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Article ; Online: Decrease in ultrasound Brain Tissue Pulsations as a potential surrogate marker of response to antidepressant.

Desmidt, Thomas / Dujardin, Paul-Armand / Brizard, Bruno / Réméniéras, Jean-Pierre / Gissot, Valérie / Dufour-Rainfray, Diane / Atanasova, Boriana / Kazour, François / Belzung, Catherine / Camus, Vincent / El-Hage, Wissam

Journal of psychiatric research

2022 Volume 146, Page(s) 186–191

Abstract: Previous cross-sectional studies found excessive Brain Tissue Pulsations (BTP) in mid-life depression, which could constitute a mechanism of brain damage in depression. However, it remains unclear whether successful antidepressant therapy restores BTP ... ...

Abstract	Previous cross-sectional studies found excessive Brain Tissue Pulsations (BTP) in mid-life depression, which could constitute a mechanism of brain damage in depression. However, it remains unclear whether successful antidepressant therapy restores BTP amplitudes. In this prospective study, we investigated longitudinal changes in BTP in patients with a major depressive episode (MDE), among responders and non-responders to escitalopram. Fifty-two individuals with a MDE, free of antidepressants at baseline, were included in an 8-week open-labeled escitalopram trial. Ultrasound Tissue Pulsatility Imaging (TPI) was applied to measure resting BTP and BTP reactivity in an orthostatic challenge, at baseline and at week 8. TPI data were available for 48 participants divided into responders (n = 28, 58.3%) and non-responders (n = 20, 41.7%) according to change in the MADRS score. MaxBTP significantly decreased between baseline and week 8, only in responders. In addition, changes in MaxBTP during the orthostatic challenge were no longer significant at week 8 but only in responders. Because excessive BTP constitutes a potential mechanism for brain damage, our results suggest that a successful pharmacotherapy could benefit patients to lower the risk of brain damage in individuals with depression, a population exposed to stroke, small arteries disease and brain atrophy. TPI could provide a surrogate biomarker to monitor antidepressant response and brain health in depression in clinical routine.
MeSH term(s)	Antidepressive Agents/therapeutic use ; Biomarkers ; Brain/diagnostic imaging ; Citalopram/therapeutic use ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Humans ; Prospective Studies ; Treatment Outcome
Chemical Substances	Antidepressive Agents ; Biomarkers ; Citalopram (0DHU5B8D6V)
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2021.12.056
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Article ; Online: Changes in cerebral connectivity and brain tissue pulsations with the antidepressant response to an equimolar mixture of oxygen and nitrous oxide: an MRI and ultrasound study.

Molecular psychiatry

2023 Volume 28, Issue 9, Page(s) 3900–3908

Abstract: Nitrous oxide ( ... ...

Abstract	Nitrous oxide (N
MeSH term(s)	Female ; Humans ; Nitrous Oxide/therapeutic use ; Depressive Disorder, Major/drug therapy ; Oxygen/therapeutic use ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Gyrus Cinguli/diagnostic imaging
Chemical Substances	Nitrous Oxide (K50XQU1029) ; Oxygen (S88TT14065) ; Antidepressive Agents
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02217-6
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Article ; Online: A Case of Sustained Antidepressant Effects and Large Changes in the Brain With a Single Brief Exposure to Nitrous Oxide.

Desmidt, Thomas / Gissot, Valérie / Dujardin, Paul-Armand / Andersson, Frédéric / Barantin, Laurent / Brizard, Bruno / Arlicot, Nicolas / Réméniéras, Jean-Pierre / Espitalier, Fabien / El-Hage, Wissam / Camus, Vincent

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2021 Volume 29, Issue 12, Page(s) 1298–1300

MeSH term(s)	Antidepressive Agents ; Brain/diagnostic imaging ; Humans ; Nitrous Oxide/adverse effects
Chemical Substances	Antidepressive Agents ; Nitrous Oxide (K50XQU1029)
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1016/j.jagp.2021.01.138
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Article ; Online: Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study.

Siragusa, Marta Andrea / Rufin, Thomas / Courtois, Robert / Belzung, Catherine / Andersson, Frédéric / Brizard, Bruno / Dujardin, Paul-Armand / Cottier, Jean-Philippe / Patat, Frédéric / Réméniéras, Jean-Pierre / Gissot, Valérie / El-Hage, Wissam / Camus, Vincent / Desmidt, Thomas

Brain imaging and behavior

2020 Volume 15, Issue 3, Page(s) 1499–1507

Abstract: Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow ( ... ...

Abstract	Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (n = 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.
MeSH term(s)	Amygdala/diagnostic imaging ; Brain/diagnostic imaging ; Cerebrovascular Circulation ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neuroticism
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2377165-3
ISSN	1931-7565 ; 1931-7557
ISSN (online)	1931-7565
ISSN	1931-7557
DOI	10.1007/s11682-020-00348-w
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Article ; Online: A systematic review of ultrasound imaging and therapy in mental disorders.

Siragusa, Marta Andrea / Réméniéras, Jean-Pierre / Bouakaz, Ayache / Escoffre, Jean-Michel / Patat, Frédéric / Dujardin, Paul-Armand / Brizard, Bruno / Belzung, Catherine / Camus, Vincent / El-Hage, Wissam / Desmidt, Thomas

Progress in neuro-psychopharmacology & biological psychiatry

2020 Volume 101, Page(s) 109919

Abstract: Background: Increasing evidence suggests that ultrasound (US) imaging may provide biomarkers and therapeutic options in mental disorders. We systematically reviewed the literature to provide a global overview of the possibilities of US for psychiatry.!## ...

Abstract	Background: Increasing evidence suggests that ultrasound (US) imaging may provide biomarkers and therapeutic options in mental disorders. We systematically reviewed the literature to provide a global overview of the possibilities of US for psychiatry. Methods: Original English language articles published between January 2000 and September 2019 were identified through databases searching and analyzed to summarize existing evidence according to PRISMA methodology. Results: A total of 81 articles were included. Various US techniques and markers have been used in mental disorders, including Transcranial Doppler and Intima-Media Thickness. Most of the studies have focused on characterizing the pathophysiology of mental disorders, especially vascular physiology. Studies on therapeutic applications are still scarce. Discussion: US imaging has proved to be useful in characterizing vascular impairment and structural and functional brain changes in mental disorders. Preliminary findings also suggest potential interests for therapeutic applications. Growing evidence suggests that US imaging could provide a non-invasive, portable and low-cost tool for pathophysiological characterization, prognostic assessment and therapeutic applications in mental disorders.
MeSH term(s)	Brain/diagnostic imaging ; Cross-Sectional Studies ; Humans ; Longitudinal Studies ; Mental Disorders/diagnostic imaging ; Mental Disorders/psychology ; Mental Disorders/therapy ; Ultrasonography, Doppler, Transcranial/methods
Language	English
Publishing date	2020-03-10
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2020.109919
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Article ; Online: Trypanosoma vivax

Ramirez-Barrios, Roger / Reyna-Bello, Armando / Parra, Omaira / Valeris, Robert / Tavares-Marques, Lucinda / Brizard, Jean-Paul / Demettre, Edith / Seveno, Martial / Martinez-Moreno, Alvaro / Holzmuller, Philippe

Veterinary parasitology: X

2019 Volume 2, Page(s) 100014

Abstract: Cattle trypanosomosis caused ... ...

Abstract	Cattle trypanosomosis caused by
Language	English
Publishing date	2019-06-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1389
ISSN (online)	2590-1389
DOI	10.1016/j.vpoa.2019.100014
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Article ; Online: When classical music relaxes the brain: An experimental study using Ultrasound Brain Tissue Pulsatility Imaging.

Siragusa, Marta Andrea / Brizard, Bruno / Dujardin, Paul-Armand / Réméniéras, Jean-Pierre / Patat, Frédéric / Gissot, Valérie / Camus, Vincent / Belzung, Catherine / El-Hage, Wissam / Wosch, Thomas / Desmidt, Thomas

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

2020 Volume 150, Page(s) 29–36

Abstract: Introduction: Recent evidence suggests that biomechanical parameters of the brain, such as Brain Tissue Pulsatility (BTP), could be involved in emotional reactivity. However, no study has investigated the impact of an emotional task on BTP. We used the ... ...

Abstract	Introduction: Recent evidence suggests that biomechanical parameters of the brain, such as Brain Tissue Pulsatility (BTP), could be involved in emotional reactivity. However, no study has investigated the impact of an emotional task on BTP. We used the ultrasound method of Tissue Pulsatility Imaging (TPI) to assess changes in BTP to exciting and relaxing classical music, in a musical perception task, as a validated paradigm to assess emotional reactivity. Methods: 25 healthy volunteers were exposed via earphones to four 5-minute musical excerpts (two exciting and two relaxing musical excerpts) presented in a randomized order and intersected by 5 silence periods. Measures of BTP, Heart Rate (HR) and Skin Conductance (SC) were collected during the entire task. Results: The BTP significantly decreased with relaxing music compared to silence, and especially with the excerpt 'Entrance of the Shades' by Minkus. The HR and SC, but not Heart Rate Variability, were also decreased with relaxing music. We found no significant effect of exciting music. Discussion: We report, for the first time, that classical relaxing music decreases the amplitude of the brain pulsatile movements related to cerebral blood flow and mechanical properties of the brain parenchyma, which provides further evidence of the involvement of BTP in emotional reactivity. In addition, we validate the use of TPI as a non-invasive, portable and low cost tool for studies in psychophysiology, with the potential to be implemented as a biomarker in musicotherapy trials notably.
MeSH term(s)	Adolescent ; Adult ; Brain/physiology ; Cerebrovascular Circulation/physiology ; Echoencephalography/methods ; Emotions/physiology ; Female ; Functional Neuroimaging/methods ; Galvanic Skin Response/physiology ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Music/psychology ; Random Allocation ; Relaxation/physiology ; Young Adult
Language	English
Publishing date	2020-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605645-3
ISSN	1872-7697 ; 0167-8760
ISSN (online)	1872-7697
ISSN	0167-8760
DOI	10.1016/j.ijpsycho.2020.01.007
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Article ; Online: Optimized transitory ectopic expression of promastigote surface antigen protein in Nicotiana benthamiana, a potential anti-leishmaniasis vaccine candidate.

Lacombe, Séverine / Bangratz, Martine / Brizard, Jean-Paul / Petitdidier, Elodie / Pagniez, Julie / Sérémé, Drissa / Lemesre, Jean-Loup / Brugidou, Christophe

Journal of bioscience and bioengineering

2017 Volume 125, Issue 1, Page(s) 116–123

Abstract: In recent years, plants have been shown to be an efficient alternative expression system for high-value pharmaceuticals such as vaccines. However, constitutive expression of recombinant protein remains uncertain on their level of production and ... ...

Abstract	In recent years, plants have been shown to be an efficient alternative expression system for high-value pharmaceuticals such as vaccines. However, constitutive expression of recombinant protein remains uncertain on their level of production and biological activity. To overcome these problems, transitory expression systems have been developed. Here, a series of experiments were performed to determine the most effective conditions to enhance vaccine antigen transient accumulation in Nicotiana benthamiana leaves using the promastigote surface antigen (PSA) from the parasitic protozoan Leishmania infantum. This protein has been previously identified as the major antigen of a licensed canine anti-leishmaniasis vaccine. The classical prokaryote Escherichia coli biosystem failed in accumulating PSA. Consequently, the standard plant system based on N. benthamiana has been optimized for the production of putatively active PSA. First, the RNA silencing defense mechanism set up by the plant against PSA ectopic expression was abolished by using three viral suppressors acting at different steps of the RNA silencing pathway. Then, we demonstrated that the signal peptide at the N-terminal side of the PSA is required for its accumulation. The PSA ER signaling and retention with the PSA signal peptide and the KDEL motif, respectively were optimized to significantly increase its accumulation. Finally, we demonstrate that the production of recombinant PSA in N. benthamiana leaves allows the conservation of its immunogenic property. These approaches demonstrate that based on these optimizations, plant based systems can be used to effectively produce the biological active PSA protein.
MeSH term(s)	Animals ; Antigens, Surface/genetics ; Antigens, Surface/immunology ; Gene Expression Regulation ; Leishmania infantum/genetics ; Leishmania infantum/immunology ; Leishmaniasis Vaccines/genetics ; Leishmaniasis Vaccines/immunology ; Leishmaniasis, Visceral/immunology ; Leishmaniasis, Visceral/parasitology ; Leishmaniasis, Visceral/prevention & control ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Plant Leaves/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Nicotiana/genetics
Chemical Substances	Antigens, Surface ; Leishmaniasis Vaccines ; Membrane Proteins ; Recombinant Proteins
Language	English
Publishing date	2017-08-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
DOI	10.1016/j.jbiosc.2017.07.008
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Article: Optimized transitory ectopic expression of promastigote surface antigen protein in Nicotiana benthamiana, a potential anti-leishmaniasis vaccine candidate

Lacombe, Séverine / Christophe Brugidou / Drissa Sérémé / Elodie Petitdidier / Jean-Loup Lemesre / Jean-Paul Brizard / Julie Pagniez / Martine Bangratz

The Society for Biotechnology, Japan Journal of bioscience and bioengineering. 2018 Jan., v. 125, no. 1

2018

Abstract	In recent years, plants have been shown to be an efficient alternative expression system for high-value pharmaceuticals such as vaccines. However, constitutive expression of recombinant protein remains uncertain on their level of production and biological activity. To overcome these problems, transitory expression systems have been developed. Here, a series of experiments were performed to determine the most effective conditions to enhance vaccine antigen transient accumulation in Nicotiana benthamiana leaves using the promastigote surface antigen (PSA) from the parasitic protozoan Leishmania infantum. This protein has been previously identified as the major antigen of a licensed canine anti-leishmaniasis vaccine. The classical prokaryote Escherichia coli biosystem failed in accumulating PSA. Consequently, the standard plant system based on N. benthamiana has been optimized for the production of putatively active PSA. First, the RNA silencing defense mechanism set up by the plant against PSA ectopic expression was abolished by using three viral suppressors acting at different steps of the RNA silencing pathway. Then, we demonstrated that the signal peptide at the N-terminal side of the PSA is required for its accumulation. The PSA ER signaling and retention with the PSA signal peptide and the KDEL motif, respectively were optimized to significantly increase its accumulation. Finally, we demonstrate that the production of recombinant PSA in N. benthamiana leaves allows the conservation of its immunogenic property. These approaches demonstrate that based on these optimizations, plant based systems can be used to effectively produce the biological active PSA protein.
Keywords	bioactive properties ; dogs ; Escherichia coli ; gene expression ; leaves ; Leishmania infantum ; Nicotiana benthamiana ; prokaryotic cells ; recombinant proteins ; RNA interference ; signal peptide ; surface antigens ; vaccines
Language	English
Dates of publication	2018-01
Size	p. 116-123.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
DOI	10.1016/j.jbiosc.2017.07.008
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Trypanosoma vivax infection in sheep: Different patterns of virulence and pathogenicity associated with differentially expressed proteomes.

Veterinary parasitology

2019 Volume 276S, Page(s) 100014

Abstract: Cattle trypanosomosis caused by Trypanosoma vivax is a widely distributed disease in Africa and Latin America. It causes significant losses in the livestock industry and is characterized by fluctuating parasitemia, anemia, fever, lethargy, and weight ... ...

Abstract	Cattle trypanosomosis caused by Trypanosoma vivax is a widely distributed disease in Africa and Latin America. It causes significant losses in the livestock industry and is characterized by fluctuating parasitemia, anemia, fever, lethargy, and weight loss. In this study we evaluated the virulence (capacity to multiply inside the host and to modulate the host response) and pathogenicity (ability to produce disease and/or mortality) patterns of two T. vivax strains (TvMT1 and TvLIEM176) in experimentally-infected sheep and determined the proteins differentially expressed in the proteomes of these two strains. Hematological and clinical parameters were monitored in experimentally-infected versus non-infected sheep for 60 days. All the infected animals developed discernable parasitemia at 3 days post-infection (dpi), and the first parasitemia peak was observed at 6 dpi. The maximum average value of parasitemia was 1.3×10
Language	English
Publishing date	2019-06-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vpoa.2019.100014
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