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Article ; Online: Simultaneous high-performance liquid chromatography analysis of anthraquinones in sicklepod sprouts with α-glucosidase inhibitory activity.

Muraoka, Takuya / Imahori, Daisuke / Miyagi, Rina / Shinohara, Naoki / Tanaka, Hiroyuki

2024

Abstract: Introduction: Sicklepod [Cassia obtusifolia L. syn Senna obtusifolia (L.) H.S. Irwin & Barneby, Fabaceae] sprouts are promising ingredients with health-promoting benefits. Notwithstanding, the pharmacologically active compounds in sicklepod sprouts have ...

Abstract	Introduction: Sicklepod [Cassia obtusifolia L. syn Senna obtusifolia (L.) H.S. Irwin & Barneby, Fabaceae] sprouts are promising ingredients with health-promoting benefits. Notwithstanding, the pharmacologically active compounds in sicklepod sprouts have not been studied or analysed in detail. Objective: This study aimed to isolate and structurally identify phytochemicals showing α-glucosidase inhibitory activity in sicklepod sprouts and simultaneously quantify the compounds in the sprouts to determine the optimal cultivation method and germination time to maximise active compounds. Method: A simultaneous high-performance liquid chromatography-ultraviolet (HPLC-UV) method with high sensitivity and accuracy was developed and used to analyse time-dependent changes in anthraquinone content during sicklepod germination. Results: Thirteen anthraquinones were isolated and identified, of which six-chrysoobtusin, emodin, 1-O-methyl-2-methoxychrysophanol, 7-O-methylobtusin, chrysophanol, and physcion-showed moderate α-glucosidase inhibitory activity. The maximum content of anthraquinones in a sprout was observed on Day 5 under both light and dark conditions. Conclusion: The findings of this study revealed that sicklepod sprouts which are promising functional food materials contain a variety of anthraquinones.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3353
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Zs.A 4608: Show issues

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Article ; Online: Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance.

Muraoka, Daisuke / Harada, Naozumi / Shiku, Hiroshi / Akiyoshi, Kazunari

Journal of controlled release : official journal of the Controlled Release Society

2022 Volume 347, Page(s) 175–182

Abstract: In therapeutic cancer vaccines, vaccine antigens must be efficiently delivered to the antigen-presenting cells (dendritic cells and macrophages) located in the lymphoid organs (lymph nodes and spleen) at the appropriate time to induce a potent antitumor ... ...

Abstract	In therapeutic cancer vaccines, vaccine antigens must be efficiently delivered to the antigen-presenting cells (dendritic cells and macrophages) located in the lymphoid organs (lymph nodes and spleen) at the appropriate time to induce a potent antitumor immune response. Nanoparticle-based delivery systems in cancer immunotherapy are of great interest in recent year. We have developed a novel cancer vaccine that can use self-assembled polysaccharide nanogel of cholesteryl group-modified pullulan (CHP) as an antigen delivery system for clinical cancer immunotherapy for the first time. Additionally, we recently proposed a novel technology that uses CHP nanogels to regulate the function of tumor-associated macrophages, leading to an improvement in the tumor microenvironment. When combined with other immunotherapies, macrophage function modulation using CHP nanogels demonstrated a potent inhibitory effect against cancers resistant to immune checkpoint inhibition therapies. In this review, we discuss the applications of our unique drug nanodelivery system for CHP nanogels.
MeSH term(s)	Antigens ; Cancer Vaccines ; Humans ; Nanogels ; Neoplasms/drug therapy ; Polyethylene Glycols ; Polyethyleneimine ; Polysaccharides ; Tumor Microenvironment
Chemical Substances	Antigens ; Cancer Vaccines ; Nanogels ; Polysaccharides ; polyethylene glycol polyethyleneimine nanogel ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyethyleneimine (9002-98-6)
Language	English
Publishing date	2022-05-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.05.004
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Zs.A 2055: Show issues

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Article: Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance

Muraoka, Daisuke / Harada, Naozumi / Shiku, Hiroshi / Akiyoshi, Kazunari

Journal of controlled release. 2022 July, v. 347

2022

Abstract	In therapeutic cancer vaccines, vaccine antigens must be efficiently delivered to the antigen-presenting cells (dendritic cells and macrophages) located in the lymphoid organs (lymph nodes and spleen) at the appropriate time to induce a potent antitumor immune response. Nanoparticle-based delivery systems in cancer immunotherapy are of great interest in recent year. We have developed a novel cancer vaccine that can use self-assembled polysaccharide nanogel of cholesteryl group-modified pullulan (CHP) as an antigen delivery system for clinical cancer immunotherapy for the first time. Additionally, we recently proposed a novel technology that uses CHP nanogels to regulate the function of tumor-associated macrophages, leading to an improvement in the tumor microenvironment. When combined with other immunotherapies, macrophage function modulation using CHP nanogels demonstrated a potent inhibitory effect against cancers resistant to immune checkpoint inhibition therapies. In this review, we discuss the applications of our unique drug nanodelivery system for CHP nanogels.
Keywords	antigens ; cancer vaccines ; immune response ; immunotherapy ; lymph ; macrophages ; nanogels ; neoplasms ; pullulan ; spleen
Language	English
Dates of publication	2022-07
Size	p. 175-182.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.05.004
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2055: Show issues

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Article ; Online: Changes in serum DAMPs and cytokines/chemokines during near-infrared photoimmunotherapy for patients with head and neck cancer.

Ishihara, Hiromasa / Nishikawa, Daisuke / Muraoka, Daisuke / Masago, Katsuhiro / Beppu, Shintaro / Terada, Hoshino / Matsushita, Hirokazu / Hanai, Nobuhiro

Cancer medicine

2023

Abstract: Background: Near-infrared photoimmunotherapy (NIR-PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR-PIT in real clinical settings.: Methods: Seven NIR-PIT sessions were ... ...

Abstract	Background: Near-infrared photoimmunotherapy (NIR-PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR-PIT in real clinical settings. Methods: Seven NIR-PIT sessions were administered to five patients with head and neck squamous cell carcinoma (HNSCC). Serum damage-associated molecular patterns (DAMPs) (HMGB1 and Hsp70 levels), and cytokine and chemokine production, were compared before and after NIR-PIT. Results: The serum concentration of HMGB1 increased after NIR-PIT (p = 0.031, Wilcoxon test) in all patients except one who did not achieve a clinical response. Chemokines MIP-1α (CCL3) and MIP-1β (CCL4) increased significantly 1-3 days after treatment (CCL3, p = 0.0036; CCL4, p = 0.0016, Wilcoxon test). A low pre-treatment neutrophil-to-lymphocyte ratio (NLR) was associated with a better response to therapy and survival. Conclusions: The release of DAMPs, and cytokine/chemokine production, were detected in the patients' peripheral blood. The baseline NLR may predict patient outcomes in response to NIR-PIT.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6863
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Article ; Online: A Predictive Model for Cancer-Associated Thrombosis in Japanese Cancer Patients: Findings from the J-Khorana Registry.

Shoji, Masaaki / Yamashita, Yugo / Ishii, Masanobu / Inoue, Hitoki / Kato, Hiroshi / Fujita, Shin / Matsui, Kazuhiro / Tajiri, Kazuko / Nameki, Mizuo / Muraoka, Nao / Nonaka, Akiko / Sugino, Hiroshi / Kono, Mihoko / Oka, Toru / Sueta, Daisuke / Komuro, Issei / Tsujita, Kenichi

TH open : companion journal to thrombosis and haemostasis

2024 Volume 8, Issue 1, Page(s) e9–e18

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-01-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2901738-5
ISSN	2512-9465 ; 2567-3459
ISSN (online)	2512-9465
ISSN	2567-3459
DOI	10.1055/a-2207-7715
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Zs.A 7138: Show issues

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Article ; Online: Transgenerational acclimation to acidified seawater and gene expression patterns in a sea urchin.

Iguchi, Akira / Gibu, Kodai / Yorifuji, Makiko / Nishijima, Miyuki / Suzuki, Atsushi / Ono, Tsuneo / Matsumoto, Yukio / Inoue, Mayuri / Fujii, Masahiko / Muraoka, Daisuke / Fujita, Yamato / Takami, Hideki

The Science of the total environment

2024 Volume 930, Page(s) 172616

Abstract: Transgenerational responses of susceptible calcifying organisms to progressive ocean acidification are an important issue in reducing uncertainty of future predictions. In this study, a two-generation rearing experiment was conducted using mature ... ...

Abstract	Transgenerational responses of susceptible calcifying organisms to progressive ocean acidification are an important issue in reducing uncertainty of future predictions. In this study, a two-generation rearing experiment was conducted using mature Mesocentrotus nudus, a major edible sea urchin that occurs along the coasts of northern Japan. Morphological observations and comprehensive gene expression analysis (RNA-seq) of resulting larvae were performed to examine transgenerational acclimation to acidified seawater. Two generations of rearing experiments showed that larvae derived from parents acclimated to acidified seawater tended to have higher survival and show less reduction in body size when exposed to acidified seawater of the same pH, suggesting that a positive carry-over effect occurred. RNA-seq analysis showed that gene expression patterns of larvae originated from both acclimated and non-acclimated parents to acidified seawater tended to be different than control condition, and the gene expression pattern of larvae originated from acclimated parents was substantially different than that of larvae of non-acclimated and control parents.
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172616
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Zs.A 949: Show issues

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Article ; Online: Binocular metamorphopsia in patients with branch retinal vein occlusion: a multi-center study.

Osaka, Rie / Muraoka, Yuki / Nagasato, Daisuke / Mitamura, Yoshinori / Nishigori, Naomi / Murakami, Tomoaki / Suzuma, Kiyoshi / Tabuchi, Hitoshi / Tsujikawa, Akitaka

International ophthalmology

2023 Volume 43, Issue 9, Page(s) 3279–3286

Abstract: Purpose: The pathology of branch retinal vein occlusion (BRVO), a retinal circulatory disease, is related to monocular metamorphopsia-related vision impairment of the affected eyes, but the association of binocular metamorphopsia in such patients is ... ...

Abstract	Purpose: The pathology of branch retinal vein occlusion (BRVO), a retinal circulatory disease, is related to monocular metamorphopsia-related vision impairment of the affected eyes, but the association of binocular metamorphopsia in such patients is unclear. This study aimed to examine the frequency of binocular metamorphopsia and its association with the clinical characteristics of patients with BRVO. Methods: A total of 87 patients who were treated for BRVO-associated macular edema (ME) were included in this study. At baseline and 1 and 3 months after the initiation of anti-vascular endothelial growth factor (VEGF) treatment, we quantified metamorphopsia in the affected eyes and binocular metamorphopsia using the M-CHARTS Results: At baseline, 53 and 7 patients had metamorphopsia in the affected eyes and binocular metamorphopsia, respectively. Although the visual acuity improved significantly after the initiation of anti-VEGF treatment, the mean M-CHARTS score in the affected eyes did not change from the baseline score. At 3 months, 9 patients showed binocular metamorphopsia; it was significantly associated with metamorphopsia in the affected eyes with a 95% confidence interval of 0.021-0.122 (β = 0.306, p = 0.006). Conclusion: Metamorphopsia in the affected eyes can cause binocular metamorphopsia in patients with BRVO-ME.
MeSH term(s)	Humans ; Retinal Vein Occlusion/complications ; Retinal Vein Occlusion/diagnosis ; Retinal Vein Occlusion/drug therapy ; Macular Edema/diagnosis ; Vascular Endothelial Growth Factor A ; Eye/pathology ; Vision Disorders/diagnosis ; Vision Disorders/etiology ; Intravitreal Injections ; Tomography, Optical Coherence ; Angiogenesis Inhibitors/therapeutic use ; Retrospective Studies
Chemical Substances	Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors
Language	English
Publishing date	2023-05-25
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02731-0
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Zs.A 1479: Show issues

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Article ; Online: Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models.

Takahashi, Hiroyuki / Miyoshi, Nao / Murakami, Hisashi / Okamura, Yuta / Ogo, Naohisa / Takagi, Akimitsu / Muraoka, Daisuke / Asai, Akira

Cancer immunology, immunotherapy : CII

2023 Volume 72, Issue 7, Page(s) 2473–2482

Abstract: The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival, and invasion. We discovered YHO-1701 as a small molecule inhibitor of STAT3 dimerization and demonstrated its ... ...

Abstract	The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival, and invasion. We discovered YHO-1701 as a small molecule inhibitor of STAT3 dimerization and demonstrated its potent anti-tumor activity using xenograft mouse models as monotherapy and combination therapy with molecular targeted drugs. STAT3 is also associated with cancer immune tolerance; therefore, we used the female CT26 syngeneic mouse model to examine the effect of combining YHO-1701 administration with PD-1/PD-L1 blockade. Pretreatment of the mice with YHO-1701 before starting anti-PD-1 antibody administration resulted in a significant therapeutic effect. In addition, the effect of monotherapy and combination treatment with YHO-1701 was significantly abolished by depleting natural killer (NK) cell activity. YHO-1701 was also found to restore the activity of mouse NK cells under inhibitory conditions in vitro. Furthermore, this combination therapy significantly inhibited tumor growth in an immunotherapy-resistant model of murine CMS5a fibrosarcoma. These results suggest that the combination of YHO-1701 with PD-1/PD-L1 blockade might be a new candidate for cancer immunotherapy involving the enhancement of NK cell activity in the tumor microenvironment.
MeSH term(s)	Animals ; Mice ; Mice, Inbred BALB C ; Fibrosarcoma/drug therapy ; Killer Cells, Natural/drug effects ; STAT3 Transcription Factor/metabolism ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Quinolines/administration & dosage ; Antibodies/administration & dosage ; Transplantation, Isogeneic
Chemical Substances	YHO-1701 ; Stat3 protein, mouse ; Pdcd1 protein, mouse ; STAT3 Transcription Factor ; Programmed Cell Death 1 Receptor ; Quinolines ; Antibodies
Language	English
Publishing date	2023-04-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-023-03440-4
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Zs.A 1237: Show issues

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Article ; Online: Benzo- and Thieno-Annulated Tetracenes: A One-Pot Synthesis via Cross-Dehydrogenative Annulation.

Murata, Michihisa / Togo, Masahiro / Mishima, Daisuke / Harada, Ai / Muraoka, Masahiro

Organic letters

2020 Volume 22, Issue 11, Page(s) 4160–4163

Abstract: A facile method for the direct cross-annulation of unfunctionalized tetracene is reported. The one-pot oxidative cross-dehydrogenative coupling (CDC) between tetracene and aromatic compounds, such as benzene or 2-methylthiophene, furnished annulated ... ...

Abstract	A facile method for the direct cross-annulation of unfunctionalized tetracene is reported. The one-pot oxidative cross-dehydrogenative coupling (CDC) between tetracene and aromatic compounds, such as benzene or 2-methylthiophene, furnished annulated products with an extended π-network. Moreover, relative to the benzo-annulated tetracenes, thieno-annulated tetracenes exhibited notably improved photooxidative stability. This behavior stands in sharp contrast with that of tetracene and its derivatives, such as rubrene, which readily engage in photoinduced oxidation reactions.
Language	English
Publishing date	2020-05-08
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.0c01244
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Article ; Online: CD4

Imai, Naoko / Tawara, Isao / Yamane, Makiko / Muraoka, Daisuke / Shiku, Hiroshi / Ikeda, Hiroaki

Cancer science

2020 Volume 111, Issue 6, Page(s) 1958–1968

Abstract: Polyfunctionality/multifunctionality of effector T cells at the single cell level has been shown as an important parameter to predict the quality of T cell response and immunological control of infectious disease and malignancy. However, the fate of ... ...

Abstract	Polyfunctionality/multifunctionality of effector T cells at the single cell level has been shown as an important parameter to predict the quality of T cell response and immunological control of infectious disease and malignancy. However, the fate of polyfunctional CD8
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/immunology ; Immunologic Memory/immunology ; Mice ; Neoplasms/immunology ; T-Lymphocytes, Cytotoxic/immunology
Language	English
Publishing date	2020-05-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1347-9032
ISSN (online)	1349-7006
ISSN	1347-9032
DOI	10.1111/cas.14420
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