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  1. Article ; Online: Identification of coronavirus particles by electron microscopy requires demonstration of specific ultrastructural features.

    Dittmayer, Carsten / Laue, Michael

    The European respiratory journal

    2022  

    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00266-2022
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  2. Article ; Online: Continued False-Positive Detection of SARS-CoV-2 by Electron Microscopy.

    Dittmayer, Carsten / Laue, Michael

    Annals of neurology

    2022  Volume 92, Issue 2, Page(s) 340–341

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Microscopy, Electron ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26408
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  3. Book ; Online ; Thesis: Optimierte Verfahren zur morphologischen und histochemischen Auswertung der Niere

    Dittmayer, Carsten [Verfasser]

    2019  

    Author's details Carsten Dittmayer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Congenital myopathies: The current status.

    Goebel, Hans H / Dittmayer, Carsten / Stenzel, Werner

    Indian journal of pathology & microbiology

    2022  Volume 65, Issue Supplement, Page(s) S271–S276

    Abstract: Within the history of neuromuscular diseases (NMD), congenital myopathies (CM) represent a relatively new category introduced in the mid-nineteen hundreds upon advent and subsequent application of enzyme histochemistry and electron microscopy by ... ...

    Abstract Within the history of neuromuscular diseases (NMD), congenital myopathies (CM) represent a relatively new category introduced in the mid-nineteen hundreds upon advent and subsequent application of enzyme histochemistry and electron microscopy by establishing the three major CM, central core disease, nemaline myopathy, and centronuclear myopathy which later pluralized each when the molecular era began at the end of last century. Quickly, during the following 5 decades, many new CM entities were described, based on muscle biopsies and their CM-characteristic myopathology, the former a prerequisite to recognizing an individual CM, the latter of the nosological hallmark of the individual CM. When the molecular era ushered in immunohistochemistry the spectrum and nosography of CM altered in that some CM became allelic to other cohorts of NMD, e.g., congenital muscular dystrophies, other muscular dystrophies, distal myopathies based on different or identical mutations in the same gene. The nosological spectrum of a defective gene also enlarged by recognizing several entities with mutations in the same gene, and same or similar nosological conditions originated from mutations in different genes. Lately, however, CM were reported which lacked any individual myopathological hallmarks, but were clearly based on molecular defects, a fair number of them being newly identified ones. Few CM still remain without any molecular clarification. This nosographic development rendered the original definition of such new CM questionable and brought uncertainty to their classification and nomenclature.
    MeSH term(s) Biopsy ; Histocytochemistry ; Humans ; Microscopy, Electron ; Muscular Diseases/congenital ; Muscular Diseases/genetics ; Muscular Diseases/pathology ; Mutation
    Language English
    Publishing date 2022-05-13
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_1031_21
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  5. Article ; Online: Skin lesion specimens as first choice to detect monkeypox virus - Authors' reply.

    Müller, Markus / Ingold-Heppner, Barbara / Stocker, Hartmut / Heppner, Frank L / Dittmayer, Carsten / Laue, Michael

    Lancet (London, England)

    2023  Volume 401, Issue 10384, Page(s) 1265

    MeSH term(s) Humans ; Monkeypox virus/genetics ; Mpox (monkeypox)/diagnosis ; Polymerase Chain Reaction
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00271-4
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  6. Article ; Online: Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems : Ausblick auf neue Techniken in der Elektronenmikroskopie.

    Schänzer, Anne / Dittmayer, Carsten / Weis, Joachim / Stenzel, Werner / Goebel, Hans-Hilmar

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue 2, Page(s) 113–120

    Abstract: In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. ...

    Title translation Neuropathology II: diseases of the central and peripheral nervous systems : Outlook on new techniques in electron microscopy.
    Abstract In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. Hereditary neurodegenerative and metabolic diseases, such as the lysosomal storage disease neuronal ceroid lipofuscinosis, are associated with pathognomonic storage products not only in the central nervous system (CNS) but also in extracerebral tissues such as sweat glands and lymphocytes. These tissues are easily accessible and thus function as "windows to the CNS". In addition, there are new methods that overcome limitations of conventional electron microscopy and may improve ultrastructural diagnostics. This is particularly important for the correct classification of viral particles such as SARS-CoV‑2, leading to a better understanding of COVID19-associated diseases in the CNS and peripheral nervous system.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Nervous System Diseases ; Peripheral Nervous System ; Microscopy, Electron
    Language German
    Publishing date 2023-01-30
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-022-01178-x
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  7. Article ; Online: "Amyopathic" MDA5-positive dermatomyositis with severe lung involvement presenting with net myositic morphological features - insights from an autopsy study.

    Englert, Benjamin / Dittmayer, Carsten / Goebel, Hans-Hilmar / Schneider, Udo / Holzer, Marie-Therese / Uruha, Akinori / Stenzel, Werner

    Neuromuscular disorders : NMD

    2024  Volume 36, Page(s) 42–47

    Abstract: Anti-MDA5-positive dermatomyositis (MDA5-DM) often presents with extramuscular, especially pulmonary and skin manifestations, and apparent clinical signs of frank myositis can be missing (so called amyopathic DM). We hereby present two male patients who ... ...

    Abstract Anti-MDA5-positive dermatomyositis (MDA5-DM) often presents with extramuscular, especially pulmonary and skin manifestations, and apparent clinical signs of frank myositis can be missing (so called amyopathic DM). We hereby present two male patients who died from respiratory failure during the course of MDA5-DM. While overt signs of myositis or any skin involvement were absent at admission to hospital we noticed conspicuous inflammatory alterations in various skeletal muscles morphologically, showing different degrees of affection. Furthermore, pathological changes of the lungs compatible with rapid progressive interstitial lung disease and characteristic cutaneous vasculoocclusive features were identified at autopsy. This observation shows that muscles and skin are subclinically affected in a widespread fashion, hence subtle signs of muscle involvement should be sought after in anti-MDA5-positive patients with predominant lung affection to ensure adequate treatment.
    MeSH term(s) Humans ; Male ; Dermatomyositis/complications ; Myositis ; Muscle, Skeletal ; Autopsy ; Lung ; Autoantibodies ; Interferon-Induced Helicase, IFIH1
    Chemical Substances Autoantibodies ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
    Language English
    Publishing date 2024-02-04
    Publishing country England
    Document type Case Reports
    ZDB-ID 1077681-3
    ISSN 1873-2364 ; 0960-8966
    ISSN (online) 1873-2364
    ISSN 0960-8966
    DOI 10.1016/j.nmd.2024.01.009
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    Zs.A 3258: Show issues Location:
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  8. Article ; Online: The neurobiology of SARS-CoV-2 infection.

    Meinhardt, Jenny / Streit, Simon / Dittmayer, Carsten / Manitius, Regina V / Radbruch, Helena / Heppner, Frank L

    Nature reviews. Neuroscience

    2023  Volume 25, Issue 1, Page(s) 30–42

    Abstract: Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55-60% of those infected developing COVID-19. Since the beginning of the pandemic in December 2019, different variants of concern have appeared and continue to occur. ...

    Abstract Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55-60% of those infected developing COVID-19. Since the beginning of the pandemic in December 2019, different variants of concern have appeared and continue to occur. With the emergence of different variants, an increasing rate of vaccination and previous infections, the acute neurological symptomatology of COVID-19 changed. Moreover, 10-45% of individuals with a history of SARS-CoV-2 infection experience symptoms even 3 months after disease onset, a condition that has been defined as 'post-COVID-19' by the World Health Organization and that occurs independently of the virus variant. The pathomechanisms of COVID-19-related neurological complaints have become clearer during the past 3 years. To date, there is no overt - that is, truly convincing - evidence for SARS-CoV-2 particles in the brain. In this Review, we put special emphasis on discussing the  methodological difficulties of viral detection in CNS tissue and discuss immune-based (systemic and central) effects contributing to COVID-19-related CNS affection. We sequentially review the reported changes to CNS cells in COVID-19, starting with the blood-brain barrier and blood-cerebrospinal fluid barrier - as systemic factors from the periphery appear to primarily influence barriers and conduits - before we describe changes in brain parenchymal cells, including microglia, astrocytes, neurons and oligodendrocytes as well as cerebral lymphocytes. These findings are critical to understanding CNS affection in acute COVID-19 and post-COVID-19 in order to translate these findings into treatment options, which are still very limited.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Central Nervous System ; Brain ; Blood-Brain Barrier
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00769-8
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  9. Article ; Online: Electron microscopy images of monkeypox virus infection in 24-year-old man.

    Müller, Markus / Ingold-Heppner, Barbara / Stocker, Hartmut / Heppner, Frank L / Dittmayer, Carsten / Laue, Michael

    Lancet (London, England)

    2022  Volume 400, Issue 10363, Page(s) 1618

    MeSH term(s) Male ; Humans ; Young Adult ; Adult ; Monkeypox virus ; Mpox (monkeypox)/diagnostic imaging ; Mpox (monkeypox)/epidemiology ; Microscopy, Electron ; Disease Outbreaks
    Language English
    Publishing date 2022-10-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01969-9
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  10. Article ; Online: Neuropathologie I: Muskuläre Erkrankungen.

    Schänzer, Anne / Dittmayer, Carsten / Porubsky, Stefan / Weis, Joachim / Goebel, Hans-Hilmar / Stenzel, Werner

    Pathologie (Heidelberg, Germany)

    2022  Volume 44, Issue 2, Page(s) 104–112

    Abstract: Muscle diseases include hereditary and acquired diseases with clinical manifestation in both childhood and adulthood. The different muscle diseases may have ultrastructural alterations that help us further understand the pathology of the disease. ... ...

    Title translation Neuropathology I: muscular diseases.
    Abstract Muscle diseases include hereditary and acquired diseases with clinical manifestation in both childhood and adulthood. The different muscle diseases may have ultrastructural alterations that help us further understand the pathology of the disease. Specific changes in sarcomere structure help to classify a congenital myopathy. The detection of cellular aggregates supports the classification of myositis. Pathologically altered mitochondria, on the other hand, can occur both in genetic mitochondriopathies but also secondarily in acquired muscle diseases like myositis. Ultrastructural analysis of the myocardium is also helpful in the diagnosis of hereditary cardiomyopathies in childhood. This review article highlights the ultrastructural features of different muscle diseases and pathognomonic findings in specific disease groups.
    MeSH term(s) Humans ; Muscular Diseases/genetics ; Myositis/diagnosis ; Myocardium/pathology ; Sarcomeres/pathology
    Language German
    Publishing date 2022-12-02
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-022-01163-4
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