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  1. Book: NLR proteins

    Di Virgilio, Francesco / Pelegrin, Pablo

    methods and protocols

    (Methods in molecular biology ; 2696 ; Springer protocols)

    2023  

    Author's details edited by Pablo Pelegrín, Francesco Di Virgilio
    Series title Methods in molecular biology ; 2696
    Springer protocols
    Collection
    MeSH term(s) Nod Signaling Adaptor Proteins
    Keywords Proteins
    Subject code 572.6
    Language English
    Size xii, 299 Seiten, Illustrationen
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT030343845
    ISBN 9781071633496 ; 9781071633502 ; 107163349X ; 1071633503
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2696- not available for loan Lesesaal EG

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  2. Book: NLR proteins

    Di Virgilio, Francesco / Pelegrín, Pablo

    methods and protocols

    (Methods in molecular biology ; 1417 ; Springer protocols)

    2016  

    Author's details edited by Francesco Di Virgilio, Pablo Pelegrín
    Series title Methods in molecular biology ; 1417
    Springer protocols
    Collection
    Keywords Nod Signaling Adaptor Proteins / immunology
    Language English
    Size XI, 256 Seiten, Illustrationen, Diagramme, 26 cm
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019121082
    ISBN 978-1-4939-3564-2 ; 1-4939-3564-X ; 9781493935666 ; 1493935666
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1417- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Editorial - Purinergic signalling: 50 years.

    Illes, Peter / Di Virgilio, Francesco / Tang, Yong

    Neuropharmacology

    2023  Volume 245, Page(s) 109826

    Abstract: The function of almost all cells of the human and animal body is synchronized by purinergic/pyrimidinergic extracellular signalling molecules. This network activity is especially efficient in the central and peripheral nervous systems, driven by ... ...

    Abstract The function of almost all cells of the human and animal body is synchronized by purinergic/pyrimidinergic extracellular signalling molecules. This network activity is especially efficient in the central and peripheral nervous systems, driven by secretion of the (co)transmitter ATP (including its enzymatic degradation products ADP, AMP, and adenosine), as well as ATP/UTP (including UDP) released from the cytoplasm by either Ca
    MeSH term(s) Animals ; Humans ; Nucleotides/metabolism ; Signal Transduction ; Adenosine ; Receptors, Purinergic/metabolism ; Adenosine Triphosphate/metabolism
    Chemical Substances Nucleotides ; Adenosine (K72T3FS567) ; Receptors, Purinergic ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Editorial
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2023.109826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.242: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Editorial overview: Immunometabolism.

    Di Virgilio, Francesco / Borges da Silva, Henrique

    Current opinion in pharmacology

    2021  Volume 60, Page(s) 168–169

    MeSH term(s) Energy Metabolism ; Humans
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Editorial
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2021.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Editorial: Geoffrey Burnstock - An Accidental Pharmacologist.

    Di Virgilio, Francesco / Jacobson, Kenneth A / Williams, Michael

    Biochemical pharmacology

    2021  Volume 187, Page(s) 114421

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Laboratory Personnel/history ; Pharmacology/history
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Editorial ; Historical Article ; Introductory Journal Article ; Portrait
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2021.114421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: P2X7 is a cytotoxic receptor….maybe not: implications for cancer.

    Di Virgilio, Francesco

    Purinergic signalling

    2020  Volume 17, Issue 1, Page(s) 55–61

    Abstract: The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. ... ...

    Abstract The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff Burnstock prompted innovative investigation in this field and provided the intellectual framework to interpret a myriad of experimental findings. This is a short appraisal of how Geoff's inspiration influenced cancer studies and my own investigation highlighting the key role of the P2X7 receptor.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Humans ; Neoplasms/metabolism ; Receptors, Purinergic P2Y/metabolism ; Signal Transduction/physiology ; Tumor Microenvironment/physiology
    Chemical Substances Receptors, Purinergic P2Y ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2020-10-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-020-09735-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article: Ectonucleotidases in Acute and Chronic Inflammation.

    Giuliani, Anna Lisa / Sarti, Alba Clara / Di Virgilio, Francesco

    Frontiers in pharmacology

    2021  Volume 11, Page(s) 619458

    Abstract: Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and ... ...

    Abstract Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD
    Language English
    Publishing date 2021-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.619458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The NFATc1/P2X7 receptor relationship in human intervertebral disc cells.

    Notarangelo, Maria Pina / Penolazzi, Letizia / Lambertini, Elisabetta / Falzoni, Simonetta / De Bonis, Pasquale / Capanni, Cristina / Di Virgilio, Francesco / Piva, Roberta

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1368318

    Abstract: A comprehensive understanding of the molecules that play key roles in the physiological and pathological homeostasis of the human intervertebral disc (IVD) remains challenging, as does the development of new therapeutic treatments. We recently found a ... ...

    Abstract A comprehensive understanding of the molecules that play key roles in the physiological and pathological homeostasis of the human intervertebral disc (IVD) remains challenging, as does the development of new therapeutic treatments. We recently found a positive correlation between IVD degeneration (IDD) and P2X7 receptor (P2X7R) expression increases both in the cytoplasm and in the nucleus. Using immunocytochemistry, reverse transcription PCR (RT-PCR), overexpression, and chromatin immunoprecipitation, we found that NFATc1 and hypoxia-inducible factor-1α (HIF-1α) are critical regulators of P2X7R. Both transcription factors are recruited at the promoter of the
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1368318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells.

    Vultaggio-Poma, Valentina / Di Virgilio, Francesco

    Biomolecules

    2022  Volume 12, Issue 7

    Abstract: Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected ...

    Abstract Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected by numerous single nucleotide polymorphisms (SNPs) associated with diverse disease conditions. Stimulation by released nucleotides (purinergic signalling) modulates several T-lymphocyte functions, among which energy metabolism. Energy metabolism, whether oxidative or glycolytic, in turn deeply affects T-cell activation, differentiation and effector responses. Specific P2R subtypes, among which the P2X7 receptor (P2X7R), are either up- or down-regulated during T-cell activation and differentiation; thus, they can be considered indexes of activation/quiescence, reporters of T-cell metabolic status and, in principle, markers of immune-mediated disease conditions.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Humans ; Inflammation/metabolism ; Lymphocyte Activation ; Signal Transduction ; T-Lymphocytes
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12070983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Macrophage Activation in Follicular Conjunctivitis during the COVID-19 Pandemic.

    Gallenga, Carla Enrica / Maritati, Martina / Mura, Marco / Di Virgilio, Francesco / Conti, Pio / Contini, Carlo

    Microorganisms

    2023  Volume 11, Issue 9

    Abstract: Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells ... ...

    Abstract Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the 'asymptomatic' patient.
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11092198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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