacology ; Apigenin/chemistry ; Polyphenols
    Chemical Substances Antiviral Agents ; Plant Extracts ; Iridoids ; Iridoid Glucosides ; oleuropein (2O4553545L) ; Glucosides ; acteoside (3TGX09BD5B) ; luteolin-7-glucoside (98J6XDS46I) ; Methyltransferases (EC 2.1.1.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Luteolin (KUX1ZNC9J2) ; RNA Helicases (EC 3.6.4.13) ; Apigenin (7V515PI7F6) ; Polyphenols
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cutaneous macroglobulinosis with Waldenström macroglobulinemia.

    Hassab-El-Naby, Hussein M M / El-Khalawany, Mohamed / Rageh, Mahmoud A

    JAAD case reports

    2020  Volume 6, Issue 8, Page(s) 771–775

    Language English
    Publishing date 2020-06-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2020.06.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Antioxidant and Enzyme Inhibitory Potential of

    Fayez, Shaimaa / Zengin, Gokhan / Al-Rashood, Sara T / El Hassab, Mahmoud A / Eldehna, Wagdy M / Dall'Acqua, Stefano / Eldahshan, Omayma A

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: ... Duranta ... ...

    Abstract Duranta erecta
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11101937
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