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  1. Article ; Online: Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine.

    Good, Michael F / Yanow, Stephanie K

    Trends in parasitology

    2023  Volume 39, Issue 11, Page(s) 929–935

    Abstract: Recent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of ... ...

    Abstract Recent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain an immune response protective against multiple Plasmodium strains. Non-immunodominant, conserved epitopes are crucial. The evidence comes from studying the immune response to red cell surface-expressed antigens but should also be applicable to merozoite surface antigens. Strategies to define the targets of these highly focused immune responses are provided.
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2898: Show issues Location:
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  2. Article ; Online: Malaria Vaccines: Progress to Date.

    Stanisic, Danielle I / Good, Michael F

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2023  Volume 37, Issue 6, Page(s) 737–756

    Abstract: Malaria is a mosquito-borne disease caused by protozoan parasites of the genus Plasmodium. Despite significant declines in malaria-attributable morbidity and mortality over the last two decades, it remains a major public health burden in many countries. ... ...

    Abstract Malaria is a mosquito-borne disease caused by protozoan parasites of the genus Plasmodium. Despite significant declines in malaria-attributable morbidity and mortality over the last two decades, it remains a major public health burden in many countries. This underscores the critical need for improved strategies to prevent, treat and control malaria if we are to ultimately progress towards the eradication of this disease. Ideally, this will include the development and deployment of a highly effective malaria vaccine that is able to induce long-lasting protective immunity. There are many malaria vaccine candidates in development, with more than a dozen of these in clinical development. RTS,S/AS01 (also known as Mosquirix) is the most advanced malaria vaccine and was shown to have modest efficacy against clinical malaria in phase III trials in 5- to 17-month-old infants. Following pilot implementation trials, the World Health Organisation has recommended it for use in Africa in young children who are most at risk of infection with P. falciparum, the deadliest of the human malaria parasites. It is well recognised that more effective malaria vaccines are needed. In this review, we discuss malaria vaccine candidates that have progressed into clinical evaluation and highlight the most advanced candidates: Sanaria's irradiated sporozoite vaccine (PfSPZ Vaccine), the chemoattenuated sporozoite vaccine (PfSPZ-CVac), RTS,S/AS01 and the novel malaria vaccine candidate, R21, which displayed promising, high-level efficacy in a recent small phase IIb trial in Africa.
    MeSH term(s) Infant ; Animals ; Child ; Humans ; Child, Preschool ; Malaria Vaccines/therapeutic use ; Plasmodium falciparum ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/prevention & control ; Malaria/prevention & control ; Sporozoites
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2023-09-20
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-023-00623-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4112: Show issues Location:
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  3. Article ; Online: Vaccinating Children against COVID-19: Commentary and Mathematical Modeling.

    Hawkes, Michael T / Good, Michael F

    mBio

    2022  Volume 13, Issue 1, Page(s) e0378921

    Abstract: With the recent licensure of mRNA vaccines against COVID-19 in the 5- to 11-year-old age group, the public health impact of a childhood immunization campaign is of interest. Using a mathematical epidemiological model, we project that childhood ... ...

    Abstract With the recent licensure of mRNA vaccines against COVID-19 in the 5- to 11-year-old age group, the public health impact of a childhood immunization campaign is of interest. Using a mathematical epidemiological model, we project that childhood vaccination carries minimal risk and yields modest public health benefits. These include large relative reductions in child morbidity and mortality, although the absolute reduction is small because these events are rare. Furthermore, the model predicts "altruistic" absolute reductions in adult cases, hospitalizations, and mortality. However, vaccinating children to benefit adults should be considered from an ethical as well as a public health perspective. From a global health perspective, an additional ethical consideration is the justice of giving priority to children in high-income settings at low risk of severe disease while vaccines have not been made available to vulnerable adults in low-income settings.
    MeSH term(s) Humans ; Child ; Aged ; Child, Preschool ; COVID-19 ; SARS-CoV-2 ; COVID-19 Vaccines ; Australia ; Canada ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03789-21
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  4. Article ; Online: Streptococcus: An organism causing diseases beyond neglect.

    Good, Michael F

    PLoS neglected tropical diseases

    2020  Volume 14, Issue 5, Page(s) e0008095

    MeSH term(s) Humans ; Neglected Diseases/microbiology ; Neglected Diseases/mortality ; Neglected Diseases/prevention & control ; Streptococcal Infections/microbiology ; Streptococcal Infections/mortality ; Streptococcal Infections/prevention & control ; Streptococcus/genetics ; Streptococcus/isolation & purification ; Streptococcus/physiology
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0008095
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  5. Article ; Online: Biological strategies and political hurdles in developing malaria vaccines.

    Good, Michael F / Stanisic, Danielle I

    Expert review of vaccines

    2021  Volume 20, Issue 2, Page(s) 93–95

    MeSH term(s) Animals ; Humans ; Malaria/parasitology ; Malaria/prevention & control ; Malaria Vaccines/administration & dosage ; Malaria Vaccines/immunology ; Politics
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2021.1889094
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  6. Article: A whole parasite transmission-blocking vaccine for malaria: an ignored strategy.

    Good, Michael F / Yanow, Stephanie K

    Emerging topics in life sciences

    2021  Volume 1, Issue 6, Page(s) 547–552

    Abstract: Malaria vaccine approaches can be divided into 'subunit' and 'whole parasite', and these can be directed at the sporozoite, liver stage, asexual or sexual stages. All combinations of approach and stage are under development with the exception of a whole ... ...

    Abstract Malaria vaccine approaches can be divided into 'subunit' and 'whole parasite', and these can be directed at the sporozoite, liver stage, asexual or sexual stages. All combinations of approach and stage are under development with the exception of a whole parasite sexual stage (gametocyte) vaccine. A gametocyte vaccine would aim primarily to block transmission of malaria from the human host to the mosquito vector and as such is referred to as a 'transmission-blocking vaccine'. An immunological feature of whole parasite vaccines for the sporozoite/liver stage and for the asexual blood stage is the reliance on cellular immunity involving T-cells to control parasite growth. T-cells can also respond vigorously to gametocytes and kill them in the vertebrate host and/or arrest their development. To date, cellular immunity has not been exploited in transmission-blocking vaccine development. Here, the data supporting a gametocyte whole parasite vaccine are reviewed and a strategy for vaccine development and testing is outlined.
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20170117
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  7. Article ; Online: Vaccinating children against COVID-19: commentary and mathematical modelling

    Hawkes, Michael T / Good, Michael F

    medRxiv

    Abstract: With the recent licensure of mRNA vaccines against COVID-19 in the 5-11 year old age group, the public health impact of a childhood immunization campaign is of interest. Using a mathematical epidemiological model, we project that childhood vaccination ... ...

    Abstract With the recent licensure of mRNA vaccines against COVID-19 in the 5-11 year old age group, the public health impact of a childhood immunization campaign is of interest. Using a mathematical epidemiological model, we project that childhood vaccination carries minimal risk and yields modest public health benefits. These include large relative reductions in child morbidity and mortality, although the absolute reduction is small because these events are rare. Furthermore, the model predicts altruistic absolute reductions in adult cases, hospitalizations, and mortality. However, vaccinating children to benefit adults should be considered from an ethical as well as a public health perspective. From a global health perspective, an additional ethical consideration is the justice of giving priority to children in high-income settings at low risk of severe disease while vaccines have not been made available to vulnerable adults in low-income settings.
    Keywords covid19
    Language English
    Publishing date 2022-01-06
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.01.05.22268820
    Database COVID19

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  8. Article ; Online: Streptococcus

    Michael F Good

    PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e

    An organism causing diseases beyond neglect.

    2020  Volume 0008095

    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic.

    Good, Michael F / Hawkes, Michael T

    mBio

    2020  Volume 11, Issue 5

    Abstract: The existence and nature of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently unknown; however, neutralizing antibodies are thought to play the major role and data from studying other coronaviruses suggest that ... ...

    Abstract The existence and nature of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently unknown; however, neutralizing antibodies are thought to play the major role and data from studying other coronaviruses suggest that partial clinical immunity lasting up to 1 year will occur postinfection. We show how immunity, depending on its durability, may work with current social practices to limit the spread of the virus. We further show that a vaccine that is 50% effective and taken by 50% of the population will prevent further loss of life, providing that social distancing is still practiced and that immunity does not wane quickly.
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Forecasting ; Humans ; Immunity ; Models, Theoretical ; Mortality/trends ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02617-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nonessential Research in the New Normal: The Impact of COVID-19.

    Yanow, Stephanie K / Good, Michael F

    The American journal of tropical medicine and hygiene

    2020  Volume 102, Issue 6, Page(s) 1164–1165

    MeSH term(s) Betacoronavirus/pathogenicity ; Biomedical Research/economics ; Biomedical Research/ethics ; COVID-19 ; Clinical Trials as Topic ; Containment of Biohazards ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Global Health/economics ; Global Health/ethics ; Global Health/trends ; Health Facility Closure ; Humans ; Malaria/drug therapy ; Malaria/epidemiology ; Pandemics/economics ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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