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  1. Article: In silico

    Gurung, Arun Bahadur

    Gene reports

    2020  Volume 21, Page(s) 100860

    Abstract: The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals. SARS-CoV-2 relies on non- ... ...

    Abstract The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals. SARS-CoV-2 relies on non-structural proteins such as Nsp13 helicase and nsp14 which are the key components of the replication-transcription complex (RTC) to complete its infectious life cycle. Therefore, targeting these essential viral proteins with small molecules will most likely to halt the disease pathogenesis. The lack of experimental structures of these proteins deters the process of structure-based identification of their specific inhibitors. In the present study, the
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2452-0144
    ISSN 2452-0144
    DOI 10.1016/j.genrep.2020.100860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors

    Gurung, Arun Bahadur

    Gene Reports

    2020  Volume 21, Page(s) 100860

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2452-0144
    DOI 10.1016/j.genrep.2020.100860
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors

    Gurung, Arun Bahadur

    Gene Reports

    Abstract: The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals SARS-CoV-2 relies on non- ... ...

    Abstract The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals SARS-CoV-2 relies on non-structural proteins such as Nsp13 helicase and nsp14 which are the key components of the replication-transcription complex (RTC) to complete its infectious life cycle Therefore, targeting these essential viral proteins with small molecules will most likely to halt the disease pathogenesis The lack of experimental structures of these proteins deters the process of structure-based identification of their specific inhibitors In the present study, the in silico models of SARS-CoV-2 nsp13 helicase and nsp14 protein were elucidated using a comparative homology modelling approach These in silico model structures were validated using various parameters such as Ramachandran plot, Verify 3D score, ERRAT score, knowledge-based energy and Z-score The in silico models were further used for virtual screening of the Food and Drug Administration (FDA) approved antiviral drugs Simeprevir (SMV), Paritaprevir (PTV) and Grazoprevir (GZR) were the common leads identified which show higher binding affinity to both nsp13 helicase and nsp14 as compared to the control inhibitors and therefore, they might be potential dual-target inhibitors The leads also establish a network of hydrogen bonds and hydrophobic interactions with the key residues lining the active site pockets The present findings suggest that these FDA approved antiviral drugs can be subjected to repurposing against SARS-CoV-2 infection after verifying the in silico results through in vitro and in vivo studies
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733848
    Database COVID19

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  4. Article ; Online: Exploring the phytochemicals of

    Gurung, Arun Bahadur / Ali, Mohammad Ajmal / Lee, Joongku / Aljowaie, Reem M / Almutairi, Saeedah M

    Journal of King Saud University. Science

    2022  Volume 34, Issue 6, Page(s) 102155

    Abstract: Platycodon ... ...

    Abstract Platycodon grandiflorus
    Language English
    Publishing date 2022-06-09
    Publishing country Saudi Arabia
    Document type Journal Article
    ISSN 2213-686X
    ISSN (online) 2213-686X
    DOI 10.1016/j.jksus.2022.102155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: In silico

    Bahadur Gurung, Arun / Ajmal Ali, Mohammad / Al-Hemaid, Fahad / El-Zaidy, Mohamed / Lee, Joongku

    Saudi journal of biological sciences

    2021  Volume 29, Issue 1, Page(s) 65–74

    Abstract: Boesenbergia ... ...

    Abstract Boesenbergia rotunda
    Language English
    Publishing date 2021-11-26
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2021.11.053
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  6. Article ; Online: Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients.

    Basnet, Ajaya / Chand, Arun Bahadur / Pokhrel, Nayanum / Acharya, Sadikchya / Gurung, Parbati / Khanal, Laxmi Kant / Shrestha, Kundu / Shrestha, Lok Bahadur / Raghubanshi, Bijendra Raj

    Journal of Nepal Health Research Council

    2023  Volume 20, Issue 3, Page(s) 664–671

    Abstract: Background:  Brought with the advancements in transplantation science and the development of immunosuppressive agents, immunocompromised patients characterized with defective immunity have increased throughout the world with increased risk for ... ...

    Abstract Background:  Brought with the advancements in transplantation science and the development of immunosuppressive agents, immunocompromised patients characterized with defective immunity have increased throughout the world with increased risk for opportunistic infections. This study provides an overview of the antimicrobial susceptibility pattern among opportunistic pathogens isolated from immunocompromised patients.  Methods: Clinical and laboratory records of immunocompromised patients [patients with chronic kidney disease neutropenia, diabetes, rheumatic heart disease acquired immune deficiency syndrome hepatitis B, hepatitis C, who were subjected to microbiological culture analysis in the Department of Clinical Microbiology, KIST Medical College and Teaching Hospital, for 2 years (January 2019 and December 2020) were analyzed.
    Results:  Out of 8,402 immunocompromised patients, 954 (11.4%) patients were subjected to microbiological culture analysis. Among 954 patients, 253 (26.5%) patients [median(interquartile range) age: 52(31-67) years; male 138 (54.5%)] were infected. A total of 295 pathogens were isolated from 1,331 cultured samples. Infections due to Escherichia coli (n=71, 24.1%), Klebsiella spp. (n=55, 18.6%), Acinetobacter calcoaceticus-baumannii complex (n=35, 11.9%), Candida albicans (n=30, 10.2%), and Staphylococcus aureus (n=28, 9.5%) were frequently observed. Among the bacterial isolates (n=239), 81.6% (n=195) of bacteria were β-lactamase producers, 51.0% (n=122) were multi-drug resistant, 9.2% (n=195) were extensively-drug resistant, 0.8% (n=195) were pan-drug resistant, and 35.7% (n=10) of S. aureus were methicillin-resistant Staphylococcus aureus.
    Conclusions:  The majority of infection in immunocompromised patients is caused by Gram-negative bacteria, and is often associated with a higher number of β-lactamase producers and multi-drug resistant organisms. Prescriptions of antibiotics on the grounds of antimicrobial stewardship might help to reduce the burden of antimicrobial resistance.
    MeSH term(s) Humans ; Male ; Middle Aged ; Aged ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Drug Resistance, Bacterial ; Microbial Sensitivity Tests ; Nepal ; Gram-Negative Bacteria ; beta-Lactamases ; Anti-Bacterial Agents/pharmacology
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-09
    Publishing country Nepal
    Document type Journal Article
    ZDB-ID 2551251-1
    ISSN 1999-6217 ; 1999-6217
    ISSN (online) 1999-6217
    ISSN 1999-6217
    DOI 10.33314/jnhrc.v20i3.4047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients

    Ajaya Basnet / Arun Bahadur Chand / Nayanum Pokhrel / Sadikchya Acharya / Parbati Gurung / Laxmi Kant Khanal / Kundu Shrestha / Lok Bahadur Shrestha / Bijendra Raj Raghubanshi

    Journal of Nepal Health Research Council, Vol 20, Iss

    2023  Volume 3

    Abstract: ...

    Abstract .
    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nepal Health Research Council
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Masitinib analogues with the

    Gurung, Arun Bahadur / Ali, Mohammad Ajmal / Aljowaie, Reem M / Almutairi, Saeedah M / Sami, Hiba / Lee, Joongku

    Journal of King Saud University. Science

    2022  Volume 35, Issue 1, Page(s) 102397

    Abstract: Masitinib is an orally acceptable tyrosine kinase inhibitor that is currently investigated under clinical trials against cancer, asthma, Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis. A recent study confirmed the anti-severe ... ...

    Abstract Masitinib is an orally acceptable tyrosine kinase inhibitor that is currently investigated under clinical trials against cancer, asthma, Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis. A recent study confirmed the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) activity of masitinib through inhibition of the main protease (M
    Language English
    Publishing date 2022-10-31
    Publishing country Saudi Arabia
    Document type Journal Article
    ISSN 2213-686X
    ISSN (online) 2213-686X
    DOI 10.1016/j.jksus.2022.102397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Identification of SARS-CoV-2 inhibitors from extracts of

    Bahadur Gurung, Arun / Ajmal Ali, Mohammad / Lee, Joongku / Abul Farah, Mohammad / Mashay Al-Anazi, Khalid / Al-Hemaid, Fahad

    Saudi journal of biological sciences

    2021  Volume 28, Issue 12, Page(s) 7517–7527

    Abstract: Houttuynia ... ...

    Abstract Houttuynia cordata
    Language English
    Publishing date 2021-09-06
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2021.08.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Met117 oxidation leads to enhanced flexibility of cardiovascular biomarker- lipoprotein- associated phospholipase A

    Gurung, Arun Bahadur / Bhattacharjee, Atanu

    International journal of biological macromolecules

    2018  Volume 112, Page(s) 831–840

    Abstract: Human Lipoprotein-associated phospholipase ... ...

    Abstract Human Lipoprotein-associated phospholipase A
    MeSH term(s) 1-Alkyl-2-acetylglycerophosphocholine Esterase/chemistry ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism ; Apoproteins/chemistry ; Biomarkers/metabolism ; Cardiovascular Diseases/metabolism ; Humans ; Hydrogen Bonding ; Methionine/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Oxidation-Reduction ; Platelet Activating Factor/metabolism ; Principal Component Analysis ; Substrate Specificity ; Thermodynamics
    Chemical Substances Apoproteins ; Biomarkers ; Platelet Activating Factor ; Methionine (AE28F7PNPL) ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47)
    Language English
    Publishing date 2018-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2018.01.210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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