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  1. Article: Trostkultur. Vermittlungsweisen des Tröstens in der antiken Literatur

    Hafner, Markus

    Praxis PalliativeCare

    2021  Volume 53, Issue trösten, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 2469387-X
    ISSN 1867-7126
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7063: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Machine-guided discovery of a real-world rogue wave model.

    Häfner, Dion / Gemmrich, Johannes / Jochum, Markus

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 48, Page(s) e2306275120

    Abstract: Big data and large-scale machine learning have had a profound impact on science and engineering, particularly in fields focused on forecasting and prediction. Yet, it is still not clear how we can use the superior pattern-matching abilities of machine ... ...

    Abstract Big data and large-scale machine learning have had a profound impact on science and engineering, particularly in fields focused on forecasting and prediction. Yet, it is still not clear how we can use the superior pattern-matching abilities of machine learning models for scientific discovery. This is because the goals of machine learning and science are generally not aligned. In addition to being accurate, scientific theories must also be causally consistent with the underlying physical process and allow for human analysis, reasoning, and manipulation to advance the field. In this paper, we present a case study on discovering a symbolic model for oceanic rogue waves from data using causal analysis, deep learning, parsimony-guided model selection, and symbolic regression. We train an artificial neural network on causal features from an extensive dataset of observations from wave buoys, while selecting for predictive performance and causal invariance. We apply symbolic regression to distill this black-box model into a mathematical equation that retains the neural network's predictive capabilities, while allowing for interpretation in the context of existing wave theory. The resulting model reproduces known behavior, generates well-calibrated probabilities, and achieves better predictive scores on unseen data than current theory. This showcases how machine learning can facilitate inductive scientific discovery and paves the way for more accurate rogue wave forecasting.
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2306275120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The End of Carnivalism, or The Making of the Corpus Lucianeum

    Markus Hafner

    Araucaria, Vol 21, Iss 41, Pp 209-

    2019  Volume 231

    Abstract: En un pasaje clave para entender la obra de Luciano, Piscator 25–27, el filósofo Diógenes de Sinope se queja de que Parresíades, una figura de autoría parecida a Luciano, no se burla de los filósofos dentro de los límites carnavalescos del festival, como ...

    Abstract En un pasaje clave para entender la obra de Luciano, Piscator 25–27, el filósofo Diógenes de Sinope se queja de que Parresíades, una figura de autoría parecida a Luciano, no se burla de los filósofos dentro de los límites carnavalescos del festival, como lo hacía la Comedia Vieja, a la que tanto debe la obra de Luciano, sino mediante constantes publicaciones de escritos. Esta afirmación adquiere aún mayor importancia por el hecho de que el Piscator pertenece a un grupo de textos que muestra evidentes referencias cruzadas a otros escritos del corpus (como Pro imaginibus, Apologia o Fugitivi). Al crear indirectamente comentarios de autoría y referencias intertextuales a través de su obra ‘multitemática’ – por así decir, una (auto)bibliobiografía escondida –, Luciano refuerza la idea de una obra literaria orgánica y un corpus coherente que se encuentra – a pesar de la variatio temática – bien divulgado y lejos de la excepcionalidad carnavalesca. Así, la estética de la trasgresión perpetua está relacionada de manera única con la construcción de la auto-referencialidad como autor en las sátiras de Luciano.
    Keywords carnavalismo ; publicación ; intratextualidad ; biobibliografía ; pseudo ; lucianea ; ficciones autoriales ; History of scholarship and learning. The humanities ; AZ20-999 ; Political science ; J ; Philosophy (General) ; B1-5802
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Universidad de Sevilla
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Epigenetic repression of antiviral genes by SARS-CoV-2 NSP1.

    Anastasakis, Dimitrios G / Benhalevy, Daniel / Çuburu, Nicolas / Altan-Bonnet, Nihal / Hafner, Markus

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0297262

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the innate immune machinery through multiple viral proteins, including nonstructural protein 1 (NSP1). While NSP1 is known to suppress translation of host mRNAs, the mechanisms ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the innate immune machinery through multiple viral proteins, including nonstructural protein 1 (NSP1). While NSP1 is known to suppress translation of host mRNAs, the mechanisms underlying its immune evasion properties remain elusive. By integrating RNA-seq, ribosome footprinting, and ChIP-seq in A549 cells we found that NSP1 predominantly represses transcription of immune-related genes by favoring Histone 3 Lysine 9 dimethylation (H3K9me2). G9a/GLP H3K9 methyltransferase inhibitor UNC0638 restored expression of antiviral genes and restricted SARS-CoV-2 replication. Our multi-omics study unravels an epigenetic mechanism underlying host immune evasion by SARS-CoV-2 NSP1. Elucidating the factors involved in this phenomenon, may have implications for understanding and treating viral infections and other immunomodulatory diseases.
    MeSH term(s) Humans ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/virology ; Epigenetic Repression ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; Viral Nonstructural Proteins/metabolism
    Chemical Substances Viral Nonstructural Proteins ; NSP1 protein, SARS-CoV-2
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Real-world rogue wave probabilities.

    Häfner, Dion / Gemmrich, Johannes / Jochum, Markus

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 10084

    Abstract: Rogue waves are dangerous ocean waves at least twice as high as the surrounding waves. Despite an abundance of studies conducting simulations or wave tank experiments, there is so far no reliable forecast for them. In this study, we use data mining and ... ...

    Abstract Rogue waves are dangerous ocean waves at least twice as high as the surrounding waves. Despite an abundance of studies conducting simulations or wave tank experiments, there is so far no reliable forecast for them. In this study, we use data mining and interpretable machine learning to analyze large amounts of observational data instead (more than 1 billion waves). This reveals how rogue wave occurrence depends on the sea state. We find that traditionally favored parameters such as surface elevation kurtosis, steepness, and Benjamin-Feir index are weak predictors for real-world rogue wave risk. In the studied regime, kurtosis is only informative within a single wave group, and is not useful for forecasting. Instead, crest-trough correlation is the dominating parameter in all studied conditions, water depths, and locations, explaining about a factor of 10 in rogue wave risk variation. For rogue crests, where bandwidth effects are unimportant, we find that skewness, steepness, and Ursell number are the strongest predictors, in line with second-order theory. Our results suggest that linear superposition in bandwidth-limited seas is the main pathway to "everyday" rogue waves, with nonlinear contributions providing a minor correction. This casts some doubt whether the common rogue wave definition as any wave exceeding a certain height threshold is meaningful in practice.
    Language English
    Publishing date 2021-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-89359-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Leitlinie Delir

    Baumgartner, Markus / Georgescu, Dan / Hafner, Martina / Kressig, Reto W. / Popp, Julius / Rohrbach, Erich / Schmid, Ruth / Verloo, Henk / Savaskan, Egemen / Hasemann, Wolfgang

    Empfehlungen zur Prävention, Diagnostik und Therapie des Delirs im Alter

    2017  

    Author's details Egemen Savaskan, Wolfgang Hasemann (Herausgeber) ; unter Mitautorenschaft von Markus Baumgartner, Dan Georgescu, Martina Hafner, Reto W. Kressig, Julius Popp, Erich Rohrbach, Ruth Schmid, Henk Verloo
    Keywords Alter ; Delirium ; Evidenz-basierte Medizin
    Subject Evidence-based medicine ; Gutachtenbasierte Medizin ; Evidenzbasierte Medizin ; Delir ; Delirantes Syndrom ; Alter Mensch ; Betagter ; Senioren ; Senior
    Language German
    Size 170 Seiten, Diagramme
    Edition 1. Auflage
    Publisher Hogrefe
    Publishing place Bern
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019231943
    ISBN 978-3-456-85761-9 ; 3-456-85761-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 282 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: Proximity-CLIP Provides a Snapshot of Protein-Occupied RNA Elements at Subcellular Resolution and Transcriptome-Wide Scale.

    Benhalevy, Daniel / Hafner, Markus

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2166, Page(s) 283–305

    Abstract: The distribution of messenger RNAs (mRNAs) to specific subcellular locations has been studied for the past two decades. Technically, studies of RNA localization are lagging those related to protein localization. Here we provide a detailed protocol for ... ...

    Abstract The distribution of messenger RNAs (mRNAs) to specific subcellular locations has been studied for the past two decades. Technically, studies of RNA localization are lagging those related to protein localization. Here we provide a detailed protocol for Proximity-CLIP, a method recently developed by our group, that combines proximity biotinylation of proteins with photoactivatable ribonucleoside-enhanced protein-RNA cross-linking to simultaneously profile the proteome including RNA-binding proteins (RBPs) and the RBP-bound transcriptome in any given subcellular compartment. The approach is fractionation independent and also enables studying localized RNA-processing intermediates, as well as the identification of regulatory cis-acting elements on RNAs occupied by proteins in a cellular compartment-specific manner.
    MeSH term(s) Animals ; Ascorbate Peroxidases/chemistry ; Biotinylation/methods ; Cell Line ; Chromatin Immunoprecipitation Sequencing/methods ; Chromatography, Affinity ; Gene Library ; High-Throughput Nucleotide Sequencing/methods ; Immunoprecipitation ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Messenger/radiation effects ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/radiation effects ; Streptavidin/chemistry ; Transcriptome/genetics ; Ultraviolet Rays
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins ; Streptavidin (9013-20-1) ; Ascorbate Peroxidases (EC 1.11.1.11)
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0712-1_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Real-world rogue wave probabilities

    Dion Häfner / Johannes Gemmrich / Markus Jochum

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Abstract Rogue waves are dangerous ocean waves at least twice as high as the surrounding waves. Despite an abundance of studies conducting simulations or wave tank experiments, there is so far no reliable forecast for them. In this study, we use data ... ...

    Abstract Abstract Rogue waves are dangerous ocean waves at least twice as high as the surrounding waves. Despite an abundance of studies conducting simulations or wave tank experiments, there is so far no reliable forecast for them. In this study, we use data mining and interpretable machine learning to analyze large amounts of observational data instead (more than 1 billion waves). This reveals how rogue wave occurrence depends on the sea state. We find that traditionally favored parameters such as surface elevation kurtosis, steepness, and Benjamin–Feir index are weak predictors for real-world rogue wave risk. In the studied regime, kurtosis is only informative within a single wave group, and is not useful for forecasting. Instead, crest-trough correlation is the dominating parameter in all studied conditions, water depths, and locations, explaining about a factor of 10 in rogue wave risk variation. For rogue crests, where bandwidth effects are unimportant, we find that skewness, steepness, and Ursell number are the strongest predictors, in line with second-order theory. Our results suggest that linear superposition in bandwidth-limited seas is the main pathway to “everyday” rogue waves, with nonlinear contributions providing a minor correction. This casts some doubt whether the common rogue wave definition as any wave exceeding a certain height threshold is meaningful in practice.
    Keywords Medicine ; R ; Science ; Q
    Subject code 535
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Editorial: The Mechanisms Underlying the Human Minimal Self.

    Hafner, Verena / Hommel, Bernhard / Kayhan, Ezgi / Lee, Dongheui / Paulus, Markus / Verschoor, Stephan

    Frontiers in psychology

    2022  Volume 13, Page(s) 961480

    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.961480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: PAR-CLIP: A Method for Transcriptome-Wide Identification of RNA Binding Protein Interaction Sites.

    Danan, Charles / Manickavel, Sudhir / Hafner, Markus

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2404, Page(s) 167–188

    Abstract: During post-transcriptional gene regulation (PTGR), RNA binding proteins (RBPs) interact with all classes of RNA to control RNA maturation, stability, transport, and translation. Here, we describe Photoactivatable-Ribonucleoside-Enhanced Crosslinking and ...

    Abstract During post-transcriptional gene regulation (PTGR), RNA binding proteins (RBPs) interact with all classes of RNA to control RNA maturation, stability, transport, and translation. Here, we describe Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP), a transcriptome-scale method for identifying RBP binding sites on target RNAs with nucleotide-level resolution. This method is readily applicable to any protein directly contacting RNA, including RBPs that are predicted to bind in a sequence- or structure-dependent manner at discrete RNA recognition elements (RREs), and those that are thought to bind transiently, such as RNA polymerases or helicases.
    MeSH term(s) Binding Sites ; Immunoprecipitation ; Protein Binding ; RNA/genetics ; RNA/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribonucleosides ; Transcriptome
    Chemical Substances RNA-Binding Proteins ; Ribonucleosides ; RNA (63231-63-0)
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1851-6_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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