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Article ; Online: Reply to: Erroneous predictions of auxotrophies by CarveMe.

Machado, Daniel / Patil, Kiran R

Nature ecology & evolution

2022 Volume 7, Issue 2, Page(s) 196–197

Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Letter
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-022-01939-0
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Article: Pyriform Turbinoplasty and Lateral Nasal Wall Lateralization: Practical Hints on How We Do It.

De Sousa Machado, André / Briner, Hans R / Simmen, Daniel

Cureus

2022 Volume 14, Issue 12, Page(s) e32584

Abstract: Pyriform turbinoplasty (PT) is a surgical option for the management of turbinate hypertrophy. The philosophy and goal of the procedure are to improve the symptoms of a restricted airway while preserving function. We report a case of surgical management ... ...

Abstract	Pyriform turbinoplasty (PT) is a surgical option for the management of turbinate hypertrophy. The philosophy and goal of the procedure are to improve the symptoms of a restricted airway while preserving function. We report a case of surgical management of inferior turbinate (IT) hypertrophy with PT and lateral nasal wall lateralization (LNWL). PT and LNWL improve nasal airflow, providing a wider nasal cavity by the removal of the bone of the IT. Sustained symptomatic improvement has been documented and is less susceptible to the influence of turbinate hypertrophy with other techniques.
Language	English
Publishing date	2022-12-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.32584
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Article ; Online: Nitric oxide and potassium channels but not opioid and cannabinoid receptors mediate tramadol-induced peripheral antinociception in rat model of paw pressure withdrawal.

Soares-Santos, Raquel R / Machado, Daniel P / Romero, Thiago L / Duarte, Igor D G

Canadian journal of physiology and pharmacology

2023 Volume 102, Issue 3, Page(s) 218–227

Abstract: Tramadol, an analgesic classified as an "atypical opioid", exhibits both opioid and non-opioid mechanisms of action. This study aimed to explore these mechanisms, specifically the opioid-, cannabinoid-, nitric oxide-, and potassium channel-based ... ...

Abstract	Tramadol, an analgesic classified as an "atypical opioid", exhibits both opioid and non-opioid mechanisms of action. This study aimed to explore these mechanisms, specifically the opioid-, cannabinoid-, nitric oxide-, and potassium channel-based mechanisms, which contribute to the peripheral antinociception effect of tramadol, in an experimental rat model. The nociceptive threshold was determined using paw pressure withdrawal. To examine the mechanisms of action, several substances were administered intraplantarly: naloxone, a non-selective opioid antagonist (50 µg/paw); AM251 (80 µg/paw) and AM630 (100 µg/paw) as the selective antagonists for types 1 and 2 cannabinoid receptors, respectively; nitric oxide synthase inhibitors L-NOArg, L-NIO, L-NPA, and L-NIL (24 µg/paw); and the enzyme inhibitors of guanylatocyclase and phosphodiesterase of cGMP, ODQ, and zaprinast. Additionally, potassium channel blockers glibenclamide, tetraethylammonium, dequalinium, and paxillin were used. The results showed that opioid and cannabinoid receptor antagonists did not reverse tramadol's effects. L-NOarg, L-NIO, and L-NPA partially reversed antinociception, while ODQ completely reversed, and zaprinast enhanced tramadol's antinociception effect. Notably, glibenclamide blocked tramadol's antinociception in a dose-dependent manner. These findings suggest that tramadol's peripheral antinociception effect is likely mediated by the nitrergic pathway and sensitive ATP potassium channels, rather than the opioid and cannabinoid pathways.
MeSH term(s)	Rats ; Animals ; Analgesics, Opioid/pharmacology ; Tramadol/pharmacology ; Tramadol/therapeutic use ; Nitric Oxide/metabolism ; Rats, Wistar ; Potassium Channels/metabolism ; Hyperalgesia/metabolism ; Nitroarginine ; Receptors, Cannabinoid/metabolism ; Glyburide ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Cyclic GMP/metabolism ; Cannabinoids/adverse effects
Chemical Substances	Analgesics, Opioid ; Tramadol (39J1LGJ30J) ; Nitric Oxide (31C4KY9ESH) ; Potassium Channels ; Nitroarginine (2149-70-4) ; Receptors, Cannabinoid ; Glyburide (SX6K58TVWC) ; Analgesics ; Cyclic GMP (H2D2X058MU) ; Cannabinoids
Language	English
Publishing date	2023-11-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	127527-6
ISSN	1205-7541 ; 0008-4212
ISSN (online)	1205-7541
ISSN	0008-4212
DOI	10.1139/cjpp-2023-0314
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Zs.A 589: Show issues

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Article ; Online: A Rare Finding of Thrombosed Bilateral Giant External Iliac Vein Aneurysms.

Mendes, Daniel / Machado, Rui

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2022 Volume 64, Issue 1, Page(s) 91

MeSH term(s)	Aneurysm ; Humans ; Iliac Vein ; Vena Cava, Inferior
Language	English
Publishing date	2022-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2022.04.039
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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Article ; Online: Kidney autotransplantation as a key solution for a BEVAR type IIIb endoleak.

Mendes, Daniel / Machado, Rui / Almeida, Rui

Vascular

2023 , Page(s) 17085381231155672

Abstract: Objectives: Target vessel endoleaks are one of the most common causes of revision procedures after a fenestrated or branched endovascular aneurysm repair. Usually, a redo stenting is an effective therapy, however, not always feasible. We present a case ... ...

Abstract	Objectives: Target vessel endoleaks are one of the most common causes of revision procedures after a fenestrated or branched endovascular aneurysm repair. Usually, a redo stenting is an effective therapy, however, not always feasible. We present a case of a hybrid treatment for a type IIIb endoleak using the renal autotransplantation technique. Methods: A 60-year-old man with a thoracoabdominal aortic aneurysm has been treated with a custom-made branched endoprosthesis. Occlusion of the bridging stent to the right renal artery with total infarction of the right kidney was identified one week later and conservatively managed. After four years, a type IIIb endoleak was identified. Endovascular treatment was attempted unsuccessfully. So, the endoleak was corrected using a hybrid strategy with the kidney autotransplantation technique. Results: A left kidney autotransplantation followed by an aortic stent-graft relining with a tubular graft has been done uneventfully, in a phased manner. Postoperative computed tomography angiography confirmed the patency of vascular reconstructions with no endoleaks. No adverse events occurred during one year of follow-up. Conclusion: Our case highlights kidney autotransplantation as a viable solution for a hybrid treatment of target vessel endoleaks and shows that this technique can assist complex endovascular aortic reconstructions.
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381231155672
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Zs.A 4277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 590: Show issues

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Article: Pourfour Du Petit Syndrome Due to Ipsilateral Internal Jugular Vein Distention.

Salazar-Orellana, Jaime Leonardo I / Aceytuno, R Daniel / Vásquez-Cortez, Nelson A / Umaña-Cerros, Juan R / Medrano-Machado, Enyis Y

Cureus

2023 Volume 15, Issue 4, Page(s) e37853

Abstract: Pourfour du Petit Syndrome (PdPS) is characterized by signs of oculosympathetic hyperactivity caused by irritation in the oculosympathetic pathway and shares etiologies with Horner Syndrome. We present the case of a 64-year-old woman with Pourfour du ... ...

Abstract	Pourfour du Petit Syndrome (PdPS) is characterized by signs of oculosympathetic hyperactivity caused by irritation in the oculosympathetic pathway and shares etiologies with Horner Syndrome. We present the case of a 64-year-old woman with Pourfour du Petit syndrome due to compression of the second-order cervical sympathetic chain neuron from a dominant and prominent right internal jugular vein compensatory for contralateral agenesis. Internal jugular vein agenesis is a rare developmental vascular anomaly and is asymptomatic in the majority of patients with this condition.
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.37853
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Article ; Online: Systemic salmonellosis in 4 cats.

Riker, Jesse / Miller, Doris M / Blas-Machado, Uriel / Lieske, Danielle E / Stilwell, Justin M / McCullough, Kathryn / Sanchez, Susan / Rissi, Daniel R

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2023 Volume 35, Issue 5, Page(s) 581–584

Abstract: Clinical signs in 4 cases of salmonellosis in cats included vomiting, diarrhea (2 cases each), fever, dystocia, icterus, and seizures (1 case each). Three cats died, and one was euthanized. Grossly, all cats were in poor body condition and had yellow-to- ... ...

Abstract	Clinical signs in 4 cases of salmonellosis in cats included vomiting, diarrhea (2 cases each), fever, dystocia, icterus, and seizures (1 case each). Three cats died, and one was euthanized. Grossly, all cats were in poor body condition and had yellow-to-dark-red perianal feces (3 cases), oral and ocular pallor (2 cases) or icterus (1 case), fluid or pasty yellow intestinal contents (4 cases), white or dark-red-to-black depressed areas on the hepatic surface (2 cases), yellow abdominal fluid with swollen abdominal lymph nodes (1 case), and fibrin strands on the placental chorionic surface (1 case). Histologically, all cats had necrotizing enterocolitis and random hepatocellular necrosis. Other histologic findings included mesenteric (4 cases) or splenic (2 cases) lymphoid necrosis, and endometrial and chorioallantoic necrosis (1 case). Gram-negative bacilli were observed within neutrophils and macrophages in the intestinal lamina propria (4 cases), liver, spleen, lymph node, endometrium, and placenta (1 case each). Aerobic bacterial culture on frozen samples of small intestine, mesenteric lymph node, lung, and liver yielded
MeSH term(s)	Pregnancy ; Cats ; Female ; Animals ; Salmonella Infections, Animal/pathology ; Placenta/pathology ; Salmonella ; Salmonella enterica ; Necrosis/veterinary ; Cat Diseases
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387231181389
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Zs.A 3645: Show issues

Location:
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Institutional Experience With Venous Aneurysms - Insights On The Natural History And Outcomes Of Surgical Treatment.

Azevedo Mendes, Daniel / Machado, Rui / Veiga, Carlos / Almeida, Rui

Portuguese journal of cardiac thoracic and vascular surgery

2023 Volume 30, Issue 2, Page(s) 23–33

Abstract: Introduction: Venous aneurysms are rare, so their natural history is not fully understood. Indications for treatment are often determined by the location and size of the aneurysm; however, considering the scarcity of data, there are no specific ... ...

Abstract	Introduction: Venous aneurysms are rare, so their natural history is not fully understood. Indications for treatment are often determined by the location and size of the aneurysm; however, considering the scarcity of data, there are no specific recommendations. Surgery is the mainstay for venous aneurysm treatment, but some authors reported successful endovascular treatment. We intend to describe our experience with this type of rare disorder. Methods: A post hoc observational study of a prospectively maintained registry including consecutive patients admitted with the diagnosis of a venous aneurysm at different locations between January 2007 and September 2021. Demographic data, anatomic location, and medical history, including trauma or venous surgery, were analyzed. All vascular reconstructions and outcomes have been evaluated. Results: We identified 30 venous aneurysms in 24 patients. Fifteen patients were male (63%). The most common anatomical location was the popliteal vein (n=19; 63%). Four patients had multiple venous aneurysms, and three patients had synchronous arterial aneurysms. Twelve (63%) of the popliteal vein aneurysms identified were surgically treated, most commonly by tangential aneurysmectomy and lateral venorrhaphy. The average diameter at the time of surgery was 22,8±3,6 mm. After discharge, all patients were anticoagulated for 6 to 12 months, in most cases with rivaroxaban. With a median follow-up time of 32 months (12 - 168 months), primary patency was 92%. Aneurysm recurrence was only observed in one case (1/12; 8%) with non-occlusive thrombosis of the aneurysm 14 years after surgery. One patient had a 21 mm gemelar vein aneurysm, having been proposed for surgery, with thrombosis before the intervention. Two patients had common femoral vein aneurysms treated with partial aneurysmectomy and lateral venorrhaphy without thromboembolic events during follow-up. Two patients presented with portal system aneurysms, one associated with portal hypertension. No treatment was performed, and an increase in aneurysm size was observed during follow-up. Another patient presented with acute deep vein thrombosis on chronically thrombosed bilateral iliac vein aneurysms. Three patients had aneurysms of the superficial venous system associated with previous trauma, which were treated with simple ligation and excision. Conclusion: Venous aneurysms are rare and most commonly located in the popliteal vein, which seems to be associated with chronic venous disease. Treating these aneurysms, even without symptoms, can be important to avoid thromboembolic complications. However, close long-term follow-up with duplex ultrasound should be considered to detect late recurrence. Aneurysms from other locations are even rarer, and treatment decisions should be individualized, weighing the risks and benefits of the intervention.
MeSH term(s)	Humans ; Male ; Female ; Vascular Surgical Procedures/adverse effects ; Thrombosis/complications ; Popliteal Vein ; Thromboembolism/diagnosis ; Iliac Aneurysm/complications
Language	English
Publishing date	2023-07-07
Publishing country	Portugal
Document type	Observational Study ; Journal Article
ISSN	2184-9927
ISSN	2184-9927
DOI	10.48729/pjctvs.319
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Article ; Online: Recanalization of a Chronically Occluded Popliteal Artery Aneurysm Using a Covered Stent-A Viable Alternative to Open Surgery.

Mendes, Daniel / Machado, Rui / Almeida, Rui

Journal of vascular and interventional radiology : JVIR

2022 Volume 34, Issue 2, Page(s) 317–319

MeSH term(s)	Humans ; Popliteal Artery Aneurysm ; Aneurysm/diagnostic imaging ; Aneurysm/surgery ; Stents ; Popliteal Artery/diagnostic imaging ; Popliteal Artery/surgery ; Treatment Outcome
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Letter
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2022.10.032
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Zs.A 3720: Show issues

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Article ; Online: Hybrid Approach of a Complex Aneurysm of the Subclavian-Axillary-Brachial Axis: A Case Report.

Mendes, Daniel / Vaz, Carolina / Machado, Rui / Almeida, Rui

Vascular and endovascular surgery

2022 Volume 56, Issue 8, Page(s) 784–789

Abstract: Background: Upper extremity arterial aneurysms are a rare, potentially limb-threatening disorder. Due to its rarity, the best treatment modality and outcomes are not entirely established; however, there is a consensus that open surgery is the first-line ...

Abstract	Background: Upper extremity arterial aneurysms are a rare, potentially limb-threatening disorder. Due to its rarity, the best treatment modality and outcomes are not entirely established; however, there is a consensus that open surgery is the first-line treatment. We present a complex case of an arterial aneurysm of the subclavian-axillary-brachial axis adequately treated using a hybrid surgical and endovascular treatment. Case presentation: A 59-year-old man presented to the emergency department with acute ischemia of the right upper limb. An extensive thrombosed aneurysm of the subclavian-axillary-brachial axis was identified. The treatment was carried out in two stages. In the first phase, urgent limb revascularization was performed using the great saphenous vein to perform a subclavian-brachial artery bypass. Later, the aneurysm was excluded using a vascular plug and multiple coils. Successful treatment was achieved with no morbidity for the patient. Conclusions: Although the gold standard for treating upper limb aneurysms is open surgery, endovascular techniques can be a significant adjunct, reducing treatment morbidity and even mortality.
MeSH term(s)	Aneurysm/diagnostic imaging ; Aneurysm/etiology ; Aneurysm/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Brachial Artery/surgery ; Endovascular Procedures/adverse effects ; Humans ; Male ; Middle Aged ; Subclavian Artery/diagnostic imaging ; Subclavian Artery/surgery ; Treatment Outcome
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744221110404
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Zs.A 622: Show issues

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