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  1. Article ; Online: The fate of drug discovery in academia; dumping in the publication landfill?

    Saqib, Uzma / Demaree, Isaac S / Obukhov, Alexander G / Baig, Mirza S / Ariel, Amiram / Hajela, Krishnan

    Oncotarget

    2024  Volume 15, Page(s) 31–34

    MeSH term(s) Humans ; Academia ; Drug Discovery ; Drug Industry ; Waste Disposal Facilities
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Endovascular repair of traumatic axillary artery transection associated with scapulothoracic dissociation complicated by stent separation.

    Shih, Michael / Lee, K Benjamin / Baig, Mirza S / Klein, Andrea / Rodriguez, Alejandra / Kirkwood, Melissa

    Journal of vascular surgery cases and innovative techniques

    2023  Volume 9, Issue 1, Page(s) 101110

    Abstract: We report the case of a 23-year-old female pedestrian who had been struck by a car and had presented with axillary artery transection in the setting of scapulothoracic dissociation. The initial endovascular repair was compromised by her shoulder ... ...

    Abstract We report the case of a 23-year-old female pedestrian who had been struck by a car and had presented with axillary artery transection in the setting of scapulothoracic dissociation. The initial endovascular repair was compromised by her shoulder instability and had required the addition of bridging stent placement. Caution is advised with endovascular repair in this clinical scenario because of possible stent separation.
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Case Reports
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2023.101110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Matrix metalloproteinase-8 (MMP-8) regulates the activation of hepatic stellate cells (HSCs) through the ERK-mediated pathway.

    Naim, Adnan / Baig, Mirza S

    Molecular and cellular biochemistry

    2020  Volume 467, Issue 1-2, Page(s) 107–116

    Abstract: Hepatic stellate cells (HSCs) are known to play a key role in the progression of liver fibrosis by producing excessive extracellular matrix (ECM). Matrix metalloproteinases (MMPs) belong to a family of endopeptidases, which have a well-established role ... ...

    Abstract Hepatic stellate cells (HSCs) are known to play a key role in the progression of liver fibrosis by producing excessive extracellular matrix (ECM). Matrix metalloproteinases (MMPs) belong to a family of endopeptidases, which have a well-established role in the degradation of ECM. Our study suggests that, besides the degradation of the extracellular matrix, matrix metalloproteinase-8 (MMP-8) has a non-canonical role in activating the quiescent HSCs to myofibroblasts by regulating the expression of Col1A1 and αSMA. We have identified that MMP-8 secreted from macrophages as a response to LPS stimulation activates HSCs via ERK1/2-dependent pathway. In addition to this, we determined that MMP-8 may regulate the homodimerization of c-Jun in LX-2 cells, during the trans-differentiation process from quiescent HSC to activate myofibroblasts. Macrophage-released MMP-8 plays a master role in activating the dormant HSCs to activate myofibroblasts through the Erk-mediated pathway and Jun cellular translocation leading to liver fibrosis. Significance MMP-8 can be used as a therapeutic target against liver fibrosis.
    MeSH term(s) Cell Culture Techniques ; Cell Transdifferentiation ; Collagen Type I/metabolism ; Hepatic Stellate Cells/cytology ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Humans ; Lipopolysaccharides/adverse effects ; MAP Kinase Signaling System ; Matrix Metalloproteinase 8/metabolism ; Myofibroblasts/cytology ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Protein Multimerization ; Proto-Oncogene Proteins c-jun/chemistry ; Survival of Motor Neuron 1 Protein/metabolism ; THP-1 Cells
    Chemical Substances Collagen Type I ; JUN protein, human ; Lipopolysaccharides ; Proto-Oncogene Proteins c-jun ; SMN1 protein, human ; Survival of Motor Neuron 1 Protein ; collagen type I, alpha 1 chain ; MMP8 protein, human (EC 3.4.24.34) ; Matrix Metalloproteinase 8 (EC 3.4.24.34)
    Language English
    Publishing date 2020-02-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-020-03705-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 892: Show issues Location:
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  4. Article ; Online: Editorial: Targeting signalling pathways in inflammatory diseases.

    Baig, Mirza S / Thurston, Teresa L M / Sharma, Rahul / Atre, Rajat / Saqib, Uzma / Khabiya, Rakhi / Bharti, Shreya / Poh, Chit L

    Frontiers in immunology

    2023  Volume 14, Page(s) 1241440

    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1241440
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  5. Article: Up and over staged endoconduit technique for endovascular aortic aneurysm repair.

    Figueroa, Andres V / Tanenbaum, Mira T / Costa-Filho, Jose Eduardo / Gonzalez, Marilisa S / Baig, Mirza S / Timaran, Carlos H

    Journal of vascular surgery cases and innovative techniques

    2024  Volume 10, Issue 3, Page(s) 101449

    Abstract: Adverse iliofemoral anatomy can preclude complex endovascular aortic aneurysm repair. This study aims to describe the "up-and-over" staged endoconduit technique to improve access and avoid vascular injury before complex endovascular aneurysm repair. A ... ...

    Abstract Adverse iliofemoral anatomy can preclude complex endovascular aortic aneurysm repair. This study aims to describe the "up-and-over" staged endoconduit technique to improve access and avoid vascular injury before complex endovascular aneurysm repair. A staged procedure for complex endovascular aortic aneurysm repair is performed using an endoconduit (W.L. Gore & Associates). After obtaining contralateral femoral access, the extension of iliofemoral disease is assessed using angiography. The endoconduit is advanced "up and over" the aortic bifurcation and delivered percutaneously into the common femoral artery to treat a diseased access site and maintain intact the ipsilateral femoral access for future stent graft deployment. Internal iliac artery patency is maintained when feasible. During complex aneurysm repair, the endoconduit is accessed directly under ultrasound guidance using sequential dilation to avoid vascular injury. PerClose sutures (Abbott Vascular) are used to close the endoconduit femoral access site. This study found that staged "up and over" endoconduit creation is a useful technique before complex endovascular aneurysm repair in patients with adverse iliofemoral anatomy. Avoiding accessing the main femoral access site during the first stage prevents vascular or access site injuries and allows for both iliac and femoral disease to be addressed.
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2024.101449
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  6. Article: Editorial: Lipids and inflammation in health and disease, volume II.

    Bezsonov, Evgeny / Baig, Mirza S / Bukrinsky, Michael / Myasoedova, Veronika / Ravani, Alessio / Sukhorukov, Vasily / Zhang, Dongwei / Khotina, Victoria / Orekhov, Alexander

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1174902

    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1174902
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  7. Article ; Online: An improved mouse model of sepsis based on intraperitoneal injections of the enriched culture of cecum slurry.

    Atre, Rajat / Sharma, Rahul / Obukhov, Alexander G / Saqib, Uzma / Umar, Sadiq / Darwhekar, Gajanan N / Baig, Mirza S

    Life sciences

    2024  Volume 345, Page(s) 122584

    Abstract: Aim: Sepsis is a life-threatening clinical syndrome comprising multiorgan dysfunctions caused by a disproportionate body immune response. There are several animal sepsis models which are based on cecum ligation, cecal puncture, and cecum slurry ... ...

    Abstract Aim: Sepsis is a life-threatening clinical syndrome comprising multiorgan dysfunctions caused by a disproportionate body immune response. There are several animal sepsis models which are based on cecum ligation, cecal puncture, and cecum slurry injection. The major limitation of all current sepsis models is the high variability owing to the variable degree of ligation, puncture and inconsistent microbial composition used for sepsis initiation. The primary objective of this work is to demonstrate the feasibility of a standardized method for sepsis development.
    Materials and methods: The cecal slurry bacterial culture was developed and preserved in glycerol stocks. Antibiotics aztreonam and vancomycin were used for generating several defined, enriched cecal slurry bacterial cultures. Mice survival was assessed until 48 hrs post injection, and the tissue samples were collected after 10 hrs from sepsis initiation.
    Key findings: The results indicate that increasing polymicrobial load resulted in lower survival rates and was associated with the higher number of infiltrating immune cells and necrosis. H&E (haematoxylin & eosin) staining & serum markers revealed that septic mice exhibited increased inflammation and significant damage to the liver and kidneys. The defined Gram-negative and Gram-positive specific cecal slurry bacterial cultures were developed and their efficiency in inducing sepsis was characterized.
    Significance: Enriched cecal slurry bacterial cultures can be stored in glycerol stocks at -80 °C. This has an ethical advantage of avoiding unnecessary animal euthanasia for each experiment and provides a standardization capability of sepsis development.
    MeSH term(s) Mice ; Animals ; Injections, Intraperitoneal ; Glycerol ; Sepsis/drug therapy ; Inflammation/complications ; Disease Models, Animal ; Cecum ; Ligation/adverse effects
    Chemical Substances Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2024.122584
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
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  8. Article ; Online: Effect of reactive oxygen, nitrogen, and sulfur species on signaling pathways in atherosclerosis.

    Solanki, Kundan / Bezsonov, Evgeny / Orekhov, Alexander / Parihar, Suraj P / Vaja, Shivani / White, Fletcher A / Obukhov, Alexander G / Baig, Mirza S

    Vascular pharmacology

    2024  Volume 154, Page(s) 107282

    Abstract: Atherosclerosis is a chronic inflammatory disease in which fats, lipids, cholesterol, calcium, proliferating smooth muscle cells, and immune cells accumulate in the intima of the large arteries, forming atherosclerotic plaques. A complex interplay of ... ...

    Abstract Atherosclerosis is a chronic inflammatory disease in which fats, lipids, cholesterol, calcium, proliferating smooth muscle cells, and immune cells accumulate in the intima of the large arteries, forming atherosclerotic plaques. A complex interplay of various vascular and immune cells takes place during the initiation and progression of atherosclerosis. Multiple reports indicate that tight control of reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) production is critical for maintaining vascular health. Unrestricted ROS and RNS generation may lead to activation of various inflammatory signaling pathways, facilitating atherosclerosis. Given these deleterious consequences, it is important to understand how ROS and RNS affect the signaling processes involved in atherogenesis. Conversely, RSS appears to exhibit an atheroprotective potential and can alleviate the deleterious effects of ROS and RNS. Herein, we review the literature describing the effects of ROS, RNS, and RSS on vascular smooth muscle cells, endothelial cells, and macrophages and focus on how changes in their production affect the initiation and progression of atherosclerosis. This review also discusses the contribution of ROS, RNS, and RSS in mediating various post-translational modifications, such as oxidation, nitrosylation, and sulfation, of the molecules involved in inflammatory signaling.
    MeSH term(s) Humans ; Reactive Oxygen Species/metabolism ; Oxygen ; Nitrogen ; Endothelial Cells/metabolism ; Signal Transduction ; Reactive Nitrogen Species/metabolism ; Sulfur ; Atherosclerosis
    Chemical Substances Reactive Oxygen Species ; Oxygen (S88TT14065) ; Nitrogen (N762921K75) ; Reactive Nitrogen Species ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2024.107282
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Transcatheter electrosurgical septotomy technique for chronic postdissection aortic aneurysms.

    Baghbani-Oskouei, Aidin / Savadi, Safa / Mesnard, Thomas / Sulzer, Titia / Mirza, Aleem K / Baig, Shadman / Timaran, Carlos H / Oderich, Gustavo S

    Journal of vascular surgery cases and innovative techniques

    2023  Volume 10, Issue 2, Page(s) 101402

    Abstract: Aortic dissection often results in chronic aneurysmal degeneration due to progressive false lumen expansion. Thoracic endovascular aortic repair and other techniques of vessel incorporation such as fenestrated-branched or parallel grafts have been ... ...

    Abstract Aortic dissection often results in chronic aneurysmal degeneration due to progressive false lumen expansion. Thoracic endovascular aortic repair and other techniques of vessel incorporation such as fenestrated-branched or parallel grafts have been increasingly used to treat chronic postdissection aneurysms. True lumen compression or a vessel origin from the false lumen can present considerable technical challenges. In these cases, the limited true lumen space can result in inadequate stent graft expansion or restrict the ability to reposition the device or manipulate catheters. Reentrance techniques can be used selectively to assist with target vessel catheterization. Transcatheter electrosurgical septotomy is a novel technique that has evolved from the cardiology experience with transseptal or transcatheter aortic valve procedures. This technique has been applied in select patients with chronic dissection to create a proximal or distal landing zone, disrupt the septum in patients with an excessively compressed true lumen, or connect the true and false lumen in patients with vessels that have separate origins. In the present report, we summarize the indications and technical pitfalls of transcatheter electrosurgical septotomy in patients treated by endovascular repair for chronic postdissection aortic aneurysms.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2023.101402
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  10. Article: Successful Primary Treatment of Ankle Fractures in Diabetic Patients with Peripheral Neuropathy Using a Tibiotalocalcaneal Nail: A Case Series.

    Baig, Mirza Shahid / Mehta, Samir / Morales, Daniela S / Maniar, Hemil H / Dahodwala, Taikhoom / Horwitz, Daniel Scott

    Indian journal of orthopaedics

    2023  Volume 57, Issue 7, Page(s) 1068–1075

    Abstract: Background: Among diabetics, patients with peripheral neuropathy are at increased risk of developing complications following an ankle fracture. While the outcomes in these patients treated nonoperatively have been poor, the outcomes in those undergoing ... ...

    Abstract Background: Among diabetics, patients with peripheral neuropathy are at increased risk of developing complications following an ankle fracture. While the outcomes in these patients treated nonoperatively have been poor, the outcomes in those undergoing open reduction and internal fixation are at the best modest. We hypothesize that closed reduction and internal fixation with tibiotalocalcaneal nail is an effective primary procedure in this complication prone patient group.
    Methods: A retrospective review of diabetic patients with peripheral neuropathy who underwent acute treatment of an ankle fracture with closed reduction and internal fixation with a tibiotalocalcaneal nail at two Level 1 trauma centers was performed. 30 patients were identified and divided into 2 groups with respect to their postoperative weight bearing protocol: 20 patients in the early weight bearing (EWB) group and 10 patients in the touch-down weight bearing (TDWB). The primary outcome was the rate of return to baseline function and the secondary outcomes included the incidence of wound dehiscence, wound infection, implant failure, loss of fixation, loss of reduction and amputation.
    Results: In the EWB group, 15/20 patients returned to their baseline function, 5/20 had wound dehiscence and infection, 2/20 had implant failure, 5/20 had loss of fixation, 4/20 had loss of reduction, and 4/20 underwent amputation. In the TDWB group, 9/10 patients returned to their baseline function, 1/10 had implant failure, 1/10 had loss of fixation. No patients from this group had loss of reduction or underwent amputation.
    Conclusion: Treatment with tibiotalocalcaneal nail is an effective primary procedure in this complication prone group of patients, assuming that weight bearing is delayed for six weeks to protect soft tissues and surgical incisions.
    Level of evidence: Level IV, retrospective case series.
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 603194-8
    ISSN 0019-5413
    ISSN 0019-5413
    DOI 10.1007/s43465-023-00882-x
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