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  1. Article ; Online: An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes.

    Long, Zhongjie / Chi, Yongting / Zhang, Xianbo / Li, Hongbing / Yang, Dejin / Li, Diangeng / Jiang, Zhouxiang

    Annals of biomedical engineering

    2024  Volume 52, Issue 5, Page(s) 1435–1447

    Abstract: Flexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to ... ...

    Abstract Flexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor. A three-stage calibration protocol was presented in an extensor. First, the orientation of the endoscope tube was derived by conducting a circular rotation of the endoscope around its axis utilizing a pair of tightly bearing stands. Second, the 3D position of the endoscope tip was acquired by having the tip come into contact with a flat plane. Third, the pose model of the bending section was derived and transformed into the local coordinate system of the EM sensor attached to the endoscope handle. To assess the accuracy of the proposed calibration approach, two experiments were designed and performed. Experimental results indicate accuracies of 0.09 ± 0.06 deg and 0.03 ± 0.19 deg in the estimation of the endoscope tube orientation and 0.52 ± 0.29, 0.33 ± 0.11, and 0.29 ± 0.17 mm in the x, y, and z estimations of the endoscope tip position, respectively. The proposed approach is accurate and easy to operate, does not require the employment of custom calibration markers, and can be used not only in surgical training systems but also in the endoscopic-based tools tracking.
    MeSH term(s) Endoscopes ; Endoscopy ; Electromagnetic Phenomena ; Phantoms, Imaging ; Equipment Design
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-024-03469-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of m6A-regulated genes and subtype classification in lupus nephritis.

    Li, Diangeng / Li, Yanchun / Zhu, Kaiyi / Yuan, Yuqing / He, Zheng / Sun, Qianmei / Jin, Meiling

    BMC nephrology

    2024  Volume 25, Issue 1, Page(s) 119

    Abstract: Background: Lupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A) is a reversible RNA modification and has been implicated in various biological processes. However, the ... ...

    Abstract Background: Lupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A) is a reversible RNA modification and has been implicated in various biological processes. However, the roles of m6A regulators in LN are not fully demonstrated.
    Methods: We downloaded the kidney tissue transcriptome dataset of LN patients and normal controls from the GEO database and extracted the expression levels of m6A regulators. We constructed and compared Random Forest (RF) and Support Vector Machine (SVM) models, and subsequently selected featured genes to develop nomogram models. The m6A subtypes were identified based on significantly differentially expressed m6A regulators, and the m6A gene subtypes were identified based on m6A-associated differential genes, and the two m6A modification patterns were comprehensively evaluated.
    Results: We obtained the GSE32591 and GSE112943 datasets from the GEO database, including 78 LN samples and 36 normal control samples. We extracted the expression levels of 20 m6A regulators. By RF analysis we identified 7 characteristic m6A regulators and constructed nomogramh models with these 7 genes. We identified two m6A subtypes based on these seven important m6A regulators, and the immune cell infiltration levels of the two subtype clusters were significantly different. We identified two more m6A gene subtypes based on m6A-associated DEGs. We calculated the m6A scores using the principal component analysis (PCA) algorithm and found that the m6A scores of m6A cluster A and gene cluster A were lower than those of m6A cluster B and gene cluster B. In addition, we found that the levels of inflammatory factors were also significantly different between m6A clusters and gene clusters.
    Conclusion: This study confirms that m6A regulators are involved in the LN process through different modes of action and provide new diagnostic and therapeutic targets for LN.
    MeSH term(s) Humans ; Lupus Nephritis/genetics ; Lupus Erythematosus, Systemic ; Adenine ; Adenosine
    Chemical Substances Adenine (JAC85A2161) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-024-03549-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Integrative analysis of the association between circadian rhythm and lupus nephritis.

    Jin, Meiling / Teng, Fei / Cao, Baoping / Sun, Qianmei / Li, Diangeng

    Clinical kidney journal

    2023  Volume 16, Issue 9, Page(s) 1489–1499

    Abstract: Background: Lupus nephritis (LN) is an autoimmune nephropathy associated with systemic lupus erythematosus. Circadian rhythms are involved in the development of several diseases, especially inflammation-related diseases, but their relationship with LN ... ...

    Abstract Background: Lupus nephritis (LN) is an autoimmune nephropathy associated with systemic lupus erythematosus. Circadian rhythms are involved in the development of several diseases, especially inflammation-related diseases, but their relationship with LN is unclear.
    Methods: This was an integrative bioinformatics study. The expression profile from glomeruli, tubular interstitium and renal whole tissue samples was used to assess the expression levels and relevance of circadian rhythm-related genes. To screen for circadian rhythm-related signatures, we employed the LASSO and SVM-RFE algorithms. A consensus clustering algorithm was used to classify LN patients into two circadian rhythm patterns (cluster A and cluster B). We made immune cell infiltration analysis. We used the weighted gene co-expression network analysis (WGCNA) algorithm to identify cluster-specific differentially expressed genes. Nephroseq data were used to observe the relationship between genes and renal function.
    Results: We found more significant differences in circadian rhythm-related gene expression in LN glomeruli compared with tubulointerstitial and whole-kidney tissues. We established a circadian rhythm-related signature consisting of eight genes that can easily distinguish LN from healthy individuals. Patients in cluster A were associated with B-cell-dominated immunity, whereas patients in cluster B were associated with T-cell-dominated immunity. As most of the patients with proliferative LN combined with membranous LN belonged to cluster B, patients in cluster B may have more severe renal pathology compared with patients in cluster A. Fifteen circadian rhythm-related genes associated with LN and LN typing were screened using the WGCNA algorithm, with COL1A2 and DOCK2 associated with renal prognosis.
    Conclusions: This study found that circadian rhythms are associated with the occurrence of LN, providing new ideas for the development of new LN treatment options from the perspective of circadian rhythms.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad092
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  4. Article: A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma.

    Dang, Ruijie / Jin, Meiling / Nan, Jingzhu / Jiang, Xuege / He, Zheng / Su, Fang / Li, Diangeng

    International journal of general medicine

    2022  Volume 15, Page(s) 207–222

    Abstract: Purpose: Papillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs can be used as independent biomarkers for the ... ...

    Abstract Purpose: Papillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs can be used as independent biomarkers for the diagnosis and prognosis of a variety of tumors.
    Methods: Gene expression profile and clinical information of patients with PRCC were obtained from The Cancer Genome Atlas (TCGA) database. Lasso penalized Cox regression and univariate Cox regression analysis were utilized for model construction. The Kaplan-Meier (K-M) and receiver operating characteristic (ROC) curves were plotted to validate the predictive effect of the prognostic signature. Immune cell infiltration and immune function were compared between the high-risk and low-risk groups. Chemotherapy sensitivity analysis was also performed.
    Results: We constructed a prognostic signature consisting of 15 ferroptosis-related lncRNAs. The K-M curves validated the fine predictive accuracy of the prognostic signature (
    Conclusion: We demonstrated that a ferroptosis-related lncRNA prognostic signature could be a novel biomarker for PRCC.
    Language English
    Publishing date 2022-01-06
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S341034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Modification Mechanism of Nano-Liquids on Streamer Morphology and Breakdown Strength under Microsecond Pulse

    Diangeng Li / Zicheng Zhang / Shifei Liu / Song Li

    Applied Sciences, Vol 10, Iss 7376, p

    2020  Volume 7376

    Abstract: In liquid mediums, whether the breakdown strength can be greatly improved after introducing the nano-particles has been widely investigated, however, there has been no scientific consensus on the modification mechanism of this anomalous phenomenon. In ... ...

    Abstract In liquid mediums, whether the breakdown strength can be greatly improved after introducing the nano-particles has been widely investigated, however, there has been no scientific consensus on the modification mechanism of this anomalous phenomenon. In this paper, we first experimentally measured the streamer morphology and breakdown strength in pure transformer oil, TiO <math display="inline"><semantics><msub><mrow></mrow><mn>2</mn></msub></semantics></math> nano-liquids and Al <math display="inline"><semantics><msub><mrow></mrow><mn>2</mn></msub></semantics></math> O <math display="inline"><semantics><msub><mrow></mrow><mn>3</mn></msub></semantics></math> nano-liquids under microsecond pulse. The results demonstrated that there are significant differences in streamer morphology between pure transformer oil and nano-liquids, as the streamers in pure transformer oil exhibit thick bush-like qualities, while in nano-liquids they exhibit tree-like qualities. Moreover, the breakdown voltage results show that the breakdown strength of transformer oil is improved after nano-modification, and the TiO <math display="inline"><semantics><msub><mrow></mrow><mn>2</mn></msub></semantics></math> nano-liquids and Al <math display="inline"><semantics><msub><mrow></mrow><mn>2</mn></msub></semantics></math> O <math display="inline"><semantics><msub><mrow></mrow><mn>3</mn></msub></semantics></math> nano-liquids have nearly the same optimal volume fraction. The results of the analysis indicate that the modification mechanism of nano-particles is significantly linked to the trapped electrons process. Specifically, the addition of nano-particles can affect the electrons’ density ...
    Keywords modification mechanism ; pure transformer oil ; nano-liquids ; streamer morphology ; breakdown strength ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 511
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A compact repetitive high energy-density accelerator HEART-20 based on propylene carbonate pulse forming line.

    Zhang, Zicheng / Liu, Shifei / Yang, Hanwu / Li, Diangeng / Fan, Yuwei / Zhang, Jiande

    The Review of scientific instruments

    2022  Volume 93, Issue 10, Page(s) 104703

    Abstract: The development of pulsed power technology requires an electron beam accelerator with high output power and repetitive operation. A compact repetitive electron beam accelerator based on a pulse transformer and a pulse forming line of high permittivity ... ...

    Abstract The development of pulsed power technology requires an electron beam accelerator with high output power and repetitive operation. A compact repetitive electron beam accelerator based on a pulse transformer and a pulse forming line of high permittivity liquid, as an essential type of one, has attracted extensive attention at the present time. In this paper, the development of a compact high energy-density electron beam accelerator, viz., HEART-20, based on a propylene carbonate (PC) forming line is presented. The accelerator HEART-20 consists of a primary energy source, a pulse transformer, a PC pulse forming line, a gas spark gap switch, and a vacuum diode. First, the operation principle of the accelerator is described. Second, the design of the accelerator's parameters is presented. A pulse transformer is developed for rapid charging of the PC-filled pulse forming line. The coupling coefficient is above 0.9, the voltage ratio is about 200, and the operation voltage is about 800 kV. Third, the energy storage characteristics of PC are investigated. The insulation characteristics of PC under positive charging voltage are found to perform better than those under negative charging voltage. The insulating strength of PC can be improved by pressurization. Finally, the development of the accelerator HEART-20 is presented. Across a vacuum diode load, it can steadily operate at a 20 GW output power in 5 Hz rep-rate. Moreover, it can drive a magnetically insulated line oscillator to produce about 2.0 GW microwave. These findings provide a good foundation for the development of a rep-rate intensive electron beam accelerator with promising applications for the future.
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0103221
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  7. Article ; Online: Effect of Leptin Levels of Type 2 Diabetes Mellitus and Diabetic Complications.

    Nan, Jingzhu / Zhang, Xu / Li, Diangeng / Jin, Meiling / Guo, Guanghong / Dong, Jin / Li, Xiujuan

    Clinical and investigative medicine. Medecine clinique et experimentale

    2022  Volume 45, Issue 3, Page(s) E32–46

    Abstract: Purpose: To investigate serum leptin levels in patients with type 2 diabetes mellitus (T2DM) and the relationship between leptin levels and T2DM complications and prevalence.: Methods: A total of 355 patients, 282 cases with T2DM and 73 normal ... ...

    Abstract Purpose: To investigate serum leptin levels in patients with type 2 diabetes mellitus (T2DM) and the relationship between leptin levels and T2DM complications and prevalence.
    Methods: A total of 355 patients, 282 cases with T2DM and 73 normal controls, were recruited at 1st Medical Centre, Chinese PLA General Hospital (Beijing, China) between November 2013 and July 2014. Levels of serum leptin, biochemical markers and sexual hormones were measured, and clinical characteristics were retrieved through the electronic medical record system.
    Results: Leptin levels in females were higher than that in males. Leptin levels in T2MD patients were positively correlated with body mass index, percent body fat, triglyceride, cystatin C homocysteine and salivary acid, and negatively correlated with glycosylated serum protein and glycosylated albumin levels. Leptin levels in males were positively correlated with systolic pressure and estradiol, and negatively correlated with testosterone and high density lipoprotein cholesterol. Sex (female) was positively correlated with the duration of disease. Leptin levels in T2DM patients with complications such as hypertension, diabetic nephropathy, diabetic peripheral neuropathy and coronary heart disease were higher than that in patients without such complications. Leptin levels in females with diabetic retinopathy and diabetic macroangiopathy were higher than that in patients without such complications, but there was no difference in males.
    Conclusions: Leptin has significant gender differences. Leptin levels are related to body mass index, percent body fat and sex hormone level in T2DM patients and may affect short-term blood glucose control in T2DM patients. Leptin levels are related to complications in patients with T2DM and affect the prevalence rates of complications.
    MeSH term(s) Albumins ; Biomarkers ; Body Mass Index ; Cholesterol, HDL ; Cystatin C ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy ; Estradiol ; Female ; Homocysteine ; Humans ; Leptin ; Male ; Polyesters ; Testosterone ; Triglycerides
    Chemical Substances Albumins ; Biomarkers ; Cholesterol, HDL ; Cystatin C ; Leptin ; Polyesters ; Triglycerides ; Homocysteine (0LVT1QZ0BA) ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2022-09-21
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 434004-8
    ISSN 1488-2353 ; 0147-958X
    ISSN (online) 1488-2353
    ISSN 0147-958X
    DOI 10.25011/cim.v45i3.38873
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  8. Article ; Online: Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019.

    Li, Diangeng / Jin, Meiling / Bao, Pengtao / Zhao, Weiguo / Zhang, Shixi

    JAMA network open

    2020  Volume 3, Issue 5, Page(s) e208292

    MeSH term(s) Adult ; Betacoronavirus/isolation & purification ; COVID-19 ; China/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Progression ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Prospective Studies ; SARS-CoV-2 ; Semen/virology ; Sexually Transmitted Diseases, Viral/prevention & control ; Virus Shedding/physiology
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2020.8292
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  9. Article ; Online: RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.

    Li, Diangeng / Tang, Liangyou / Liu, Bo / Xu, Shibo / Jin, Meiling / Bo, Wu

    Aging

    2021  Volume 13, Issue 7, Page(s) 10450–10467

    Abstract: ... Receptor ... ...

    Abstract Receptor Interacting
    MeSH term(s) Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Prognosis ; Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism ; Signal Transduction/physiology
    Chemical Substances Receptor-Interacting Protein Serine-Threonine Kinase 2 (EC 2.7.11.1)
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.202808
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  10. Article ; Online: Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19

    Huang, Baozhen / Niu, Yanlin / Zhao, Weiguo / Bao, Pengtao / Li, Diangeng

    2020  

    Abstract: Baozhen Huang,1 Yanlin Niu,2 Weiguo Zhao,3 Pengtao Bao,4 Diangeng Li1,5 1Nanlou ... Center for Kidney Diseases, Beijing, People’s Republic of ChinaCorrespondence: Diangeng LiNanlou ...

    Abstract Baozhen Huang,1 Yanlin Niu,2 Weiguo Zhao,3 Pengtao Bao,4 Diangeng Li1,5 1Nanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Beijing Center for Disease Prevention and Control, Institute for Nutrition and Food Hygiene, Beijing, People’s Republic of China; 3Department of Respiratory Medicine, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese, Beijing, People’s Republic of China; 5Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, People’s Republic of ChinaCorrespondence: Diangeng LiNanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, 28th Fuxing Road, Beijing 100853, People’s Republic of ChinaEmail lidiangeng@126.comPengtao BaoDepartment of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese PLA General Hospital, 17th Heishanhu Road, Beijing 100093, People’s Republic of ChinaEmail bao03@163.comBackground: The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out.Objective: To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients.Methods: This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.7%) of the infected participants and 188 (82.5%) of the uninfected participants answering a doctor-administered telephone questionnaire on lifestyle. The binary logistic regression model and the ordinal logit model were used to observe relevance.Results: Comparing sick and non-sick patients, we found that irregular exercise (P=0.004), sedentary lifestyle (P=0.010), and overexertion (P< 0.001) may be associated with the susceptibility to COVID-19. In symptomatic patients, using the recommended status as a reference, risk of severe infection increased with decreased sleep status, being 6.729 (95% CI=2.138– 21.181) times higher for potentially appropriate sleep (P=0.001) and peaking at 8.612 (95% CI=1.913– 38.760) times higher for lack of sleep (P=0.005). Reduction in average daily sleep time significantly increased the likely severity (P=0.002).Discussion: Through further examination of damage of external lung organs, we found that lack of sleep affected not only disease severity but also prognosis. Based on these findings, the public should prioritize a healthy lifestyle and get adequate sleep in response to the outbreak. The study of life habits may bring new ideas for the prevention and treatment of COVID-19.Keywords: COVID-19, disease severity, sleep status, damage of external lung organs
    Keywords Nature and Science of Sleep ; covid19
    Subject code 610
    Language English
    Publishing date 2020-11-12
    Publisher Dove Press
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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