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  1. Book: Looking beneath the surface of agricultural safety and health

    Murphy, Dennis J.

    2003  

    Author's details Dennis J. Murphy
    Language English
    Size VII, 104 S. : graph. Darst.
    Publisher American Soc. of Agricultural Engineers
    Publishing place St. Joseph, Mich
    Publishing country United States
    Document type Book
    HBZ-ID HT013690198
    ISBN 1-892769-28-X ; 978-1-892769-28-2
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    Shelf markLoan statusLocation
    034/467 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Capitalizing on Federal Agencies' Intentions To Protect Youth Working in Agriculture.

    Murphy, Dennis J

    Journal of agromedicine

    2017  Volume 22, Issue 4, Page(s) 304–308

    Abstract: Nearly 750,000 youth work on farms across the United States. The U.S. Department of Labor's (U.S. DOL) Fair Labor Standards Act (FLSA) Hazardous Occupations Orders for Agriculture (HOOA) applies to approximately 37% of these youth. The HOOA regulations ... ...

    Abstract Nearly 750,000 youth work on farms across the United States. The U.S. Department of Labor's (U.S. DOL) Fair Labor Standards Act (FLSA) Hazardous Occupations Orders for Agriculture (HOOA) applies to approximately 37% of these youth. The HOOA regulations had not been updated since their inception in the late 1960s and the early 1970s. An attempt by U.S. DOL to update the regulations in 2011 was met with fierce opposition by the agricultural community, and the proposed updated regulations were withdrawn. One impactful outcome of these two events was a rededication by USDA and the farm community to address agricultural youth farm safety through education rather than through regulation. An agriculturally based National Steering Committee has developed consensus Belief Statements and Guiding Principles to proactively influence agricultural youth safety. In this case, USDA was clearly a 'sphere of influence' for youth agricultural safety.
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2017.1353469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Apneic events - A proposed new target for respiratory safety pharmacology.

    Murphy, Dennis J

    Regulatory toxicology and pharmacology : RTP

    2016  Volume 81, Page(s) 194–200

    Abstract: Current practice in respiratory safety pharmacology generally follows the regulatory guidance provided by the ICH document S7A and focuses on measures of pulmonary ventilation. What these measures do not account for is the ability of drugs to cause ... ...

    Abstract Current practice in respiratory safety pharmacology generally follows the regulatory guidance provided by the ICH document S7A and focuses on measures of pulmonary ventilation. What these measures do not account for is the ability of drugs to cause ventilatory instability or interruptions in ventilatory rhythm. Ventilatory instability can be identified by the presence of prolonged end-expiratory pauses or apneic periods. An apneic event has been defined as an apneic period of sufficient duration to cause hypoxia (i.e., decrease in hemoglobin oxygen saturation ≥ 3%). Repeated apneic events are often referred to as intermittent hypoxia. Characterizing ventilatory instability is important since (1) occurrence of apneic events in humans can lead to serious adverse outcomes such as systemic and pulmonary hypertension, cardiac arrhythmia, stroke, CNS dysfunction, metabolic disorders, enhanced tumor growth and death, (2) drugs are known to cause or exacerbate apneic events in humans, and (3) there is a preexisting condition of ventilatory instability referred to as sleep apnea that is prevalent in the human population. Evaluating this new target in respiratory safety pharmacology studies is needed to ensure that the potential for new drugs to cause or exacerbate apneic events can be identified and the impact on patient safety characterized.
    MeSH term(s) Animals ; Dogs ; Humans ; Hypoxia/chemically induced ; Hypoxia/diagnosis ; Hypoxia/physiopathology ; Pharmaceutical Preparations/administration & dosage ; Pulmonary Ventilation/drug effects ; Respiration/drug effects ; Safety ; Sleep Apnea, Obstructive/chemically induced ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2016-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2016.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Safety and health for production agriculture

    Murphy, Dennis J.

    (ASAE textbook ; 5)

    1992  

    Title variant Production agriculture
    Author's details Dennis J. Murphy
    Series title ASAE textbook ; 5
    Collection
    Keywords Landwirtschaftlicher Betrieb ; Arbeitssicherheit ; Landarbeiter ; Gesundheitsvorsorge
    Subject Gefahrenschutz ; Technischer Arbeitsschutz ; Bäuerlicher Betrieb ; Landwirtschaftliches Unternehmen ; Landwirtschaftsbetrieb ; Farm ; Agrarbetrieb ; Landwirtschaftliche Betriebe
    Size IX, 253 S. : graph. Darst.
    Edition 1. ed.
    Publisher ASAE
    Publishing place St. Joseph, Mich
    Publishing country United States
    Document type Book
    HBZ-ID HT004952994
    ISBN 0-929355-32-6 ; 978-0-929355-32-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    938/2205 available for loan (reading room) Freihandmagazin (U1)

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  5. Article ; Online: Highlights of the Virtual 2021 North American Agricultural Safety Summit.

    Lee, Barbara C / Hair, Dan M / McCluer, Jess / Murphy, Dennis J / Swenson, Andrea V R

    Journal of agromedicine

    2021  Volume 26, Issue 3, Page(s) 289–293

    MeSH term(s) Agriculture ; Humans ; North America ; Occupational Health
    Language English
    Publishing date 2021-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2021.1931607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Optimizing the use of methods and measurement endpoints in respiratory safety pharmacology.

    Murphy, Dennis J

    Journal of pharmacological and toxicological methods

    2014  Volume 70, Issue 3, Page(s) 204–209

    Abstract: A variety of methods and measurement endpoints are currently available for evaluating respiratory function in animal models. To evaluate drug-induced effects on respiratory function, respiratory safety pharmacology studies generally emphasize the use of ... ...

    Abstract A variety of methods and measurement endpoints are currently available for evaluating respiratory function in animal models. To evaluate drug-induced effects on respiratory function, respiratory safety pharmacology studies generally emphasize the use of conscious animal models and measures of pulmonary ventilation. Respiratory rate, tidal volume and/or a measure of arterial blood gases are the standard measurement parameters. Although these parameters will provide a measure of ventilation, other ventilatory parameters, which can provide mechanistic insight or identify site of action, should also be considered. Such parameters include inspiratory and expiratory times, flows and pauses, and apneic time. Stimulation models involving exercise and exposure to elevated CO2 or reduced O2 should also be considered when enhancing measurement sensitivity or quantifying reductions in ventilatory functional reserve is desired. Although ventilatory measurements are capable of assessing the functional status of the respiratory pumping apparatus, such measurements are generally not capable of assessing the status of the other functional component of the respiratory system, namely, the gas exchange unit or lung. To characterize drug-induced effects on the gas exchange unit, measures of airway patency, lung elastic recoil and gas diffusion capacity need to be considered. The objective of this review is to discuss the value and utility of the methods and measurement endpoints currently available for assessing respiratory function to help optimize the design of respiratory safety pharmacology studies.
    MeSH term(s) Animals ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Humans ; Respiratory System/drug effects ; Safety
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1105919-9
    ISSN 1873-488X ; 1056-8719
    ISSN (online) 1873-488X
    ISSN 1056-8719
    DOI 10.1016/j.vascn.2014.03.174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1440: Show issues Location:
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  7. Article ; Online: Respiratory safety pharmacology - current practice and future directions.

    Murphy, Dennis J

    Regulatory toxicology and pharmacology : RTP

    2014  Volume 69, Issue 1, Page(s) 135–140

    Abstract: Current practice in respiratory safety pharmacology generally follows the guidance provided by the ICH document S7A and, in general, focuses on measures of pulmonary ventilation. Respiratory rate, tidal volume and/or a measure of arterial blood gases are ...

    Abstract Current practice in respiratory safety pharmacology generally follows the guidance provided by the ICH document S7A and, in general, focuses on measures of pulmonary ventilation. Respiratory rate, tidal volume and/or a measure of arterial blood gases are the recommended ventilatory measurement parameters. Although these parameters will provide a measure of ventilation, other ventilatory parameters, which can provide mechanistic insight, should also be considered. Such parameters include inspiratory and expiratory times and flows and apneic time. Stimulation models involving exercise and exposure to elevated CO2 or reduced O2 should also be considered when enhancing measurement sensitivity or quantifying reductions in ventilatory functional reserve are desired. Although ventilatory measurements are capable of assessing the functional status of the respiratory pumping apparatus, such measurements are generally not capable of assessing the status of the other functional component of the respiratory system, namely, the gas exchange unit or lung. To characterize drug-induced effects on the gas exchange unit, measures of airway patency, lung elastic recoil and gas diffusion capacity need to be considered. Thus, a variety of methodologies and measurement endpoints are available for detecting and characterizing drug-induced respiratory dysfunction in animal models and should be considered when designing respiratory safety pharmacology studies.
    MeSH term(s) Animals ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Humans ; Respiration/drug effects ; Respiratory System/drug effects ; Respiratory Tract Diseases/chemically induced
    Language English
    Publishing date 2014-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2013.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Capitalizing on Federal Agencies’ Intentions To Protect Youth Working in Agriculture

    Murphy, Dennis J

    Journal of agromedicine. 2017 Oct. 2, v. 22, no. 4

    2017  

    Abstract: Nearly 750,000 youth work on farms across the United States. The U.S. Department of Labor’s (U.S. DOL) Fair Labor Standards Act (FLSA) Hazardous Occupations Orders for Agriculture (HOOA) applies to approximately 37% of these youth. The HOOA regulations ...

    Abstract Nearly 750,000 youth work on farms across the United States. The U.S. Department of Labor’s (U.S. DOL) Fair Labor Standards Act (FLSA) Hazardous Occupations Orders for Agriculture (HOOA) applies to approximately 37% of these youth. The HOOA regulations had not been updated since their inception in the late 1960s and the early 1970s. An attempt by U.S. DOL to update the regulations in 2011 was met with fierce opposition by the agricultural community, and the proposed updated regulations were withdrawn. One impactful outcome of these two events was a rededication by USDA and the farm community to address agricultural youth farm safety through education rather than through regulation. An agriculturally based National Steering Committee has developed consensus Belief Statements and Guiding Principles to proactively influence agricultural youth safety. In this case, USDA was clearly a ‘sphere of influence’ for youth agricultural safety.
    Keywords USDA ; agricultural health and safety ; education ; farms ; labor ; occupations ; youth ; United States
    Language English
    Dates of publication 2017-1002
    Size p. 304-308.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2017.1353469
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Leadership and Funding: Changes Ahead for Agricultural Safety and Health.

    Murphy, Dennis J / Lee, Barbara C

    Journal of agromedicine

    2017  Volume 23, Issue 1, Page(s) 3–6

    Abstract: For the last several decades, financial support for agricultural safety and health programs and professionals has primarily been covered by public dollars through federal and state government grant programs and appropriations. This federal and state ... ...

    Abstract For the last several decades, financial support for agricultural safety and health programs and professionals has primarily been covered by public dollars through federal and state government grant programs and appropriations. This federal and state funding provided a tremendous boost to farm safety and health professionals and program efforts for 30+ years and has provided the foundation and structure for current agricultural safety and health efforts and activities. However, there is reason to question long-term sustainability of a sufficient level of federal and state dollars for agricultural safety and health. Public funding for agricultural safety and health has never quite kept up to inflation, but even more ominous is that the entire agricultural safety and health program has been proposed for elimination each year by the White House budget beginning with the fiscal year 2012. It seems prudent, perhaps even imperative, for the agricultural safety and health community to find alternative support mechanisms. We suggest that now is a great time for agricultural businesses, services, and organizations to step up their financial support. Fortunately, several positive examples have recently surfaced within the agricultural community. As the agricultural industry continues to be a dominant enterprise in the United States, the integration of significant funding and the role of leadership from within the industry must continue to expand.
    MeSH term(s) Agriculture/economics ; Agriculture/organization & administration ; Government Programs/economics ; Government Programs/legislation & jurisprudence ; Humans ; Leadership ; Occupational Health/economics ; United States
    Language English
    Publishing date 2017-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2017.1404949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of

    Vogel, Charles L / Cobleigh, Melody A / Tripathy, Debu / Gutheil, John C / Harris, Lyndsay N / Fehrenbacher, Louis / Slamon, Dennis J / Murphy, Maureen / Novotny, William F / Burchmore, Michael / Shak, Steven / Stewart, Stanford J / Press, Michael

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 9, Page(s) 1638–1645

    Abstract: Purpose: To evaluate the efficacy and safety of first-line, single-agent trastuzumab in women with : Patients and methods: One hundred fourteen women with : Results: The objective response rate was 26% (95% confidence interval [CI], 18.2% to 34.4%) ...

    Abstract Purpose: To evaluate the efficacy and safety of first-line, single-agent trastuzumab in women with
    Patients and methods: One hundred fourteen women with
    Results: The objective response rate was 26% (95% confidence interval [CI], 18.2% to 34.4%), with seven complete and 23 partial responses. Response rates in 111 assessable patients with 3+ and 2+
    Conclusion: Single-agent trastuzumab is active and well tolerated as first-line treatment of women with metastatic breast cancer with
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Corrected and Republished Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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