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Article ; Online: Mechanism of H

Tanahashi, Yuki / Takahashi, Kosuke / Tsubonouchi, Yuta / Nozawa, Shunsuke / Adachi, Shin-Ichi / Hirahara, Masanari / Mohamed, Eman A / Zahran, Zaki N / Saito, Kenji / Yui, Tatsuto / Yagi, Masayuki

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 52

Abstract: The understanding of O-O bond formation is of great importance for revealing the mechanism of water oxidation in photosynthesis and for developing efficient catalysts for water oxidation in artificial photosynthesis. The chemical oxidation of the ... ...

Abstract	The understanding of O-O bond formation is of great importance for revealing the mechanism of water oxidation in photosynthesis and for developing efficient catalysts for water oxidation in artificial photosynthesis. The chemical oxidation of the Ru
Language	English
Publishing date	2021-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2113910118
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Zs.A 1148: Show issues

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Article ; Online: In Vitro Reconstitution of Pseudouridylation Catalyzed by Human Box H/ACA Ribonucleoprotein Particles.

Adachi, Hironori / Chen, Jonathan L / Yin, Qiangzong / Morais, Pedro / Yu, Yi-Tao

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2666, Page(s) 177–191

Abstract: ... pseudouridine synthases, mainly guided by box H/ACA snoRNAs, convert uridine to Ψ. Ψ stabilizes RNA structure ... of in vitro pseudouridylation assays using purified and reconstituted box H/ACA RNPs. Here, we describe ... an in vitro system for box H/ACA RNA-guided RNA pseudouridylation using human cell extracts. We show ...

Abstract	Pseudouridine (Ψ) is the most common chemical modification in RNA. In eukaryotes and archaea, pseudouridine synthases, mainly guided by box H/ACA snoRNAs, convert uridine to Ψ. Ψ stabilizes RNA structure and alters RNA-RNA and RNA-protein interactions, conferring important roles in gene expression. Notably, several Ψ-linked human diseases have been identified over the years. In addition, Ψ has also been extensively used in developing mRNA vaccines. Furthermore, it has been shown that pseudouridylation can be site-specifically directed to modify specific nonsense codons, leading to nonsense suppression. All of these, together with a need to better understand the specific functions of Ψs, have motivated the development of in vitro pseudouridylation assays using purified and reconstituted box H/ACA RNPs. Here, we describe an in vitro system for box H/ACA RNA-guided RNA pseudouridylation using human cell extracts. We show that a half guide RNA (only one hairpin) is just as functionally competent as the full-length guide RNA (two hairpins) in guiding site-specific pseudouridylation in the human cell extracts. This discovery offers the opportunity for direct delivery of a short guide RNA to human cells to promote site-specific nonsense suppression and therefore has potential clinical applications.
MeSH term(s)	Humans ; Cell Extracts ; Pseudouridine/genetics ; RNA, Small Nucleolar ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Catalysis
Chemical Substances	Cell Extracts ; Pseudouridine (1445-07-4) ; RNA, Small Nucleolar ; Ribonucleoproteins
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3191-1_14
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Article: Association between anti-complement factor H antibodies and renal outcome in primary membranous nephropathy.

Kagaya, Yu / Hayashi, Norifumi / Fujimoto, Keiji / Adachi, Hiroki / Furuichi, Kengo / Yokoyama, Hitoshi

Clinical nephrology

2021 Volume 96, Issue 2, Page(s) 82–89

Abstract: Aims: The complement factor H (CFH) is a regulator for the alternative complement pathway ...

Abstract	Aims: The complement factor H (CFH) is a regulator for the alternative complement pathway. The prevalence and roles of anti-CFH antibodies in the clinical outcome of primary membranous nephropathy (MN) patients remain unclear. Materials and methods: A total of 106 biopsy-proven kidney disease patients and 18 healthy controls were retrospectively investigated in this study. 36 patients had primary MN and 70 patients were diseased controls (31 minimal change nephrotic syndrome (MCNS), 19 rapidly progressive glomerulonephritis (RPGN), and 20 IgA glomerulonephritis (IgAGN)). Serum anti-CFH antibody titers were measured by enzyme-linked immunosorbent assay. Results: 77.8% of MN patients were positive for anti-CFH antibodies. However, only 27.1% of diseased control patients and 5.6% of healthy controls were positive for anti-CFH antibodies. Moreover, median anti-CFH antibody titers were significantly higher in MN patients (4.69 AU/mL) than in diseased control patients (MCNS patients (0 AU/mL, p < 0.01), RPGN patients (0 AU/mL, p < 0.05), IgAGN patients (0 AU/mL, p < 0.01)), and healthy controls (0 AU/mL, p < 0.01). Anti-CFH antibody titer was selected as an independent unfavorable predictor of renal dysfunction by Cox proportional hazards analysis. Conclusion: These data suggest that anti-CFH antibodies may be involved in the deterioration of renal function in primary MN.
Language	English
Publishing date	2021-05-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185101-9
ISSN	0301-0430
ISSN	0301-0430
DOI	10.5414/CN110479
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Zs.A 873: Show issues

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Article ; Online: A Thermally Activated Delayed Fluorescence Green OLED with 4500 h Lifetime and 20% External Quantum Efficiency by Optimizing the Emission Zone using a Single-Emission Spectrum Technique.

Mac Ciarnáin, Rossa / Mo, Hin Wai / Nagayoshi, Kaori / Fujimoto, Hiroshi / Harada, Kentaro / Gehlhaar, Robert / Ke, Tung Huei / Heremans, Paul / Adachi, Chihaya

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 34, Issue 29, Page(s) e2201409

Abstract: ... these findings, a device with an ultralong 4500 h T ...

Abstract	Device optimization of light-emitting diodes (LEDs) targets the most efficient conversion of electrically injected charges into emitted light. The emission zone in an LED is where charges recombine and light is emitted from. It is believed that the emission zone is strongly linked to device efficiency and lifetime. However, the emission zone size is below the optical diffraction limit, so it is difficult to measure. An accessible method based on a single emission spectrum that enables emission zone measurements with sub-second time resolution is shown. A procedure is introduced to study and control the emission zone of an LED system and correlate it with device performance. A thermally activated delayed fluorescence organic LED emission zone is experimentally measured over all luminescing current densities, while varying the device structure and while ageing. The emission zone is shown to be finely controlled by emitter doping because electron transport via the emitter is the charge-transport bottleneck of the system. Suspected quenching/degradation mechanisms are linked with the emission zone changes, device structure variation, and ageing. Using these findings, a device with an ultralong 4500 h T
Language	English
Publishing date	2022-06-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202201409
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Article ; Online: Change in the strategy for prophylactic diazepam use for febrile seizures and the impact on seizure recurrence within 24 h.

Inoue, Masataka / Adachi, Shunichi / Kawakami, Isao / Koga, Hiroshi

Seizure

2019 Volume 75, Page(s) 70–74

Abstract: ... of diazepam (0.3-0.5 mg/kg) after the first seizure and seizure recurrence within 24 h were compared between ... increased FS recurrence within 24 h in Japan. Prophylactic diazepam use should be determined based ...

Abstract	Purpose: To investigate the association between reduced prophylactic diazepam usage and short-term recurrence of febrile seizures (FSs) after the FS practice guideline was updated in Japan. Method: In this single-center, retrospective study, children (6-60 months of age) with FS who were transported to our center by ambulance from January 2011 through December 2018 were included. Rectal administration of diazepam (0.3-0.5 mg/kg) after the first seizure and seizure recurrence within 24 h were compared between 2011-2015 (pre-guideline revision) and 2016-2018 (post-guideline revision). Results: Among the total of 509 children, 297 were transported to our hospital in 2011-2015 and 212 in 2016-2018. Rectal diazepam administration was decreased in 2016-2018 (17 %) compared to 2011-2015 (53 %, P < 0.0001), while seizure recurrence was increased in 2016-2018 (20 %) compared to 2011-2015 (12 %, P = 0.0087). Similarly, hospital revisits (23 %) and hospital admissions (26 %) were increased in 2016-2018 compared to 2011-2015 (15 %, P = 0.031 and 18 %, P = 0.026, respectively). Multiple logistic regression analyses showed that prophylactic diazepam administration was the only factor related to preventing seizure recurrence. FS recurrence after the initial seizure was significantly less frequent with diazepam use (6 %) than without diazepam use (21 %, P < 0.0001; relative risk reduction, 70 %; number needed to treat, 6.8 children). Conclusion: The FS practice guideline revision was associated with reduced prophylactic diazepam usage and increased FS recurrence within 24 h in Japan. Prophylactic diazepam use should be determined based on clinical safety, local health infrastructure, and parental anxiety.
MeSH term(s)	Anticonvulsants/administration & dosage ; Child, Preschool ; Diazepam/administration & dosage ; Drug Administration Routes ; Female ; Humans ; Infant ; Japan/epidemiology ; Male ; Pre-Exposure Prophylaxis/methods ; Pre-Exposure Prophylaxis/trends ; Recurrence ; Retrospective Studies ; Seizures, Febrile/diagnosis ; Seizures, Febrile/drug therapy ; Seizures, Febrile/epidemiology ; Time Factors
Chemical Substances	Anticonvulsants ; Diazepam (Q3JTX2Q7TU)
Language	English
Publishing date	2019-12-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2019.12.021
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Zs.A 3573: Show issues

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Article ; Online: Leucinostatin Y: A Peptaibiotic Produced by the Entomoparasitic Fungus Purpureocillium lilacinum 40-H-28.

Momose, Isao / Onodera, Takefumi / Doi, Hiroyasu / Adachi, Hayamitsu / Iijima, Masatomi / Yamazaki, Yohko / Sawa, Ryuichi / Kubota, Yumiko / Igarashi, Masayuki / Kawada, Manabu

Journal of natural products

2019 Volume 82, Issue 5, Page(s) 1120–1127

Abstract: ... fungus Purpureocillium lilacinum 40-H-28. The planar structure was elucidated by detailed analysis ...

Abstract	Leucinostatin Y, a new peptaibiotic, was isolated from the culture broth of the entomoparasitic fungus Purpureocillium lilacinum 40-H-28. The planar structure was elucidated by detailed analysis of its NMR and MS/MS data. The absolute configurations of the amino acids were partially determined by an advanced Marfey's method. The biological activities of leucinostatin Y were assessed using human pancreatic cancer cells, revealing the importance of the C-terminus of leucinostatins for preferential cytotoxicity to cancer cells under glucose-deprived conditions and inhibition of mitochondrial function.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Magnetic Resonance Spectroscopy ; Paecilomyces/chemistry ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Peptaibols/chemistry ; Peptaibols/isolation & purification ; Peptaibols/pharmacology
Chemical Substances	Antineoplastic Agents ; Peptaibols ; leucinostatin Y
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.8b00839
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Zs.A 1144: Show issues

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Article ; Online: Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T

Tamehiro, Norimasa / Nishida, Kyoko / Sugita, Yu / Hayakawa, Kunihiro / Oda, Hiroyo / Nitta, Takeshi / Nakano, Miwa / Nishioka, Akiko / Yanobu-Takanashi, Reiko / Goto, Motohito / Okamura, Tadashi / Adachi, Reiko / Kondo, Kazunari / Morita, Akimichi / Suzuki, Harumi

The Journal of allergy and clinical immunology

2018 Volume 143, Issue 5, Page(s) 1878–1891

Abstract: Background: Ras homolog gene family H (RhoH) is a membrane-bound adaptor protein involved ...

Abstract	Background: Ras homolog gene family H (RhoH) is a membrane-bound adaptor protein involved in proximal T-cell receptor signaling. Therefore RhoH plays critical roles in the differentiation of T cells; however, the function of RhoH in the effecter phase of the T-cell response has not been fully characterized. Objective: We sought to explore the role of RhoH in inflammatory immune responses and investigated the involvement of RhoH in the pathogenesis of psoriasis. Methods: We analyzed effector T-cell and systemic inflammation in wild-type and RhoH-null mice. RhoH expression in T cells in human PBMCs was quantified by using RT-PCR. Results: RhoH deficiency in mice induced T Conclusion: Our results indicate that RhoH inhibits T
MeSH term(s)	Animals ; Cell Differentiation ; Cells, Cultured ; Chronic Disease ; Dermatitis/drug therapy ; Dermatitis/genetics ; Dermatitis/metabolism ; Disease Models, Animal ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/metabolism ; Receptors, Interleukin/therapeutic use ; Repressor Proteins/genetics ; Th17 Cells/immunology ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/genetics ; rho GTP-Binding Proteins/genetics ; rho GTP-Binding Proteins/metabolism ; Interleukin-22
Chemical Substances	IL22RA2 protein, human ; Interleukins ; Nr2f6 protein, mouse ; Receptors, Interleukin ; Repressor Proteins ; RhoH protein, mouse ; Transcription Factors ; UBR5 protein, mouse (EC 2.3.2.26) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; rho GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2018-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2018.09.032
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Article ; Online: Asteltoxins from the Entomopathogenic Fungus Pochonia bulbillosa 8-H-28.

Adachi, Hayamitsu / Doi, Hiroyasu / Kasahara, Yuichi / Sawa, Ryuichi / Nakajima, Kaori / Kubota, Yumiko / Hosokawa, Nobuo / Tateishi, Ken / Nomoto, Akio

Journal of natural products

2015 Volume 78, Issue 7, Page(s) 1730–1734

Abstract: ... bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was ...

Abstract	New asteltoxins C (3) and D (4) were found in the extract of the entomopathogenic fungus Pochonia bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was isolated, and structural analysis led to a revision of the structure of asteltoxin B. Compounds 2 and 4 have a novel tricyclic ring system connected to a dienyl α-pyrone structure. Compound 3 has a 2,8-dioxabicyclo[3.3.0]octane ring similar to that of asteltoxin (1). Compound 3 showed potent antiproliferative activity against NIAS-SL64 cells derived from the fat body of Spodoptera litura larvae, while 2 and 4 were inactive.
MeSH term(s)	Animals ; Cell Survival/drug effects ; Depsipeptides/pharmacology ; Hypocreales/chemistry ; Japan ; Larva/drug effects ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pyrones/chemistry ; Pyrones/isolation & purification ; Pyrones/pharmacology ; Spodoptera/drug effects
Chemical Substances	Depsipeptides ; Pyrones ; asteltoxin C ; asteltoxin D ; beauvericin (26S048LS2R) ; asteltoxin (72061-91-7)
Language	English
Publishing date	2015-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np500676j
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Article ; Online: Serum Anti-Helicobacter pylori IgG Antibody Titer in H. pylori-negative Cases with a Different Gastric Mucosal Atrophy Status.

Adachi, Kyoichi / Kishi, Kanako / Notsu, Takumi / Mishiro, Tomoko / Sota, Kazunari / Ishimura, Norihisa / Ishihara, Shunji

Internal medicine (Tokyo, Japan)

2020 Volume 59, Issue 22, Page(s) 2817–2823

Abstract: ... antibody serum titers in H. pylori-negative subjects with different degrees of gastric mucosal atrophy ... including C0 grade atrophy. Methods The absence of H. pylori infection was determined based on both negative ... serum anti-H. pylori IgG antibody test findings and no endoscopic evidence of that infection. Cases ...

Abstract	Objective This retrospective study was performed to investigate the anti-Helicobacter pylori IgG antibody serum titers in H. pylori-negative subjects with different degrees of gastric mucosal atrophy including C0 grade atrophy. Methods The absence of H. pylori infection was determined based on both negative serum anti-H. pylori IgG antibody test findings and no endoscopic evidence of that infection. Cases negative for the antibody and with positive endoscopic findings of H. pylori infection were defined as H. pylori-positive. The serum anti-H. pylori IgG antibody titers were analyzed in H. pylori-negative (n=1,087), -positive (n=69), and post-eradicated (n=278) subjects. Results The serum antibody titer in subjects with H. pylori-positive endoscopy findings was significantly higher than that in H. pylori-negative subjects, even when the serum titer indicated a negative result. In addition, the anti-H. pylori IgG antibody serum titer was higher in H. pylori-negative subjects with a greater degree of gastric mucosal atrophy. In a comparison between H. pylori-negative C0 and C1 gastric mucosal atrophy cases, the antibody serum titer in those classified as C0 was significantly lower. An analysis of H. pylori post-eradicated cases showed that the serum antibody titer decreased over time after successful eradication. Conclusion The disappearance of H. pylori infection in H. pylori-negative individuals may occur later in those with a greater degree of gastric mucosal atrophy. The serum antibody titer difference between the H. pylori-negative C0 and C1 groups might have been caused by the differences in distribution between H. pylori-uninfected subjects and those in whom the infection had disappeared, thus additional investigation is needed to clarify the significance of gastric mucosal classification including the C0 grade.
MeSH term(s)	Antibodies, Bacterial ; Atrophy/pathology ; Gastric Mucosa/pathology ; Helicobacter Infections/pathology ; Helicobacter pylori ; Humans ; Immunoglobulin G ; Retrospective Studies
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin G
Language	English
Publishing date	2020-07-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.5132-20
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Article ; Online: Prevalence of Barrett's Epithelium Shown by Endoscopic Observations with Linked Color Imaging in Subjects with Different H. pylori Infection Statuses.

Adachi, Kyoichi / Ishimura, Norihisa / Kishi, Kanako / Notsu, Takumi / Mishiro, Tomoko / Sota, Kazunari / Ishihara, Shunji

Internal medicine (Tokyo, Japan)

2020 Volume 60, Issue 5, Page(s) 667–674

Abstract: ... between the presence of Barrett's epithelium (BE) and the status of H. pylori infection was investigated ... whose status of H. pylori infection had been determined. An endoscopic observation using LCI was performed ... 20-29, and ≥30 mm found in 1,005, 851, 27, and 1, respectively. Its prevalence in H. pylori-negative ...

Abstract	Objective This study was conducted to clarify the prevalence of short segment Barrett's esophagus (SSBE) using endoscopic observations with linked color imaging (LCI). In addition, the relationship between the presence of Barrett's epithelium (BE) and the status of H. pylori infection was investigated. Methods The study subjects were 3,353 individuals (2,186 men, 1,167 women; mean age 55.2±9.4 years old) whose status of H. pylori infection had been determined. An endoscopic observation using LCI was performed to examine the distal margin of palisade vessels and confirm the area of BE. The prevalence of BE ≥5 mm in length was investigated. Results BE was diagnosed in 1,884 (56.2%) subjects, with lengths of <10, 10-19, 20-29, and ≥30 mm found in 1,005, 851, 27, and 1, respectively. Its prevalence in H. pylori-negative, H. pylori-positive, and post-eradicated subjects was 41.7%, 64.4%, and 69.9%, respectively (p<0.001). The duration since successful eradication of H. pylori did not affect the prevalence of BE. The degree of gastric mucosal atrophy was higher in cases with BE (p<0.001), although negativity for H. pylori infection and mild gastric mucosal atrophy were significant factors for the development of longer BE. Conclusion A high prevalence of SSBE was noted when LCI was used to determine the area of BE, as the distal end of the palisade vessels was easily visualized. Negativity for H. pylori infection and mild gastric mucosal atrophy were not correlated with SSBE prevalence.
MeSH term(s)	Barrett Esophagus/diagnostic imaging ; Barrett Esophagus/epidemiology ; Epithelium ; Female ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Prevalence
Language	English
Publishing date	2020-09-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.5676-20
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