LIVIVO - Search results -

Search results

Result 1 - 10 of total 93

Search options

Article ; Online: Identification of potentially anti-COVID-19 active drugs using the connectivity MAP.

Bonnet, Raphaël / Mariault, Lee / Peyron, Jean-François

2022 Volume 17, Issue 1, Page(s) e0262751

Abstract: Drug repurposing can be an interesting strategy for an emergency response to the severe acute respiratory syndrome-coronavirus-2, (SARS-COV-2), the causing agent of the coronavirus disease-19 (COVID-19) pandemic. For this, we applied the Connectivity Map ...

Abstract	Drug repurposing can be an interesting strategy for an emergency response to the severe acute respiratory syndrome-coronavirus-2, (SARS-COV-2), the causing agent of the coronavirus disease-19 (COVID-19) pandemic. For this, we applied the Connectivity Map (CMap) bioinformatic resource to identify drugs that generate, in the CMap database, gene expression profiles (GEP) that negatively correlate with a SARS-COV-2 GEP, anticipating that these drugs could antagonize the deleterious effects of the virus at cell, tissue or organism levels. We identified several anti-cancer compounds that target MDM2 in the p53 pathway or signaling proteins: Ras, PKBβ, Nitric Oxide synthase, Rho kinase, all involved in the transmission of proliferative and growth signals. We hypothesized that these drugs could interfere with the high rate of biomass synthesis in infected cells, a feature shared with cancer cells. Other compounds including etomoxir, triacsin-c, PTB1-IN-3, are known to modulate lipid metabolism or to favor catabolic reactions by activating AMPK. Four different anti-inflammatory molecules, including dexamethasone, fluorometholone and cytosporone-b, targeting the glucocorticoid receptor, cyclooxygenase, or NUR77 also came out of the analysis. These results represent a first step in the characterization of potential repositioning strategies to treat SARS-COV-2.
MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Computational Biology/methods ; Databases, Genetic ; Drug Repositioning/methods ; Gene Expression/drug effects ; Humans ; Models, Theoretical ; Pandemics ; Pharmaceutical Preparations ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Transcriptome/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; Antiviral Agents ; Pharmaceutical Preparations
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0262751
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Identification of potentially anti-COVID-19 active drugs using the connectivity MAP.

Raphaël Bonnet / Lee Mariault / Jean-François Peyron

PLoS ONE, Vol 17, Iss 1, p e

2022 Volume 0262751

Abstract	Drug repurposing can be an interesting strategy for an emergency response to the severe acute respiratory syndrome-coronavirus-2, (SARS-COV-2), the causing agent of the coronavirus disease-19 (COVID-19) pandemic. For this, we applied the Connectivity Map (CMap) bioinformatic resource to identify drugs that generate, in the CMap database, gene expression profiles (GEP) that negatively correlate with a SARS-COV-2 GEP, anticipating that these drugs could antagonize the deleterious effects of the virus at cell, tissue or organism levels. We identified several anti-cancer compounds that target MDM2 in the p53 pathway or signaling proteins: Ras, PKBβ, Nitric Oxide synthase, Rho kinase, all involved in the transmission of proliferative and growth signals. We hypothesized that these drugs could interfere with the high rate of biomass synthesis in infected cells, a feature shared with cancer cells. Other compounds including etomoxir, triacsin-c, PTB1-IN-3, are known to modulate lipid metabolism or to favor catabolic reactions by activating AMPK. Four different anti-inflammatory molecules, including dexamethasone, fluorometholone and cytosporone-b, targeting the glucocorticoid receptor, cyclooxygenase, or NUR77 also came out of the analysis. These results represent a first step in the characterization of potential repositioning strategies to treat SARS-COV-2.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transvenous retrograde thoracic duct embolization for effective treatment of recurrent plastic bronchitis after fontan palliation.

Haddad, Raymond N / Dautry, Raphael / Bonnet, Damien / Malekzadeh-Milani, Sophie

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 101, Issue 5, Page(s) 863–869

Abstract: We report the case of a 5.5-year-old patient (16 kg/105 cm) who presented with plastic bronchitis (PB) refractory to conservative treatment 3 months after completion of Fontan palliation. Bi-inguinal transnodal fluoroscopy-guided lymphangiogram confirmed ...

Abstract	We report the case of a 5.5-year-old patient (16 kg/105 cm) who presented with plastic bronchitis (PB) refractory to conservative treatment 3 months after completion of Fontan palliation. Bi-inguinal transnodal fluoroscopy-guided lymphangiogram confirmed the chylous leak originating from the thoracic duct (TD) into the chest and did not opacify any central lymphatic vessel for direct transabdominal puncture. Retrograde transfemoral approach was adopted to catheterize the TD and selectively embolize its caudal portion using microcoils and liquid embolic adhesive. Recurrence of symptoms after 2 months indicated a redo catheterization to occlude the TD entirely using the same technique. The procedure was successful and the patient was discharged after 2 days with sustained clinical improvement at 24 months postoperative. In the context of refractory PB, end-to-end transvenous retrograde embolization of the TD appears to be an interesting alternative to more complex interventions such as transabdominal puncture, decompression, or surgical ligation of the TD.
MeSH term(s)	Humans ; Child, Preschool ; Thoracic Duct/diagnostic imaging ; Fontan Procedure/adverse effects ; Treatment Outcome ; Bronchitis/diagnostic imaging ; Bronchitis/etiology ; Bronchitis/therapy ; Embolization, Therapeutic/methods
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30611
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1226: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Non thermal 2.45 GHz electromagnetic exposure causes rapid changes in Arabidopsis thaliana metabolism.

Porcher, Alexis / Girard, Sébastien / Bonnet, Pierre / Rouveure, Raphaël / Guérin, Vincent / Paladian, Françoise / Vian, Alain

Journal of plant physiology

2023 Volume 286, Page(s) 153999

Abstract: Numerous studies report different types of responses following exposure of plants to high frequency electromagnetic fields (HF-EMF). While this phenomenon is related to tissue heating in animals, the situation is much less straightforward in plants where ...

Abstract	Numerous studies report different types of responses following exposure of plants to high frequency electromagnetic fields (HF-EMF). While this phenomenon is related to tissue heating in animals, the situation is much less straightforward in plants where metabolic changes seem to occur without tissue temperature increase. We have set up an exposure system allowing reliable measurements of tissue heating (using a reflectometric probe and thermal imaging) after a long exposure (30 min) to an electromagnetic field of 2.45 GHz transmitted through a horn antenna (about 100 V m
MeSH term(s)	Animals ; Arabidopsis/metabolism ; Electromagnetic Fields ; Plants/metabolism ; Hydrogen Peroxide/metabolism ; Lipid Peroxidation
Chemical Substances	Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-05-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2023.153999
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 46/302: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dynamic estimation of soft tissue stiffness for use in modeling socket, orthosis or exoskeleton interfaces with lower limb segments.

Guitteny, Sacha / Lafon, Yoann / Bonnet, Vincent / Aissaoui, Rachid / Dumas, Raphael

Journal of biomechanics

2022 Volume 134, Page(s) 110987

Abstract: Modeling the interface between the lower limb segments and a socket, orthosis or exoskeleton is crucial to the design, control, and assessment of such devices. The present study aimed to estimate translational and rotational soft tissue stiffness at the ... ...

Abstract	Modeling the interface between the lower limb segments and a socket, orthosis or exoskeleton is crucial to the design, control, and assessment of such devices. The present study aimed to estimate translational and rotational soft tissue stiffness at the thigh and shank during daily living activities performed by six subjects. Smooth orthogonal decomposition (SOD) was used on skin marker trajectories and fluoroscopy-based knee joint kinematics to compute stiffness coefficients during squatting, sitting and rising from a chair, level walking, and stair descending. On average, for all subjects and for all activities, in the anatomical directions observed, the translational and rotational stiffness coefficients for the shank were, respectively, 1.4 ± 1.99kN/m (median and interquartile range) and 41.5 ± 34.3Nm/deg. The results for the thigh segment were 1.79 ± 2.73kN/m and 30.5 ± 50.4Nm/deg. As previously reported in the literature dealing with the soft tissue artifact - considered as soft tissue deformation in this study - the computed stiffness coefficients were dependent on tasks, subjects, segments, and anatomical directions. The main advantage of SOD over previous methods lies in enabling estimation of a task-dependent 6 × 6 stiffness matrix of the interface between segments and external devices, useful in their modeling and assessment.
MeSH term(s)	Biomechanical Phenomena ; Exoskeleton Device ; Humans ; Knee Joint ; Lower Extremity ; Orthotic Devices
Language	English
Publishing date	2022-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2022.110987
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 700: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Validating instructional design and predicting student performance in histology education: Using machine learning via virtual microscopy.

Fries, Allyson / Pirotte, Marie / Vanhee, Laurent / Bonnet, Pierre / Quatresooz, Pascale / Debruyne, Christophe / Marée, Raphaël / Defaweux, Valérie

Anatomical sciences education

2023

Abstract: As a part of modern technological environments, virtual microscopy enriches histological learning, with support from large institutional investments. However, existing literature does not supply empirical evidence of its role in improving pedagogy. ... ...

Abstract	As a part of modern technological environments, virtual microscopy enriches histological learning, with support from large institutional investments. However, existing literature does not supply empirical evidence of its role in improving pedagogy. Virtual microscopy provides fresh opportunities for investigating user behavior during the histology learning process, through digitized histological slides. This study establishes how students' perceptions and user behavior data can be processed and analyzed using machine learning algorithms. These also provide predictive data called learning analytics that enable predicting students' performance and behavior favorable for academic success. This information can be interpreted and used for validating instructional designs. Data on the perceptions, performances, and user behavior of 552 students enrolled in a histology course were collected from the virtual microscope, Cytomine®. These data were analyzed using an ensemble of machine learning algorithms, the extra-tree regression method, and predictive statistics. The predictive algorithms identified the most pertinent histological slides and descriptive tags, alongside 10 types of student behavior conducive to academic success. We used these data to validate our instructional design, and align the educational purpose, learning outcomes, and evaluation methods of digitized histological slides on Cytomine®. This model also predicts students' examination scores, with an error margin of <0.5 out of 20 points. The results empirically demonstrate the value of a digital learning environment for both students and teachers of histology.
Language	English
Publishing date	2023-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483491-9
ISSN	1935-9780 ; 1935-9772
ISSN (online)	1935-9780
ISSN	1935-9772
DOI	10.1002/ase.2346
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6787: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A comparative study of three-dimensional cone-beam CT sialography and MR sialography for the detection of non-tumorous salivary pathologies.

Bertin, Hélios / Bonnet, Raphael / Le Thuaut, Aurélie / Huon, Jean-François / Corre, Pierre / Frampas, Eric / Langlois, Emmanuelle Mourrain / Chesneau, Anne-Sophie Delemazure

BMC oral health

2023 Volume 23, Issue 1, Page(s) 463

Abstract: Background: Imaging of the salivary ductal system is relevant prior to an endoscopic or a surgical procedure. Various imaging modalities can be used for this purpose. The aim of this study was to compare the diagnostic capability of three-dimensional ( ... ...

Abstract	Background: Imaging of the salivary ductal system is relevant prior to an endoscopic or a surgical procedure. Various imaging modalities can be used for this purpose. The aim of this study was to compare the diagnostic capability of three-dimensional (3D)-cone-beam computed tomography (CBCT) sialography versus magnetic resonance (MR) sialography in non-tumorous salivary pathologies. Methods: This prospective, monocenter, pilot study compared both imaging modalities in 46 patients (mean age 50.1 ± 14.9 years) referred for salivary symptoms. The analyses were performed by two independent radiologists and referred to identification of a salivary disease including sialolithiasis, stenosis, or dilatation (primary endpoint). The location and size of an abnormality, the last branch of division of the salivary duct that can be visualized, potential complications, and exposure parameters were also collected (secondary endpoints). Results: Salivary symptoms involved both the submandibular (60.9%) and parotid (39.1%) glands. Sialolithiasis, dilatations, and stenosis were observed in 24, 25, and 9 patients, respectively, with no statistical differences observed between the two imaging modalities in terms of lesion identification (p Conclusions: Both imaging procedures warrant being part of the diagnostic arsenal of non-tumorous salivary pathologies. However, MR sialography may be more effective than 3D-CBCT sialography for the identification of sialolithiasis and ductal dilatations. Trial registration: NCT02883140.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Sialography/methods ; Salivary Gland Calculi/diagnostic imaging ; Constriction, Pathologic/diagnostic imaging ; Prospective Studies ; Pilot Projects ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Cone-Beam Computed Tomography/methods
Language	English
Publishing date	2023-07-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03159-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: A comparative study of three-dimensional cone beam computed tomographic sialography and ultrasonography in the detection of non-tumoral salivary duct diseases.

Cetinkaya, Volkan / Bonnet, Raphael / Le Thuaut, Aurélie / Corre, Pierre / Mourrain-Langlois, Emmanuelle / Delemazure-Chesneau, Anne-Sophie / Bertin, Hélios

Dento maxillo facial radiology

2023 Volume 52, Issue 5, Page(s) 20220371

Abstract: Objectives: To compare the overall diagnostic outcomes of 3D-CBCT sialography and ultrasonography (US) in the detection of sialolithiasis, ductal dilatation, and ductal stenosis.: Methods: This retrospective monocentric study compared the two imaging ...

Abstract	Objectives: To compare the overall diagnostic outcomes of 3D-CBCT sialography and ultrasonography (US) in the detection of sialolithiasis, ductal dilatation, and ductal stenosis. Methods: This retrospective monocentric study compared the two imaging modalities carried out in the same patients referred for salivary symptoms of the parotid and submandibular glands. The primary endpoint was the capacity of the imaging procedure to diagnose a lesion. The secondary objectives were the detection rates according to the type of lesion, analysis of the causes of failure, and the parameters of radiation exposure and safety (for 3D-CBCT sialography). Results: Of the 236 patients who received a 3D-CBCT sialography in our institution, 157 were ultimately included in the per-protocol analysis. 3D-CBCT sialography allowed detection of ductal lesions in 113 patients versus 86 with US. The two imaging modalities yielded congruent interpretations in 104 out of 157 subjects (66.2%). Higher sensitivity and negative predictive value were observed with 3D-CBCT sialography compared with US, irrespective of the lesions studied: 0.85 Conclusions: US remains the first-line examination for exploration of the salivary lesions. 3D-CBCT sialography is an alternative in case of inconclusive US, and prior to any endoscopic procedure.
MeSH term(s)	Humans ; Sialography/methods ; Salivary Ducts/diagnostic imaging ; Retrospective Studies ; Salivary Gland Diseases/diagnostic imaging ; Salivary Gland Calculi/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	221323-0
ISSN	1476-542X ; 0250-832X ; 0349-490X
ISSN (online)	1476-542X
ISSN	0250-832X ; 0349-490X
DOI	10.1259/dmfr.20220371
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2620: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Long-term vertical stability of horseshoe osteotomy for the correction of large vertical excess of the maxilla, a retrospective assessment in 15 patients.

Goguet, Quentin / Mercier, Jacques / Longis, Julie / Bonnet, Raphael / Perrin, Jean Philippe / Corre, Pierre / Bertin, Hélios

Journal of stomatology, oral and maxillofacial surgery

2023 Volume 124, Issue 5, Page(s) 101474

Abstract: Introduction: Vertical stability after a Le Fort I (LF1) osteotomy with substantial upward movement can be compromised by the position and the volume of the inferior turbinate. A horseshoe (HS) osteotomy represents then an alternative as it preserves ... ...

Abstract	Introduction: Vertical stability after a Le Fort I (LF1) osteotomy with substantial upward movement can be compromised by the position and the volume of the inferior turbinate. A horseshoe (HS) osteotomy represents then an alternative as it preserves the hard palate and the intranasal volume. The aim of this study was to assess the vertical stability of the maxilla after HS osteotomy. Materials and methods: Patients who underwent a HS osteotomy for the correction of long-face syndrome were retrospectively analyzed. The vertical stability was assessed on lateral cephalograms performed preoperatively (T0), immediately postoperatively (T1), and at the last follow-up (T2) by studying points C (the distal cusp of the first maxillary molar), point P (the prosthion, the lowest edge of the maxillary alveolus of the central incisor), and point I (the upper central incisor edge) in a coordinate system. Postoperative complications and aesthetics of the smile were also investigated. Results: Fifteen patients were included (7 females, 8 males, mean age 25.5 ± 9.8 yeras). The mean impaction ranged from 5 mm on point P to 6.1 mm on point C, with a maximal movement of 9.5 mm. A non-significant relapse of 0.8 ± 1.7, 0.6 ± 0.8, and 0.5 ± 1.8 mm was observed after a mean 20.7 months on point C, P, and I respectively. Smile parameters were significantly improved by the procedure, mainly regarding the correction of the gum smile. Conclusion: HS osteotomy represents a good alternative to total LF1 osteotomy for substantial maxillary upward movement in long face syndrome deformities.
MeSH term(s)	Female ; Male ; Humans ; Adolescent ; Young Adult ; Adult ; Maxilla/surgery ; Retrospective Studies ; Molar ; Incisor ; Osteotomy
Language	English
Publishing date	2023-04-16
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2023.101474
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: L’actualité scientifique vue par les étudiants du Master Biologie-Santé de l’université de Montpellier.

Amara, Amine / Barthes, Arthur / Benzzaher, Al Mahdi / Berger, Adrien / Bonnet, Estelle / Diaz, Mathilda / Fournie, Chloé / Guimbaud, Loic / Hammami, Cédric / Le Fé, Manon / Lopez, Raphael / Mathieu, Paul / Meire, Valentin / Mery, Louis / Rossi, Soléna

Medecine sciences : M/S

2023 Volume 39, Issue 11, Page(s) 899–903

Title translation	Some scientific highlights: A selection by the students of the Master Biology-Health of Montpellier University.
MeSH term(s)	Humans ; Universities ; Students ; Biology
Language	French
Publishing date	2023-11-29
Publishing country	France
Document type	Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2023166
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito