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  1. Article: Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients.

    Al-Dulaimi, Nuhad Mohammed / Mohammed, Mahmood Jassim / Mutlk, Saad T / Al-Rawi, Khalid F / Ali, Hameed Hussein / Aldahham, Bilal J M / Al-Ani, Faisal / Al-Ani, Osamah / Hamed, Yaqout A / Ali, Aus T

    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti

    2024  Volume 73, Issue 1, Page(s) 223–232

    Abstract: Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to  assess  the  relationship  between  the  severity of Covid-19 ... ...

    Title translation Hyperferitinemie jako faktor spojený se špatnou prognózou u pacientů s COVID-19.
    Abstract Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to  assess  the  relationship  between  the  severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19.
    MeSH term(s) Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hyperferritinemia ; Prospective Studies ; COVID-19 ; Ferritins ; Prognosis
    Chemical Substances Ferritins (9007-73-2)
    Language English
    Publishing date 2024-01-07
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1187133-7
    ISSN 1210-7816 ; 0009-0530
    ISSN 1210-7816 ; 0009-0530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients.

    Al-Dulaimi, Nuhad Mohammed / Mohammed, Mahmood Jassim / Mutlk, Saad T / Al-Rawi, Khalid F / Ali, Hameed Hussein / Aldahham, Bilal J M / Al-Ani, Faisal / Al-Ani, Osamah / Hamed, Yaqout A / Ali, Aus T

    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti

    2024  Volume 72, Issue 5, Page(s) 223–232

    Abstract: Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to  assess  the  relationship  between  the  severity of Covid-19 ... ...

    Title translation Hyperferitinemie jako faktor spojený se špatnou prognózou u pacientů s COVID-19.
    Abstract Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to  assess  the  relationship  between  the  severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19.
    MeSH term(s) Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hyperferritinemia ; Prospective Studies ; COVID-19 ; Ferritins ; Prognosis
    Chemical Substances Ferritins (9007-73-2)
    Language English
    Publishing date 2024-01-09
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1187133-7
    ISSN 1210-7816 ; 0009-0530
    ISSN 1210-7816 ; 0009-0530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of naphthyridine and quinoline derivatives as potential Nsp16-Nsp10 inhibitors: a pharmacoinformatics study.

    Aldahham, Bilal J M / Al-Khafaji, Khattab / Saleh, Mohanad Yakdhan / Abdelhakem, Adel Mohamed / Alanazi, Amer M / Islam, Md Ataul

    Journal of biomolecular structure & dynamics

    2020  Volume 40, Issue 9, Page(s) 3899–3906

    Abstract: This research is a recent effort to explore some new heterocyclic compounds as novel and potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibition. ...

    Abstract This research is a recent effort to explore some new heterocyclic compounds as novel and potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibition. The SARS-CoV-2 is causative agent of coronavirus disease 2019 (COVID-19) pandemic. A set of 58 molecules belongs to the naphthyridine and quinoline derivatives have been recently synthesized and considered for structure-based virtual screening against Nsp16-Nsp10. Molecular docking was virtually performed to screen for anti-SARS-CoV-2 activity against Nsp16-Nsp10. Fourteen out of fifty-eight compounds were exhibited binding affinity higher than co-crystal bound ligand s-adenosylmethionine (SAM) toward Nsp16-Nsp10. Further, the
    MeSH term(s) COVID-19/drug therapy ; Humans ; Ligands ; Methyltransferases/chemistry ; Molecular Docking Simulation ; Naphthyridines/pharmacology ; SARS-CoV-2 ; Viral Nonstructural Proteins/chemistry
    Chemical Substances Ligands ; Naphthyridines ; Viral Nonstructural Proteins ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2020-11-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1851305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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