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  1. Article ; Online: Identifying Barriers to Career Progression for Women in Science: Is COVID-19 Creating New Challenges?

    Hansen, Diana S

    Trends in parasitology

    2020  Volume 36, Issue 10, Page(s) 799–802

    Abstract: This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career progression in science for women and minority groups, along with suggestions to overcome ... ...

    Abstract This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career progression in science for women and minority groups, along with suggestions to overcome ongoing roadblocks, are discussed. The emerging challenges that coronavirus disease 2019 (COVID-19) is bringing to this sector are also considered.
    MeSH term(s) COVID-19 ; Career Mobility ; Coronavirus Infections ; Female ; Humans ; Pandemics ; Pneumonia, Viral ; Science/statistics & numerical data ; Women's Rights/trends
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2020.07.016
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  2. Article ; Online: Identifying Barriers to Career Progression for Women in Science

    Hansen, Diana S.

    Trends in Parasitology

    Is COVID-19 Creating New Challenges?

    2020  Volume 36, Issue 10, Page(s) 799–802

    Keywords Parasitology ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2020.07.016
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Identifying Barriers to Career Progression for Women in Science: Is COVID-19 Creating New Challenges?

    Hansen, Diana S

    Trends parasitol

    Abstract: This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career progression in science for women and minority groups, along with suggestions to overcome ... ...

    Abstract This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career progression in science for women and minority groups, along with suggestions to overcome ongoing roadblocks, are discussed. The emerging challenges that coronavirus disease 2019 (COVID-19) is bringing to this sector are also considered.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #694089
    Database COVID19

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  4. Article: Identifying Barriers to Career Progression for Women in Science: Is COVID-19 Creating New Challenges?

    Hansen, Diana S

    Trends in parasitology. 2020 Oct., v. 36, no. 10

    2020  

    Abstract: This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career progression in science for women and minority groups, along with suggestions to overcome ... ...

    Abstract This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career progression in science for women and minority groups, along with suggestions to overcome ongoing roadblocks, are discussed. The emerging challenges that coronavirus disease 2019 (COVID-19) is bringing to this sector are also considered.
    Keywords Coronavirus infections ; Orthocoronavirinae ; gender ; malaria ; minorities (people) ; parasitology ; women
    Language English
    Dates of publication 2020-10
    Size p. 799-802.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2020.07.016
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: CyTOF mass cytometry analysis of human memory CD4

    Ioannidis, Lisa J / Mitchell, Andrew J / Zheng, Tian / Hansen, Diana S

    STAR protocols

    2022  Volume 3, Issue 2, Page(s) 101269

    Abstract: High-dimensional mass cytometry provides unparalleled insight into the cellular composition of the immune system. Here, we describe a mass-cytometry-based protocol to examine memory ... ...

    Abstract High-dimensional mass cytometry provides unparalleled insight into the cellular composition of the immune system. Here, we describe a mass-cytometry-based protocol to examine memory CD4
    MeSH term(s) CD4-Positive T-Lymphocytes ; Flow Cytometry/methods ; Humans ; Lymphocyte Count ; Memory B Cells ; T-Lymphocytes
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development of B Cell Memory in Malaria.

    Ly, Ann / Hansen, Diana S

    Frontiers in immunology

    2019  Volume 10, Page(s) 559

    Abstract: A single exposure to many viral and bacterial pathogens typically induces life-long immunity, however, the development of the protective immunity ... ...

    Abstract A single exposure to many viral and bacterial pathogens typically induces life-long immunity, however, the development of the protective immunity to
    MeSH term(s) Animals ; Antibodies, Protozoan/immunology ; Antigens, Protozoan/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Humans ; Immunologic Memory ; Malaria/immunology ; Malaria/pathology ; Mice ; Plasmodium/immunology
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan
    Language English
    Publishing date 2019-04-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: IgM

    Pietrzak, Halina M / Ioannidis, Lisa J / Hansen, Diana S

    Parasitology

    2020  Volume 147, Issue 9, Page(s) 994–998

    Abstract: Emerging evidence started to delineate multiple layers of memory B cells, with distinct effector functions during recall responses. Whereas most studies examining long-lived memory B cell responses have focussed on the IgG+ memory B cell compartment, IgM+ ...

    Abstract Emerging evidence started to delineate multiple layers of memory B cells, with distinct effector functions during recall responses. Whereas most studies examining long-lived memory B cell responses have focussed on the IgG+ memory B cell compartment, IgM+ memory B cells have only recently started to receive attention. It has been proposed that unlike IgG+ memory B cells, which differentiate into antibody-secreting plasma cells upon antigen re-encounter, IgM+ memory B cells might have the additional capacity to establish secondary germinal centre (GC) responses. The precise function of IgM+ memory B cells in the humoral immune response to malaria has not been fully defined. Using a murine model of severe malaria infection and adoptive transfer strategies we found that IgM+ memory B cells induced in responses to P. berghei ANKA readily proliferate upon re-infection and adopt a GC B cell-like phenotype. The results suggest that that IgM+ memory B cells might play an important role in populating secondary GCs after re-infection with Plasmodium, thereby initiating the induction of B cell clones with enhanced affinity for antigen, at faster rates than naive B cells.
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Coinfection/parasitology ; Germinal Center/parasitology ; Immunoglobulin M/immunology ; Mice ; Mice, Inbred C57BL ; Plasmodium berghei/immunology
    Chemical Substances Immunoglobulin M
    Language English
    Publishing date 2020-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207627-5
    ISSN 1469-8161 ; 0031-1820
    ISSN (online) 1469-8161
    ISSN 0031-1820
    DOI 10.1017/S003118202000061X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Role of Financial Security on Physical and Mental Health in Young-Midlife Couples Surviving Cancer.

    Lyons, Karen S / Firkins, Jenny / Hanan, Diana M / Hansen, Lissi / Hayes-Lattin, Brandon

    Cancer nursing

    2022  Volume 45, Issue 3, Page(s) 242–248

    Abstract: Background: A cancer diagnosis carries a significant economic burden. Yet little is known about perceived financial security on the health of couples with a partner diagnosed with cancer.: Objective: The current study explored perceived financial ... ...

    Abstract Background: A cancer diagnosis carries a significant economic burden. Yet little is known about perceived financial security on the health of couples with a partner diagnosed with cancer.
    Objective: The current study explored perceived financial security in young-midlife couples.
    Methods: The study included 49 couples (aged 27-58 years) 1 to 3 years after diagnosis. Multilevel modeling was used to examine the association of perceived financial security on physical and mental health of couples controlling for interdependent data; hierarchical linear regression was used to examine perceived financial security on survivor symptoms and partner care strain.
    Results: Mean age of survivors was 43.5 (±9.0) years. Most survivors were female (69%) and 2.2 (±0.6) years after diagnosis. Lower levels of perceived financial security were significantly associated with poorer physical (P < .001) and mental (P < .05) health status for survivors, controlling for age, sex, education, and years since diagnosis; there were no significant associations with partner health status. Lower levels of perceived financial security were significantly associated with higher survivor pain severity (P < .001), pain interference (P < .001), and fatigue (P < .01); there was no significant association with partner care strain.
    Conclusions: Financial security plays a role on the physical and mental health of couples after diagnosis.
    Implications for practice: Screening for financial hardship at diagnosis and posttreatment can identify couples at high risk and in need of additional resources and counseling. Greater assessment and reporting of financial security in studies of families surviving cancer are needed to understand the impact on health outcomes.
    MeSH term(s) Adult ; Fatigue ; Female ; Health Status ; Humans ; Male ; Mental Health ; Middle Aged ; Neoplasms/psychology ; Survivors
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391995-x
    ISSN 1538-9804 ; 0162-220X
    ISSN (online) 1538-9804
    ISSN 0162-220X
    DOI 10.1097/NCC.0000000000001028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: CyTOF mass cytometry analysis of human memory CD4+ T cells and memory B cells

    Lisa J. Ioannidis / Andrew J. Mitchell / Tian Zheng / Diana S. Hansen

    STAR Protocols, Vol 3, Iss 2, Pp 101269- (2022)

    2022  

    Abstract: Summary: High-dimensional mass cytometry provides unparalleled insight into the cellular composition of the immune system. Here, we describe a mass-cytometry-based protocol to examine memory CD4+ T cell and memory B cell (MBC) responses in human ... ...

    Abstract Summary: High-dimensional mass cytometry provides unparalleled insight into the cellular composition of the immune system. Here, we describe a mass-cytometry-based protocol to examine memory CD4+ T cell and memory B cell (MBC) responses in human peripheral blood. This approach allows for the identification of >50 distinct memory CD4+ T cell and MBC populations from a single clinical sample. This highly reproducible protocol has been successfully applied to multiple infectious disease settings to identify correlates of susceptibility or protection from infection.For complete details on the use and execution of this protocol, please refer to Ioannidis et al. (2021).
    Keywords Cell Biology ; Flow Cytometry/Mass Cytometry ; Health Sciences ; Immunology ; Systems biology ; Science (General) ; Q1-390
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A mixed methods study of perceptions of bias among neonatal intensive care unit staff.

    Fraiman, Yarden S / Cheston, Christine C / Morales, Diana / Leeman, Kristen T / Hansen, Anne R

    Pediatric research

    2022  Volume 93, Issue 6, Page(s) 1672–1678

    Abstract: Background: Inequity in neonatology may be potentiated within neonatal intensive care units (NICUs) by the effects of bias. Addressing bias can lead to improved, more equitable care. Understanding perceptions of bias can inform targeted interventions to ...

    Abstract Background: Inequity in neonatology may be potentiated within neonatal intensive care units (NICUs) by the effects of bias. Addressing bias can lead to improved, more equitable care. Understanding perceptions of bias can inform targeted interventions to reduce the impact of bias. We conducted a mixed methods study to characterize the perceptions of bias among NICU staff.
    Methods: Surveys were distributed to all staff (N = 245) in a single academic Level IV NICU. Respondents rated the impact of bias on their own and others' behaviors on 5-point Likert scales and answered one open-ended question. Kruskal-Wallis test (KWT) and Levene's test were used for quantitative analysis and thematic analysis was used for qualitative analysis.
    Results: We received 178 responses. More respondents agreed that bias had a greater impact on others' vs. their own behaviors (KWT p < 0.05). Respondents agreed that behaviors were influenced more by implicit than explicit biases (KWT p < 0.05). Qualitative analysis resulted in nine unique themes.
    Conclusions: Staff perceive a high impact of bias across different domains with increased perceived impact of implicit vs. explicit bias. Staff perceive a greater impact of others' biases vs. their own. Mixed methods studies can help identify unique, unit-responsive approaches to reduce bias.
    Impact: Healthcare staff have awareness of bias and its impact on their behaviors with patients, families, and staff. Healthcare staff believe that implicit bias impacts their behaviors more than explicit bias, and that they have less bias than others. Healthcare staff have ideas for strategies and approaches to mitigate the impact of bias. Mixed method studies are effective ways of understanding environment-specific perceptions of bias, and contextual assets and barriers when creating interventions to reduce bias and improve equity. Generating interventions to reduce the impact of bias in healthcare requires a context-specific understanding of perceptions of bias among staff.
    MeSH term(s) Infant, Newborn ; Humans ; Intensive Care Units, Neonatal ; Neonatology ; Attitude of Health Personnel ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-02217-2
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