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  1. Article: RNA folding kinetics control riboswitch sensitivity in vivo.

    Bushhouse, David Z / Fu, Jiayu / Lucks, Julius B

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Riboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity is controlled is critical to understanding how highly conserved aptamer domains are ... ...

    Abstract Riboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity is controlled is critical to understanding how highly conserved aptamer domains are deployed in a variety of contexts with different sensitivity demands. Here we uncover new roles by which RNA folding dynamics control riboswitch sensitivity in cells. By investigating the
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.29.587317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thickness ranges calculation method of double asphalt overlay on concrete pavement.

    Fu, Xiang / Huang, Jiayu / Ban, Yuxin / Duan, Jun / Xie, Jianuo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4939

    Abstract: Asphalt overlay is widely used in maintaining and rehabilitating highway system performance. However, explicit calculation methods for the asphalt overlay thickness range is lacking. Taking stone mastic asphalt (SMA) and asphalt concrete (AC) asphalt ... ...

    Abstract Asphalt overlay is widely used in maintaining and rehabilitating highway system performance. However, explicit calculation methods for the asphalt overlay thickness range is lacking. Taking stone mastic asphalt (SMA) and asphalt concrete (AC) asphalt overlay on cement concrete pavement as examples, the paper proposed a design method for the asphalt overlay thickness range based on the shear performance of the interlayer. Firstly, the shear stress distribution regularities on the asphalt overlay and Portland cement concrete interlayer was calculated with a multilayer elastic theory. Meanwhile, the shear strength was obtained from a series of direct shear tests. The shear characters of the asphalt overlay met with the Mohr-Coulomb criterion, and the shear strength parameters cohesive force
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54827-x
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  3. Article ; Online: Polydopamine-Mediated Metal-Organic Frameworks Modification for Improved Biocompatibility.

    Feng, Jiayu / Xu, Liwang / Qi, Lulu / Fu, Zhengwei / Hu, Qinglian

    Macromolecular bioscience

    2024  , Page(s) e2400071

    Abstract: Engineered nanomaterials are promising in biomedical application. However, insufficient understanding of their biocompatibility at the cellular and organic levels prevents their widely biomedical applications. Metal-organic frameworks (MOFs) have ... ...

    Abstract Engineered nanomaterials are promising in biomedical application. However, insufficient understanding of their biocompatibility at the cellular and organic levels prevents their widely biomedical applications. Metal-organic frameworks (MOFs) have attracted increasing attention in recent years. In this work, zeolitic imidazolate framework-8 (ZIF-8) and polydopamine (PDA)-modified ZIF-8 are chosen as model nanomaterials due to its emergent role in nanomedicine. In vitro, the results demonstrate that the PDA coating greatly alleviates the cytotoxicity of ZIF-8 to RAW264.7, LO2, and HST6, which represent three different cell types in liver organs. Mechanistically, ZIF-8 entering into the cells can greatly induce the reactive oxygen species generation, which subsequently induces cell cycle delay and autophagy, ultimately leads to enhanced cytotoxicity. Further, human umbilical vein endothelial cells model and zebrafish embryos assay also confirm that PDA can compromise the ZIF-8 toxicity significantly. This study reveals that PDA-coated MOFs nanomaterials show great potential in nano-based drug delivery systems .
    Language English
    Publishing date 2024-04-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039130-4
    ISSN 1616-5195 ; 1616-5187
    ISSN (online) 1616-5195
    ISSN 1616-5187
    DOI 10.1002/mabi.202400071
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  4. Article ; Online: A Review of Recent Progress in Drug Doping and Gene Doping Control Analysis.

    Lu, Yuze / Yan, Jiayu / Ou, Gaozhi / Fu, Li

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 14

    Abstract: The illicit utilization of performance-enhancing substances, commonly referred to as doping, not only infringes upon the principles of fair competition within athletic pursuits but also poses significant health hazards to athletes. Doping control ... ...

    Abstract The illicit utilization of performance-enhancing substances, commonly referred to as doping, not only infringes upon the principles of fair competition within athletic pursuits but also poses significant health hazards to athletes. Doping control analysis has emerged as a conventional approach to ensuring equity and integrity in sports. Over the past few decades, extensive advancements have been made in doping control analysis methods, catering to the escalating need for qualitative and quantitative analysis of numerous banned substances exhibiting diverse chemical and biological characteristics. Progress in science, technology, and instrumentation has facilitated the proliferation of varied techniques for detecting doping. In this comprehensive review, we present a succinct overview of recent research developments within the last ten years pertaining to these doping detection methodologies. We undertake a comparative analysis, evaluating the merits and limitations of each technique, and offer insights into the prospective future advancements in doping detection methods. It is noteworthy that the continual design and synthesis of novel synthetic doping agents have compelled researchers to constantly refine and innovate doping detection methods in order to address the ever-expanding range of covertly employed doping agents. Overall, we remain in a passive position for doping detection and are always on the road to doping control.
    MeSH term(s) Humans ; Doping in Sports/prevention & control ; Sports ; Performance-Enhancing Substances ; Athletes ; Technology ; Substance Abuse Detection/methods
    Chemical Substances Performance-Enhancing Substances
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28145483
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  5. Article: Editorial: Human decision-making behaviors in engineering and management: A neuropsychological perspective.

    Fu, Hanliang / Ye, Gui / Chen, Jiayu / Liao, Pin-Chao

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 1062171

    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1062171
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  6. Article: Ado-tratuzumab emtansine beyond breast cancer: therapeutic role of targeting other HER2-positive cancers.

    Zheng, Yang / Zou, Jiayu / Sun, Chen / Peng, Fu / Peng, Cheng

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1165781

    Abstract: Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved by the FDA in 2013 for advanced HER2-positive breast cancer treatment exhibiting promising clinical benefits. However, HER2 overexpression and gene amplification have also been ... ...

    Abstract Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved by the FDA in 2013 for advanced HER2-positive breast cancer treatment exhibiting promising clinical benefits. However, HER2 overexpression and gene amplification have also been reported in other cancers like gastric cancer, non-small cell lung cancer (NSCLC), and colorectal cancer
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1165781
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  7. Article ; Online: Sodium-glucose co-transporter 1 promotes the bio-functions of perivascular preadipocytes mediated by Akt/mTOR/p70S6K signaling pathway.

    Liu, Zhiquan / Wang, Jiayu / Tian, Peiqing / Liu, Yixuan / Xing, Liyun / Fu, Caihua / Huang, Xianwei / Liu, Ping

    American journal of physiology. Cell physiology

    2024  

    Abstract: The influence of SGLT-1 on perivascular preadipocytes (PVPACs) and vascular remodeling is not well understood. This study aimed to elucidate the role and mechanism of SGLT-1-mediated PVPACs bioactivity. PVPACs were ... ...

    Abstract The influence of SGLT-1 on perivascular preadipocytes (PVPACs) and vascular remodeling is not well understood. This study aimed to elucidate the role and mechanism of SGLT-1-mediated PVPACs bioactivity. PVPACs were cultured
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00606.2023
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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  8. Article ; Online: Does deception involve more cognitive control than truth-telling? Meta-analyses of N2 and MFN ERP studies.

    Sai, Liyang / Cheng, Jiayu / Shang, Siyuan / Fu, Genyue / Verschuere, Bruno

    Psychophysiology

    2023  Volume 60, Issue 10, Page(s) e14333

    Abstract: A number of psychological theories propose that deception involves more cognitive control than truth-telling. Over the last decades, event-related potentials (ERPs) have been used to unravel this question, but the findings are mixed. To address this ... ...

    Abstract A number of psychological theories propose that deception involves more cognitive control than truth-telling. Over the last decades, event-related potentials (ERPs) have been used to unravel this question, but the findings are mixed. To address this controversy, two meta-analyses were conducted to quantify the results of existing studies reporting N2 or medial frontal negativity (MFN) associated with deception. In total, 32 papers consisting of 1091 participants were included, which yielded 32 effect sizes for N2 and 7 effect sizes for MFN. We found that deception was associated with a more negative N2 and MFN than truth-telling with medium and large effect sizes (r = .25 and .51, respectively). We also found that the deception paradigm modulated the results (p = .043), but found no evidence for publication bias. Our findings indicate that deception involves more cognitive control than truth-telling. Our review also identifies gaps in this literature, including a need for more ERP studies using spontaneous deception.
    MeSH term(s) Humans ; Deception ; Evoked Potentials ; Cognition
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.14333
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 502: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Analysis of the current state of cervical cancer prevention awareness and its influencing factors among rural women in Luohe City.

    Zhang, Qingwei / Zhang, Weikai / Xu, Tenghan / Song, Jiayu / Li, Suhong / Zhang, Hewei / Fu, Xiuhong

    Medicine

    2024  Volume 103, Issue 7, Page(s) e35136

    Abstract: The purpose of this cross-sectional study was to identify the current awareness about cervical cancer prevention among rural women in Luohe City as well as its potential influencing factors. Meanwhile, these data were expected to provide a theoretical ... ...

    Abstract The purpose of this cross-sectional study was to identify the current awareness about cervical cancer prevention among rural women in Luohe City as well as its potential influencing factors. Meanwhile, these data were expected to provide a theoretical basis for Luohe future cervical cancer prevention and therapy. Based on geographical distribution, 40 villages in Luohe City were randomly selected, and questionnaires were given to women in each village. In this study, a total of 4665 questionnaires were distributed, and 4561 valid questionnaires were returned, with a recovery rate of 97.98%. The average score was 4.06 ± 2.46 out of 10. It was found that women had a high awareness rate of cervical cancer screening (55.25%) but a low awareness rate of human papillomavirus (HPV) and HPV vaccine (10.17%). Moreover, univariate and multivariable analyses showed that age > 45 years, low household income, low education level, being a farmer, spouse unemployment, no pregnancy or birth delivery history, no family or personal history of cervical disease, and no previous complimentary 2-cancer screening (i.e., breast cancer and cervical cancer) were all factors influencing the cognitive level of rural women in Luohe City (P < .05). However, ethnicity, marital status, and spouse education level were not correlated with cognitive level (P > .05). In conclusion, low awareness of cervical cancer prevention among rural women in Luohe was correlated with individual, family, and social factors. So it was recommended to cultivate the rural population knowledge, optimize screening strategies, and conduct targeted cervical cancer prevention and treatment in rural regions.
    MeSH term(s) Humans ; Female ; Middle Aged ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Rural Population ; Cross-Sectional Studies ; Early Detection of Cancer/psychology ; Surveys and Questionnaires ; Papillomavirus Infections/epidemiology ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000035136
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    Ua VI Zs.171: Show issues Location:
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  10. Article ; Online: Effects of cycloplegia on crystalline lens morphology and location in acute acquired concomitant esotropia.

    Chen, Weibin / Liu, Jiawen / Dai, Wei / Hao, Jie / Chen, Jiayu / Fu, Jing

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2024  

    Abstract: Purpose: The study aims to compare morphology and location of crystalline lens between acute acquired concomitant esotropia (AACE) patients and control subjects, both before and after cycloplegia.: Methods: This is a prospective and observational ... ...

    Abstract Purpose: The study aims to compare morphology and location of crystalline lens between acute acquired concomitant esotropia (AACE) patients and control subjects, both before and after cycloplegia.
    Methods: This is a prospective and observational clinical study. Morphological and locational parameters of the crystalline lens in 53 AACE patients and 32 control subjects were assessed before and after cycloplegia using CASIA2 system, which represents the latest swept-source anterior segment optical coherence tomography. Cycloplegic refraction was recorded by administering 1% atropine in patients younger than 12 years and 1% cyclopentolate in those > 12 years old. Morphological parameters included anterior radius of curvature (ARC), posterior radius of curvature (PRC), lens thickness (LTH), and equivalent diameter of lens (LED). Locational parameters comprised lens decentration (LD) and lens tilt (LT). Comparison of these parameters before and after cycloplegia were conducted between AACE and controls. Additionally, the study analyzed and compared the changes in these parameter post-cycloplegia.
    Results: Our findings suggest no significant difference in morphological parameters including ARC, PRC, LTH and LED between AACE patients and controls before or after cycloplegia. However, 2D-modeling data in the 0° meridian revealed that variation post-cycloplegia of LD (lens shift) in right eyes was different in AACE patients, measuring - 0.03(0.08) [median(interquartile range)] which was significantly distinct from the control group, exhibiting a measurement of 0.01(0.06) (z =  - 2.373, p = 0.018). In left eyes, a similar trend was observed with lens shift in the 0° meridian being 0.02(0.06) in AACE, significantly differing from control group's measurement of - 0.02(0.08) (z =  - 2.809, p = 0.005). Further, correlation analysis revealed that larger temporal shift of lens was associated with greater changes in ARC (r = 0.294, p = 0.006) and LTH (r =  - 0.230, p = 0.031).
    Conclusions: The morphological features of the crystalline lens were similar in AACE patients and controls; however, the change of lens location by cycloplegia was observed only in AACE patients, suggesting an association with excessive accommodation.
    Language English
    Publishing date 2024-04-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-024-06484-z
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