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Article: Comparison of melanoma antigens in whole tumor vaccine to those from IIB-MEL-J cells.

McGee, J M / Patten, M R / Malnar, K F / Price, J A / Mayes, J S / Watson, G H

Cancer biotherapy & radiopharmaceuticals

1999 Volume 14, Issue 3, Page(s) 203–208

Abstract: ... J tissue culture (TC) cells. In this study, we compare by Western blot analyses the antigens ... that these proteins are in a higher concentration in the TC vaccine. This new vaccine from IIB-MEL-J tissue culture ...

Abstract	Immunotherapy for melanoma shows promise. Our previous whole tumor (WT) vaccine was noted to have positive clinical effects. We have now developed a new, safer melanoma vaccine that is derived from IIB-MEL-J tissue culture (TC) cells. In this study, we compare by Western blot analyses the antigens in the WT vaccine to antigens in the TC vaccine. Sera from 12 WT vaccine recipients, 8 melanoma patients who received no immunotherapy, and 8 controls served as a source of antibodies to investigate potential antigens in the vaccines. Three major antigenic peptides with approximate molecular weighs of 46, 40, and 36 kDA were present in both vaccines, while two other antigenic peptides with approximate molecular weighs of 68 and 48 kDA were present only in the TC vaccine. The reaction was similar between the patients who received the WT vaccine and those who did not receive the vaccine. Some of the individuals who did not have melanoma showed some reaction, but not to the extent of the melanoma patients. The intensity of immunostaining was greater for the TC vaccine when compared to the WT vaccine, indicating that these proteins are in a higher concentration in the TC vaccine. This new vaccine from IIB-MEL-J tissue culture cells provides a higher yield and a much more consistent source of potentially clinically relevant antigens without risk of infection or contamination by other irrelevant materials.
MeSH term(s)	Antibodies, Neoplasm/immunology ; Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Humans ; Melanoma/blood ; Melanoma/immunology ; Melanoma/pathology ; Melanoma/therapy ; Molecular Weight ; Neoplasm Staging ; Recurrence ; Tumor Cells, Cultured
Chemical Substances	Antibodies, Neoplasm ; Antigens, Neoplasm ; Cancer Vaccines
Language	English
Publishing date	1999-06
Publishing country	United States
Document type	Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1315649-4
ISSN	1084-9785
ISSN	1084-9785
DOI	10.1089/cbr.1999.14.203
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Article: Genetic conflicts and the case for licensed anthropomorphizing.

Ågren, J Arvid / Patten, Manus M

Behavioral ecology and sociobiology

2022 Volume 76, Issue 12, Page(s) 166

Abstract: The use of intentional language in biology is controversial. It has been commonly applied by researchers in behavioral ecology, who have not shied away from employing agential thinking or even anthropomorphisms, but has been rarer among researchers from ... ...

Abstract	The use of intentional language in biology is controversial. It has been commonly applied by researchers in behavioral ecology, who have not shied away from employing agential thinking or even anthropomorphisms, but has been rarer among researchers from more mechanistic corners of the discipline, such as population genetics. One research area where these traditions come into contact-and occasionally clash-is the study of genetic conflicts, and its history offers a good window to the debate over the use of intentional language in biology. We review this debate, paying particular attention to how this interaction has played out in work on genomic imprinting and sex chromosomes. In light of this, we advocate for a synthesis of the two approaches, a form of licensed anthropomorphizing. Here, agential thinking's creative potential and its ability to identify the fulcrum of evolutionary pressure are combined with the rigidity of formal mathematical modeling.
Language	English
Publishing date	2022-12-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	194510-5
ISSN	1432-0762 ; 0340-5443
ISSN (online)	1432-0762
ISSN	0340-5443
DOI	10.1007/s00265-022-03267-6
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Article ; Online: Adaptation in the face of internal conflict: the paradox of the organism revisited.

Patten, Manus M / Schenkel, Martijn A / Ågren, J Arvid

Biological reviews of the Cambridge Philosophical Society

2023 Volume 98, Issue 5, Page(s) 1796–1811

Abstract: The paradox of the organism refers to the observation that organisms appear to function as coherent purposeful entities, despite the potential for within-organismal components like selfish genetic elements and cancer cells to erode them from within. ... ...

Abstract	The paradox of the organism refers to the observation that organisms appear to function as coherent purposeful entities, despite the potential for within-organismal components like selfish genetic elements and cancer cells to erode them from within. While it is commonly accepted that organisms may pursue fitness maximisation and can be thought to hold particular agendas, there is a growing recognition that genes and cells do so as well. This can lead to evolutionary conflicts between an organism and the parts that reside within it. Here, we revisit the paradox of the organism. We first outline its conception and relationship to debates about adaptation in evolutionary biology. Second, we review the ways selfish elements may exploit organisms, and the extent to which this threatens organismal integrity. To this end, we introduce a novel classification scheme that distinguishes between selfish elements that seek to distort transmission versus those that seek to distort phenotypic traits. Our classification scheme also highlights how some selfish elements elude a multi-level selection decomposition using the Price equation. Third, we discuss how the organism can retain its status as the primary fitness-maximising agent in the face of selfish elements. The success of selfish elements is often constrained by their strategy and further limited by a combination of fitness alignment and enforcement mechanisms controlled by the organism. Finally, we argue for the need for quantitative measures of both internal conflicts and organismality.
MeSH term(s)	Adaptation, Physiological ; Biological Evolution ; Acclimatization ; Models, Genetic
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1423558-4
ISSN	1469-185X ; 0006-3231 ; 1464-7931
ISSN (online)	1469-185X
ISSN	0006-3231 ; 1464-7931
DOI	10.1111/brv.12983
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Article: Practical Understanding of Cancer Model Identifiability in Clinical Applications.

Phan, Tin / Bennett, Justin / Patten, Taylor

Life (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Mathematical models are a core component in the foundation of cancer theory and have been developed as clinical tools in precision medicine. Modeling studies for clinical applications often assume an individual's characteristics can be represented as ... ...

Abstract	Mathematical models are a core component in the foundation of cancer theory and have been developed as clinical tools in precision medicine. Modeling studies for clinical applications often assume an individual's characteristics can be represented as parameters in a model and are used to explain, predict, and optimize treatment outcomes. However, this approach relies on the identifiability of the underlying mathematical models. In this study, we build on the framework of an observing-system simulation experiment to study the identifiability of several models of cancer growth, focusing on the prognostic parameters of each model. Our results demonstrate that the frequency of data collection, the types of data, such as cancer proxy, and the accuracy of measurements all play crucial roles in determining the identifiability of the model. We also found that highly accurate data can allow for reasonably accurate estimates of some parameters, which may be the key to achieving model identifiability in practice. As more complex models required more data for identification, our results support the idea of using models with a clear mechanism that tracks disease progression in clinical settings. For such a model, the subset of model parameters associated with disease progression naturally minimizes the required data for model identifiability.
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13020410
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Article ; Online: NMJ Analyser: a novel method to quantify neuromuscular junction morphology in zebrafish.

Singh, Jaskaran / Pan, Yingzhou Edward / Patten, Shunmoogum A

Bioinformatics (Oxford, England)

2023 Volume 39, Issue 12

Abstract: Motivation: Neuromuscular junction (NMJ) structural integrity is crucial for transducing motor neuron signals that initiate skeletal muscle contraction. Zebrafish has emerged as a simple and efficient model to study NMJ structural morphology and ... ...

Abstract	Motivation: Neuromuscular junction (NMJ) structural integrity is crucial for transducing motor neuron signals that initiate skeletal muscle contraction. Zebrafish has emerged as a simple and efficient model to study NMJ structural morphology and function in the context of developmental neurobiology and neuromuscular diseases. However, methods to quantify NMJ morphology from voluminous data of NMJ confocal images accurately, rapidly, and reproducibly are lacking. Results: We developed an ImageJ macro called "NMJ Analyser" to automatically and unbiasedly analyse NMJ morphology in zebrafish. From the Z-stack of a zebrafish hemisomite, both presynaptic and postsynaptic fluorescently labeled termini at NMJs are extracted from background signal, with larger clusters of termini being segmented into individual termini using an unbiased algorithm. The program then determines whether each presynaptic terminus is co-localized with a postsynaptic terminus and vice versa, or whether it is orphaned, and tabulates the number of orphan and co-localized pre- and postsynaptic termini. The usefulness of this ImageJ macro plugin will be helpful to quantify NMJ parameters in zebrafish, particularly during development and in disease models of neuromuscular diseases. It can enable high-throughput NMJ phenotypic screens in the drug discovery process for neuromuscular diseases. It could also be further applied to the investigation of NMJ of other developmental systems. Availability and implementation: NMJ Analyser is available for download at https://github.com/PattenLab/NMJ-Analyser.git.
MeSH term(s)	Animals ; Zebrafish ; Neuromuscular Junction/physiology ; Neuromuscular Diseases
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btad720
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Zs.A 2374: Show issues

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Article: Opting In and Out: A Qualitative Study Exploring Career Break Experiences of Registered Dietitian Nutritionists.

Vaterlaus Patten, Emily / Vaterlaus, J Mitchell / Anderson, Carolyn / Borden, Roya

Journal of the Academy of Nutrition and Dietetics

2023 Volume 124, Issue 2, Page(s) 181–193

Abstract: Background: Since 2002, an average of 17.5% of registered dietitian nutritionists (RDNs) have reported being out of the paid dietetics workforce, and approximately half of those report intention to return. With the Academy of Nutrition and Dietetics' ... ...

Abstract	Background: Since 2002, an average of 17.5% of registered dietitian nutritionists (RDNs) have reported being out of the paid dietetics workforce, and approximately half of those report intention to return. With the Academy of Nutrition and Dietetics' focus on expanding workforce demand and capacity, understanding why and how dietitians opt in and out of the dietetics workforce may provide insights into how to potentially reduce the number of career breaks or expedite and enhance the reentry process. Objective: To explore the lived experiences and perspectives of dietitians who were taking (with intention to return) or had taken a career break and returned to the paid dietetics' workforce. Design: A qualitative study with semistructured interviews was conducted. Participants/setting: Participants (n = 22) were recruited through purposive sampling over social media. They were required to be credentialed as RDNs, reside in the United States, and have either previously or currently (with intent to return) taken a break from the dietetics workforce. Interviews were conducted using Zoom videoconferencing technology during September 2021. Data analysis: Data were analyzed using a Coding Reliability Thematic Analysis approach. Results: The data are summarized in four themes: (1) motivations to leave and return, (2) staying connected with dietetics, (3) preparing to return and returning to the dietetics workforce, and (4) desired resources for career breaks and reentry. Conclusions: Understanding the experiences of dietitians who take career breaks may help inform career reentry and help the profession meet the current and future workforce demand.
MeSH term(s)	Humans ; United States ; Nutritionists ; Reproducibility of Results ; Dietetics ; Qualitative Research ; Workforce
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2646718-5
ISSN	2212-2672
ISSN	2212-2672
DOI	10.1016/j.jand.2023.09.002
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Article: Gene-environment interactions determine risk for dementia: the influence of lifestyle on genetic risk for dementia.

Patten, Kelley T / Lein, Pamela J

Annals of translational medicine

2020 Volume 7, Issue Suppl 8, Page(s) S322

Language	English
Publishing date	2020-03-06
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2019.09.155
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Article ; Online: GPR119 agonists for type 2 diabetes: past failures and future hopes for preclinical and early phase candidates.

Hryciw, Deanne H / Patten, Rhiannon K / Rodgers, Raymond J / Proietto, Joseph / Hutchinson, Dana S / McAinch, Andrew J

Expert opinion on investigational drugs

2024 Volume 33, Issue 3, Page(s) 183–190

Abstract: Introduction: Type 2 diabetes (T2D) is metabolic disorder associated with a decrease in insulin activity and/or secretion from the β-cells of the pancreas, leading to elevated circulating glucose. Current management practices for T2D are complex with ... ...

Abstract	Introduction: Type 2 diabetes (T2D) is metabolic disorder associated with a decrease in insulin activity and/or secretion from the β-cells of the pancreas, leading to elevated circulating glucose. Current management practices for T2D are complex with varying long-term effectiveness. Agonism of the G protein-coupled receptor GPR119 has received a lot of recent interest as a potential T2D therapeutic. Areas covered: This article reviews studies focused on GPR119 agonism in animal models of T2D and in patients with T2D. Expert opinion: GPR119 agonists
MeSH term(s)	Animals ; Humans ; Diabetes Mellitus, Type 2/drug therapy ; Glucose/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Incretins ; Insulin/metabolism ; Receptors, G-Protein-Coupled/agonists
Chemical Substances	Glucose (IY9XDZ35W2) ; GPR119 protein, human ; Hypoglycemic Agents ; Incretins ; Insulin ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1080/13543784.2024.2321271
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Article ; Online: Prevalence of Depression, Anxiety, and Stress in Undergraduate Dietetics Students.

Patten, Emily Vaterlaus / Vaterlaus, J Mitchell

Journal of nutrition education and behavior

2020 Volume 53, Issue 1, Page(s) 67–74

Abstract: Objective: To understand the mental health and stressors of current nutrition and dietetics students.: Design: Cross-sectional survey.: Participants: A total of 611 current Didactic Program in Dietetics (DPD) students in the US were recruited ... ...

Abstract	Objective: To understand the mental health and stressors of current nutrition and dietetics students. Design: Cross-sectional survey. Participants: A total of 611 current Didactic Program in Dietetics (DPD) students in the US were recruited through DPD program directors. Methods: Electronic survey included measures of anxiety, stress, depression, and specific stressors. Data analysis included descriptive statistics, chi-square analysis, and qualitative thematic analysis. Results: Most students experienced normal levels of depression, anxiety, and stress compared with the general population. A subset experienced some level of depression (30%), anxiety (40%), and stress (27%). Significant sources of stress were postgraduation plans (including internships), managing time, dietetics courses, finances, and self-imposed expectations. Conclusions and implications: The identification of a subset of DPD students experiencing symptoms of mental health challenges and recognition that there are common stressors among DPD students may increase awareness among educators, guide development of course policies, and highlight the importance of mitigating major sources of stress for students.
MeSH term(s)	Anxiety/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Dietetics ; Humans ; Prevalence ; Students
Language	English
Publishing date	2020-11-26
Publishing country	United States
Document type	Journal Article
ISSN	1878-2620
ISSN (online)	1878-2620
DOI	10.1016/j.jneb.2020.10.005
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Article ; Online: Phase IV PROVE study: Perampanel in real-world clinical care of pediatric patients with epilepsy.

Moretz, Katherine / Wheless, James / Santos, Cesar / Segal, Eric / Lancman, Marcelo / Patten, Anna / Malhotra, Manoj

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2024 Volume 50, Page(s) 23–30

Abstract: Introduction: The non-interventional Phase IV PROVE study (NCT03208660) assessed retention, efficacy, safety and tolerability, and perampanel dosing in patients with epilepsy during routine clinical care. This analysis evaluated final data from patients ...

Abstract	Introduction: The non-interventional Phase IV PROVE study (NCT03208660) assessed retention, efficacy, safety and tolerability, and perampanel dosing in patients with epilepsy during routine clinical care. This analysis evaluated final data from patients aged <4 years and 4-<12 years. Methods: Data were obtained retrospectively from medical/pharmacy records of patients in the United States initiating perampanel after January 1, 2014, according to treating clinician recommendations. Retention rate was the primary endpoint. Secondary assessments included median percent changes in seizure frequency, seizure-freedom rates, investigator impression of seizure effect, and safety and tolerability. Results: The Safety Analysis Set (SAS) included 41 patients (<4 years; mean maximum dose, 3.5 mg/day) and 203 patients (4-<12 years; mean maximum dose, 5.3 mg/day); 24-month retention rates were 35.7% (n = 5/14) and 42.0% (n = 47/112), respectively. In the Full Analysis Set, during Months 1-3, median percent reductions in seizure frequency were 33.3% (n = 8 [<4 years]) and 26.0% (n = 32 [4-<12 years]), and seizure-freedom rates were 12.5% in both groups (n = 1/8 and n = 4/32); patient numbers were low at later time points. Most patients showed improvements in seizure control (45.9% [<4 years] versus 52.4% [4-<12 years]) or no change (45.9% versus 34.5%) (SAS). Treatment-emergent adverse events (TEAEs) were reported in 12 (<4 years: 29.3%; most common, irritability [7.3%]) and 64 patients (4-<12 years: 31.5%; most common, aggression [6.9%]). Conclusions: Perampanel was generally well tolerated with <21% of TEAEs leading to withdrawal at 24 months, had favorable retention rates (≥50% and >35% at 12 and 24 months, respectively), and sustained efficacy in pediatric patients during routine clinical care.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2024.02.008
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 641: Show issues

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