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  1. Article: Potentiality of Self-Cloned Lactobacillus plantarum Taj-Apis362 for Enhancing GABA Production in Yogurt under Glucose Induction: Optimization and Its Cardiovascular Effect on Spontaneous Hypertensive Rats

    Hussin, Farah Salina / Chay, Shyan Yea / Zarei, Mohammad / Meor Hussin, Anis Shobirin / Ibadullah, Wan Zunairah Wan / Zaharuddin, Nurul Dhania / Wazir, Hazrati / Saari, Nazamid

    Foods. 2020 Dec. 09, v. 9, no. 12

    2020  

    Abstract: ... strains of lactic acid bacteria (L. plantarum Taj-Apis362, assigned as UPMC90, UPMC91, and UPMC1065 ...

    Abstract The current study evaluated the γ-aminobutyric acid (GABA) producing ability from three novel strains of lactic acid bacteria (L. plantarum Taj-Apis362, assigned as UPMC90, UPMC91, and UPMC1065) co-cultured with starter culture in a yogurt. A combination of UPMC90 + UPMC91 with starter culture symbiotically revealed the most prominent GABA-producing effect. Response surface methodology revealed the optimized fermentation conditions at 39.0 °C, 7.25 h, and 11.5 mM glutamate substrate concentration to produce GABA-rich yogurt (29.96 mg/100 g) with desirable pH (3.93) and water-holding capacity (63.06%). At 2% glucose to replace pyridoxal-5-phosphate (PLP), a cofactor typically needed during GABA production, GABA content was further enhanced to 59.00 mg/100 g. In vivo study using this sample revealed a blood pressure-lowering efficacy at 0.1 mg/kg GABA dosage (equivalent to 30 mg/kg GABA-rich yogurt) in spontaneously hypertensive rats. An improved method to produce GABA-rich yogurt has been established, involving shorter fermentation time and lower glutamate concentration than previous work, along with glucose induction that omits the use of costly PLP, fostering the potential of developing a GABA-rich functional dairy product through natural fermentation with desirable product quality and antihypertensive property.
    Keywords Lactobacillus plantarum ; blood ; coculture ; dosage ; fermentation ; glucose ; in vivo studies ; lactic acid bacteria ; pH ; product quality ; rats ; response surface methodology ; starter cultures ; strains ; water holding capacity ; yogurt
    Language English
    Dates of publication 2020-1209
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods9121826
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Drug susceptibility, Prevalence and effect of Pseudomonas aeruginosa on wound healing of burn patients.

    Azam, Saima / Mustafa, Mohammad Zahid / Taj, Muhammad Kamran / Mengal, Muhammad Azam / Mengal, Muhammad Alam / Hussain, Ashiq

    JPMA. The Journal of the Pakistan Medical Association

    2024  Volume 74, Issue 1, Page(s) 67–71

    Abstract: Objective: To determine the prevalence, antibiotic susceptibility and effect of Pseudomonas aeruginosa in relation to burn patients.: Methods: The cross-sectional study was conducted at the Centre for Advanced Studies in Vaccinology and Biotechnology, ...

    Abstract Objective: To determine the prevalence, antibiotic susceptibility and effect of Pseudomonas aeruginosa in relation to burn patients.
    Methods: The cross-sectional study was conducted at the Centre for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan, Quetta, Pakistan, from March 2018 to May 2021, and comprised pus swab cultures were isolated from inpatients with 2nd and 3rd degree burns aged up to 60 years at Bolan Medical Complex Hospital and Sandeman Provinical Hospital, the two main government tertiary care hospitals in Quetta. The samples were immediately cultured, and evaluated using biochemical tests, antibiotic susceptibility and molecular identification using polymerase chain reaction. Data was analysed using SPSS 20.
    Results: Of the 720 burn wound samples, 424(58.9%) were positive for Pseudomonas aeruginosa; 304(42%) males and 120(16%) females (p<0.02). The overall mean age of the patients was 27.7±6.2 years (range: 1-60 years). The mean total burn surface area was not significantly different in positive 29.6±6.2% and negative 30.3±6.2% cases (p>0.05). The time leading to skin grafts in positive patients was 29.5±6.5 days compared to 22.3±6.3 days for negative patients (p< 0.007), and the time required for wound healing was 25.0±4.7 days and 16.7±5.2 days, respectively (p<0.001). Length of hospital stay of Pseudomonas aeruginosa positive patients was 38.0±7.8 days compared to 32.1±6.8 days for negative patients (p<0.001).
    Conclusion: Nosocomial infections and multidrug resistance species were observed frequently at the burn wound site. P. aeruginosa.
    MeSH term(s) Male ; Female ; Humans ; Aged ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Pseudomonas aeruginosa ; Prevalence ; Cross-Sectional Studies ; Wound Infection/drug therapy ; Wound Infection/epidemiology ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/epidemiology ; Burns/epidemiology ; Burns/drug therapy ; Wound Healing ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-13
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.8477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Understanding the impact of socioeconomic and health factors on geriatric depression: A comparative study in rural and urban Bangladesh.

    Hossain, Mohammad Kamal / Islam, Md Nazrul / Uddin, Mohammed Taj / Hossain, Md Sabbir

    Health science reports

    2024  Volume 7, Issue 2, Page(s) e1849

    Abstract: Background and aims: The prevalence of depression among the elderly is a growing concern, and this study examines the differences between urban and rural areas in terms of geriatric depression.: Methods: Using a two-stage random sampling approach in ... ...

    Abstract Background and aims: The prevalence of depression among the elderly is a growing concern, and this study examines the differences between urban and rural areas in terms of geriatric depression.
    Methods: Using a two-stage random sampling approach in urban areas and a multistage random sampling approach in rural areas, the study surveyed 944 elderly individuals of both sexes.
    Results: The results indicate that the prevalence of depression was high, with 52.5% of the elderly population experiencing mild to severe depression. The study found that increasing age, female gender, nuclear family structure, and involvement of housewives or others were significant factors affecting depression in urban areas, while increasing age and elderly people without spouses were significant factors in rural areas. Additionally, the study identified hearing impairment, asthma, and arthritis as risk factors for depression in rural areas, and bronchitis, heart disease, and thyroid illness as significant factors in urban areas.
    Conclusion: These findings highlight the need for policymakers to focus on addressing the mental health needs of older people, particularly women and those without spouses.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pylephlebitis-induced acute liver failure: A case report and review of literature.

    Hapshy, Vera / Imburgio, Steven / Sanekommu, Harshavardhan / Nightingale, Brandon / Taj, Sobaan / Hossain, Mohammad A / Patel, Swapnil

    World journal of hepatology

    2024  Volume 16, Issue 1, Page(s) 103–108

    Abstract: Background: Pylephlebitis is an extremely rare form of septic thrombophlebitis involving the portal vein, carrying high rates of morbidity and mortality.: Case summary: We present a case of a 42-year-old male with no past medical history who ... ...

    Abstract Background: Pylephlebitis is an extremely rare form of septic thrombophlebitis involving the portal vein, carrying high rates of morbidity and mortality.
    Case summary: We present a case of a 42-year-old male with no past medical history who presented with acute onset of abdominal pain and altered mental status with laboratory tests demonstrating new-onset acute liver failure. Pylephlebitis was determined to be the underlying etiology due to subsequent workup revealing polymicrobial gram-negative anaerobic bacteremia and complete thrombosis of the main and left portal veins. To our knowledge, this is the first documented case of acute liver failure as a potential life-threatening complication of pylephlebitis.
    Conclusion: Our case highlights the importance of considering pylephlebitis in the broad differential for abdominal pain, especially if there are co-existing risk factors for hypercoagulability. We also demonstrate that fulminant hepatic failure in these patients can potentially be reversible with the immediate initiation of antibiotics and anticoagulation.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v16.i1.103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Appendiceal Bulge on Routine Colonoscopy: Not All Disease Is Luminal.

    Taj, Sobaan / Akbar, Usman Ali / Philip, Shawn / Miller, Brett / Haq, ZakaUl / Sanekommu, Harshavardhan / Hossain, Mohammad A / Sciarra, Michael

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35466

    Abstract: Appendiceal ... ...

    Abstract Appendiceal mucocele
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ominous Sign of Pneumatosis Intestinalis With Portal Venous Gas.

    Miller, Brett / Taj, Sobaan / Pannu, Viraaj S / Tavakolian, Kameron / Joseph, Liz / Hossain, Mohammad A

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35605

    Abstract: The presence of gas and free air in the extraluminal space of the intestines is known as pneumatosis intestinalis (PI). There are many different causes of this finding, including gastrointestinal, pulmonary, autoimmune, and many more. It is often ... ...

    Abstract The presence of gas and free air in the extraluminal space of the intestines is known as pneumatosis intestinalis (PI). There are many different causes of this finding, including gastrointestinal, pulmonary, autoimmune, and many more. It is often difficult to differentiate the etiology and clinical importance of the radiographic evidence on pneumatosis intestinalis due to the unclear pathophysiology causing the disease. To complicate things further, the ominous sign of portal venous gas poses the question of whether surgical intervention is needed. We report two cases both with clinical and radiographic evidence of secondary pneumatosis intestinalis with an associated sinister finding of portal venous gas. The cases differ by urgent surgical intervention versus observation before surgery. In this case series, we emphasize the importance of recognizing the radiographic finding and stress the need for further research to standardize a plan of care, including indications for surgery. We encourage more cases like this to be reported to aid in diagnosing and treating this condition early on with the aim of improving the mortality associated with it.
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unique Variant of Zieve Syndrome With a Normal Reticulocyte Count.

    Vedire, Apurva / Imburgio, Steven / Sanekommu, Harshavardhan / Patel, Rushi / Johnson, Haley / Taj, Sobaan / Hossain, Mohammad

    Journal of medical cases

    2023  Volume 14, Issue 6, Page(s) 185–190

    Abstract: Zieve syndrome is a rare diagnosis seen in patients with chronic alcohol use which consists of a distinct clinical triad of hyperlipidemia, hemolytic anemia, and jaundice. Patients typically have an elevated reticulocyte count due to the hemolytic nature ...

    Abstract Zieve syndrome is a rare diagnosis seen in patients with chronic alcohol use which consists of a distinct clinical triad of hyperlipidemia, hemolytic anemia, and jaundice. Patients typically have an elevated reticulocyte count due to the hemolytic nature of the anemia. We present the case of a 44-year-old female who was discovered to have an unusual variant of Zieve syndrome with a normal reticulocyte count, which was believed to be due to suppression of bone marrow from excessive alcohol consumption. She was treated with steroids and complete alcohol cessation, with remarkable improvement on subsequent follow-up. An exhaustive literature review of 31 documented cases of Zieve syndrome was conducted to better understand the clinical presentation and overall prognosis of these patients. This case report and literature review aimed to improve patient outcomes through increased recognition of this underrecognized syndrome.
    Language English
    Publishing date 2023-06-29
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4163
    ISSN (online) 1923-4163
    ISSN 1923-4163
    DOI 10.14740/jmc4077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identification of High-Affinity Inhibitors of TANK-Binding Kinase 1 (TBK1): A Promising Frontier for Controlling Inflammatory Signaling in Cancer.

    Jairajpuri, Deeba Shamim / Mohammad, Taj / Hussain, Afzal / Alajmi, Mohamed F / Yadav, Dharmendra Kumar / Hassan, Md Imtaiyaz

    Discovery medicine

    2024  Volume 36, Issue 180, Page(s) 129–139

    Abstract: Background: TANK-binding kinase 1 (TBK1) is an important serine/threonine kinase involved in inflammatory signaling pathways, influencing cellular processes such as proliferation, programmed cell death, autophagy, and immune response regulation. ... ...

    Abstract Background: TANK-binding kinase 1 (TBK1) is an important serine/threonine kinase involved in inflammatory signaling pathways, influencing cellular processes such as proliferation, programmed cell death, autophagy, and immune response regulation. Dysregulation of TBK1 has been linked to cancer progression and neurodegenerative disorders, making it an attractive target for therapeutic development. This study aimed to identify potential TBK1 inhibitors using a structure-based virtual screening approach.
    Methods: We conducted a comprehensive screening of the ZINC database to identify compounds with high binding affinity for TBK1, employing molecular docking as the primary selection criterion. The top candidates were then subjected to extensive 200 ns molecular dynamics (MD) simulations to assess the conformational dynamics of TBK1 and the stability of the protein-ligand complexes, with a focus on ZINC02095133 and ZINC02130647.
    Results: The findings revealed that TBK1 forms stable complexes with ZINC02095133 and ZINC02130647, demonstrating consistent interactions throughout the MD simulations. This suggests that these compounds hold promise as potential lead molecules for future therapies targeting TBK1.
    Conclusions: This study identifies ZINC02095133 and ZINC02130647 as promising TBK1 inhibitors with therapeutic potential. However, further experimental validation and optimization are required to develop novel inhibitors for diseased conditions associated with TBK1 signaling. These findings pave the way for future investigations into the clinical utility of these compounds in combating TBK1-related pathologies.
    MeSH term(s) Humans ; Molecular Docking Simulation ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Molecular Dynamics Simulation ; Neoplasms/drug therapy
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2415544-5
    ISSN 1944-7930 ; 1944-7930
    ISSN (online) 1944-7930
    ISSN 1944-7930
    DOI 10.24976/Discov.Med.202436180.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Identification of high-affinity pyridoxal kinase inhibitors targeting cancer therapy: an integrated docking and molecular dynamics simulation approach.

    Banerjee, Pallabi / Chandra, Anshuman / Mohammad, Taj / Singh, Nagendra / Hassan, Md Imtaiyaz / Qamar, Imteyaz

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–18

    Abstract: Pyridoxal kinase (PDXK) is a vitamin B6-dependent transferase enzyme encoded by ... ...

    Abstract Pyridoxal kinase (PDXK) is a vitamin B6-dependent transferase enzyme encoded by the
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2246580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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  10. Article ; Online: Complete Genome Sequences of Nine Streptococcus pneumoniae Serotype 3 Clonal Complex 180 Strains.

    Shambhu, Smitha / Cella, Eleonora / Jubair, Mohammad / Azarian, Taj

    Microbiology resource announcements

    2022  Volume 11, Issue 7, Page(s) e0027522

    Abstract: We announce the complete genomes of nine Streptococcus pneumoniae strains belonging to serotype 3 clonal complex 180 (CC180). The genomes consist of a single circularized contig with an average length of 2.033 Mbp. Pangenome analysis identified 1,762 ... ...

    Abstract We announce the complete genomes of nine Streptococcus pneumoniae strains belonging to serotype 3 clonal complex 180 (CC180). The genomes consist of a single circularized contig with an average length of 2.033 Mbp. Pangenome analysis identified 1,762 core genes and 412 accessory genes. These genomes are the basis for future population genomic studies.
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00275-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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