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  1. Article ; Online: MICA, un nouveau gène d’histocompatibilité en transplantation rénale.

    Carapito, Raphael / Bahram, Seiamak

    Medecine sciences : M/S

    2024  Volume 40, Issue 1, Page(s) 102–103

    Title translation MICA, a novel histocompatibility antigen in kidney transplantation.
    MeSH term(s) Humans ; Kidney Transplantation ; Histocompatibility Antigens ; Histocompatibility Antigens Class I ; Graft Rejection
    Chemical Substances Histocompatibility Antigens ; Histocompatibility Antigens Class I
    Language French
    Publishing date 2024-02-01
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2023183
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    Zs.B 2872: Show issues Location:
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  2. Article ; Online: Advances in Research on COVID-19 Vaccination for People Living with HIV.

    Jin, Junyan / Wang, Xiuwen / Carapito, Raphael / Moog, Christiane / Su, Bin

    Infectious diseases & immunity

    2022  Volume 2, Issue 4, Page(s) 213–218

    Language English
    Publishing date 2022-09-01
    Publishing country China
    Document type Journal Article
    ISSN 2693-8839
    ISSN (online) 2693-8839
    DOI 10.1097/ID9.0000000000000065
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  3. Article ; Online: Fc receptors and the diversity of antibody responses to HIV infection and vaccination.

    Lin, Li-Yun / Carapito, Raphael / Su, Bin / Moog, Christiane

    Genes and immunity

    2022  Volume 23, Issue 5, Page(s) 149–156

    Abstract: The development of an effective vaccine against HIV is desperately needed. The successive failures of HIV vaccine efficacy trials in recent decades have shown the difficulty of inducing an appropriate protective immune response to fight HIV. Different ... ...

    Abstract The development of an effective vaccine against HIV is desperately needed. The successive failures of HIV vaccine efficacy trials in recent decades have shown the difficulty of inducing an appropriate protective immune response to fight HIV. Different correlates of antibody parameters associated with a decreased risk of HIV-1 acquisition have been identified. However, these parameters are difficult to reproduce and improve, possibly because they have an intricate and combined action. Here, we describe the numerous antibody (Ab) functions associated with HIV-1 protection and report the interrelated parameters regulating their complex functions. Indeed, besides neutralizing and Fc-mediated activity, additional factors such as Ab type, concentration and kinetics of induction, and Fc-receptor expression and binding capacity also influence the protective effect conferred by Abs. As these parameters were described to be associated with ethnicity, age and sex, these additional factors must be considered for the development of an effective immune response. Therefore, future vaccine designs need to consider these multifaceted Ab functions together with the demographic attributes of the patient populations.
    MeSH term(s) AIDS Vaccines ; Antibodies, Neutralizing ; Antibody Formation ; HIV Antibodies/pharmacology ; HIV Infections ; HIV-1 ; Humans ; Receptors, Fc ; Vaccination
    Chemical Substances AIDS Vaccines ; Antibodies, Neutralizing ; HIV Antibodies ; Receptors, Fc
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-022-00175-7
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  4. Article ; Online: Measuring the transcriptome-wide effects of aging on murine adipocytes using RNAseq.

    De Cauwer, Aurore / Pichot, Angélique / Molitor, Anne / Stemmelen, Tristan / Carapito, Raphael / Bahram, Seiamak / Georgel, Philippe

    STAR protocols

    2023  Volume 4, Issue 3, Page(s) 102397

    Abstract: Adipose tissue plays a central role in age-related diseases. While RNAseq protocols exist for many tissues, few data have been generated with this technology to explore gene expression in adipocytes, particularly during aging. Here, we present a protocol ...

    Abstract Adipose tissue plays a central role in age-related diseases. While RNAseq protocols exist for many tissues, few data have been generated with this technology to explore gene expression in adipocytes, particularly during aging. Here, we present a protocol to analyze the transcriptional changes that occur in adipose tissue during normal and accelerated aging in mouse models. We describe steps for genotyping, diet control, euthanasia, and dissection. We then detail RNA purification and genome-wide data generation and analysis. For complete details on the use and execution of this protocol, please refer to De Cauwer et al. (2022) iScience. Sep 16;25(10):105149.
    MeSH term(s) Animals ; Mice ; Transcriptome/genetics ; Adipocytes ; Adipose Tissue ; Aging/genetics ; Disease Models, Animal
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102397
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  5. Article ; Online: Multiomics of three hematological malignancies in a patient reveal their origin from clonal hematopoietic stem cells.

    Mayeur, Sylvain / Molitor, Anne / Miguet, Laurent / Rigolot, Lucie / Naegely, Lydie / Stemmelen, Tristan / Meyer, Sébastien / Toussaint, Elise / Vallat, Laurent / Eischen, Alice / Chenard, Marie-Pierre / Tavian, Manuela / Bahram, Seiamak / Carapito, Raphael / Nicolae, Alina

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 118

    MeSH term(s) Humans ; Multiomics ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/pathology ; Hematopoietic Stem Cells/pathology
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-023-00892-w
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  6. Article ; Online: Measuring the transcriptome-wide effects of aging on murine adipocytes using RNAseq

    Aurore De Cauwer / Angélique Pichot / Anne Molitor / Tristan Stemmelen / Raphael Carapito / Seiamak Bahram / Philippe Georgel

    STAR Protocols, Vol 4, Iss 3, Pp 102397- (2023)

    2023  

    Abstract: Summary: Adipose tissue plays a central role in age-related diseases. While RNAseq protocols exist for many tissues, few data have been generated with this technology to explore gene expression in adipocytes, particularly during aging. Here, we present a ...

    Abstract Summary: Adipose tissue plays a central role in age-related diseases. While RNAseq protocols exist for many tissues, few data have been generated with this technology to explore gene expression in adipocytes, particularly during aging. Here, we present a protocol to analyze the transcriptional changes that occur in adipose tissue during normal and accelerated aging in mouse models. We describe steps for genotyping, diet control, euthanasia, and dissection. We then detail RNA purification and genome-wide data generation and analysis.For complete details on the use and execution of this protocol, please refer to De Cauwer et al. (2022) iScience. Sep 16;25(10):105149. : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords RNAseq ; Model Organisms ; Gene Expression ; Science (General) ; Q1-390
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis.

    Mary, Benjamin / Asokan, Nandini / Jerabkova-Roda, Katerina / Larnicol, Annabel / Busnelli, Ignacio / Stemmelen, Tristan / Pichot, Angélique / Molitor, Anne / Carapito, Raphaël / Lefebvre, Olivier / Goetz, Jacky G / Hyenne, Vincent

    EMBO reports

    2023  Volume 24, Issue 12, Page(s) e57042

    Abstract: Extracellular vesicles released by tumors (tEVs) disseminate via circulatory networks and promote microenvironmental changes in distant organs favoring metastatic seeding. Despite their abundance in the bloodstream, how hemodynamics affect the function ... ...

    Abstract Extracellular vesicles released by tumors (tEVs) disseminate via circulatory networks and promote microenvironmental changes in distant organs favoring metastatic seeding. Despite their abundance in the bloodstream, how hemodynamics affect the function of circulating tEVs remains unsolved. We demonstrated that efficient uptake of tEVs occurs in venous endothelial cells that are subjected to hemodynamics. Low flow regimes observed in veins partially reroute internalized tEVs toward non-acidic and non-degradative Rab14-positive endosomes, at the expense of lysosomes, suggesting that endothelial mechanosensing diverts tEVs from degradation. Subsequently, tEVs promote the expression of pro-angiogenic transcription factors in low flow-stimulated endothelial cells and favor vessel sprouting in zebrafish. Altogether, we demonstrate that low flow regimes potentiate the pro-tumoral function of circulating tEVs by promoting their uptake and rerouting their trafficking. We propose that tEVs contribute to pre-metastatic niche formation by exploiting endothelial mechanosensing in specific vascular regions with permissive hemodynamics.
    MeSH term(s) Animals ; Endothelial Cells ; Zebrafish ; Extracellular Vesicles/metabolism ; Hemodynamics ; Neoplasms/pathology ; Angiogenesis
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202357042
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    Zs.A 5433: Show issues Location:
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    Zs.MG 41: Show issues

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  8. Article ; Online: Genomic profiling of a metastatic anaplastic melanocytic neuroectodermal tumor arising from a mature thymic teratoma as part of a mediastinal germ cell tumor.

    Mayeur, Sylvain / Lhermitte, Benoit / Gantzer, Justine / Molitor, Anne / Stemmelen, Tristan / Meyer, Sébastien / Kolmer, Aline / Kurtz, Jean-Emmanuel / Bahram, Seiamak / Carapito, Raphael

    Cold Spring Harbor molecular case studies

    2023  Volume 9, Issue 2

    Abstract: Following chemotherapy, a mediastinal germ cell tumor can lead to a mature teratoma that is composed of tissues derived from all three germ layers. Although teratoma is usually curable, in rare cases it can give rise to various somatic tumors and ... ...

    Abstract Following chemotherapy, a mediastinal germ cell tumor can lead to a mature teratoma that is composed of tissues derived from all three germ layers. Although teratoma is usually curable, in rare cases it can give rise to various somatic tumors and exceptionally it undergoes melanocytic neuroectodermal tumor (MNT) transformation, a process that is not well-described. We report a patient with a postchemotherapy thymic teratoma associated with an MNT component who, 10 years later, additionally presented a vertebral metastasis corresponding to an anaplastic MNT. Using exome sequencing of the mature teratoma, the MNT and its metastatic vertebral anaplastic MNT components, we identified 19 somatic mutations shared by at least two components. Six mutations were common to all three components, and three of them were located in the known cancer-related genes
    MeSH term(s) Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Teratoma/genetics ; Neoplasms, Germ Cell and Embryonal ; Neuroectodermal Tumors ; Genomics
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835759-0
    ISSN 2373-2873 ; 2373-2873
    ISSN (online) 2373-2873
    ISSN 2373-2873
    DOI 10.1101/mcs.a006257
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  9. Article ; Online: Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers.

    Fonta, Charlotte M / Loustau, Thomas / Li, Chengbei / Poilil Surendran, Suchithra / Hansen, Uwe / Murdamoothoo, Devadarssen / Benn, Mario C / Velazquez-Quesada, Ines / Carapito, Raphael / Orend, Gertraud / Vogel, Viola

    Matrix biology : journal of the International Society for Matrix Biology

    2023  Volume 116, Page(s) 1–27

    Abstract: Tracks rich in matrix and cells, as described in several cancer types, have immunosuppressive functions and separate tumor nests and stroma, yet their origin is unknown. Immunostainings of cryosections from mouse breast tumors show that these tracks are ... ...

    Abstract Tracks rich in matrix and cells, as described in several cancer types, have immunosuppressive functions and separate tumor nests and stroma, yet their origin is unknown. Immunostainings of cryosections from mouse breast tumors show that these tracks are bordered by an endothelial-like basement membrane, filled with fibers of collagen adjacent to tenascin-C (TNC) and low-tension fibronectin (Fn) fibers. While present in early-stage tumors and maturing with time, tracks still form under TNC KO conditions, however, host (not tumor cell)-derived TNC is important for track maturation. Tumor infiltrating leukocytes (mostly M2 macrophages and CD8+ T cells) are retained in tracks of early-stage tumors. Following track maturation, retained tumor infiltrating leukocyte (TIL) numbers get reduced and more CD8+ TIL enter the tumor nests in the absence of TNC. As these tracks are enriched with platelets and fibrinogen and have a demarcating endothelial-like basement membrane often adjacent to endothelial cells, this suggests a role of blood vessels in the formation of these tracks. The Fn fiber tension probe FnBPA5 colocalizes with TNC and immune cells in the tracks and shows decreased binding in tracks lacking TNC. Consequently, FnBPA5 can serve as probe for tumor matrix tracks that have immune suppressive properties.
    MeSH term(s) Mice ; Animals ; Fibronectins/metabolism ; Endothelial Cells/metabolism ; Neoplasms/pathology ; Macrophages/metabolism ; Tenascin/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; T-Lymphocytes/metabolism
    Chemical Substances Fibronectins ; Tenascin
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2023.01.002
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    Zs.A 1694: Show issues Location:
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  10. Article ; Online: Genetics, genomics, and evolutionary biology of NKG2D ligands.

    Carapito, Raphael / Bahram, Seiamak

    Immunological reviews

    2015  Volume 267, Issue 1, Page(s) 88–116

    Abstract: Human and mouse NKG2D ligands (NKG2DLs) are absent or only poorly expressed by most normal cells but are upregulated by cell stress, hence, alerting the immune system in case of malignancy or infection. Although these ligands are numerous and highly ... ...

    Abstract Human and mouse NKG2D ligands (NKG2DLs) are absent or only poorly expressed by most normal cells but are upregulated by cell stress, hence, alerting the immune system in case of malignancy or infection. Although these ligands are numerous and highly variable (at genetic, genomic, structural, and biochemical levels), they all belong to the major histocompatibility complex class I gene superfamily and bind to a single, invariant, receptor: NKG2D. NKG2D (CD314) is an activating receptor expressed on NK cells and subsets of T cells that have a key role in the recognition and lysis of infected and tumor cells. Here, we review the molecular diversity of NKG2DLs, discuss the increasing appreciation of their roles in a variety of medical conditions, and propose several explanations for the evolutionary force(s) that seem to drive the multiplicity and diversity of NKG2DLs while maintaining their interaction with a single invariant receptor.
    MeSH term(s) Animals ; Genetic Variation/genetics ; Genetic Variation/immunology ; Genomics ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Ligands ; Mice ; Models, Genetic ; Models, Immunological ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; NK Cell Lectin-Like Receptor Subfamily K/immunology
    Chemical Substances Histocompatibility Antigens Class I ; Ligands ; NK Cell Lectin-Like Receptor Subfamily K
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12328
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