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  1. Article ; Online: Nature and Strength of Sulfur-Centered Hydrogen Bond in Methanethiol Aqueous Solutions.

    Tripathi, Manish Kumar / Ramanathan, V

    The journal of physical chemistry. A

    2023  Volume 127, Issue 10, Page(s) 2265–2273

    Abstract: Methanethiol (M) and water (W) clusters like dimers ( ... ...

    Abstract Methanethiol (M) and water (W) clusters like dimers (M
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c08314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Conformational and structural stability of

    Tripathi, Manish Kumar / Ramanathan, Venkatnarayan

    RSC advances

    2022  Volume 12, Issue 17, Page(s) 10336–10344

    Abstract: The conformational and structural stability ... ...

    Abstract The conformational and structural stability of
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra01034h
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  3. Article ; Online: Seasonal Immune Rhythms of head kidney and spleen cells in the freshwater Teleost,

    Chandra, Rakesh Kumar / Bhardwaj, Ajay Kumar / Pati, Atanu Kumar / Tripathi, Manish Kumar

    Fish and shellfish immunology reports

    2023  Volume 5, Page(s) 100110

    Abstract: Annual rhythms in immune function are the reflection of a crucial physiological strategy to deal with environmental stressors. The fish are pivotal animal models to study the annual rhythm and to understand the evolution of the vertebrate biological ... ...

    Abstract Annual rhythms in immune function are the reflection of a crucial physiological strategy to deal with environmental stressors. The fish are pivotal animal models to study the annual rhythm and to understand the evolution of the vertebrate biological system. The current research was planned to assess the annual changes in the innate immune functions of immune cells in a teleost,
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ISSN 2667-0119
    ISSN (online) 2667-0119
    DOI 10.1016/j.fsirep.2023.100110
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  4. Article ; Online: Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain.

    Tripathi, Manish Kumar / Ojha, Shashank Kumar / Kartawy, Maryam / Khaliulin, Igor / Hamoudi, Wajeha / Amal, Haitham

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 10

    Abstract: ... The estimated prevalence rate of male individuals diagnosed with ASD prevails over females is in a proportion ... of 4:1. Consequently, males remain the main focus in ASD studies in clinical and experimental settings ... the sex differences of the synaptic and behavioral phenotypes of ASD mouse models. Juvenile male and female Shank3 ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder based on synaptic abnormalities. The estimated prevalence rate of male individuals diagnosed with ASD prevails over females is in a proportion of 4:1. Consequently, males remain the main focus in ASD studies in clinical and experimental settings. Meanwhile, some studies point to an underestimation of this disorder in females. In this work, we studied the sex differences of the synaptic and behavioral phenotypes of ASD mouse models. Juvenile male and female Shank3
    MeSH term(s) Mice ; Female ; Male ; Animals ; Autistic Disorder ; Autism Spectrum Disorder/genetics ; Mutation ; Behavior, Animal/physiology ; Cerebral Cortex ; Disease Models, Animal ; Microfilament Proteins/genetics ; Nerve Tissue Proteins/genetics
    Chemical Substances Shank3 protein, mouse ; Microfilament Proteins ; Nerve Tissue Proteins
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50248-4
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  5. Article ; Online: Photoperiodic regulation of the splenocyte immune responses in the fresh water snake, Natrixpiscator.

    Tripathi, Manish Kumar / Singh, Ramesh

    Developmental and comparative immunology

    2022  Volume 132, Page(s) 104403

    Abstract: Photoperiod and melatonin are important regulators of immunity. We hypothesized that these two factors play an important role in the regulation of immune responses in the Natrix piscator. Animals were kept in either short or long days and splenocyte ... ...

    Abstract Photoperiod and melatonin are important regulators of immunity. We hypothesized that these two factors play an important role in the regulation of immune responses in the Natrix piscator. Animals were kept in either short or long days and splenocyte immune responses were studied. Respiratory burst activity of splenocytes was assessed through reduction of nitrobluetetrazolium salt while production of nitric oxide was assessed indirectly by nitrite assay. Density gradient centrifugation was used to isolate splenic lymphocytes which were utilized to study proliferation with and without mitogens. Super oxide production by splenocytes was reduced significantly in the cultures obtained from animals kept either in short or long days. Nitrite release was decreased when animals were subjected to long days. The photoperiodic alterations acted differentially on proliferations of the splenic lymphocytes. Spontaneous and mitogen-induced proliferation of splenic lymphocytes were enhanced in cultures obtained from snakes maintained in short days when compared with cultures from snakes obtained either from long day or natural day length conditions. In vitro melatonin significantly enhanced the splenic lymphocyte proliferation of the cultures obtained from animals kept in long days when compared with splenic lymphocyte proliferations of the cultures obtained from long day animals or the animals kept in natural day length conditions. We found evidence which suggest that photoperiod may influence seasonal energy budgets and induce adjustments which optimize energy allocation for costly physiological processes such as immune function. In seasonally breeding animals such as Natrix piscator, the pineal hormone melatonin assists in the suppression of reproduction and elevation of immunity, which are the crucial adaptation for perpetuation of species.
    MeSH term(s) Animals ; Colubridae ; Fresh Water ; Lymphocyte Activation ; Melatonin ; Nitrites ; Photoperiod ; Seasons ; Spleen
    Chemical Substances Nitrites ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2022.104403
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    Zs.A 1327: Show issues Location:
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  6. Article ; Online: Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain

    Manish Kumar Tripathi / Shashank Kumar Ojha / Maryam Kartawy / Igor Khaliulin / Wajeha Hamoudi / Haitham Amal

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 10

    Abstract: ... abnormalities. The estimated prevalence rate of male individuals diagnosed with ASD prevails over females is ... in a proportion of 4:1. Consequently, males remain the main focus in ASD studies in clinical and experimental ... In this work, we studied the sex differences of the synaptic and behavioral phenotypes of ASD mouse models. Juvenile male ...

    Abstract Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder based on synaptic abnormalities. The estimated prevalence rate of male individuals diagnosed with ASD prevails over females is in a proportion of 4:1. Consequently, males remain the main focus in ASD studies in clinical and experimental settings. Meanwhile, some studies point to an underestimation of this disorder in females. In this work, we studied the sex differences of the synaptic and behavioral phenotypes of ASD mouse models. Juvenile male and female Shank3Δ4–22 and Cntnap2−/− mutant mice and their WT littermates were used in the experiments. The animals were subjected to a Three-Chamber Sociability Test, then euthanized, and the whole cortex was used for the evaluation of the synaptic phenotype. Protein levels of glutamatergic (NR1) and GABAergic (GAD1 and VGAT) neuronal markers were measured. Protein level of synaptophysin (Syp) was also measured. Dendritic spine density in somatosensory neurons was analyzed by Golgi staining methods. Spine Density and GAD1, NR1, VGAT, and Syp levels were significantly reduced in Shank3Δ4–22 and Cntnap2−/− mice compared to the control group irrespective of sex, indicating impaired synaptic development in the mutant mice. These results were consistent with the lack of differences in the three-chamber sociability test between male and female mice. In conclusion, female ASD mice of both mutations undergo similar synaptic aberrations as their male counterparts and need to be studied along with the male animals. Finally, this work urges the psychiatry scientific community to use both sexes in their investigations.
    Keywords Medicine ; R ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Conformational and structural stability of n and 2-propylthiols: a revisit

    Tripathi, Manish Kumar / Ramanathan, Venkatnarayan

    RSC advances. 2022 Apr. 01, v. 12, no. 17

    2022  

    Abstract: The conformational and structural stability of n-propanethiol (nP) is revisited owing to the prevailing ambiguity in the literature reported hitherto, and the rationale for 2-propanethiol's (2P) most stable conformers is analyzed. Based on the rotation ... ...

    Abstract The conformational and structural stability of n-propanethiol (nP) is revisited owing to the prevailing ambiguity in the literature reported hitherto, and the rationale for 2-propanethiol's (2P) most stable conformers is analyzed. Based on the rotation around the C–C and C–S bonds, four conformers for nP and two conformers for 2-propanethiol (2P) were found to have the lowest energies at the CCSD/cc-pVDZ level of theory. The two conformers of 2P are anti (T), and gauche (G), and those of nP are T–G, G–G, T–T, and G–T. Rotational barriers, geometrical parameters, fundamental vibrational modes, and energy parameters reported herein agree exceedingly well with the reported experimental values for nP and 2P molecules. Furthermore, natural bond orbital (NBO), frontier molecular orbital (FMO), Mulliken charge (MC), electrostatic potential charge (ESP), and vibrational mode analyses were carried out to get a better understanding of both the thiols.
    Keywords electrostatic interactions ; energy ; thiols
    Language English
    Dates of publication 2022-0401
    Size p. 10336-10344.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d2ra01034h
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Photoperiodic regulation of the splenocyte immune responses in the fresh water snake, Natrixpiscator

    Tripathi, Manish Kumar / Singh, Ramesh

    Developmental and comparative immunology. 2022 July, v. 132

    2022  

    Abstract: Photoperiod and melatonin are important regulators of immunity. We hypothesized that these two factors play an important role in the regulation of immune responses in the Natrix piscator. Animals were kept in either short or long days and splenocyte ... ...

    Abstract Photoperiod and melatonin are important regulators of immunity. We hypothesized that these two factors play an important role in the regulation of immune responses in the Natrix piscator. Animals were kept in either short or long days and splenocyte immune responses were studied. Respiratory burst activity of splenocytes was assessed through reduction of nitrobluetetrazolium salt while production of nitric oxide was assessed indirectly by nitrite assay. Density gradient centrifugation was used to isolate splenic lymphocytes which were utilized to study proliferation with and without mitogens. Super oxide production by splenocytes was reduced significantly in the cultures obtained from animals kept either in short or long days. Nitrite release was decreased when animals were subjected to long days. The photoperiodic alterations acted differentially on proliferations of the splenic lymphocytes. Spontaneous and mitogen-induced proliferation of splenic lymphocytes were enhanced in cultures obtained from snakes maintained in short days when compared with cultures from snakes obtained either from long day or natural day length conditions. In vitro melatonin significantly enhanced the splenic lymphocyte proliferation of the cultures obtained from animals kept in long days when compared with splenic lymphocyte proliferations of the cultures obtained from long day animals or the animals kept in natural day length conditions. We found evidence which suggest that photoperiod may influence seasonal energy budgets and induce adjustments which optimize energy allocation for costly physiological processes such as immune function. In seasonally breeding animals such as Natrix piscator, the pineal hormone melatonin assists in the suppression of reproduction and elevation of immunity, which are the crucial adaptation for perpetuation of species.
    Keywords Natrix ; density gradient centrifugation ; energy ; freshwater ; immune response ; lymphocyte proliferation ; melatonin ; mitogens ; nitric oxide ; nitrites ; photoperiod ; respiratory burst ; snakes ; splenocytes
    Language English
    Dates of publication 2022-07
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2022.104403
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Conformational stability and structural analysis of methanethiol clusters: a revisit.

    Tripathi, Manish Kumar / Ramanathan, Venkatnarayan

    RSC advances

    2021  Volume 11, Issue 47, Page(s) 29207–29214

    Abstract: B3LYP/cc-pV(D/T/Q)Z and CCSD/cc-pVDZ levels of theory predict three minima for both dimers and trimers of methanethiol. Predictions at B3LYP/cc-pVDZ corroborates exceedingly well with the earlier reported experimental value but significantly differ from ... ...

    Abstract B3LYP/cc-pV(D/T/Q)Z and CCSD/cc-pVDZ levels of theory predict three minima for both dimers and trimers of methanethiol. Predictions at B3LYP/cc-pVDZ corroborates exceedingly well with the earlier reported experimental value but significantly differ from the previous computational predictions. Interaction energy between the molecules decreases with an increase in the size of the basis set for both the dimer and trimer. The dipole moment of methanethiol dimer gets reduced at the B3LYP/cc-pVDZ level of theory relative to all minima configurations, and the same is seen for trimer also. These new predictions are well supported by atoms in molecules (AIM), frontier molecular orbital (FMO), Mulliken charge (MC), and natural bond orbital (NBO) analysis.
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra04900c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Passage number of cancer cell lines: Importance, intricacies, and way-forward.

    Prasad, Chandra Prakash / Tripathi, Satyendra Chandra / Kumar, Manish / Mohapatra, Purusottam

    Biotechnology and bioengineering

    2023  Volume 120, Issue 8, Page(s) 2049–2055

    Abstract: Cancer cell lines play a crucial role as invaluable models in cancer research, facilitating the examination of cancer progression as well as the advancement of diagnostics and treatments. While they may not perfectly replicate the original tumor, they ... ...

    Abstract Cancer cell lines play a crucial role as invaluable models in cancer research, facilitating the examination of cancer progression as well as the advancement of diagnostics and treatments. While they may not perfectly replicate the original tumor, they generally exhibit similar characteristics. Low-passage cancer cell lines are generally preferred due to their closer resemblance to the original tumor, as long-term culturing can alter the genetic and molecular profiles of a cell line thereby highlighting the importance of monitoring the passage number (PN). Variations in proliferation, migration, gene expression, and drug sensitivity can be linked to PN differences. PN can also influence DNA methylation levels, metabolic profiles, and the expression of genes/or proteins in cancer cell lines. When conducting research on cancer cell lines, it is crucial for researchers to carefully select the appropriate PN to maintain consistency and reliability of results. Moreover, to ensure dependability and replicability, scientists ought to actively track the growth, migration, and gene/or protein profiles of cancer cell lines at specific PNs. This approach enables the identification of the most suitable range of PNs for experiments, guaranteeing consistent and precise results. Additionally, such efforts serve to minimize disparities and uphold the integrity of research. In this review, we have laid out recommendations for laboratories to overcome these PN discrepancies when working with cancer cell lines.
    MeSH term(s) Humans ; Reproducibility of Results ; Neoplasms/genetics ; Cell Line ; DNA Methylation/genetics ; Cell Line, Tumor
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 960: Show issues Location:
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