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  1. Article ; Online: A macro-micro FE and ANN framework to assess site-specific bone ingrowth around the porous beaded-coated implant: an example with BOX® tibial implant for total ankle replacement.

    Minku / Ghosh, Rajesh

    Medical & biological engineering & computing

    2024  

    Abstract: The use of mechanoregulatory schemes based on finite element (FE) analysis for the evaluation of bone ingrowth around porous surfaces is a viable approach but requires significant computational time and effort. The aim of this study is to develop a ... ...

    Abstract The use of mechanoregulatory schemes based on finite element (FE) analysis for the evaluation of bone ingrowth around porous surfaces is a viable approach but requires significant computational time and effort. The aim of this study is to develop a combined macro-micro FE and artificial neural network (ANN) framework for rapid and accurate prediction of the site-specific bone ingrowth around the porous beaded-coated tibial implant for total ankle replacement (TAR). A macroscale FE model of the implanted tibia was developed based on CT data. Subsequently, a microscale FE model of the implant-bone interface was created for performing bone ingrowth simulations using mechanoregulatory algorithms. An ANN was trained for rapid and accurate prediction of bone ingrowth. The results predicted by ANN are well comparable to FE-predicted results. Predicted site-specific bone ingrowth using ANN around the implant ranges from 43.04 to 98.24%, with a mean bone ingrowth of around 74.24%. Results suggested that the central region exhibited the highest bone ingrowth, which is also well corroborated with the recent explanted study on BOX®. The proposed methodology has the potential to simulate bone ingrowth rapidly and effectively at any given site over any implant surface.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-024-03034-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of silencing

    Rajesh, Vavilapalli / Jangra, Sumit / Ghosh, Amalendu

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1254246

    Abstract: ... Thrips ... ...

    Abstract Thrips palmi
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1254246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of the depth of resection of the distal tibia on biomechanical performance of the tibial component for TAR: A finite element analysis with three implant designs.

    Jyoti / Ghosh, Rajesh

    Medical engineering & physics

    2023  Volume 119, Page(s) 104034

    Abstract: The depth of resection of the tibia bone in total ankle replacement (TAR) may influence implant-bone micromotion and stress shielding. High implant-bone micromotion and stress-shielding lead to aseptic loosening of the tibial component for TAR. The aim ... ...

    Abstract The depth of resection of the tibia bone in total ankle replacement (TAR) may influence implant-bone micromotion and stress shielding. High implant-bone micromotion and stress-shielding lead to aseptic loosening of the tibial component for TAR. The aim was to improve the outcomes of the different designs of TAR (STAR, Mobility, and Salto) with the variation of the depth of resection of the distal tibia bone. Finite element (FE) models of the implanted tibia with the depth of resection varying from 6 mm to 16 mm and of the intact tibia was prepared. The value of micromotion increased as the depth of resection increased. The micromotion increased in the proximal anterior-posterior portion of the pegs for STAR, the posterior part of the stem for Mobility, and the proximal lateral portion of the keel for Salto with the increase in the depth of resection. Whereas, the stresses (von Mises) decreased in some regions and increased in some regions depending upon the implant design. But overall stresses decreased in the tibia bone. Furthermore, the mean stress shielding increased in all the designs as the depth of resection increased. This in silico study indicated that the depth of resection should be given more importance during TAR surgery. The ideal depth of resection should be minimum i.e., 6 mm based on this FE study.
    MeSH term(s) Finite Element Analysis ; Tibia/surgery ; Arthroplasty, Replacement, Ankle ; Prostheses and Implants
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2023.104034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ni

    Chakrabortty, Rajesh / Ghosh, Suman / Ganesh, Venkataraman

    Organic letters

    2024  Volume 26, Issue 4, Page(s) 792–797

    Abstract: In the present work, we demonstrate a regioselective [2 + 2 + 2] cyclotrimerization of 1,3-diynes catalyzed by ... ...

    Abstract In the present work, we demonstrate a regioselective [2 + 2 + 2] cyclotrimerization of 1,3-diynes catalyzed by Ni
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A combined FE-hybrid MCDM framework for improving the performance of the conical stem tibial design for TAR with the addition of pegs.

    Jyoti / Ghosh, Rajesh

    Computer methods and programs in biomedicine

    2023  Volume 237, Page(s) 107574

    Abstract: Background and objectives: The conical stemmed design of the tibial component for total ankle replacement (TAR) (example Mobility design) uses a single intramedullary stem for primary fixation. Tibial component loosening is a common mode of failure for ... ...

    Abstract Background and objectives: The conical stemmed design of the tibial component for total ankle replacement (TAR) (example Mobility design) uses a single intramedullary stem for primary fixation. Tibial component loosening is a common mode of failure for TAR. Primary causes of loosening are lack of bone ingrowth due to excessive micromotion at the implant-bone interface and bone resorption due to stress shielding after implantation. The fixation feature of the conical stemmed design can be modified with the addition of small pegs to avoid loosening. The aim of the study is to select the improved design for conical stemmed TAR using a combined Finite Element (FE) hybrid Multi-Criteria Decision-Making (MCDM) framework.
    Methods: The geometry and material properties of the bone for FE modeling were extracted from the CT data. Thirty-two design alternatives with varying pegs in number (one, two, four, eight), location (anterior, posterior, medial, lateral, anterior-posterior, medial-lateral, equally spaced), and height (5 mm, 4 mm, 3 mm, 2 mm) were prepared. All models were analyzed for dorsiflexion, neutral, and plantarflexion loading. The proximal part of the tibia was fixed. The implant-bone interface coefficient of friction was taken as 0.5. The implant-bone micromotion, stress shielding, volume of bone resection, and surgical simplicity were the important criteria considered for evaluating the performance of TAR. The designs were compared using a hybrid MCDM method of WASPAS, TOPSIS, EDAS, and VIKOR. The weight calculations were based on fuzzy AHP and the final ranks on the Degree of Membership method.
    Results: The addition of pegs decreased the mean implant-bone micromotions and increased stress shielding. There was a marginal decrease in micromotion and a marginal increase in stress shielding when the peg heights were increased. The results of hybrid MCDM indicated that the most preferable alternative designs were two pegs of 4 mm height in the AP direction to the main stem, two pegs of 4 mm height in the ML direction, and one peg of 3 mm height in the A direction.
    Conclusions: Outcomes of this study suggest that the addition of pegs can reduce the implant-bone micromotions. Modified three designs would be useful by considering implant-bone micromotions, stress shielding, volume of bone resection, and surgical simplicity.
    MeSH term(s) Tibia/surgery ; Arthroplasty, Replacement, Ankle ; Prosthesis Design ; Arthroplasty, Replacement, Knee/methods ; Finite Element Analysis ; Stress, Mechanical
    Language English
    Publishing date 2023-04-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2023.107574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A new mathematical model of compressive stress-strain behaviour of low viscosity and high viscosity bone cement with different strain rates.

    Chaurasiya, Sonalal Prasad / Ghosh, Rajesh

    Medical engineering & physics

    2023  Volume 117, Page(s) 104001

    Abstract: A new mathematical model of compressive stress-strain behaviour of low viscosity (LV) and high viscosity (HV) bone cement has been proposed to capture large uniaxial deformation under constant applied strain rate by incorporating three-term power law. ... ...

    Abstract A new mathematical model of compressive stress-strain behaviour of low viscosity (LV) and high viscosity (HV) bone cement has been proposed to capture large uniaxial deformation under constant applied strain rate by incorporating three-term power law. The modeling capacity of the proposed model has been validated using uniaxial compressive test under eight different low strain rates ranging from 1.39 × 10
    MeSH term(s) Bone Cements ; Polymethyl Methacrylate ; Viscosity ; Pressure ; Models, Theoretical ; Compressive Strength
    Chemical Substances Bone Cements ; Polymethyl Methacrylate (9011-14-7)
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2023.104001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparative studies on the aggregate formation of synthesized zwitterionic gemini and monomeric surfactants in the presence of the amphiphilic antipsychotic drug chlorpromazine hydrochloride in aqueous solution: an experimental and theoretical approach.

    Banik, Rajesh / Das, Sourav / Ghosh, Asitanga / Ghosh, Soumen

    Soft matter

    2023  Volume 19, Issue 41, Page(s) 7995–8010

    Abstract: The formation of aggregates, which are widely used in the field of biochemistry and the medical industry, was studied with different compositions of alkyl betaine gemini surfactant ( ... ...

    Abstract The formation of aggregates, which are widely used in the field of biochemistry and the medical industry, was studied with different compositions of alkyl betaine gemini surfactant (C
    MeSH term(s) Surface-Active Agents/chemistry ; Antipsychotic Agents/chemistry ; Chlorpromazine/chemistry ; Water/chemistry ; Chemical Phenomena
    Chemical Substances Surface-Active Agents ; Antipsychotic Agents ; Chlorpromazine (U42B7VYA4P) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d3sm00907f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fabrication of highly conductive graphene paper for supercapacitors with a one-step hydrothermal method

    Rajesh Ghosh / Mohd Salman Siddiqui / Hemen Kalita

    Carbon Trends, Vol 14, Iss , Pp 100317- (2024)

    1481  

    Abstract: We present a facile one-step hydrothermal method for the fabrication of free-standing graphene paper using aqueous graphene oxide (GO) dispersion as the starting material. Notably, the method does not require the use of any additives for the reduction ... ...

    Abstract We present a facile one-step hydrothermal method for the fabrication of free-standing graphene paper using aqueous graphene oxide (GO) dispersion as the starting material. Notably, the method does not require the use of any additives for the reduction and preparation of the graphene paper. The resulting graphene paper exhibits a high degree of reduction, as confirmed by X-ray photoelectron spectroscopy (XPS) analysis, revealing a carbon-to-oxygen (C/O) ratio of ∼7. The fabricated graphene paper also demonstrates excellent conductivity, with a measured value of ∼1900 S/m, and sheet resistance of around 100 Ω/sq. Furthermore, the energy storage capability of the graphene paper based electrode is evaluated, which shows a promising specific capacity of 249 F/g at a current density of 1 A/g in 1M H2SO4 as the ionic medium. Additionally, the electrode has also demonstrated remarkable energy density and power density values of 28.68 Wh/Kg and 455 W/Kg, respectively. Overall, the resulting graphene paper exhibits high conductivity and excellent electrochemical performance, making it a promising candidate for various energy storage applications.
    Keywords graphene paper ; hydrothermal ; additive free ; highly conducting ; supercapacitor ; Chemistry ; QD1-999
    Subject code 620
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Induction of abortion in the first trimester of pregnancy using letrozole and misoprostol combination versus misoprostol alone - A comparative observational study

    Swarnali Biswas / Mallika Sengupta / Debdatta Ghosh / Rajesh De

    Asian Journal of Medical Sciences, Vol 15, Iss 1, Pp 94-

    2024  Volume 101

    Abstract: Background: Medical abortion is safer than surgical abortion. Several studies have shown that combination of antiprogesterone drug mifepristone and prostaglandin misoprostol can increase complete abortion rate in medical management of first-trimester ... ...

    Abstract Background: Medical abortion is safer than surgical abortion. Several studies have shown that combination of antiprogesterone drug mifepristone and prostaglandin misoprostol can increase complete abortion rate in medical management of first-trimester miscarriage compared to misoprostol alone. Letrozole, an aromatase inhibitor, has emerged as an alternative to mifepristone for induction of medical abortion as mifepristone is expensive and not registered in many countries. Aims and Objectives: The aim of the present study was to evaluate the safety and efficacy of combined regimen of letrozole and misoprostol in first-trimester medical abortion compared to misoprostol alone. Materials and Methods: It was a comparative observational study conducted at R. G. Kar Medical College, a tertiary care hospital in West Bengal, India. The study population was the antenatal mothers booked at antenatal clinic willing for termination of pregnancy at <12 weeks of gestational age. Participants were allocated, 39 in each group in a non-randomized manner. Patients in one group (Group A) were posted for medical abortion with combination regimen of tablet letrozole (10 mg) once daily for 3 days followed by application of tablet misoprostol 800 mcg sublingually on day 4. In other group (Group B), patients were on misoprostol-only regimen with the application of tablet misoprostol 800 mcg sublingually. Results: Induction-abortion time was significantly less in the letrozole group (11±0.79 h) than the misoprostol group (13.23±0.81 h), P=0.0001. Complete abortion rate was significantly higher in the letrozole group compared to misoprostol group (84.62% and 64.10%, respectively, P=0.03). 15.38% patients in the letrozole group and 35.90% patients in the misoprostol group had excessive vaginal bleeding and the difference was statistically significant, P=0.03. The duration of vaginal bleeding was also significantly less in the letrozole group (2.45±0.29 days) than the misoprostol group (2.82±0.37 days), P<0.0001. Incidence of ...
    Keywords induction of abortion ; letrozole and misoprostol ; gestational age ; mifepristone ; antenatal mothers ; Medicine ; R
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Exploration of the impact of graphene oxide, acetylenic gemini, and CTAT on the photophysical and aggregation properties of dipolar coumarin 153.

    Sardar, Raju / Das, Sourav / Banik, Rajesh / Bhunia, Sayani / Ghosh, Soumen

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 11, Page(s) 8900–8918

    Abstract: Advanced spectroscopic techniques have been utilized to study the interaction between the laser dye coumarin 153 (C153) and graphene oxide (GO) nanoparticles. GO was synthesized using a modified Hummers' method and characterized by UV-vis spectroscopy, ... ...

    Abstract Advanced spectroscopic techniques have been utilized to study the interaction between the laser dye coumarin 153 (C153) and graphene oxide (GO) nanoparticles. GO was synthesized using a modified Hummers' method and characterized by UV-vis spectroscopy, Raman laser spectroscopy, FTIR-ATR spectroscopy, FESEM, HR-TEM, and XRD techniques. The GO@C153 composite was formed by mixing two aqueous solutions of GO and C153 due to their strong interaction through stacking and hydrophobic interactions. In this case, GO acts as an effective fluorescence quencher for C153 molecules, which undergo H-type aggregation in the presence of GO. The Stern-Volmer equation and time-dependent fluorescence studies were utilized to analyse the mechanism of fluorescence quenching. According to the findings, both static and dynamic quenching processes are responsible for the reduction in fluorescence intensity. The effect of surfactants (both cetyltrimethylammonium
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp05361j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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