LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 123

Search options

  1. Article ; Online: Impact of the LEAVO Study in Asia.

    Zhang, Xinyuan / Lai, Timothy Y Y

    Eye (London, England)

    2019  Volume 34, Issue 2, Page(s) 211–212

    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Editorial
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-019-0710-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 603: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A cloth-based single-working-electrode electrochemiluminescence sensor for simultaneous detection of diabetes complication markers.

    Lai, Wei / Liang, Yi / Mao, Xinyuan / Xue, Kaifa / Zhang, Chunsun

    Analytica chimica acta

    2023  Volume 1254, Page(s) 341121

    Abstract: As one of the most common noninfectious diseases, diabetes and diabetic complications (DDC) have attracted great attention in the field of life and health. However, simultaneous detection of DDC markers usually requires labor- and time-consuming steps. ... ...

    Abstract As one of the most common noninfectious diseases, diabetes and diabetic complications (DDC) have attracted great attention in the field of life and health. However, simultaneous detection of DDC markers usually requires labor- and time-consuming steps. Here, a novel cloth-based single-working-electrode electrochemiluminescence (SWE-ECL) sensor was designed for the simultaneous detection of multiple DDC markers. For this sensor, three independent ECL cells are distributed on the SWE, which is a simplification of the configuration of traditional sensors for simultaneous detection. In this way, the modification processes and ECL reactions occur at the back of the SWE, eliminating the adverse effects caused by human intervention on the electrode. Under optimized conditions, glucose, uric acid and lactate were determined, with corresponding linear dynamic ranges of 80-4000 μM, 45-1200 μM and 60-2000 μM, and detection limits of 54.79 μM, 23.95 μM and 25.82 μM, respectively. In addition, the cloth-based SWE-ECL sensor exhibited good specificity and satisfactory reproducibility, and its actual application potential was verified by measuring complex human serum samples. Overall, this work developed a simple, sensitive, low-cost and rapid method for the simultaneous quantitative determination of multiple markers related to DDC and demonstrated a new route for multiple-marker detection.
    MeSH term(s) Humans ; Reproducibility of Results ; Luminescent Measurements/methods ; Electrodes ; Photometry ; Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Limit of Detection ; Diabetes Mellitus/diagnosis
    Language English
    Publishing date 2023-03-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341121
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Protocol for characterizing the inhibition of SARS-CoV-2 infection by a protein of interest in cultured cells.

    Lai, Xinyuan / Zhuang, Hui / Li, Tong / Xiang, Kuanhui

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101802

    Abstract: ... of this protocol, please refer to Lai et al. (2022). ...

    Abstract Here, we present a protocol to characterize the antiviral ability of a protein of interest to SARS-CoV-2 infection in cultured cells, using MUC1 as an example. We use SARS-CoV-2 ΔN trVLP system, which utilizes transcription and replication-competent SARS-CoV-2 virus-like particles lacking nucleocapsid gene. We describe the optimized procedure to analyze protein interference of viral attachment and entry into cells, and qRT-PCR-based quantification of viral infection. The protocol can be applied to characterize more antiviral candidates and clarify their functioning stage. For complete details on the use and execution of this protocol, please refer to Lai et al. (2022).
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Nucleocapsid ; Cell Line ; Antiviral Agents/pharmacology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101802
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Protocol for characterizing the inhibition of SARS-CoV-2 infection by a protein of interest in cultured cells

    Xinyuan Lai / Hui Zhuang / Tong Li / Kuanhui Xiang

    STAR Protocols, Vol 3, Iss 4, Pp 101802- (2022)

    2022  

    Abstract: ... of this protocol, please refer to Lai et al. (2022). : Publisher’s note: Undertaking any experimental protocol ...

    Abstract Summary: Here, we present a protocol to characterize the antiviral ability of a protein of interest to SARS-CoV-2 infection in cultured cells, using MUC1 as an example. We use SARS-CoV-2 ΔN trVLP system, which utilizes transcription and replication-competent SARS-CoV-2 virus-like particles lacking nucleocapsid gene. We describe the optimized procedure to analyze protein interference of viral attachment and entry into cells, and qRT-PCR-based quantification of viral infection. The protocol can be applied to characterize more antiviral candidates and clarify their functioning stage.For complete details on the use and execution of this protocol, please refer to Lai et al. (2022). : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Cell Biology ; Cell-based Assays ; Microbiology ; Molecular Biology ; Protein Bbiochemistry ; Science (General) ; Q1-390
    Subject code 570
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Biochemical and metabolomics analyses reveal the mechanisms underlying ascorbic acid and chitosan coating mediated energy homeostasis in postharvest papaya fruit.

    Zhou, Yan / Liu, Xiaocheng / Liang, Xinyuan / Li, Huangming / Lai, Jiahui / Liao, Yiran / Liu, Kaidong

    Food chemistry

    2023  Volume 439, Page(s) 138168

    Abstract: Papaya is a climacteric fruit that undergoes rapid ripening and quality deterioration during postharvest storage, resulting in significant economic losses. This study employed biochemical techniques and targeted metabolomics to investigate the impact of ... ...

    Abstract Papaya is a climacteric fruit that undergoes rapid ripening and quality deterioration during postharvest storage, resulting in significant economic losses. This study employed biochemical techniques and targeted metabolomics to investigate the impact of exogenous AsA + CTS application on the energy metabolism regulation of papaya fruit during postharvest storage. We found that AsA + CTS treatment significantly increased the levels of key metabolic compounds and enzymes, such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), and the energy charge, as well as the succinic acid content and the activities of succinic dehydrogenase (SDH), cytochrome c oxidase (CCO), H
    MeSH term(s) Fruit/chemistry ; Ascorbic Acid/analysis ; Chitosan/analysis ; Carica ; Homeostasis
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.138168
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Probing the functional hotspots inside protein hydrophobic pockets by

    Lai, Can / Tang, Zhiyao / Liu, Zheyi / Luo, Pan / Zhang, Wenxiang / Zhang, Tingting / Zhang, Wenhao / Dong, Zhe / Liu, Xinyuan / Yang, Xueming / Wang, Fangjun

    Chemical science

    2024  Volume 15, Issue 7, Page(s) 2545–2557

    Abstract: Due to the complex high-order structures and interactions of proteins within an aqueous solution, a majority of chemical functionalizations happen on the hydrophilic sites of protein external surfaces which are naturally exposed to the solution. However, ...

    Abstract Due to the complex high-order structures and interactions of proteins within an aqueous solution, a majority of chemical functionalizations happen on the hydrophilic sites of protein external surfaces which are naturally exposed to the solution. However, the hydrophobic pockets inside proteins are crucial for ligand binding and function as catalytic centers and transporting tunnels. Herein, we describe a reagent pre-organization and
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05106d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: Adaptive Control Strategy for Quadruped Robots in Actuator Degradation Scenarios

    Wu, Xinyuan / Dong, Wentao / Lai, Hang / Yu, Yong / Wen, Ying

    2023  

    Abstract: Quadruped robots have strong adaptability to extreme environments but may also experience faults. Once these faults occur, robots must be repaired before returning to the task, reducing their practical feasibility. One prevalent concern among these ... ...

    Abstract Quadruped robots have strong adaptability to extreme environments but may also experience faults. Once these faults occur, robots must be repaired before returning to the task, reducing their practical feasibility. One prevalent concern among these faults is actuator degradation, stemming from factors like device aging or unexpected operational events. Traditionally, addressing this problem has relied heavily on intricate fault-tolerant design, which demands deep domain expertise from developers and lacks generalizability. Learning-based approaches offer effective ways to mitigate these limitations, but a research gap exists in effectively deploying such methods on real-world quadruped robots. This paper introduces a pioneering teacher-student framework rooted in reinforcement learning, named Actuator Degradation Adaptation Transformer (ADAPT), aimed at addressing this research gap. This framework produces a unified control strategy, enabling the robot to sustain its locomotion and perform tasks despite sudden joint actuator faults, relying exclusively on its internal sensors. Empirical evaluations on the Unitree A1 platform validate the deployability and effectiveness of Adapt on real-world quadruped robots, and affirm the robustness and practicality of our approach.

    Comment: 13 pages, 14 figures, in proceeding of DAI'23
    Keywords Computer Science - Robotics ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
    Subject code 629
    Publishing date 2023-12-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Rationally designed calcium carbonate multifunctional trap for contaminants adsorption.

    Sheng, Xin / Chen, Shengnan / Zhao, Zhiwei / Li, Li / Zou, Yuanpeng / Shi, Hui / Shao, Penghui / Yang, Liming / Wu, Jingsheng / Tan, Yaofu / Lai, Xinyuan / Luo, Xubiao / Cui, Fuyi

    The Science of the total environment

    2023  Volume 903, Page(s) 166142

    Abstract: Adsorption technology has been widely developed to control environmental pollution, which plays an important role in the sustainable development of modern society. Calcium carbonate ( ... ...

    Abstract Adsorption technology has been widely developed to control environmental pollution, which plays an important role in the sustainable development of modern society. Calcium carbonate (CaCO
    Language English
    Publishing date 2023-08-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.166142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Metal element-based adsorbents for phosphorus capture: Chaperone effect, performance and mechanism.

    Sheng, Xin / Chen, Shengnan / Zhao, Zhiwei / Li, Li / Zou, Yuanpeng / Shi, Hui / Shao, Penghui / Yang, Liming / Wu, Jingsheng / Tan, Yaofu / Lai, Xinyuan / Luo, Xubiao / Cui, Fuyi

    Chemosphere

    2024  Volume 352, Page(s) 141350

    Abstract: Excessive phosphorus (P) enters the water bodies via wastewater discharges or agricultural runoff, triggering serious environmental problems such as eutrophication. In contrast, P as an irreplaceable key resource, presents notable supply-demand ... ...

    Abstract Excessive phosphorus (P) enters the water bodies via wastewater discharges or agricultural runoff, triggering serious environmental problems such as eutrophication. In contrast, P as an irreplaceable key resource, presents notable supply-demand contradictions due to ineffective recovery mechanisms. Hence, constructing a system that simultaneously reduce P contaminants and effective recycling has profound theoretical and practical implications. Metal element-based adsorbents, including metal (hydro) oxides, layered double hydroxides (LDHs) and metal-organic frameworks (MOFs), exhibit a significant chaperone effect stemming from strong orbital hybridization between their intrinsic Lewis acid sites and P (Lewis base). This review aims to parse the structure-effect relationship between metal element-based adsorbents and P, and explores how to optimize the P removal properties. Special emphasis is given to the formation of the metal-P chemical bond, which not only depends on the type of metal in the adsorbent but also closely relates to its surface activity and pore structure. Then, we delve into the intrinsic mechanisms behind these adsorbents' remarkable adsorption capacity and precise targeting. Finally, we offer an insightful discussion of the prospects and challenges of metal element-based adsorbents in terms of precise material control, large-scale production, P-directed adsorption and effective utilization.
    MeSH term(s) Phosphorus ; Water Pollutants, Chemical/analysis ; Metals ; Wastewater ; Hydroxides ; Adsorption
    Chemical Substances Phosphorus (27YLU75U4W) ; Water Pollutants, Chemical ; Metals ; Wastewater ; Hydroxides
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141350
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Pre-diagnostic plasma proteomics profile for hepatocellular carcinoma.

    Zhang, Xinyuan / Zhao, Longgang / Ngo, Long H / Dillon, Simon T / Gu, Xuesong / Lai, Michelle / Simon, Tracey G / Chan, Andrew T / Giovannucci, Edward L / Libermann, Towia A / Zhang, Xuehong

    Journal of the National Cancer Institute

    2024  

    Abstract: Objective: Proteomics may discover pathophysiological changes related to hepatocellular carcinoma (HCC), an aggressive and lethal type of cancer with low sensitivity for early-stage diagnosis.: Design: We measured 1,305 pre-diagnostic (median 12.7 ... ...

    Abstract Objective: Proteomics may discover pathophysiological changes related to hepatocellular carcinoma (HCC), an aggressive and lethal type of cancer with low sensitivity for early-stage diagnosis.
    Design: We measured 1,305 pre-diagnostic (median 12.7 years) SOMAscan proteins from 54 pairs of healthy individuals who subsequently developed HCC and matched non-HCC controls from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Candidate proteins were validated in the independent, prospective UK Biobank Pharma Proteomics Project (UKB-PPP).
    Results: In NHS/HPFS, we identified 56 elevated proteins in HCC with absolute fold-change >1.2 and Wald test P < .05 in conditional logistic regression analysis. Ingenuity Pathway Analysis identified enrichment of pathways associated with cell viability, adhesion, proteolysis, apoptosis, and inflammatory response. Four proteins, chitinase-3-like protein 1, growth/differentiation factor 15, interleukin-1 receptor antagonist protein, and E-selectin, showed strong positive associations with HCC and were thus validated by ELISA (odds ratio ranged 2.48-14.7, all P < .05) in the NHS/HPFS and by Olink platform (hazard ratio ranged 1.90-3.93, all P < .05) in the UKB-PPP. Adding these four proteins to a logistic regression model of traditional HCC risk factors increased the area under the curve (AUC) from 0.67 to 0.87 in the NHS/HPFS. Consistently, model AUC was 0.88 for HCC risk prediction in the UKB-PPP.
    Conclusion: However, the limited number of HCC cases in the cohorts necessitates caution in interpreting our findings, emphasizing the need for further validation in high-risk populations.
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djae079
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top