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  1. Article ; Online: John D. Bredehoeft (1933-2023)-A Geologist at the Frontiers of Hydrogeology.

    Konikow, Leonard F / Reichard, Eric G / King, Michael J

    Ground water

    2023  Volume 61, Issue 3, Page(s) 446–451

    MeSH term(s) Groundwater ; Geology
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 246212-6
    ISSN 1745-6584 ; 0017-467X
    ISSN (online) 1745-6584
    ISSN 0017-467X
    DOI 10.1111/gwat.13313
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    In stock of ZB MED Bonn / Germany

    Z 4456: Show issues

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  2. Book ; Online ; E-Book: Succinct pediatrics

    Feld, Leonard G. / Mahan, John D.

    evaluation and management for common and critical care

    2015  

    Author's details Leonard G. Feld, John D. Mahan
    Language English
    Size 1 Online-Ressource (xxxv, 812 Seiten)
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village, Chicago
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018958941
    ISBN 978-1-58110-955-9 ; 978-1-58110-968-9 ; 1-58110-955-5 ; 1-58110-968-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Correction: Blanco et al. Synthesis and Characterization of [Fe(Htrz)

    Blanco, Alexis A / Adams, Daniel J / Azoulay, Jason D / Spinu, Leonard / Wiley, John B

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 1

    Abstract: After publication of the paper [ ... ]. ...

    Abstract After publication of the paper [...].
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29010266
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Correction

    Alexis A. Blanco / Daniel J. Adams / Jason D. Azoulay / Leonard Spinu / John B. Wiley

    Molecules, Vol 29, Iss 1, p

    Blanco et al. Synthesis and Characterization of [Fe(Htrz) 2 (trz)](BF 4 )] Nanocubes. Molecules 2022, 27 , 1213

    2024  Volume 266

    Abstract: After publication of the paper [.] ...

    Abstract After publication of the paper [.]
    Keywords n/a ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Trends in Prescription Drug Monitoring Program Search Activity and Opioid Prescribing by Oral-Maxillofacial Surgeons in Massachusetts 2016-2022.

    Wang, Tim T / Lee, Cameron C / Young, Leonard D / Tannyhill, R John / Keith, David A

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2024  Volume 82, Issue 4, Page(s) 386–389

    MeSH term(s) Humans ; Analgesics, Opioid/therapeutic use ; Prescription Drug Monitoring Programs ; Oral and Maxillofacial Surgeons ; Practice Patterns, Dentists' ; Massachusetts ; Drug Prescriptions ; Practice Patterns, Physicians'
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2023.12.007
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.113: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Building Synthetic Biosensors Using Red Blood Cell Proteins.

    Dolberg, Taylor B / Gunnels, Taylor F / Ling, Te / Sarnese, Kelly A / Crispino, John D / Leonard, Joshua N

    ACS synthetic biology

    2024  Volume 13, Issue 4, Page(s) 1273–1289

    Abstract: As the use of engineered cell therapies expands from pioneering efforts in cancer immunotherapy to other applications, an attractive but less explored approach is the use of engineered red blood cells (RBCs). Compared to other cells, RBCs have a very ... ...

    Abstract As the use of engineered cell therapies expands from pioneering efforts in cancer immunotherapy to other applications, an attractive but less explored approach is the use of engineered red blood cells (RBCs). Compared to other cells, RBCs have a very long circulation time and reside in the blood compartment, so they could be ideally suited for applications as sentinel cells that enable
    MeSH term(s) Ligands ; Erythrocytes/metabolism ; Biosensing Techniques ; Membrane Proteins/metabolism
    Chemical Substances Ligands ; Membrane Proteins
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.3c00754
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  7. Article ; Online: Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.

    Levina, Aleksandra / Fleming, Kaelin D / Burke, John E / Leonard, Thomas A

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1874

    Abstract: 3-phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a 'master' kinase due to its ability to activate at least 23 downstream ... ...

    Abstract 3-phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a 'master' kinase due to its ability to activate at least 23 downstream protein kinases implicated in various signaling pathways. In this study, we have elucidated the mechanism of phosphoinositide-driven PDK1 auto-activation. We show that PDK1 trans-autophosphorylation is mediated by a PIP
    MeSH term(s) 3-Phosphoinositide-Dependent Protein Kinases/metabolism ; Phosphatidylinositols ; Phosphorylation ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics
    Chemical Substances Phosphatidylinositols ; Protein Kinases (EC 2.7.-) ; 3-Phosphoinositide-Dependent Protein Kinases (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29368-4
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  8. Article ; Online: Impact of imaging frequency on progression-free survival in Alliance trials enrolling patients with follicular lymphoma.

    Rutherford, Sarah C / Yin, Jun / Pederson, Levi D / Blum, Kristie A / Martin, Peter / Jung, Sin-Ho / Grant, Barbara / Rosenbaum, Cara / Cheson, Bruce D / Bartlett, Nancy L / Mandrekar, Sumithra J / Leonard, John P

    Blood advances

    2024  Volume 8, Issue 6, Page(s) 1464–1468

    MeSH term(s) Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/therapy ; Progression-Free Survival ; Rituximab ; Antibodies, Monoclonal, Murine-Derived ; Diagnostic Imaging
    Chemical Substances Rituximab (4F4X42SYQ6) ; Antibodies, Monoclonal, Murine-Derived
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023012090
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Defining Volume Targets for Regionalization of Pancreaticoduodenectomy, Esophagectomy, and Major Lung Resection Centers to Improve Oncologic and Surgical Outcomes.

    Ju, Michelle R / Karalis, John D / Leonard, Grey / Mansour, John C / Karagkounis, Georgios / Wang, Sam C / Reznik, Scott I / Porembka, Matthew R

    Annals of surgical oncology

    2023  Volume 31, Issue 1, Page(s) 499–513

    Abstract: Background: Performance of complex cancer surgeries at high-volume (HV) centers has been shown to reduce operative mortality. However, the case volume threshold that should be used to define HV centers is unknown. In this study, we determined thresholds ...

    Abstract Background: Performance of complex cancer surgeries at high-volume (HV) centers has been shown to reduce operative mortality. However, the case volume threshold that should be used to define HV centers is unknown. In this study, we determined thresholds to define HV pancreaticoduodenectomy, esophagectomy, and major lung resection centers based on clinical parameters. Then, we assessed the association of hospital volume with oncologic outcomes and overall survival.
    Methods: We identified adult NCDB patients undergoing pancreaticoduodenectomy, esophagectomy, and major lung resections between 2004 and 2015. Multivariable models with restricted cubic splines were built to predict 5-year overall survival for each surgery group according to average yearly case volume, adjusting for demographic and clinicopathologic factors. The change point procedure was then used to identify volume cut-points for each surgery type.
    Results: We identified the following thresholds to define HV status: 25 cases/year for pancreaticoduodenectomy; 18 cases/year for esophagectomy; and 54 cases/year for major lung resections. For all surgery types, treatment at a HV center was associated with an increased likelihood of R0 resection and adequate lymph node evaluation. HV centers had significantly decreased 30- and 90-day, postoperative mortality after adjusting for age, sex, race, comorbidities, histology, and stage. An overall survival benefit also was observed for patients undergoing resections at HV centers.
    Conclusions: Using novel methodology, our study identified volume thresholds for HV pancreaticoduodenectomy, esophagectomy, and major lung resection centers that were associated with improved oncologic outcomes and overall survival. These definitions of HV centers should be considered when evaluating regionalization of complex cancer care.
    MeSH term(s) Adult ; Humans ; Pancreaticoduodenectomy ; Esophagectomy ; Retrospective Studies ; Treatment Outcome ; Lung ; Hospital Mortality ; Hospitals, High-Volume
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-14339-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Building synthetic biosensors using red blood cell proteins.

    Dolberg, Taylor B / Gunnels, Taylor F / Ling, Te / Sarnese, Kelly A / Crispino, John D / Leonard, Joshua N

    bioRxiv : the preprint server for biology

    2023  

    Abstract: As the use of engineered cell therapies expands from pioneering efforts in cancer immunotherapy to other applications, an attractive but less explored approach is the use of engineered red blood cells (RBCs). Compared to other cells, RBCs have a very ... ...

    Abstract As the use of engineered cell therapies expands from pioneering efforts in cancer immunotherapy to other applications, an attractive but less explored approach is the use of engineered red blood cells (RBCs). Compared to other cells, RBCs have a very long circulation time and reside in the blood compartment, so they could be ideally suited for applications as sentinel cells that enable
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.16.571988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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